• Title/Summary/Keyword: Type I Analysis

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Survival analysis of spinal muscular atrophy type I

  • Park, Hyun-Bin;Lee, Soon-Min;Lee, Jin-Sung;Park, Min-Soo;Park, Kook-In;NamGung, Ran;Lee, Chul
    • Clinical and Experimental Pediatrics
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    • v.53 no.11
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    • pp.965-970
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    • 2010
  • Purpose: The life expectancy of patients with spinal muscular atrophy (SMA) type I is generally considered to be less than 2 years. Recently, with the introduction of proactive treatments, a longer survival and an improved survival rate have been reported. In this study, we analyzed the natural courses and survival statistics of SMA type I patients and compared the clinical characteristics of the patients based on their survival periods. Methods: We reviewed the medical records of 14 pediatric patients diagnosed with SMA type I during a 9-year period. We examined the demographic and clinical characteristics of these patients, calculated their survival probabilities, and plotted survival curves as on the censoring date, January 1, 2010. We also compared the characteristics of the patients who died before the age of 24 months (early-death, ED group) and those who survived for 24 months or longer (long-survival, LS group). Results: The mean survival time was $22.8{\pm}2.0$ months. The survival probabilities at 6 months, 12 months, 18 months, 24 months, and 30 months were 92.9%, 92.9%, 76.0%, 76.0%, and 65.1%, respectively. Birth weight was the only factor that showed a statistically significant difference between the ED and LS groups ($P$=0.048). Conclusion: In this study, the survival probabilities at 2 years were far greater than expected. Because of the limited number of patients and information in this study, the contribution of improved supportive care on longer survival could not be clarified; this may be elucidated in larger cohort studies.

THE EFFECTS OF SODIUM FLUORIDE ON TYPE I $\alpha$ 2 COLLAGEN RIBONUCLEIC ACID (mRNA) LEVEL IN MURIN OSTEOBLAST LIKE (MC3T3-E1) CELLS (Sodium Fluoride가 조골세포주 MC3T3-E1의 제 1 형 ${\alpha}2$ 교원질 mRNA에 미치는 영향에 관한 연구)

  • Hwang, Jeung-Bin;Chung, Kyu-Rhim;Park, Young-Guk
    • The korean journal of orthodontics
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    • v.23 no.3 s.42
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    • pp.415-425
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    • 1993
  • Fluoride is one of the most potent stimulators of bone formation in vivo. But its direct effects on osteoblast is not yet clear This study was to investigate the effects of Sodium fluoride on alkaline phosphatase(ALP) activity, cAMP formation responsive to parathormone(PTH) and type I $\alpha$ 2 collagen ribonucleic acid (mRNA) level in Murin osteoblast-like (MC3T3-E1) cells. The cells were cultured in $\alpha-Minimal$ essential medium $(\alpha-MEM)$ supplemente with $10\%$ fetal bovine serum (FBS) and then changed to $0.1\%$ FBS with various concentration of Sodium fluoride. The ALP activity was assayed by the method of Lowry with disodium phenyl phosphated as substrate. cAMP formation was measured by Radioimmuno Assay(RIA). Type I $\alpha$ 2 collagen ribonucleic acid(mRNA) expression was studied by Nothern blot analysis. The results were as follows: 1. cAMP level was increased by PTH in MC3T3-E1 cells. 2. Sodium fluoride showed the tendency of inhibitory effects on cAMP responsiveness to PTH in MC3T3-E1 cells. 3. Sodium fluoride increased ALP activity at cocentration of $2{\mu}M,\;4{\mu}M,\;and\;10{\mu}M$ significantly different from control at the 0.001 level. ALP activity revealed maximum value at $10{\mu}M$ in this study. 4. Nothern blot analysis of Sodium fluoride treated cells, using Type I $\alpha$ 2 collagen prove, revealed significant increase at $10{\mu}M$ in MC3T3-E1 cells.

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Analysis of Binocular Vision by Wesson Fixation Disparity Card (Wesson Fixation Disparity Card를 이용한 양안시 분석)

  • Park, Hyun-Ju
    • Journal of Korean Ophthalmic Optics Society
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    • v.12 no.1
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    • pp.53-59
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    • 2007
  • A commonly used device to determine fixation disparity curves is the Wesson Fixation Disparity Card. A fixation disparity curve is an x, y coordinate plot of the angular amount of fixation disparity as a function of the power of prisms through which the patient views. The fixation disparity curve variables that are used to aid in the diagnosis and management of binocular vision disorders include the x-intercept, y-intercept, curve slope and curve type. Fixation disparity curves were measured on 102 subjects with the Wesson fixation disparity card. The purpose of this study is to investigate distribution of the curve types obtained with Wesson card. Fixation Disparity by Wesson Fixation Disparity Card were that in case of type I 63.0%, in case of type II 0.0%, in case of type III 25.0% and in case of type IV 12.0%.

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Development of Accident Analysis Model in Car to Pedestrian Accident (차 대 보행자 충돌 시 사고해석 모델 개발)

  • Kang, D.M.;Ahn, S.M.
    • Journal of Power System Engineering
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    • v.13 no.5
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    • pp.76-81
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    • 2009
  • The fatalities of pedestrian account for about 21.2% of all fatalities at 2007 year in Korea. To reconstruct exactly the accident, it is important to calculate the throw distance of pedestrian in car to pedestrian accident. The frontal shape of SUV vehicle is dissimilar to passenger car and bus, so the trajectory and throw distance of pedestrian by SUV vehicle is not the same of passenger car and bus. The influencing on it can be classified into the factors of vehicle and pedestrian, and road factor. It was analyzed by PC-CRASH for simulation, and SPSS s/w was used for regression analysis. From the simulation results, the maximum impact energy of multi-body of pedestrian was occurred to that of torso body at the same time. And the throw distance increased with the increasing of impact velocity, and decreased with the increasing of impact offset. Also it decreased with the increasing of velocity of pedestrian at accident, and the throw distance of wet road was longer than that of dry road. Finally, the regression analysis model of SUV(Nissan Pathfinder type)vehicle in car to pedestrian accident was as follows; $$disti_i=-0.87-0.11offseti_i+0.69speed_i-4.27height_i+0.004walk_i+0.63wet_i+{\epsilon}_i$$.

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A Study on Characteristics and Correspondence of Men's Back and Chest Types (20대 남성의 등면 및 가슴부위 형태특성과 대응에 관한 연구)

  • Paek, Kyung-Ja;Lee, Jeong-Ran
    • Fashion & Textile Research Journal
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    • v.6 no.3
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    • pp.357-366
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    • 2004
  • The purpose of this study is to classify the types of men's back and chest through the criteria which represent the characteristic of men's back and chest. We have the following conclusions based on our sample size of 291 men's back and chest. The result of factor analysis concerned with men's back indicates that six factors are extracted and they are consist of 80.6% of total variance. We divide the shape of back into three categories: bent, protrusion of the scapula, and breadth. Each category is divided into subcategories. According to the frequency based on our data entries of 291 men's back, we introduce five new types of men's back. 83.8% of examined men's back belong to one of these five types: (i) 15.5% of protrudent and lordotic type; (ii) 6.5% of flat and lordotic type; (iii) 22.7% of protrudent and normal type; (iv) 34.4% of flat and normal type; (v) 4.8% of flat and bent type. The result of factor analysis related to with men's chest shows that six factors are extracted and they are consist of 76.0% of total variance. We divide the shape of chest into three categories: thickness, breadth, and protrusion of the breast. Each category is divided into subcategories. According to the frequency based on our data entries of 291 men's chest, we introduce four new types of men's chest. 65.0% of examined men's chest belong to one of these four types: (i) 7.2% of full and well-developed type; (ii) 24.1% of full and developed type; (iii) 25.8% of flat and developed type; (iv) 7.9% of flat and under-developed type. In order to consider the shape of the upper body as a whole, the back and the chest types should be corresponded.

An Analysis on the Salespeople typed of Apparel Steres in Daegu(Part I) (의류제품 판매원 유형 분석(제1보) -대구지역 의류매장을 중심으로-)

  • 임선영;김정원
    • Journal of the Korean Society of Clothing and Textiles
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    • v.22 no.3
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    • pp.396-406
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    • 1998
  • The purpose of this study was to classify the types of salespeople in the apparel stores. A questionnaire was administered to 267 fashion sales related persons in apparel store in downtown, Daegu. Data were analyzed by using frequency, i-test, cluster analysis, MANOVA, ANOVA and Duncan test by using J.M.p(v.2.01) Mac. program and SAS for windows(v. 6.02) PC program. The results of this study were as follows: The types of salespeople were classified into 4 types: "complaining type as a salespeople", "sensitive type for other affairs than their duty", "satisfying as a salespeople" and "performance reaction type". There were significant differences in academic background, selling apparel type/apparel store type, and in all factors in job satisfaction/dissatisfaction, attitude toward working condition, customer type, and selling training by the different types of salespeople. Complaining type as a salespeople were dissatisfied with most items related with job attitude and showed negative response as salespeople. Sensitive type for other affairs than their duty responded more keenly to other affairs than their duty and showed the highest dissatisfaction on the job dissatisfaction factors, and showed the most emotional reaction on attitude toward working condition, customer type, and regulation. Satisfying type as salespeople showed the positive and active attitude for their job. Performance reaction type were satisfied with their job as salespeople only when their performance is tangible as sales increases and showed highest satisfaction only on the job satisfaction factors. The necessity of professional training was shown in all types of salespeople.g was shown in all types of salespeople.

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Human Cardiac Troponin I 면역분석을 위한 단일클론 항체의 특성화

  • O, Heung-Il;Yang, Jin-A;Baek, Ui-Hwan;Baek, Se-Hwan
    • 한국생물공학회:학술대회논문집
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    • 2000.11a
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    • pp.713-714
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    • 2000
  • Six monoclonal antibodies to human cardiac troponin I (hcTnI) were produced to eventually develop an immunosensor for acute myocardial infarction (AMI). For the characterization of these antibodies, a set of 11 different peptides covering selected ranges of the complete amino acid sequence of hcTnI was prepared and used for epitope mapping. Such analysis allowed to select an appropriate pair of antibodies that can form a sandwich type of immune complexes and was consequently used for an immunoassay.

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A STUDY ON THE PRACTICAL ANALYSIS OF KOREAN PO'S (포의 실증적 분석에 관한연구)

  • 이해영
    • Journal of the Korean Society of Costume
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    • v.28
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    • pp.99-112
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    • 1996
  • In this study I purpose a new approach to the study of Korean costume history which includes a statistical method used in the prac-tical measurement of excavated Po's and the analysis of their quantitative changes. In the framework used in this study I de-pend on the nineteen variables picked out from the typological and chronological analysis of excavated clothes. The interrelationship of the variables as well as the standard of each part and its deviation in other forms are may main concern. Other methods are also very useful in my thesis: Correlation analysis Regression analysis Discrimination analysis Cluster analysis Discrimination analysis Cluster analysis Factor analysis One way analysis of variance. The findings of my study can be summarized as follows: 1. Every type of po has a general tendency to have more broadened sleeves while it does not show any considerable changes in the total length and in the width of armholes. 2. In the Correlation analysis each part of Po's is handled separately accordign to its chronology and type. The Regreesion analysis makes it possible to provide the sizes of miss-ing parts in excavated clothes and the numeri-cal value of each part needed in the pattern making. 3. The Discrimination analysis of the Po's whose types are unknown leads to the con-clusion that Chongsam and Chikryong Po are classified into Chikryong Po whereas Hongui is classified into Jooui In addition I propose discriminational function by which the age classification is possible discovering the variables associated with time change. 4. Five items-Gerneral Park's clothes Taewongun's clothes and three others produced later for the purpose of preserving Korean costume are proved to be in a differ-ent group and hence analyzed separately in the visual grouping of changui which is done after the cluster analysis and the factor analysis. 5. The results of the one way analysis of variance reveal that there is a difference in each part from period: the back width the sleeve length the sleeve width thelean fig-ure the breasttie length the breasttie width outside quesset upper inside quesset lower outside neckband length insideneckband length etc.

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