• 대한기계학회논문집A
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• 제21권5호
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• pp.780-790
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• 1997

In this study, the stress-strain relations of steels have been calculated as a function of microstructural morphologies of each phase by use of FEM program(i.e. ABAQUS). The mechanical behavior of low carbon steels is affected by the microstructural factors such as yield ratio, volume fraction, shape and distribution of each phase and so on. The effects of shape, volume fraction and yield ratio of each phase on the mechanical behavior were analyzed by using unit cell and whole specimen size models. Results obtained are summarized as follows. As the yield ratio of hard phase to that of soft phase and volume fraction of hard phase were increased, stress level of flow curves were increased. It was found that in whole specimen size model, as the particle size was decreased, higher stress level was shown. Lastly the relationship between microstructure and tensile properties was examined by using the steels with various microstructural morphologies.

• 대한전자공학회논문지SD
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• 제48권7호
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• pp.1-9
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• 2011

멤리스터(Memristor)는 메모리 레지스터의 합성어로 흐른 전하량에 따라 저항이 스스로 변하고 전원이 끊긴 상태에서도 저항 상태가 기억되는 특수한 메모리 소자이다. 본 논문에서는 차세대 메모리소자로 주목받고 있는 멤리스터를 모델링하고 SPICE 시뮬레이션을 위한 behavior모델을 제시한다. 그리고 제안된 모델을 바탕으로 멤리스터 기반의 M_CAM(Memristor MOS content addressable memory)을 설계하였다. 제안된 M_CAM은 기존의 CAM에 비해서 단위 셀 면적과 평균 전력소모가 각각 40%, 96% 감소하였다. 칩은 0.13${\mu}m$ CMOS 공정에서 공급전압이 1.2V를 갖도록 설계되었다.

• 대한전자공학회논문지TC
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• 제44권10호
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• pp.83-98
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• 2007

이동 무선 환경에서 핸드오버 특히, 이종 망이 중첩된 네트워크 환경에서의 핸드오버는 서로 다른 서비스 특성과 서비스 영역의 영향을 받는다. 핸드오버로 인한 서비스 단절 현상과 서비스 품질 저하를 방지하기 위해서는 서비스 요구 사항(bandwidth, throughput, delay 등)을 지속적으로 유지시킬 수 있는 자원 예약 알고리즘은 필수적인 요소이다. 자원 예약은 이동 단말의 핸드오버 처리 시간과 자원 낭비를 최소화시키기 위해 사전에 미리 진행되어야 하는데, 이는 단말의 위치 정보, 이동 속도 이동 경로, 서비스 요구 사항, 주변 셀 정보 등이 개개의 단말과 서비스에 대한 정확한 예측과 높은 신뢰도를 바탕으로 이루어져야 한다. 본 논문에서는 단말 이동에 따른 셀 변경 확률 및 셀 선정 알고리즘을 기반으로 이동 속도별 서비스 계층을 두어 특정 속도에 대해 핸드오버를 효과적으로 처리하고, 네트워크 오버헤드 및 자원 낭비를 최소화시킬 수 있는 사전 자원 예약 알고리즘을 제안한다. 또한 3개 계층으로 구성된 네트워크 모델 상에서 가상 시나리오에 따라 PMS(Predictive Mobility Support) 및 VCDS(Velocity and Call Duration Support scheme)와의 성능 비교를 통해 제안 알고리즘의 효율성을 살펴본다.

• Smart Structures and Systems
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• 제19권4호
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• pp.341-350
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• 2017

Based on the super elastic properties of the shape memory alloy (SMA) and the inverse piezoelectric effect of piezoelectric (PZT) ceramics, a kind of hybrid semi-active control device was designed and made, its mechanical properties test was done under different frequency and different voltage. The local search ability of genetic algorithm is poor, which would fall into the defect of prematurity easily. A kind of adaptive immune memory cloning algorithm(AIMCA) was proposed based on the simulation of clone selection and immune memory process. It can adjust the mutation probability and clone scale adaptively through the way of introducing memory cell and antibody incentive degrees. And performance indicator based on the modal controllable degree was taken as antigen-antibody affinity function, the optimization analysis of damper layout in a space truss structure was done. The structural seismic response was analyzed by applying the neural network prediction model and T-S fuzzy logic. Results show that SMA and PZT friction composite damper has a good energy dissipation capacity and stable performance, the bigger voltage, the better energy dissipation ability. Compared with genetic algorithm, the adaptive immune memory clone algorithm overcomes the problem of prematurity effectively. Besides, it has stronger global searching ability, better population diversity and faster convergence speed, makes the damper has a better arrangement position in structural dampers optimization leading to the better damping effect.

• 대한기계학회논문집B
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• 제34권5호
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• pp.471-479
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• 2010

다른 세장비에 따른 단일 사각 마이크로 채널 내의 이상유동연구를 수행하였다. 본 연구에서는 대략 넓이가 $500\;{\mu}m$ 이며 수력직경이 각각 490, 322, $143\;{\mu}m$ 인 사각 마이크로채널 내에서의 물-질소 유동에 대한 실험이 수행되었다. 또한, 고속카메라와 장거리 현미경을 통해 이상유동양식을 가시화하였다. 본 연구는 이상유동 중 기포류에 중점을 두었으며 가시화 결과를 통해 기포의 속도, 기포의 길이, 관 내 기포의 개수, 기공률을 산출하였고 단위 셀 모델을 기반으로 늘어진 단일 기포의 압력강하를 해석하였다. 실험을 통해 기포의 속도, 기공률, 단일 기포의 압력강하가 각각 겉보기 속도와 체적건도, 세장비와 연관이 있음을 확인하였으며, 사각 마이크로 채널 내 늘어진 단일 기포의 압력강하에 대한 상관식을 개발하였다.

• 한국축산식품학회지
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• 제36권5호
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• pp.635-640
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• 2016

Lactobacillus acidophilus n.v. Er2 317/402 strain Narine is known as a health beneficial functional probiotic culture and supplementary source of nutrition for newborns. In this study, in vitro antimicrobial activities of Narine-lyophilized (Narine-L), Narine-heat treated (Narine-HT), and Narine crude cell-free extract (Narine-CCFE) were evaluated against pathogen Cronobacter sakazakii (C. sakazakii) in agar as well as in a reconstituted powdered infant formula (RPIF) model. Inhibition zones of 30 mg Narine-L and Narine-HT were both 150 U, whereas inhibition zone of 30 mg Narine-CCFE was 200 U. Narine-L (1 g) and Narine-HT (1 g) were added to 10 mL of artificially contaminated RPIF, respectively, containing 100 μL of C. sakazakii (1.62×10⁸ colony forming unit (CFU)/mL). After treatment with Narine-L and Narine-HT for 3 h and 6 h at 37℃, less than ≤107 CFU/mL of C. sakazakii was detected in RPIF. Without Narine-L and Narine-HT treatment, the population of C. sakazakii increased up to 5.36×10⁹ CFU/mL after 6 h. Examination by transmission electron microscopy confirmed C. sakazakii cells were damaged by Narine-CCFE. Thus, employing Narine culture as a natural and safe bio-preservative may protect infants from C. sakazakii.

• Geomechanics and Engineering
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• 제6권2호
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• pp.173-194
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• 2014

Laboratory and field data showed that deep mixed (DM) columns accelerated the rate of consolidation of the soft foundations. Most analyses of consolidation of DM column-improved foundations so far have been based on the elastic theory. In reality, the DM columns may yield due to the stress concentration from the soft soil and its limited strength. The influence of column yielding on the degree of consolidation of the soft foundation improved by DM columns has not been well investigated. A three-dimensional mechanically and hydraulically-coupled numerical method was adopted in this study to investigate the degree of consolidation of the DM column foundation considering column yielding. A unit cell model was used, in which the soil was modeled as a linearly elastic material. For a comparison purpose, the DM column was modeled as an elastic or elastic-plastic material. This study examined the aspects of stress transfer, settlement, and degree of consolidation of the foundations without or with the consideration of the yielding of the DM column. A parametric study was conducted to investigate the influence of the column yielding on the stress concentration ratio, settlement, and average degree of consolidation of the DM column foundation. The stress concentration ratio increased and then decreased to reach a constant value with the increase of the column modulus and time. A simplified method was proposed to calculate the maximum stress concentration ratios under undrained and drained conditions considering the column yielding. The simplified method based on a composite foundation concept could conservatively estimate the consolidation settlement. An increase of the column modulus, area replacement ratio, and/or column permeability increased the rate of consolidation.

• 한국전산구조공학회논문집
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• 제34권5호
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• pp.287-292
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• 2021

본 논문에서는 CAD 시스템에서 사용하는 NURBS 기저함수를 사용하는 아이소-지오메트릭 해석(Isogeometric analysis) 방법과 기하학적으로 엄밀한 빔 모델링(geometrically exact beam model)을 활용하여 회전과 병진 운동이 결합된 새로운 형태의 메타물질(metamaterial)에 대한 해석을 진행하였다. 이차원 셀 구조는 자유형상변환(Free-form deformation) 법과 적절한 내삽법(Interpolation)을 통해 원통 위에 입혀졌다. 원통의 치수와 셀 개수가 비틀림 각도에 미치는 영향이 매개변수 연구(parametric study)를 통해 확인되었다. 비틀림과 병진 운동이 결합된 구조의 메커니즘에 대해 수치 예제를 통해 알아보았다.

• BMB Reports
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• 제55권11호
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• pp.547-552
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• 2022

Sorafenib, originally identified as an inhibitor of multiple oncogenic kinases, induces ferroptosis in hepatocellular carcinoma (HCC) cells. Several pathways that mitigate sorafenib-induced ferroptosis confer drug resistance; thus strategies that enhance ferroptosis increase sorafenib efficacy. Orphan nuclear receptor estrogen-related receptor γ (ERRγ) is upregulated in human HCC tissues and plays a role in cancer cell proliferation. The aim of this study was to determine whether inhibition of ERRγ with DN200434, an orally available inverse agonist, can overcome resistance to sorafenib through induction of ferroptosis. Sorafenib-resistant HCC cells were less sensitive to sorafenibinduced ferroptosis and showed significantly higher ERRγ levels than sorafenib-sensitive HCC cells. DN200434 induced lipid peroxidation and ferroptosis in sorafenib-resistant HCC cells. Mechanistically, DN200434 increased mitochondrial ROS generation by reducing glutathione/glutathione disulfide levels, which subsequently reduced mTOR activity and GPX4 levels. DN200434 induced amplification of the antitumor effects of sorafenib was confirmed in a tumor xenograft model. The present results indicate that DN200434 may be a novel therapeutic strategy to re-sensitize HCC cells to sorafenib.

• 한국미생물·생명공학회지
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• 제51권2호
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• pp.191-202
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• 2023

Elevated serum cholesterol is a main risk factor for heart disorders. Most probiotic products administered to lower cholesterol are dairy products which are not suitable for lactose-intolerant individuals. In this study, we assessed the cholesterol-lowering efficacy of LAB isolated from traditionally fermented drinks in diet-induced rats and determine their efficacy in the production of non-dairy, probiotic formulations using papaya juice. LAB were isolated from palm wine and corn beer on MRS agar using a pour-plate technique. Identification was carried out using 16S rRNA gene sequencing. A hypercholesterolemia model in which diet-induced Wistar albino rats were assigned into four groups was established. Oral gavage was carried out for 30 days. On the 31^st day, the rats were dissected and the serum lipid profile was analyzed using biochemical kits. A 10⁶ cfu/ml of a 24-h-old culture of selected lactobacilli was used to inoculate papaya juice and incubated at 37℃. Microbial and chemical changes were assessed during papaya fermentation and after four weeks of cold storage. Two selected isolates (Pw1 and Cb4) had in vitro cholesterol reduction of > 80%. These two isolates lowered lipid profile (triglyceride, total cholesterol, LDL-c) significantly, and increased HDL-c levels (p < 0.5) in the rat sera. Phylogenetic analysis showed that Pw1 was 98.86% similar to Limosilactobacillus fermentum, while Cb4 was 99.54% similar to Enteroccocus faecium. Both strains fermented papaya juice with cell viability reaching 8.92 × 10⁸ cfu/ml and 25.3 × 10⁸ cfu/ml respectively, and were still viable after 4 weeks of cold storage.