Browse > Article

Cytotoxic Effects of Sesquiterpene Lactones from the Flowers of Hemisteptia Iyrata B.  

Ha, Tae-Joung (Institute of Agriculture and Life Science, Gyeongsang National University)
Jang, Dae-Sik (Graduate School of Molecular Life Sciences, Ewha Womans University)
Lee, Jong-Rok (Department of Agricultural Chemistry, Division of Applied Life Science, Gyeongsang National University)
Lee, Kyung-Dong (Institute of Agriculture and Life Science, Gyeongsang National University)
Lee, Jun (Department of Agricultural Chemistry, Division of Applied Life Science, Gyeongsang National University)
Hwang, Seon-Woo (Department of Agricultural Chemistry, Division of Applied Life Science, Gyeongsang National University)
Jung, Hwa-Jin (Department of Agricultural Chemistry, Division of Applied Life Science, Gyeongsang National University)
Nam, Sang-Hae (Department of Food Processing, Chinju National University)
Park, Ki-Hun (Department of Agricultural Chemistry, Division of Applied Life Science, Gyeongsang National University)
Yang, Min-Suk (Institute of Agriculture and Life Science, Gyeongsang National University)
Publication Information
Archives of Pharmacal Research / v.26, no.11, 2003 , pp. 925-928 More about this Journal
Abstract
Four guaia-12,6-olide type sesquiterpene lactones, aguerin B (1), 8$\alpha$-acetoxyzaluzanin C (2), cynaropicrin (3), and deacylcynaropicrin (4), were isolated from the flowers of Hemisteptia Iyrata Bunge. It is the first report on the isolation of compounds 1-4 from Hemisteptia species. All the isolates (1-4) were examined for their cytotoxic activity against SK-OV-3, LOX-IMVI, A549, MCF-7, PC-3, and HCT-15 human cancer cell lines.
Keywords
Hemisteptia Iyrata Bunge; Sesquiterpene lactone; Aguerin B; $8{\alpha}-Acetoxyzaluzanin$ C; Cynaropicrin; Deacylcynaropicrin; Cytotoxic activity;
Citations & Related Records

Times Cited By Web Of Science : 9  (Related Records In Web of Science)
Times Cited By SCOPUS : 7
연도 인용수 순위
1 Ha, T. J., Yang, M. S., Pak, Y. B., Lee, J. R., Lee, K. D., Kim, H. M., and Park, K. H., New guaiane-type sesquiterpene lactones from Hemisteptia lyrata Bunge. Heterocycles, 57, 151-155 (2002c)   DOI   ScienceOn
2 Hall, I. H., Lee, K. H., and Eigebaly, S. A., Antitumor agents XXVII: Effects of helenalin on anaerobic and aerobic metabolism of ehrlich ascites cells. J. Pharm. Sci., 67, 552-554 (1978)   DOI   PUBMED
3 Lee, K. H., Hall, I. H., Mar, E. C., Starnes, C. O., Elgebaly, S. A., Waddell, T. G., Hadgraft, R. I., Ruffner, C. G., and Weidner, I., Sesquiterpene antitumor agents: Inhibitors of cellula metabolism. Science, 196, 533-536 (1977)   DOI   PUBMED
4 Peoples Press. In Encyclopedia of the Traditional Chinese Materia Medica. p. 1458-1459. Shanghai, P. R. China (1977)
5 Grippo, A. A., Hall, I. H., Kiyokawa, H. Muraoka, O., Shen, Y. C., and Lee, K. H., The cytotoxicity of helenalin, its mono and difunctional esters, and related sesquiterpene lactones in murine and human tumor cells. Drug Design Discovery, 8, 191-206 (1992)
6 Hall, I. H., Lee, K. H. Starnes, C. O., Eigebaly, S. A., Ibka, T., Wu Y. S., Kimura, T., and Haruna, M., Antitumor agents XXX: Evaluation of alpha-methylene-gamma-lactone containing agents for inhibition of tumor qrowth, respiration, and nucleic acid synthesis. J. Pharm. Sci., 67, 1235-1239 (1978)   DOI   PUBMED
7 Jang, D. S., Yang, M. S., Ha, T. J., and Park, K. H., Hemistepsins with cytotoxic activity from Hemisteptia lyrata, Planta Med., 65, 765-766 (1999)   DOI   ScienceOn
8 Hall, I. H., Grippo, A. A., Lee, K. H., Chaney, S. G., and Holbrook, D. J., Effect of helenalin and bis(helenalinyl) malonate on nucleic acid protein synthesis in human KB carcinoma cells. Pharmaceu. Sci., 4, 509-514 (1987)
9 Shehan, P., Storeng, R., Scudiero, D., Monks, A., Mcmahon, J., Vistica, D., Warren, J. T., Bokesh, H., Kenny, S., and Boyd, M. R., New colorimetric cytotoxicity assay for anticancer-drug screening. J. Natl. Cancer Inst., 82, 1107-1112 (1990)   DOI   PUBMED
10 Gonzalez, A. G., Bermejo, J., Cabrera, I., Massanet, G. M., Mansilla, H., and Galindo, A., Two sesquiterpene lactones from Centaurea canariensis. Phytochemistry, 17, 955-956 (1978)   DOI   ScienceOn
11 Jang, D. S., Yang, M. S., and Park, K. H., Sesquiterpen lactone from Hemisteptia lyrata. Planta Med., 64, 289-290 (1998)   DOI   ScienceOn
12 Asakawa, Y. and Takemoto, T., Sesquiterpene lactones of Conocephalum conicum. Phytochemistry, 18, 285-288 (1979)   DOI   ScienceOn
13 Ha, T. J., Jang, D. S., Lee, K. D., Lee, J. R., Park, K. H., and Yang, M. S., Studies on the constituents from the flowers of Hemisteptia lyrata Bunge II. Kor. J. Pharmacogn., 33, 92-95 (2002b)
14 Merrill, G. B. and Stevens, K. L., Sesquiterpene lactones from Centaurea solstitialis. Phytochemstry, 24, 2013-2018 (1985)   DOI   ScienceOn
15 Ha, T. J., Hwang, S. W., Jung, H. J., Park, K. H., and Yang, M. S., Apigenin, tyrosinase inhibitor from the flowers of Hemisteptia lyrata Bunge. Agric. Chem. Biotechnol., 45, 170-172 (2002a)
16 Hoffmann, H. M. R. and Rabe, J., Synthesis and biological activity of $\alpha$-methylene-$\gamma$-butyrolactones. Angew. Chem. Int. Ed. Engl., 24, 94-110 (1985)   DOI
17 Ha, T. J., Park, K. H., Jang, D. S., Lee, J. R., Park, K. M., and Yang, M. S., New sesquiterpene lactones from Hemisteptia lyrata bunge. Heterocycles, 60, 623-629 (2003)   DOI   ScienceOn