• Journal of Fashion Business
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• v.20 no.3
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• pp.30-42
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• 2016

The objective of this study was to perform 3D solid modeling from 3D scanned surface images of cotton and silk in order to calculate the thermal heat transfer responses using numerical simulations. Continuing from the previous methodology, which provided 3D surface data for a fabric through optical measurements of the fabric microstructure, a simplified 3D solid model, containing a defined unit cell, pattern unit and fabric structure, was prepared. The loft method was used for 3D solid-model generation, and heat transfer calculations, made for the fabric, were then carried out using the 3D solid model. As a result, comprehensive protocols for 3D solid-model generation were established based on the optical measurements of real fabric samples. This method provides an effective means of using 3D information for building 3D models of actual fabrics and applying the model in numerical simulations. The developed process can be used as the basis for other analogous research areas to investigate the physical characteristics of any fabrics.

• Journal of Microbiology and Biotechnology
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• v.9 no.3
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• pp.276-281
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• 1999

In order to determine the functional region of the antifungal protein (AFP) isolated from Aspergillus giganteus responsible for growth inhibitory activity and the promotion of phospholipid vesicle aggregation, overlapping peptides covering the complete sequence of AFP were synthesized. The antibiotic activity against bacterial, fungal, and tumor cells, and the vesicle-aggregation activity of the synthetic peptides were investigated. The AFP functional sequence responsible for antibiotic and vesicle-aggregation activity was determined to be located within the region between AFP residues 19 to 32. AFP (19-32) exhibited an a-helical conformation in a cell membrane-like environment. AFP (19-32) displayed potent antibiotic activity against bacterial, fungal, and tumor cells without peptide toxicity as indicated by hemolysis. Accordingly, AFP (19-32) could be used as a good model for the design of effective antibiotic agents with powerful antibiotic activity yet without any cytotoxic effects against the host organism.

• Proceedings of the Korean Geotechical Society Conference
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• 2008.10a
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• pp.455-465
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• 2008

In this study, the load distribution and deformation of rock-socketed drilled shafts subjected to axial load are investigated based on small scale model tests. In order to analyze the effects of major influencing factors of end bearing capacity, Hoek-cell triaxial tests were performed. From the test results, it was found that the initial slope of end bearing load transfer (q-w) curve was highly dependent on rock mass modulus and pile diameter, while the ultimate unit toe resistance ($q_{max}$) was influenced by rock mass modulus and the spacing of discontinuities. End bearing load transfer function of drilled shafts socketed in rock was proposed based on the Hoek-cell triaxial test results and the field loading tests which were performed on granite and gneiss in South Korea. Through the comparison with pile load tests, it is found that the load-transfer curve by the present study is in good agreement with the general trend observed by field loading tests, and thus represents a significant improvement in the prediction of load transfer of drilled shaft.

• 연구논문집
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• s.23
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• pp.45-56
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• 1993

In order to acquire more comprehensive understanding of textile composites, the processing-microstructure-performance relationships for a variety of material systems, reinforcing schemes and processing technologies should be established. In this paper, emphasis is placed on the integrated analysis of three-dimensional (3-D) 2-step braided composites. The analysis includes the geometric model of unit cells, identification of key process parameters and processing windows due to limiting geometries of yarn jamming, and prediction of elastic constants of the composite. The coordinate transformation and averaging of stiffness and compliance constants are utilized in the prediction of elastic constants. Since there are several types of unit cells in the thickness and width directions of the composites, characterization of mechanical properties is based upon the macro-cell, which occupies the entire cross-section and the unit pitch length of the sample. The performance map demonstrates that a wide range of elastic properties can be achieved by varying the geometric and process parameters.

• Journal of Information Processing Systems
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• v.18 no.3
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• pp.302-310
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• 2022

Efficient use of limited blood products is becoming very important in terms of socioeconomic status and patient recovery. To predict the appropriateness of patient-specific transfusions for the intensive care unit (ICU) patients who require real-time monitoring, we evaluated a model to predict the possibility of transfusion dynamically by using the Medical Information Mart for Intensive Care III (MIMIC-III), an ICU admission record at Harvard Medical School. In this study, we developed an explainable machine learning to predict the possibility of red blood cell transfusion for major medical diseases in the ICU. Target disease groups that received packed red blood cell transfusions at high frequency were selected and 16,222 patients were finally extracted. The prediction model achieved an area under the ROC curve of 0.9070 and an F1-score of 0.8166 (LightGBM). To explain the performance of the machine learning model, feature importance analysis and a partial dependence plot were used. The results of our study can be used as basic data for recommendations related to the adequacy of blood transfusions and are expected to ultimately contribute to the recovery of patients and prevention of excessive consumption of blood products.

• Clean Technology
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• v.12 no.4
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• pp.224-231
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• 2006

Collection efficiencies and pressure drops for the removal of small particles from dilute liquid suspensions by granular bed filter were calculated using network model. The network model is composed of a number of nodes connected with cylindrical bond and particles are deposited on the bond surface. The collection efficiency of each cylindrical bond was predicted using unit cell model corresponding to the pore volume of cylindrical pore both at the initial and transient states. Deposited particles on the collector surface may act as additional collector and reduce the pore size of the collector. As a result, the collection efficiency was improved and pressure drop increased with deposition. Even though the stochastic nature of network requires a large number of simulation work, the model proposed in this study can be used in investigating collection efficiency and pressure drop.

• Biotechnology and Bioprocess Engineering:BBE
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• v.3 no.1
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• pp.1-5
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• 1998

One cervical cancer cell line, C9, carrying human papillomavirus type 18 (HPV18) genes that is one of the major etiologic concoviruses for cervical cancer was characterized. This cell line was further characterized for its capacity related to the epithelial cell proliferation, stratification and differentiation in reconstituted artificial epithelial tissue. The in vitro construction of three dimensional artificial cervical opithelial tissue has been engineered using C9 epithelial cancer cells, human foreskin fibroblasts and a matrix made of type I collagen by organotypic culture of epithelial cells. The morphology of paraffin embedded artificial tissue was examined by histochemical staining. The artificial epithelial tissues were well developed having multilayer. However, the tissue morphology was similar to the cervical tissus having displasia induced by HPV infection. The characteristics of the artificial tissues were examined by determinining the expression of specific marker proteins. In the C9 derived artificial tissues, the expression of EGF receptor, as epithelial proliferation marker proteins for stratum basale was observed up to the stratum spinosum. Another epithelial proliferation marker for stratum spinosum, cytokerations 5/6/18, were observed well over the stratum spinosum. For the differentiation markers, the expression of involucrin and filaggrin were observed while the terminal differentiation marker, cytokeratins 10/13 was not detected at all. Therefore the reconstituted artificial epithelial tissues expressed the same types of differentiation marker proteins that are expressed in normal human cervical epithelial tissues but lacked the final differentiation capacity representing characteristics of C9 cell line as a cancer tissue devived cell line. Expression of HPV18 E6 oncoprotein was also observed in this artifical cervical opithelial tissue though the intensity of the staining was weak. Thus this artificial epithelial tissue could be used as a useful model system to examine the relationship between HPV-induced cervical oncogenesis and epithelial cell differentiation.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.44 no.11
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• pp.941-948
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• 2016

Textile composite materials have been widely applied in aerospace structures due to their various advantages such as high specific stiffnesses and strengths, better out-of-plane performances, impact and delamination resistances, and net shape fabrications. In this paper, a modified geometric model of repeating unit cell (RUC) is suggested based on the Naik's model for 2D plain weave textile composites. The RUC geometry is defined by various parameters. The proposed model considers another parameter which is a gap length between adjacent yarns. The effective stiffnesses are predicted by using the yarn slicing technique and stress averaging technique based on iso-strain assumption. And the stiffnesses of RUC are evaluated by adjusting the gap ratio and verified by comparing with Naik's model and experimental data for 2D plain weave composite specimens.

• Nuclear Engineering and Technology
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• v.55 no.2
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• pp.749-755
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• 2023

A new approximation method was proposed for treating the non-resonant spatial self-shielding effects of double heterogeneous region such as the double heterogeneous effect of VHTR fuel compact in the thermal energy range and that of BP compact with BISO. The method was developed based on the effective homogenization method and a spherical unit cell model with explicit coated layers and a matrix layer. The self-shielding factor was derived from the relation between the collision probabilities for a double heterogeneous compact and the effective cross section for the homogenized compact. First, the collision probabilities and transmission probabilities for all layers of the spherical model were calculated using conventional collision probability solver. Then, the effective cross section for the homogenized sphere cell representing the homogenized compact was obtained from the transmission probability calculated using the probability density function of a chord length. The verification calculations revealed that the proposed method can predict the self-shielding factor with a maximum error of 2.3% and the double heterogeneous effect with a maximum error of 200 pcm in the typical VHTR problems with various packing fractions and BP compact sizes.

• Korean Journal of Food Science and Technology
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• v.36 no.2
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• pp.349-354
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• 2004

Predictive growth model of Vibrio parahaemolyticus in modified surimi-based imitation crab broth was investigated. Growth curves of V. parahaemolyticus were obtained by measuring cell concentration in culture broth under different conditions ($Initial\;cell\;level,\;1{\times}10^{2},\;1{\times}10^{3},\;and\;1{\times}10^{4}\;colony\;forming\;unit\;(CFU)/mL$; temperature, 15, 25 37, and $40^{\circ}C$; pH 6, 7, and 8) and applying them to Gompertz model. Microbial growth indicators, maximum specific growth rate (k), lag time (LT), and generation time (GT), were calculated from Gompertz model. Maximum specific growth rate (k) of V. parahaemolyticus increased with increasing temperature, reaching maximum rate at $37^{\circ}C$. LT and GT were also the shortest at $37^{\circ}C$. pH and initial cell number did not influence k, LT, and GT values significantly (p>0.05). Polynomial model, $k=a{\cdot}\exp(-0.5{\cdot}((T-T_{max}/b)^{2}+((pH-pH_{max)/c^{2}))$, and square root model, ${\sqrt{k}\;0.06(T-9.55)[1-\exp(0.07(T-49.98))]$, were developed to express combination effects of temperature and pH under each initial cell number using Gauss-Newton Algorism of Sigma plot 7.0 (SPSS Inc.). Relative coefficients between experimental k and k Predicted by polynomial model were 0.966, 0.979, and 0.965, respectively, at initial cell numbers of $1{\times}10^{2},\;1{\times}10^{3},\;and\;1{\times}10^{4}CFU/mL$, while that between experimental k and k Predicted by square root model was 0.977. Results revealed growth of V. parahaemolyticus was mainly affected by temperature, and square root model showing effect of temperature was more credible than polynomial model for prediction of V. parahaemolyticus growth.