• 한국생물공학회:학술대회논문집
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• 2005.10a
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• pp.406-411
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• 2005

Fermented materials with enterobacteria isolated from fusiform fish, have strong anti-angiogenesis effect and anti-cell adhesion effect. PLM-f74 got from 74th fraction of size exclusion chromatography from fermented material, showed strong anti-cell adhesion effect between HUVECs and U937 monocytic cell. Adhesion of U937 cell to HUVEC stimulated with IL-1b was clearly inhibited by PLM-f74 in a dose-dependent manner by 12.1, 21.2, 50.9, and 78.2%, when U937 cells treated with each of the PLM-f74 and stimulated with PMA (100 mg/L) was added onto untreated and unstimulated HUVECs, adhesion was observed by 15.8, 31.9, 70.8, and 102%, when both cell types were pretreated with PLM-f74, the adhesion was prominently decreased by 83.7, 99.2, 110, and 120.8%, with 0.74, 3.7, 7.4, and 18.5ug/mL of PLM-f74, respectively. PLM-f74, also, reduced IL-1-stimulated HUVEC expression of adhesion molecules, VCAM-1, ICAM-1, and E-selectin dose-dependently by ELISA method.

• Koreanishche Zeitschrift fur Deutsche Sprachwissenschaft
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• v.6
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• pp.323-344
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• 2002

EuroNet ist eine multilinguale Datenbasis mit WordNets $f\"{u}r\;einige\;europ\"{a}ische$ Sprachen ($holl\"{a}ndisch$, italienisch, spanisch, deutsch, $franz\"{o}sisch$, tschechisch und estnisch). Die WordNets werden genauso wie das amerikanische WordNet $f\"{u}r$ Englisch (Princeton WordNet, Miller et al. 1990) in Synsets (Zusammensetzen der synonymen $W\"{o}rter$) mit grundlegenden lexikalisch-semantischen Relationen zwischen ihnen $ausgedr\"{u}ckt$ strukturiert. Jedes WordNet stellt also ein einzigartiges innersprachliches System $f\"{u}r$ die lexikalischen und konzeptuellen Relationen dar. $Zus\"{a}tzlich$ werden diese auf dem Princeton WordNet basierten WordNets (z.B. GermaNet) mit einem Inter-Linguale-Index (kurz, ILI) verbunden. $\"{U}ber$ diesem Index werden die Sprachen zusammengeschaltet, damit zu gehen ist $m\"{o}glich$, von den $W\"{o}rtern$ in einer Sprache zu den $\"{a}hnlichen\;W\"{o}rtern$ in jeder $m\"{o}glicher$ anderen Sprache. Der Index gibt auch Zugang zu einer geteilten Top-Ontologie von 63 semantischen Unterscheidungen. Diese Top-Ontologie stellt einen allgemeinen semantischen Rahmen $f\"{u}r$ aile Sprachen zur $Verf\"{u}gung,\;w\"{a}hrend$ sprachspezifische Eigenschaften in den einzelnen WordNets beibehalten werden. Die Datenbasis kann, unter anderen, $f\"{u}r$ einsprachige und multilinguale Informationsretrieval benutzt werden. In der vorliegenden Arbeit handelt sich also um eine methodologische Untersuchung der koreanisch-deutschen ILI-Verbindung zur Anwendung der auf dem EuroNet basierten lexikalischen, semantischen Datenbasis. Dabei werden einzelnen Lexeme in koreanischen, deutschen WordNets $zun\"{a}chst$ mit Hilfe der Sense-Analyse semantisch differenziert, und dann durch lexikalische und konzeptuelle Relationen(ILI) miteinander verbunden. Die Equivalezverbindungen dienen, sprachspezifische Konzepte zum ILI abzubilden. Sie werden von einem anderen Synset der moglichen Relationen aus der Euronet-Spezifikation genommen. Wenn es keinen ILI-Rekord gibt, der ein direktes Equivalenz zu einem gegebenen Konzept darstellt, kann das Konzept in der Frage $\"{u}ber$ EQ-Near-Synonymie, EQ-Hyperonymie oder EQ-Hyponymie Relationen verbunden werden.

• The Korean Journal of Air & Space Law and Policy
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• v.27 no.2
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• pp.29-65
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• 2012

Der neue strukturelle Ansatz der Kommbination eines Rahmen$\ddot{u}$bereinkommens und eines ausr$\ddot{u}$stungsspezifischen Sonderprotokolls bedingt einen neuen organisatorischen Anstz f$\ddot{u}$r die Zusammenarbeit zwischen internationalen Organisationen bei der Schaffung von internationalem Einheitsprivatrecht. So haben hier zwei internationale Organisationen gemeinsam die Verantwortung f$\ddot{u}$r einmultilaterales $\ddot{U}$bereinkommen $\ddot{u}$bernommen: auf der einen Seite UNIDROIT als die internationale Organisation, die generell f$\ddot{u}$r die Vereinheitlichung des Privatrechts kompetent ist; auf der anderen Seite ICAO als die f$\ddot{u}$r die private Luftfahrt zust$\ddot{a}$ndige internationale Organisation. Dieses neue, f$\ddot{u}$r die Luftfahrzeugausr$\ddot{u}$stung praktizierte organisatorische Modell eines joint venture zweier internationaler Organisation bei der Einheitsrechtsetzung, namlich die Betreuung eines allgemeinen privatrechtsvereinheitlichenden Rahmens$\ddot{u}$bereinkommens durch UNIDROIT und die Wahrnehmung der sektorspezifischen Belange in einem ausr$\ddot{u}$stungsspesifischen Sonderprotokoll durch die jeweils zust$\ddot{a}$ndige internationale Spezialorganisation, hat bereits f$\ddot{u}$r die Sektoren der Eisenbahn- und Weltraumausrustung Schule gemacht. Das in Kapstadt beschlossene v$\ddot{o}$lkervertragliche Regelungswerk hat erstmals ein einheitsrechtliches - grunds$\ddot{a}$atzlich weltweite Geltung anstrebendes - Sicherungsrecht geschafen. Dies kann f$\ddot{u}$r die Sachenrechtsintergration einen $\ddot{a}$hnlichen Durchbruch bedeuten, wis das Wiener UN-kaufrechts$\ddot{u}$bereinkommen von 1980 f$\ddot{u}$r das Schuldvertragsrecht. Voraussetzung daf$\ddot{u}$r ist allerdings die juristische Qualit$\ddot{a}$t und Praxisgerechtigkeit des Regelungswerkes und - insbesondere - das Funktionieren des Registersystems. Von wesentlicher Bedeutung f$\ddot{u}$r den Erfolg des $\ddot{U}$bereinkkommens wird auchsein, ob es Rechtssicherheit zu gew$\ddot{a}$hrleisten vermag.

• Journal of Aquaculture
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• v.6 no.2
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• pp.71-87
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• 1993

Two forms of sea mustard, Undaria Pinnatifida were cultured in order to compare the morphological characteristics and the efficiency of production. U. Pinnatifida f. distans was collected from Wando, Korea and U. Pinnatifida f. typica was transplanted from Sanriku, Japan. The latter form grew faster in length and weight than the former. Maximum growth was shown in early April for both forms, and the growth rates decreased after this. Absolute growth rates between the two forms were quite different. Average total lengths at the harvest season was 161.1cm in U. Pinnatifida f. distans and 183.5 em in U. Pinnatifida f. typica and average weights of those two forms were 1,003.4g and 1,314.6g, respectively. The weight of available parts for the salting process of the two forms were 734.8g and 968.5g, respectively. The rates of total length versus the length of the available part of the two forms were $76\%$ and $83\%$, respectively and those of the total length versus weight of the available part of them were $43.8\%$ and $52.7\%$, respectively. The results of this study suggest that the U. pinnatifida f. typica had more available part per unit weight than that of the U. pinnatifida f. distans for the efficiency of salt processing.

• Phonetics and Speech Sciences
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• v.9 no.1
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• pp.49-53
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• 2017

Formant frequencies depend on the position of tongue, the shape of lips, and larynx. In the auditory system, the external ear canal is an open-end resonator, which can modify the voice characteristics. This study investigates the effect of the real ear on formant frequencies. Fifteen subjects ranging from 22 to 30 years of age participated in the study. This study employed three corner vowels: the low central vowel /a/, the high front vowel /i/, and the high back vowel /u/. For this study, the voice of a well-educated undergraduate who majored in speech-language pathology, was recorded with a high performance condenser microphone placed in the upper pinna and in the ear canal. Paired t-test showed that there were significant difference in the formant frequencies of F1, F2, F3, and F4 between the free field and the real ear. For /a/, all formant frequencies decreased significantly in the real ear. For /i/, F2 increased and F3 and F4 decreased. For /u/, F1 and F2 increased, but F3 and F4 decreased. It seems that these voice modifications in the real ear contribute to interpreting voice quality and understanding speech, timbre, and individual characteristics, which are influenced by the shape of the outer ear and external ear canal in such a way that formant frequencies become centralized in the vowel space.

• Molecules and Cells
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• v.41 no.8
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• pp.733-741
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• 2018

Mutations in spliceosome components have been implicated in carcinogenesis of various types of cancer. One of the most frequently found is U2AF1 S34F missense mutation. Functional analyses of this mutation have been largely limited to hematological malignancies although the mutation is also frequently seen in other cancer types including lung adenocarcinoma (LUAD). We examined the impact of knockdown (KD) of wild type (wt) U2AF1 and ectopic expression of two splice variant S34F mutant proteins in terms of alternative splicing (AS) pattern and cell cycle progression in A549 lung cancer cells. We demonstrate that induction of distinct AS events and disruption of mitosis at distinct sub-stages result from KD and ectopic expression of the mutant proteins. Importantly, when compared with the splicing pattern seen in LUAD patients with U2AF1 S34F mutation, ectopic expression of S34F mutants but not KD was shown to result in common AS events in several genes involved in cell cycle progression. Our study thus points to an active role of U2AF1 S34F mutant protein in inducing cell cycle dysregulation and mitotic stress. In addition, alternatively spliced genes which we describe here may represent novel potential markers of lung cancer development.

• Journal of applied mathematics & informatics
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• v.32 no.1_2
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• pp.75-82
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• 2014

In this paper, we consider the periodic boundary value problem with sign changing nonlinearity $$u^{{\prime}{\prime}{\prime}}+{\rho}^3u=f(t,u),\;t{\in}[0,2{\pi}]$$, subject to the boundary value conditions: $$u^{(i)}(0)=u^{(i)}(2{\pi}),\;i=0,1,2$$, where ${\rho}{\in}(o,{\frac{1}{\sqrt{3}}})$ is a positive constant and f(t, u) is a continuous function. Using Leggett-Williams fixed point theorem, we provide sufficient conditions for the existence of at least three positive solutions to the above boundary value problem. The interesting point is the nonlinear term f may change sign.

• Journal of the Korean Mathematical Society
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• v.57 no.6
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• pp.1573-1590
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• 2020

In this paper, we classify all solutions bounded from below to uniformly elliptic equations of second order in the form of Lu(x) = a_ij(x)D_iju(x) + b_i(x)D_iu(x) + c(x)u(x) = f(x) or Lu(x) = D_i(a_ij(x)D_ju(x)) + b_i(x)D_iu(x) + c(x)u(x) = f(x) in unbounded cylinders. After establishing that the Aleksandrov maximum principle and boundary Harnack inequality hold for bounded solutions, we show that all solutions bounded from below are linear comb_inations of solutions, which are sums of two special solutions that exponential growth at one end and exponential decay at the another end, and a bounded solution that corresponds to the inhomogeneous term f of the equation.

• Nuclear Engineering and Technology
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• v.37 no.3
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• pp.293-298
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• 2005

We have performed the density functional theory calculations of $UO_2$ using the spin-polarized generalized gradient approximation (SP-GGA) and the SP-GGA+U approach. The SP-GGA+U approach correctly predicts the insulating electronic structure with antiferromagnetic ordering, but the SP-GGA calculations predict metallic behavior. The cohesive properties obtained from the SP-GGA+U calculations are in good agreement with the available experimental results and previous calculations. The spin-polarized local density of states shows that the antiferromagnetic ordering of $UO_2$ is governed by 5f orbitals of uranium ion. Our calculations demonstrate that the strong correlation of U 5f electrons should be taken into account for a reliable description of $UO_2$ physics.

• Communications of the Korean Mathematical Society
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• v.18 no.4
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• pp.653-659
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• 2003

Let $1{\;}\leq{\;}p{\;}\infty{\;}and{\;}{\alpha}{\;}>{\;}-1$. If f is a holomorphic self-map of the open unit disc U of C with f(0) = 0, then the quantity $\int_U\;\{\frac{$\mid$f'(z)$\mid$}{1\;-\;$\mid$f(z)$\mid$^2}\}^p\;(1\;-\;$\mid$z$\mid$)^{\alpha+p}dxdy$ is equivalent to the operator norm of the composition operator $C_f{\;}:{\;}B{\;}\rightarrow{\;}A^{p,{\alpha}$ defined by $C_fh{\;}={\;}h{\;}\circ{\;}f{\;}-{\;}h(0)$, where B and $A^{p,{\alpha}$ are the Bloch space and the weighted Bergman space on U respectively.