• Bulletin of the Korean Chemical Society
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• v.34 no.5
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• pp.1349-1354
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• 2013

Twenty two new 5-fluorouracil (5-FU) derivatives, 2-butoxy-4-substituted 5-fluoropyrimidines, were synthesized and characterized by IR, $^1H$ NMR, MS, HRMS. All compounds were preliminarily evaluated by MTT assay on human liver BEL-7402 cancer cell line in vitro. Ten compounds were selected to test their cytotoxic activity against A549, HL-60 and MCF-7 cancer cell lines in vitro. These compounds were more sensitive to BEL-7402 than other cell lines, particularly, cytotoxic activity of compounds 6b, 6d-f, 6p, 6s-u were in sub-micromolar scale. The highest cytotoxic potency against A549, HL-60 and MCF-7 was shown by 2-butoxy-4-chloro-5-fluoropyrimidine (5) with $IC_{50}$ values of 0.10, 1.66 and $0.59{\mu}M$, respectively. Compounds 6d and 6e were effective against MCF-7 with $IC_{50}$ $9.73{\mu}M$ and HL-60 with $IC_{50}$ $8.83{\mu}M$, respectively.

• Proceedings of the Materials Research Society of Korea Conference
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• 2009.05a
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• pp.38.2-38.2
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• 2009

마이크로노즐은 우주공간에서 인공위성의 자세를 바로잡는 데 필요한 마이크로 로켓에 들어가는 필수적인 부품이다. 마이크로 노즐은 또한 나노입자 적층 시스템(nano-particle deposition system, NPDS)에 들어갈 수 있다. NPDS는 세라믹 또는 금속 나노분말 입자를 노즐을 통해 초음속으로 가속시킨 뒤 상온에서 이를 기판에 적층시키는 새로운 시스템이다. 본 연구의 목표는 NPDS에 쓰이는 노즐을 일반적인 반도체 공정을 이용하여 마이크론 스케일의 목을 갖도록 한 마이크로노즐을 제작하는 데 있다. 보쉬 공정은 이러한 마이크로노즐을 제작하는데 필수적인 공정으로, 유도결합플라즈마를 이용해 실리콘 웨이퍼를 식각시키는 기술을 말한다. 보쉬 공정에 사용되는 플라즈마 기체는 $SF_6$와 $C_4F_8$인데, 이 두 가지 기체를 번갈아가면서 사용하여 실리콘 웨이퍼를 이방성 식각하는 것이 그 특징이다. 보쉬 공정에는 다양한 변수가 존재하며 이를 적절히 통제하면 마이크로노즐에 적합한 프로파일을 실리콘 웨이퍼 내에 형성시킬 수 있다. 본 연구에서는 보쉬 공정을 이용하여 3차원 마이크로 노즐을 제작하였다. 기존에 반응성이온식각(deep reactive ion etching, DRIE) 공정을 통해 마이크로노즐을 제작한 사례가 많이 보고되었지만 이들은 모두 2차원적으로 마이크로노즐을 제작하였다. 2차원적으로 제작한 마이크로노즐은 마이크로 로켓에 주로 사용되었지만, 초음속으로 가속된 분말이 노즐의 형상으로 인한 유체 흐름의 불안정성 때문에 NPDS에서는 오래도록 사용할 수 없다는 문제점이 있다. 그러므로 본 연구에서는 마이크로노즐을 3차원 형상으로 제작함으로써 이러한 문제점을 해결하고자 하였다.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.13 no.1
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• pp.72-80
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• 2009

Objective: We performed this study to check relationship of Cold-Heat attribute analyzed quantitatively by questionnaire with acoustic analysis index. Method : We checked a questionnaire composed of 15 items about the contents of Cold-Heat and asked 83 subjects to answer in the form Likert-like 7-points score. And then, we extracted Cold-Heat attribute from heat score, cold score, heat index and cold index. we measured the acoustic analysis indexes of cardinal vowels by Dr. speech program. Afterward, the data were analyzed by correlation analysis. Results : All cardinal vowels is positive correlated with cold score, heat score and cold index. NNE of vowel /a/ is negative correlated with cold index. Shimmer and F0 tremor of vowel /e/ is negative correlated with cold index. Jitter of vower /u/ is positive correlated with Cold score.

• The Transactions of the Korean Institute of Power Electronics
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• v.10 no.1
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• pp.87-94
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• 2005

This paper is about the compensation of phase angle error and amplitude difference in stationary 2 pole coordinates by the installation variation of sensor at low cost high resolution digital hybrid encoder. To solve the problem of amplitude difference at the existing hybrid encoder, we normalized the relative magnitude of the two analog signals. and also to solve the problem of installation variation when installed the sensor, we rotate the stationary 2 pole coordinates to compensate the location error of sensor. and we used and tested the QEP function and A/D port in DSP(TMS320F2812) to verify the mentioned proposed method.

• International Journal of Contents
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• v.9 no.2
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• pp.27-37
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• 2013

From the perspective of the domestic capital markets, there have been few researches on the financial characteristics of the firms belonging to the KOSDAQ(Korea Securities Dealers Automated Quotation) market, in comparison with those of the firms in the KOSPI. This study has performed three hypothesis tests to obtain the following results: By employing the 'panel data' analysis, it was found that, for the book-value based leverage, all of the six proposed IDVs were statistically significant as the financial determinants of leverage, across the two proxies measuring profitability (i.e., PFT and ROE), while all of the IDVs except VOLATILITY, also seemed to be the attributes to explain the market based dependent variable in the model with the PFT. Moreover, there may be statistically significant (structural) changes (or quasi-experiment) ) between the pre- and post-U.S. financial crisis in the year of 2008, when measured the leverage with the market-value basis with utilizing the Chow F-test. Finally, based upon the logistic regression results, the probability for a firm to be classified into the Prime section in the KOSDAQ market, may be higher, as its profit margin and asset turnover increase.

• Journal of Microbiology and Biotechnology
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• v.18 no.7
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• pp.1335-1341
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• 2008

The cell wall material from fruiting bodies of Laetporus sulphureus has been suggested as a new alternative to mutan for the mutanase induction in Trichoderma harzianum. Structural analyses revealed that the cell wall fraction from this polypore fungus contained 56.3% of (1$\rightarrow$3)-linked $\alpha$-glucans. When the strain T. harzianum F-340 was grown on a cell wall preparation from L. sulphureus, the maximal enzyme productivity obtained after 3 days of cultivation was 0.71 U/ml. This yield was about 1.8-fold higher than that achieved on mutan, known so far as the best, but expensive and inaccessible, inducer of mutanase production. Cell-wall-induced mutanase showed a high hydrolytic potential in reaction with a dextranase-pretreated mutan, where maximal degrees of saccharification and solubilization of this biopolymer (80% and 100%, respectively) were reached in 3 h at 45$^{\circ}C$. The mutanase preparation was also effective in degradation of streptococcal mutan and its removal from oral biofilms, especially in a mixture with dextranase.

• Transactions of the Korean Society of Automotive Engineers
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• v.6 no.6
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• pp.155-165
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• 1998

The resistance coefficient and heat transfer performance are studied for the turbulent water flow in a smooth coiled tube having variable curvature ratios and a corrugated-coiled tube having a ratio of coil to tube diameter of 22. Experiments are carried out for the fully developed turbulent flow of water in tube coils on the uniform wall temperature condition. This work is limited to tube coils of R/a between 22 and 60 and Reynolds numbers from 13000 to 53000. The tube having a ratio of coil to tube diameter of 27 among the 3 smooth tube coils shows the best heat transfer performance. A corrugated-coiled tube(R/a=60) shows more excellent performance than a smooth coiled tub (R/a=60) at a similar curvature ratio. The friction factor f is sensitive to changes in the velocity profile caused by a temperature gradient. Allowance was made for the pressure loss in the short inlet and outlet lengths and due to the presence of the thermocouple inlet and outlet as a result of separate experimental on a straight tube. It is to be expected that the allowance at the exit will be somewhat too low because of secondary flow effects carried over from the coil.

• Macromolecular Research
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• v.10 no.6
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• pp.332-338
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• 2002

The effect of an electron beam and ${\gamma}$-ray irradiation on the curing of epoxy resins was investigated. Diglycidyl ether of bisphenol A (DGEBA) and diglycidyl ether of bisphenol F (DGEBF) as epoxy resin were used. The epoxy resins containing 1.0-3.() wt% of triarylsulphonium hexafluoroantimonate(TASHFA) and triarylsulphonium hexafluorophosphate(TASHFP) as initiator were irradiated under nitrogen at room temperature with different dosage of EB and ${\gamma}$-rays from a Co$^{60}$ u source. The chemical and mechanical characteristics of irradiated epoxy resins were compared after curing of EB and ${\gamma}$-ray irradiation. The thermal properties of cured epoxy were investigated using dynamic mechanical thermal analysis. The chemical structures of cured epoxy were characterized using near infrared spectroscopy. Mechanical properties such as flexural strength, modulus were measured. The gel fraction of DGEBA with ${\gamma}$-ray was higher than that of the epoxy with EB at the same dose. Young's modulus of the sample irradiated by ${\gamma}$-ray is higher than that of sample cured by EB. From the result of strain at yield, it was found that the epoxy cured by ${\gamma}$-ray had a higher stiff property compared with the irradiated by EB.

• Journal of the Korean institute of surface engineering
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• v.32 no.3
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• pp.467-471
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• 1999

BN films were grown on silicon (l00) substrate by magnetically enhanced activated reactive evaporation (ME-ARE) with pulsed DC power instead of r.f. for substrate biasing. The deposited films were analyzed using Fourier transform infrared spectroscopy (FTIR) and transmission electron microscopy (TEM). FTIR results show that the intensity of absorption band of $sp^2$ bond of BN decreased and that of $sp^3$ bond of c-BN increased with increasing pulsed DC bias voltage applied to substrate. The initially grown layer at the interface was observed by TEM and considered to be of$ sp^2$-bonded BN. The cross-sectional and planar TEM micrographs show that the upper layer on the initial layer was the single phase c-BN. It is concluded that cubic boron nitride films could be synthesized by ME-ARE process with pulsed DC biasing.

• Nuclear Engineering and Technology
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• v.39 no.4
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• pp.287-298
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• 2007

As part of the $AP1000^{TM}$ pressurized water reactor design certification program, a series of integral systems tests of the nuclear steam supply system was performed at the APEX-1000 test facility at Oregon State University. These tests provided data necessary to validate Westinghouse safety analysis computer codes for AP1000 applications. In addition, the tests provided the opportunity to investigate the thermal-hydraulic phenomena expected to be important in AP1000 small-break loss of coolant accidents (SBLOCAs). The APEX-1000 facility is a 1/4-scale pressure and 1/4-scale height simulation of the AP1000 nuclear steam supply system and passive safety features. A series of eleven tests was performed in the APEX-1000 facility as part of a U.S. Department of Energy contract. In all, four SBLOCA tests representing a spectrum of break sizes and locations were simulated along with tests to study specific phenomena of interest. The focus of this paper is the SBLOCA tests. The key thermal-hydraulic phenomena simulated in the APEX-1000 tests, and the performance and interactions of the passive safety-related systems that can be investigated through the APEX-1000 facility, are emphasized. The APEX-1000 tests demonstrate that the AP1000 passive safety-related systems successfully combine to provide a continuous removal of core decay heat and the reactor core remains covered with considerable margin for all small-break LOCA events.