• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2005년도 생물공학의 동향(XVII)
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• pp.629-630
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• 2005

• 가정과삶의질연구
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• 제30권1호
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• pp.1-13
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• 2012

The purposes of this study were to find the correlation of family abuse experience, social maladaptation, ego resilience and daily life satisfaction in university students, and to explore the mediating role between ego resilience between family abuse experience, social maladaptation and daily life satisfaction. The subjects were 265 university students. The data were analyzed with frequency, Pearson's correlation and structural equation modeling by SPSS and AMOS. Instruments were Bradburn(1969)'s The Structure of Psychological Well-being, Olson and Barnes(1982)' Quality of Life, Straus(1988)'s CTSPC(Parent-Child Conflict Tactics Scales), Shin(2001)'s social maladaptation of Korean General Health, and Block and Kremen(1996)'s ego resilience. The major findings were as follows; Family abuse experience and social maladaptation were negatively correlated with ego resilience and daily life satisfaction. Ego resilience was positively correlated with daily life satisfaction. Ego resilience mediated the effects of family abuse experience, social maladaptation and daily life satisfaction. Family abuse experience and social maladaptation negatively influenced ego resilience and daily life satisfaction. Ego resilience positively influenced daily life satisfaction. Thus special education program and counseling should be provided to increase university students' daily life satisfaction through in order to built ego resilience.

• 한국균학회소식:학술대회논문집
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• 한국균학회 2015년도 춘계학술대회 및 임시총회
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• pp.59-59
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• 2015

Cryptococcus neoformans causes life-threatening meningoencephalitis in humans, but the treatment of cryptococcosis remains challenging. To develop novel therapeutic targets and approaches, signaling cascades controlling pathogenicity of C. neoformans have been extensively studied but the underlying biological regulatory circuits remain elusive, particularly due to the presence of an evolutionarily divergent set of transcription factors (TFs) in this basidiomycetous fungus. In this study, we constructed a high-quality of 322 signature-tagged gene deletion strains for 155 putative TF genes, which were previously predicted using the DNA-binding domain TF database (http://www.transcriptionfactor.org/). We tested in vivo and in vitro phenotypic traits under 32 distinct growth conditions using 322 TF gene deletion strains. At least one phenotypic trait was exhibited by 145 out of 155 TF mutants (93%) and approximately 85% of the TFs (132/155) have been functionally characterized for the first time in this study. Through high-coverage phenome analysis, we discovered myriad novel TFs that play critical roles in growth, differentiation, virulence-factor (melanin, capsule, and urease) formation, stress responses, antifungal drug resistance, and virulence. Large-scale virulence and infectivity assays in insect (Galleria mellonella) and mouse host models identified 34 novel TFs that are critical for pathogenicity. The genotypic and phenotypic data for each TF are available in the C. neoformans TF phenome database (http://tf.cryptococcus.org). In conclusion, our phenome-based functional analysis of the C. neoformans TF mutant library provides key insights into transcriptional networks of basidiomycetous fungi and ubiquitous human fungal pathogens.

• Archives of Pharmacal Research
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• 제26권11호
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• pp.925-928
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• 2003

Four guaia-12,6-olide type sesquiterpene lactones, aguerin B (1), 8$\alpha$-acetoxyzaluzanin C (2), cynaropicrin (3), and deacylcynaropicrin (4), were isolated from the flowers of Hemisteptia Iyrata Bunge. It is the first report on the isolation of compounds 1-4 from Hemisteptia species. All the isolates (1-4) were examined for their cytotoxic activity against SK-OV-3, LOX-IMVI, A549, MCF-7, PC-3, and HCT-15 human cancer cell lines.

• Animal Bioscience
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• 제36권3호
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• pp.521-528
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• 2023

Objective: This study investigated the effects of surgical castration on behavior, physiological and inflammatory indicators, and leukocyte cytokine mRNA levels in Korean cattle bull calves. Methods: Nineteen Korean cattle bull calves (average body weight, 254.5 kg; average age, 8.2 months) were divided into two treatment groups: control (n = 9) and castration (n = 10). Surgical castration was performed using Newberry knives and a Henderson castrating tool. Blood was obtained just before castration (0 h) and at 0.5 h, 6 h, 1 d, 3 d, 7 d, and 14 d after castration. Plasma cortisol (PC), saliva cortisol (SC), plasma substance P, and plasma haptoglobin concentrations, and the leucocyte mRNA levels of the interleukin-1-alpha (IL1A), interleukin-1-beta (IL1B), interleukin-1 receptor antagonist (IL1RN), and interleukin-6 (IL6) genes were analyzed. Results: Castration decreased (p<0.01) the average daily gain and gain/feed ratio. Castration reduced the time spent eating (p<0.001) and the eating frequency (p<0.01) and increased (p<0.001) the lying frequency. Castration temporarily increased (p<0.05) circulating PC and SC concentrations at 0.5 h after castration. Castration temporarily increased (p<0.05) plasma substance P concentrations at 1 d after castration. Castration increased (p<0.05) plasma haptoglobin concentrations at 1 and 3 d after castration. Castration increased (p<0.05) leukocyte mRNA levels of the IL1A, IL1B, IL1RN, and IL6 genes at 6 h after castration. Conclusion: Castration temporarily induced stress and expression of leucocyte inflammatory cytokine genes in Korean cattle bull calves.

• 한국수학교육학회지시리즈E:수학교육논문집
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• 제20권4호
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• pp.503-521
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• 2006

'Calculus for Life Science' is one of the calculus courses for students majoring life science in Seoul National University. Contrary to the other calculus courses for students in natural sciences and engineerings, in 'Calculus for life Science' we have primarily chosen computer-based curriculum that is useful to life science and so we have tried to fulfill the requirements of the students majoring life science. Like this, we are of the opinion that there are diverse requirements in life science as well as other majors in basic mathematical education of the university. Upon this view, in this research, we consider the present conditions, the points at issue and study improvements of them. In section II and III, we introduce briefly the present 'Calculus for Life Science' focused on the curriculum. In section IV, according to the course evaluations and questionnaire, we make an analysis of the present condition and the points at issue of 'Calculus for Life Science'. In section V and VI, we present the improvements of the curriculum and the several education environments.

• 한국생명과학회:학술대회논문집
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• 한국생명과학회 2005년도 국제학술심포지움 The 44th Annual Meeting of Korean Society for Life Science
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• pp.232-232
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• 2005

• 한국생명과학회:학술대회논문집
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• 한국생명과학회 2006년도 제47회 학술심포지움 및 추계국제학술대회
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• pp.45.2-45.2
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• 2006

• 한국생명과학회:학술대회논문집
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• 한국생명과학회 2006년도 제47회 학술심포지움 및 추계국제학술대회
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• pp.45.1-45.1
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• 2006

• 한국생명과학회:학술대회논문집
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• 한국생명과학회 2006년도 제47회 학술심포지움 및 추계국제학술대회
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• pp.46.1-46.1
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• 2006