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http://dx.doi.org/10.3746/jkfn.2016.45.6.797

Anti-Gout Effect of Ethanol Extracts from Chrysanthemum indicum Linne  

Park, So-Young (Department of Physiology/Aging-Associated Vascular Disease Research Center, College of Medicine, Yeungnam University)
Cho, Young-Je (School of Food Science and Biotechnology/Food & Bio-Industry Research Institute, Kyungpook National University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.45, no.6, 2016 , pp. 797-804 More about this Journal
Abstract
In an acute toxicity test for Chrysanthemum indicum Linne, 0.5~10 g/kg of Chrysanthemum indicum Linne extracts were administered. Chrysanthemum indicum Linne did not produce acute toxicity even at high doses of 10 g/kg, making it a highly safe material. In the chronic toxicity test, oral administration of Chrysanthemum indicum Linne up to 2 g/kg was carried out for 13 weeks, showing liver non-toxicity. The gout inhibitory effect of Chrysanthemum indicum Linne extracts was measured by inflammatory cytokine expression and foot thickness after 24 h of monosodium urate crystal (MSU) oral administration when inflammatory cytokine production reached a maximum. The group administered 2~4 g/kg of Chrysanthemum indicum Linne extract showed an inhibitory effect on gout inflammation and edema, whereas the 10 g/kg administered group showed an increase in inflammation. Therefore, the moderate concentration of Chrysanthemum indicum Linne extract for gout inhibitory effect was under 4 g/kg. Chrysanthemum indicum Linne extract showed an anti-inflammatory effect on MSU as a relatively safe material at high capacity. These results indicate that Chrysanthemum indicum Linne extract is thought to be an excellent substance for gout prevention.
Keywords
anti-gout; ethanol extracts; Chrysanthemum indicum; ultra fine grinding;
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Times Cited By KSCI : 7  (Citation Analysis)
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