• Molecules and Cells
• /
• 제44권9호
• /
• pp.680-687
• /
• 2021

Coronavirus disease, COVID-19 (coronavirus disease 2019), caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), has a higher case fatality rate in European countries than in others, especially East Asian ones. One potential explanation for this regional difference is the diversity of the viral infection efficiency. Here, we analyzed the allele frequencies of a nonsynonymous variant rs12329760 (V197M) in the TMPRSS2 gene, a key enzyme essential for viral infection and found a significant association between the COVID-19 case fatality rate and the V197M allele frequencies, using over 200,000 present-day and ancient genomic samples. East Asian countries have higher V197M allele frequencies than other regions, including European countries which correlates to their lower case fatality rates. Structural and energy calculation analysis of the V197M amino acid change showed that it destabilizes the TMPRSS2 protein, possibly negatively affecting its ACE2 and viral spike protein processing.

• Journal of Nutrition and Health
• /
• 제4권3호
• /
• pp.5-12
• /
• 1971

For the measurement of the fat contents and nutritional status of urban High School girls, an intensive examination was conducted on a total of 2,085 students from 13 to 19 years of age groups. Total body fat cotents were measured by Skin-fold thickness with a Skin-fold Caliper manufactured by Cambridge Scientific Industrial Inc. at four sites of the body and it was calculated by Kim's regression equation. And Heights, Weights, and Chest circumferences were measured with Martin's Anthropometer. As the results of this study, the following conclusions were obtained: 1. The averages of heights, weights and chest girths were 153.1 cm, 46.2 kg and 76.6 cm. respectively. 2. The mean Skin-fold thicknesses of each site measured with a Lange skin-fold Caliper were: Sub-scapular: $13.44\;mm{\pm}4.41\;mm$. Abdominal : $10.55\;mm{\pm}4.02\;mm$. Lumbar: $10.56\;mm{\pm}4.06\;mm$. Upper arm: $15.35\;mm{\pm}4.37\;mm$. Total Average: $12.46\;mm{\pm}4.48\;mm$. 3. The average Skin-fold thicknesaes by age were as follow: ·9.02 mm at 13 years of age. 10.04 at 14, 11.82 at 15, 14.43 at 16, 15.12 at 17, 16.48 at 18, and 16.61 at 19 respectively. 4. The mean of fat contents calculated according to regression equation was 11.04kg. (9.14 at 13, 9.98 at 14, 11.12 at 15, 11.74 at 16, 12.21 at 17, 12.96 at 18, 13.29 at 19 respectively.)

• 천문학회보
• /
• 제44권2호
• /
• pp.37.3-37.3
• /
• 2019

We study the stellar populations of the brightest group galaxies (BGGs) in groups whose halos have different dynamical states, using observational data from the GAMA survey. The two independent indicators to probe the dynamical state of the halo are the magnitude gap between two most luminous galaxies (∆M12) and offset between BGG and the luminosity center (Doffset) of the group. Such indicators complement each other in identifying relaxed and unrelaxed galaxy groups in our samples. We find that the BGGs of unrelaxed groups have significantly bluer NUV-r colours than in relaxed groups. This is also true at fixed sersic index. We find the bluer colours cannot be explained away by differing dust fraction, suggesting there are real differences in their stellar populations. SFRs derived from SED-fitting tend to be higher in unrelaxed systems. This could be partly because there is a greater fraction of BGGs with non-elliptical morphology, but also because unrelaxed systems are expected to have larger numbers of mergers, some of which may bring fuel for star formation. The SED-fitted stellar metallicities of BGGs in unrelaxed systems also tend to be higher, perhaps because the building blocks of the unrelaxed systems were more massive and had more time to enrich themselves. We find that the ∆M12 parameter is the most important parameter behind the observed differences in the relaxed/unrelaxed groups. We also find that groups selected to be unrelaxed using our criteria tend to have higher velocity offsets between the BGG and their group.

• Tuberculosis and Respiratory Diseases
• /
• 제41권2호
• /
• pp.135-143
• /
• 1994

연구목적 : 혈청 sIL-2R 농도는 T세포의 면역활성화가 관여되는 육아종성질환, 장기이식, 자가면역질환에서, 또한 혈액종양 및 림프세망내 피계종양등에서 증가 한다고 알려져있다. 최근 결핵환자에서도 질병의 활성화 정도에 따라 혈청 및 흉강 삼출액에서 sIL-2R 농도의 증가를 보고하고 있다. 임상에서 결핵성 흉강삼출과 악성 흉강삼출의 감별이 어려운 경우를 경험하게 되는데 흉강삼출액에서 sIL-2R 농도 측정이 이들 질환의 감별에 도움이 될수 있는지 알아보기 위해 늑막조직검사에서 결핵성으로 확인된 12명의 결핵성 흉강삼출액환자와 32명의 비결핵성 흉강 삼출액환자를 대상으로 혈청 및 흉강삼출액에서 sIL-2R 농도를 측정하였다. 방법 : 대상환자의 늑막삼출액을 원심분리하여 얻은 상층액과 동시에 채취한 혈청을 $-70^{\circ}C$에 보관한 후 검사를 시행하였다. 가용성 IL-2수용체 농도 측정은 Cellfree(r) IL-2R test kit(T-cell sciences Inc., Cambridge, MA, USA)를 이용하였다. 측정방법을 간단히 설명하면 IL-2R 분자의 두가지 항원 결정기(epitope)에 대한 단일 항체를 이용한 샌드위치 ELISA 검사로 측정하였다. 결과 : 1) 늑막삼출액의 sIL-2R 농도는 비결핵성 늑막삼출환자군보다 결핵성 늑막삼출환자군에서 높았다(p<0.005). 2) 늑막삼출액에서 감별진단 기준을 sIL-2R 농도 5,000u/ml로 할 경우 결핵성 늑막삼출환자군을 악성 늑막삼출환자군과 비교시 민감도는 84.6%, 특이도는 99.9%였다. 3) 혈청 sIL-2R 농도는 결핵성 늑막삼출환자군에서 세균성 늑막 삼출환자군보다 유의한 증가를 보였으나(p<0.05), 악성 늑막 삼출환자군 및 늑막여출액환자군과는 유의한 차이가 없었다(p>0.05). 4) 결핵성 늑막삼출환자군에서 sIL-2R 농도는 혈청에서보다 늑막삼출액에서 더 높았다(p<0.005). 결론 : 결핵성 늑막삼출에서 늑막삼출액내의 sIL-2R 농도는 감별기준 5,000 u/ml로 사용할 경우 결핵성 늑막삼출과 비결핵성 늑막삼출의 감별진단에 도움이 되리라 생각된다.

• Journal of Microbiology
• /
• 제40권1호
• /
• pp.11-19
• /
• 2002

Mice immunized with equine herpesvirus type-1(EHV-1) L-particles skewed a significant increase (p<7.75) in serum antibody titers. Upon a booster dose four weeks lateral antibody titers increased significantly. Interestingly, immunization via intravenous or intramuscular route induced significantly higher (p<0.75) antibody titers. However, mice iummunized with UV-treated L-particles, visions or immunization via intranasal route induced lower antibody titers. Upon challenge inoculation with wildtype EHV-1, our data showed there was a poor correlation between antibody titers and protection against virus replication. Therefore, the role of cell-mediated immunity Inwards protection was investigated. As predicted, the strongest cell-mediated immunity, as measured by delayed-hypersensitivity test, was detected in mice immunized with live virus particles. The magnitude of cell-mediated immune response correlated with the efficacy of L-particles as immunizing agent. The highest efficacy, as indicated in mice immunized via intranasal routed was highly correlated with cell-mediated immunity. A similar phenomenon was also demonstrated in mice immunized intranasally with UV-treated L-particles. However, the degree of protection was reduced when mice immunized intravenously or intramuscularly with UV-treated L-particles. In conclusion, protection conferred in these animals was highly implicated by immune cells and the least by antibodies. The route of immunization and the nature of the antigen also contributed to the efficacy of L-particles as immunizing agent. In contrast to that of herpes simplex virus type 1, our data showed EHV-1 non-infectious L-particles are highly suitable for immunization of the host against EHV-1 disease.

• STI Policy Review
• /
• 제5권1호
• /
• pp.1-33
• /
• 2014

Despite a commonly held belief that standards obstruct innovation, recent research shows that they can actually play critical roles in supporting various activities of technological innovation. Thus, providing an innovation-friendly environment through standardization has been gaining much attention in recent years; however, there is as yet limited understanding, due to complex dynamics and high uncertainties associated with innovation, as well as a variety of different types and functions of standards with various stakeholders involved. The problem becomes even more challenging for standardization in highly complex systems, such as Information and Communication Technology (ICT) systems, where a large number of domains and components are involved, along with various types of stakeholders. In order to deal with such complexity and variations, a systematic approach of standardization roadmapping has been used in many technology-leading countries as a strategic policy tool for supporting effective management of standardization. Despite its wide adoption, the current understanding of standardization roadmapping is somewhat limited, leaving significant challenges for policymakers and standards organizations in terms of how to structure and manage roadmapping exercises, and how the government should get involved. In this regard, the current research explores existing standardization roadmaps in various contexts related to ICT systems (ICT in Korea, Smart Grid in the US, and electromobility in Germany), as there is a particular need for systematic development of strategies for such complex systems of ICT. Focusing on various aspects of standardization roadmapping exercises such as their structures, processes, and participants, their common features and key characteristics are identified. Comparing these roadmaps also reveal distinct differences between standardization roadmapping approaches adopted by different countries in different contexts. Based on lessons learnt from existing practices, the study finally provides insight for the Korean ICT standards community on the ways in which their standardization roadmapping approach can be improved to support anticipatory management of standardization activities more effectively. It is expected that the current research can not only provide increased understanding of standardization roadmaps, but also help policymakers and standards organizations to develop more effective strategies for supporting innovation through the systematic management of standardization.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권4호
• /
• pp.2429-2432
• /
• 2013

Background and Objectives: Yanting in Sichuan Province is one of the highest risk areas of esophageal cancer (EC) in the world. We here summarize the epidemiology of EC in Yanting using data from the national screening programme during 2006-2011. Methods: Random cluster sampling was used to select a proportion of natural villages from six towns in Yanting, and residents aged 40-69 years old were invited for screening. Participants were screened using endoscopy with iodine staining and then confirmed by histological examinations. Results: The overall detection rates of low-grade hyperplasia (LH), moderate hyperplasia (MH), high-grade hyperplasia (HH), carcinoma in situ (CIS), intramucosal carcinoma (IC) and invasive carcinoma (INC) were 5.33%, 1.28%, 0.68%, 0.15%, 0.06% and 0.29%, respectively. The detection rates of LH, MH, HH and INC increased with age, reaching the peak among those aged 60-65 years, and the prevalences of LH and MH were higher among men than among women. In addition, the detection rates of hyperplasia were much higher in mountainous than in hilly areas. Conclusions: Among the high risk population, there are a great number of people with early-stage EC or precancerous conditions who do not have presenting symptoms. In particular, the elderly, men, or those living in mountainous areas are the most vulnerable population. It is therefore important to reinforce health education and screening services among such high risk populations.

• 한국통신학회논문지
• /
• 제33권9B호
• /
• pp.822-831
• /
• 2008

본 논문은 국내 인터넷접속서비스 시장의 괄목할 만한 성장을 이해하기 위한 수요의 동태적확산패턴을 분석, 고찰하는 것을 목적으로 한다. 서비스 제공사업자의 경쟁 강도를 반영한 시장구조 측면과 기술간 및 기술내 경쟁을 반영한 기술경쟁 측면을 고려한 인터넷접속서비스의 동태적 확산 과정을 모형화 하여 국내 인터넷접속서비스를 대상으로 실증분석 하였다. 분석결과 기술간 및 기술내 경쟁 그리고 시장경쟁의 강도가 서비스 확산에 양의 결과를 보이고 있음을 통계적으로 확인하였으며, 이에 따른 전략적, 정책적 시사점을 제시하였다.

• Journal of Magnetics
• /
• 제6권2호
• /
• pp.47-52
• /
• 2001

We present the magnetisation reversal dynamics of epitaxial Fe thin films grown on GaAs(001) and InAs(001) studied as a function of field sweep rate in the range 0.01-160 kOe/s using magneto-optic Kerr effect (MOKE). For 55 and 250 ${\AA}$ Fe/GaAs(001), we find that the hysteresis loop area A follows the scaling relation $A\propto H_{\alpha} \;with\; \alpha=0.03\sim0.05$ at low sweep rates and 0.33~0.40 at high sweep rates. For the 150${\AA}$ Fe/InAs(001) film, $\alpha$is found to be ~0.02 at low sweep rates and ~0.17 at high sweep rates. The differing values of $\alpha$ are attributed to a change of the magnetisation reversal process with increasing sweep rate. Domain wall motion dominates the magnetisation reversal at low sweep rates, but becomes less significant with increasing sweep rate. At high sweep rates, the variation of the dynamic coercivity $H_c{^*}$ is attributed to domain nucleation dominating the reversal process. The results of magnetic relaxation studies for easy-axis reversal are consistent with the sweeping of one or more walls through the entire probed region (~100$\mu m$). Domain images obtained by scanning Kerr microscopy during the easy cubic axis reversal process reveal large area domains separated by zigzag walls.

• 한국음향학회지
• /
• 제24권7호
• /
• pp.423-430
• /
• 2005

본 논문에서는 차량환경에서 잔향과 근접장 효과에 의해 발생하는 목적 음성 신호의 왜곡을 감소시킬 수 있는 마이크로폰 어레이 빔형성 기법을 제안하였다. 온라인으로 추정하기 어려운 소스와 마이크간의 전달함수 대신 상대적으로 추정이 용이한 기준 마이크와 다른 마이크간의 상대전달함수를 조향 벡터로 이용함으로써, 원격장 모델의 조향 벡터를 이용한 빔형성기에 비해 목적 음성 신호의 왜곡을 감소시킬 수 있는 준최적 빔형성 기법을 제안하였다. 제안된 방법의 성능을 검증하기 위해, 실제 차량에서 녹음된 음성 DB를 구축하고, 이를 이용하여 HTK를 통한 음성인식 실험을 수행하였다. 음성인식 실험 결과 원격장 모델을 이용한 방법보다 인식률이 최대 $15\%$까지 향상됨을 확인하였다.