• Proceedings of the Korean Society of Plant Biotechnology Conference
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• 2005.04a
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• pp.199-199
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• 2005

• Journal of Microbiology and Biotechnology
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• v.34 no.4
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• pp.828-837
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• 2024

Vancomycin (VAN) and metronidazole (MTR) remain the current drugs of choice for the treatment of non-severe Clostridioides difficile infection (CDI); however, while their co-administration has appeared in clinical treatment, the efficacy varies greatly and the mechanism is unknown. In this study, a CDI mouse model was constructed to evaluate the therapeutic effects of VAN and MTR alone or in combination. For a perspective on the intestinal ecology, 16S rRNA amplicon sequencing and non-targeted metabolomics techniques were used to investigate changes in the fecal microbiota and metabolome of mice under the co-administration treatment. As a result, the survival rate of mice under co-administration was not dramatically different compared to that of single antibiotics, and the former caused intestinal tissue hyperplasia and edema. Co-administration also significantly enhanced the activity of amino acid metabolic pathways represented by phenylalanine, arginine, proline, and histidine, decreased the level of deoxycholic acid (DCA), and downregulated the abundance of beneficial microbes, such as Bifidobacterium and Akkermansia. VAN plays a dominant role in microbiota regulation in co-administration. In addition, co-administration reduced or increased the relative abundance of antibiotic-sensitive bacteria, including beneficial and harmful microbes, without a difference. Taken together, there are some risks associated with the co-administration of VAN and MTR, and this combination mode should be used with caution in CDI treatment.

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2002.11a
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• pp.166-166
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• 2002

• International Journal of Computer Science & Network Security
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• v.22 no.8
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• pp.81-86
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• 2022

Digital technologies in the regional sector of public administration are the basis for its reform and a potential example for the whole country on how to use the benefits of the "digital" world. The synergistic potential of social, mobile, "cloud" technologies, as well as data analysis technologies and the "Internet of Things" can collectively lead to transformational changes in public administration and in general, that is, make the use of digital technologies for the economic development of the region in the system of digitalization of public administration effective, reactive and valuable. Thus, the purpose of the study is to identify modern prospects and realities of the development of digital technologies for the economic development of the region in the system of digitalization of public administration. As a result of the study, the main mechanisms and systems of digital technologies for the economic development of the region in the system of digitalization of public administration were analyzed.

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2004.11a
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• pp.103-103
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• 2004

• Proceedings of the PSK Conference
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• 2002.04a
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• pp.207.3-208
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• 2002

• Journal of the Korean Institute of Educational Facilities
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• v.3 no.3
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• pp.5-13
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• 1996

The university administration building is one of the most important structure in campuses in terms of its functional roll providing all the institutional services and its symbolic value that represents the school. But we can still find many universities carrying on without administration buildings, And even though in the cases that have their own administration buildings, the architectural qualities of the buildings often can not meet the basic requirements for a worthwhile administration building. Because of its complex and complicated nature, planning and designing university administrative facilities are not an easy task to be successful. This study aims to provide the basic directions in designing university administration building through the survey of the facilities in the existing campuses.

• International Journal of Advanced Culture Technology
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• v.10 no.4
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• pp.23-244
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• 2022

The Pulpose of this systematic review is aimed to establish the procedure of the injection with saftey and efficiency in the pre-hospital cardiac arrest patient performing the cardiopulmonary resuscitation (CPR), compared with traditional medication administration using Ampoule and medication administration with Prefilled Syringe. Databases were searched for CPR, heart arrest, resuscitation, Pre-filled Syringe, and Ampoule by the electronic data research including Pubmed, EMBASE and Cochran Library of Konyang University Library: 4 articles were selected by three co-authors using EndNote X20 and Covidence (Covidence.org) and were systematically reviewed. The Result of this study, the medication administration using Pre-fillled Syringe improves the safety of patients and Emergency medical workers by reducing the error in administration dose and administering the drug in safe than the medication adminisrtaion using Ampoule, also, contributes to the increment of survival rate of cardiac arrest and severe patients by decreasing the administration time that prevents the delay of medication administration.

• The Journal of Korean Medicine
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• v.19 no.1
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• pp.349-357
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• 1998

The aim of this experiments was to investigate the effect of Semen Plantaginis extract on. the renal function, plasma renin activity, plasma levels of atrial natriuretic peptide and aldosterone in rats. The results obtained were as follows: 1. Water balance decreased significantly after the administration of Semen Plantaginis extract. 2. Urine volume increased significantly after the administration of Semen Plantaginis extract, 0.1ml/200g. 3. Urinary excretion of sodium decreased significantly after the administration of Semen Plantaginis extract, 0.1 ml/200 g, 2week. 4. Urinary excretion of potassium decreased significantly after the administration of Semen Plantaginis extract, 0.1 ml/200 g, 2week. 5. Urinary excretion of chloride decreased significantly after the administration of Semen Plantaginis extract. 6. Free water clearance increased significantly after the administration of Semen Plantaginis extract 0.1 ml/200 g, 2 week and 0.2 ml/200 g. 7. Urinary excretion of creatinine increased significantly after the administration of Semen Plantaginis extract. 8. Plasma renin activity decreased significantly after the administration of Semen Plantaginis extract, 0.2 ml/200 g. 9. Plasma levels of aldosterone decreased significantly after the administration of Semen Plantaginis extract. 10. Plasma levels of atrial natriuretic peptide (ANP) decreased significantly after the administration of Semen Plantaginis extract.

• 한국약용작물학회:학술대회논문집
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• 2012.05a
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• pp.55-56
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• 2012