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Anti-Gout Effect of Ethanol Extracts from Chrysanthemum indicum Linne (감국(Chrysanthemum indicum Linne) 에탄올 추출물의 통풍억제 효과)

  • Park, So-Young;Cho, Young-Je
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.45 no.6
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    • pp.797-804
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    • 2016
  • In an acute toxicity test for Chrysanthemum indicum Linne, 0.5~10 g/kg of Chrysanthemum indicum Linne extracts were administered. Chrysanthemum indicum Linne did not produce acute toxicity even at high doses of 10 g/kg, making it a highly safe material. In the chronic toxicity test, oral administration of Chrysanthemum indicum Linne up to 2 g/kg was carried out for 13 weeks, showing liver non-toxicity. The gout inhibitory effect of Chrysanthemum indicum Linne extracts was measured by inflammatory cytokine expression and foot thickness after 24 h of monosodium urate crystal (MSU) oral administration when inflammatory cytokine production reached a maximum. The group administered 2~4 g/kg of Chrysanthemum indicum Linne extract showed an inhibitory effect on gout inflammation and edema, whereas the 10 g/kg administered group showed an increase in inflammation. Therefore, the moderate concentration of Chrysanthemum indicum Linne extract for gout inhibitory effect was under 4 g/kg. Chrysanthemum indicum Linne extract showed an anti-inflammatory effect on MSU as a relatively safe material at high capacity. These results indicate that Chrysanthemum indicum Linne extract is thought to be an excellent substance for gout prevention.

Investigation of TaNx diffusion barrier properties using Plasma-Enhanced ALD for copper interconnection

  • Han, Dong-Seok;Mun, Dae-Yong;Gwon, Tae-Seok;Kim, Ung-Seon;Hwang, Chang-Muk;Park, Jong-Wan
    • Proceedings of the Korean Vacuum Society Conference
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    • 2010.08a
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    • pp.178-178
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    • 2010
  • With the scaling down of ULSI(Ultra Large Scale Integration) circuit of CMOS(Complementary Metal Oxide Semiconductor)based electronic devices, the electronic devices become more faster and smaller size that are promising field of semiconductor market. However, very narrow line width has some disadvantages. For example, because of narrow line width, deposition of conformal and thin barrier is difficult. Besides, proportion of barrier width is large, thus resistance is high. Conventional PVD(Physical Vapor Deposition) thin films are not able to gain a good quality and conformal layer. Hence, in order to get over these side effects, deposition of thin layer used of ALD(Atomic Layer Deposition) is important factor. Furthermore, it is essential that copper atomic diffusion into dielectric layer such as silicon oxide and hafnium oxide. If copper line is not surrounded by diffusion barrier, it cause the leakage current and devices degradation. There are some possible methods for improving the these secondary effects. In this study, TaNx, is used of Tertiarybutylimido tris (ethylamethlamino) tantalum (TBITEMAT), was deposited on the 24nm sized trench silicon oxide/silicon bi-layer substrate with good step coverage and high quality film using plasma enhanced atomic layer deposition (PEALD). And then copper was deposited on TaNx barrier using same deposition method. The thickness of TaNx was 4~5 nm. TaNx film was deposited the condition of under $300^{\circ}C$ and copper deposition temperature was under $120^{\circ}C$, and feeding time of TaNx and copper were 5 seconds and 5 seconds, relatively. Purge time of TaNx and copper films were 10 seconds and 6 seconds, relatively. XRD, TEM, AFM, I-V measurement(for testing leakage current and stability) were used to analyze this work. With this work, thin barrier layer(4~5nm) with deposited PEALD has good step coverage and good thermal stability. So the barrier properties of PEALD TaNx film are desirable for copper interconnection.

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The Effect of Immediate Pain and Cervical ROM of Cervical Pain Patients on Stretching and Manipulation (경추통 환자에 대한 신장운동과 도수치료가 즉각적인 통증과 ROM에 미치는 효과)

  • Hyong, In-Hyouk;Kim, Hyoung-Su;Lee, Sang-Yeol
    • The Journal of Korean Physical Therapy
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    • v.21 no.4
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    • pp.1-7
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    • 2009
  • Purpose: Cervical pain is caused mainly by a static position, lasting work, bad habits and stress, and is accompanied by pain in the upper trapezius. Traditionally, heat and traction, exercise, mobilization, manipulation have been used to treat cervical pain. This study examined the effect of stretching and manipulation (high-velocity low-amplitude: HVLA) on the pain and ROM in women with chronic cervical and upper shoulder pain. Methods: Fifty-two women diagnosed with chronic cervical and upper shoulder pain were enrolled in this study. Among them, 26 patients (experiment group) were managed by passive stretching and manipulation, and another 26 patients (control group) were treated with physical therapy intervention (hat pack: HP, transcutaneous electrical nerve stimulation: TENS, ultra sound: US). Each group made use of a Visual Analogue Scale (VAS) and the highly reliable (flextion: 0.92, extention: 0.99) cervical range of motion (CROM) to compare the possible changes in pain and ROM in the two groups after treatment. Results: In the experimental group, the pain decreased and the ROM has increased in all directions. In the control group, the pain decreased but the ROM was not changed in all directions. Conclusion: According to the results, passive stretching and manipulation is effective for increasing the ROM and decreasing the level of pain. Moreover, physical therapy intervention (HP, TENS, US) is effective for immediately decreasing the pain but has little effect on the ROM.

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Anti-oxidization Effect of Extracts from Oriental Medicine and Cereal Medium Where Tricholoma matsutake Mycelia were Cultured

  • Kim, Hae-Ja;Lee, Ki-Nam
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.22 no.3
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    • pp.672-677
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    • 2008
  • In order to explore the anti-oxidization effect of oriental medicine and cereal medium(OCM) where Tricholoma matsutake mycelia were cultured, measurement of hot water extract and UMPM(extraction method using ultra sonic waves, micro waves, micro bubble) extract, the total polyphenol content of crude polysaccharide from each extract, SOD-like activity, electron donating ability(EDA), xanthine oxidase inhibitory activity, and tyrosinase inhibitory activity was conducted. The total polyphenol content of each extract was found to be 16.36% for hot water extract(HE) group and 15.73% for UMPM extract(UE) group and the amount of crude polysaccharide precipitated into ethanol of extracts was found to be 8.79% for UMPM ethanol extract(UEE) group and 6.48% for hot water ethanol extract(HEE) group. As a result of measurement of SOD-like activity by concentration of each extract, it was found to be 96.17% for UE group, 91.23% for HE group, 91.33% for UEE group, and 87.11% for HEE group at 20 mg/mL. In the case of EDA, it was found to be 47.55% for UE group, 44.93% for HE group, 25.38% for UEE group, and 18.36% for HEE group. And in the cases of the rates of xanthine oxidase inhibitory activity and tyrosinase inhibitory activity, as the concentration of each extract increased, the inhibition rate increased accordingly. As a result of comparison between hot water extract method and UMPM extract method using extracts obtained from oriental medicine compound medium where Tricholoma matsutake mycelia were cultured, all of the extracts were judged to have a high anti-oxidization effect. In particular, UMPM extracts were found to have higher polyphenol content, SOD-like activity, EDA, xanthine oxidase inhibitory activity and tyrosinase inhibitory activity compared to hot water extract method. In this regard, extracts obtained from OCM where Tricholoma matsutake mycelia were cultured are considered to have high availability as functional material when and if they are prepared using UMPM extract method.

A Hybrid Multiuser Detection Algorithm for Outer Space DS-UWB Ad-hoc Network with Strong Narrowband Interference

  • Yin, Zhendong;Kuang, Yunsheng;Sun, Hongjian;Wu, Zhilu;Tang, Wenyan
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.6 no.5
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    • pp.1316-1332
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    • 2012
  • Formation flying is an important technology that enables high cost-effective organization of outer space aircrafts. The ad-hoc wireless network based on direct-sequence ultra-wideband (DS-UWB) techniques is seen as an effective means of establishing wireless communication links between aircrafts. In this paper, based on the theory of matched filter and error bits correction, a hybrid detection algorithm is proposed for realizing multiuser detection (MUD) when the DS-UWB technique is used in the ad-hoc wireless network. The matched filter is used to generate a candidate code set which may contain several error bits. The error bits are then recognized and corrected by an novel error-bit corrector, which consists of two steps: code mapping and clustering. In the former step, based on the modified optimum MUD decision function, a novel mapping function is presented that maps the output candidate codes into a feature space for differentiating the right and wrong codes. In the latter step, the codes are clustered into the right and wrong sets by using the K-means clustering approach. Additionally, in order to prevent some right codes being wrongly classified, a sign judgment method is proposed that reduces the bit error rate (BER) of the system. Compared with the traditional detection approaches, e.g., matched filter, minimum mean square error (MMSE) and decorrelation receiver (DEC), the proposed algorithm can considerably improve the BER performance of the system because of its high probability of recognizing wrong codes. Simulation results show that the proposed algorithm can almost achieve the BER performance of the optimum MUD (OMD). Furthermore, compared with OMD, the proposed algorithm has lower computational complexity, and its BER performance is less sensitive to the number of users.

Microbial and Nutritional Quality of Extended Shelf Life (ESL) Milk

  • Imm, Jee-Young;Kim, Jong-Gun;Kim, Ji-Uk;Park, Soon-Ok;Oh, Se-Jong;Kim, Young-Jin;Chun, Ho-Nam;Jung, Hoo-Kil;You, Seung-Kwon;Whang, Kwang-Yeon;Kim, Sae-Hun
    • Food Science and Biotechnology
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    • v.14 no.6
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    • pp.752-757
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    • 2005
  • Changes in milk quality during storage of extended shelf life milk (ESL milk) and non-ESL milk were evaluated. No significant differences were observed between ESL and typical ultra high temperature-treated (UHT) milk in physicochemical properties including non-casein nitrogen (NCN) content, whey protein nitrogen index (WPNI), and L-ascorbic acid content. Low temperature and long time-treated milk (LTLT milk) had significantly higher NCN content and WPNI than those of UHT milk. In terms of microbial quality, yeast, molds, coliforms, and other bacteria were not detected in ESL milk during entire storage (21 days after expiration date) period at 4 and $25^{\circ}C$, while LTLT milk was more susceptible to microbial infection. Rats fed ESL milk resulted in significantly higher body weight, average daily gain, and feed efficiency than those given UHT milk. These results suggest ESL milk maintains better microbial quality than typical UHT milk, particularly during storage under extended refrigeration and at high temperature.

Trace Element Analysis by Neutron Activastion Analysis in the Human Cancer Tissue (폐암조직에서 중성자 방사화 분석법을 이용한 미량 원소 분석)

  • Lim, Sang-Moo;Zo, Jae-Il;Shim, Young-Mog;Chung, Young-Ju;Cho, Seung-Yeon;Chung, Yong-Sam
    • The Korean Journal of Nuclear Medicine
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    • v.27 no.1
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    • pp.104-111
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    • 1993
  • Trace elements are important components in the biological system, as a structural material and metabolic controller. Neutron activation analysis (NAA) with high neutron flux and high energy resolution Ge (Li) detector coupled to multichannel analyzer (MCA) has been one of the most accurate method for the determination of ultra-trace level components, and is applicable to biological material. In human body, the NAA can be used for quantitation of trace elements in various organs and tissue with endocrinological and metabolic disease and industrial metal poisoning. In this study, Triga Mark III nuclear reactor in Korea Atomic Research Institute was used for quantitation of trace eleement in human lung cancer tissues by neutron activation analysis. In the squamous cell carcinoma tissues, Br, Hg, La, Sb, Sc, Cl, Fe and I content were lower than normal lung tissues, and K, Rb and Se content were higher. In the adenocarcinoma tissues, Fe, Au, La, Sc and Zn content were lower than normal lung tissues, and Rb, Co and Se content were higher. Rb content was higher in the adenocarcinoma tissues than in the squamous cell carcinoma tissues. Fe and Na content were higher in the squamous cell carcinoma tissues than in the adenocarcinoma tissues.

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Fabrication of Metallic Particle Dispersed Ceramic Based Nanocomposite Powders by the Spray Pyrolysis Process Using Ultrasonic Atomizer and Reduction Process

  • Choa, Y.H.;Kim, B.H.;Jeong, Y.K.;Chae, K.W.;T.Nakayama;T. Kusunose;T.Sekino;K. Niibara
    • Journal of Powder Materials
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    • v.8 no.3
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    • pp.151-156
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    • 2001
  • MgO based nanocomposite powder including ferromagnetic iron particle dispersions, which can be available for the magnetic and catalytic applications, was fabricated by the spray pyrolysis process using ultra-sonic atomizer and reduction processes. Liquid source was prepared from iron (Fe)-nitrate, as a source of Fe nano-dispersion, and magnesium (Mg)-nitrate, as a source of MgO materials, with pure water solvent. After the chamber were heated to given temperatures (500~$^800{\circ}C$), the mist of liquid droplets generated by ultrasonic atomizer carried into the chamber by a carrier gas of air, and the ist was decomposed into Fe-oxide and MgO nano-powder. The obtained powders were reduced by hydrogen atmosphere at 600~$^800{\circ}C$. The reduction behavior was investigated by thermal gravity and hygrometry. After reduction, the aggregated sub-micron Fe/MgO powders were obtained, and each aggregated powder composed of nano-sized Fe/MgO materials. By the difference of the chamber temperature, the particle size of Fe and MgO was changed in a few 10 nm levels. Also, the nano-porous Fe-MgO sub-micron powders were obtained. Through this preparation process and the evaluation of phase and microstructure, it was concluded that the Fe/MgO nanocomposite powders with high surface area and the higher coercive force were successfully fabricated.

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End-to-End Digital Secure Speech Communication over UHF and PSTN (UHF와 PSTN간 단대단 디지털 음성보안통신)

  • Kim, Ki-Hong
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.13 no.5
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    • pp.2313-2318
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    • 2012
  • With the widely applications of tactical radio networks, end-to-end secure speech communication in the heterogeneous network has become a very significant security issue. High-grade end-to-end speech security can be achieved using encryption algorithms at user ends. However, the use of encryption techniques results in a problem that encrypted speech data cannot be directly transmitted over heterogeneous tactical networks. That is, the decryption and re-encryption process must be fulfilled at the gateway between two different networks. In this paper, in order to solve this problem and to achieve optimal end-to-end speech security for heterogeneous tactical environments, we propose a novel mechanism for end-to-end secure speech transmission over ultra high frequency (UHF) and public switched telephone network (PSTN) and evaluate against the performance of conventional mechanism. Our proposed mechanism has advantages of no decryption and re-encryption at the gateway, no processing delay at the gateway, and good inter-operability over UHF and PSTN.

CPU Parallel Processing and GPU-accelerated Processing of UHD Video Sequence using HEVC (HEVC를 이용한 UHD 영상의 CPU 병렬처리 및 GPU가속처리)

  • Hong, Sung-Wook;Lee, Yung-Lyul
    • Journal of Broadcast Engineering
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    • v.18 no.6
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    • pp.816-822
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    • 2013
  • The latest video coding standard HEVC was developed by the joint work of JCT-VC(Joint Collaborative Team on Video Coding) from ITU-T VCEG and ISO/IEC MPEG. The HEVC standard reduces the BD-Bitrate of about 50% compared with the H.264/AVC standard. However, using the various methods for obtaining the coding gains has increased complexity problems. The proposed method reduces the complexity of HEVC by using both CPU parallel processing and GPU-accelerated processing. The experiment result for UHD($3840{\times}2144$) video sequences achieves 15fps encoding/decoding performance by applying the proposed method. Sooner or later, we expect that the H/W speedup of data transfer rates between CPU and GPU will result in reducing the encoding/decoding times much more.