• Title/Summary/Keyword: Two-point correlation

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Utility of CoaguChek XS for Monitoring the Prothrombin Time (프로트롬빈시간 모니터링을 위한 CoaguChek XS의 유용성)

  • Park, Rojin;Kim, Yong-Hyun;Kwon, Kyung Ock;Na, Jongsung;Won, Yong Soon;Sung, Ki Bum;Lee, Nae-Hee;Choi, Tae Youn;Shin, Jeong Won;Shin, Hee Bong;Lee, Yong-Wha;Lee, You Kyeong
    • Tuberculosis and Respiratory Diseases
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    • v.65 no.6
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    • pp.471-475
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    • 2008
  • Background: In order to achieve a maintenance level and to prevent hemorrhagic complications, regular monitoring of the INR is mandatory for patients on oral anticoagulation therapy (OAT). A point-of-care instrument for INR monitoring is convenient for users, but the accuracy of the results has been controversial, and so this calls for exact evaluation of the point-of-care instrument that is used for INR monitoring. Methods: From Aug 2007 through Feb 2008, 85 patients on OAT among the all the patients who were admitted to Soonchunhyang University Bucheon Hospital were involved in this study. Parallel measurements of the PT INR were performed using a CoaguChek-XS and, a CA-7000 laboratory reference instrument and the results were analyzed. In addition, the patients' clinical data, including the diagnosis and the frequency and interval of the INR measurements, were also analyzed. Results: Of the 85 patients, 25 were admitted more than once to undergo INR testing and the mean interval between testing was 8.6 weeks with 39% and 38% of the tests being less than INR 2 units with using the CoaguChek-XS and the reference method, respectively. The coefficients of variation of CoaguChek-XS were 4.50 and 2.45 for the high and low INR patients, respectively. An excellent correlation was found between the two methods with a $R^2$ of 0.966 (p<0.001). Through Bland-Altman analysis, the mean INR difference between the two methods was 0.13 with the limit of agreement being -0.47~+0.72 with a 95% confidence interval. CoaguChek-XS was shown to overestimate the INR value for patients with an increasing INR, as compared to the reference method. Conclusion: CoaguChek-XS demonstrated great precision and accuracy for patients on OAT when compared to the laboratory INR results. Accordingly, the instrument should help to monitor the INR in the patients on OAT.

Development of River Recreation Index Model by Synthesis of Water Quality Parameters (수질인자의 합성에 의한 하천 레크리에이션 지수 모델의 개발)

  • Seo, Il Won;Choi, Soo Yeon
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.34 no.5
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    • pp.1395-1408
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    • 2014
  • In this research, a River Recreation Index Model (RRIM) was developed to provide sufficient information on the water quality of rivers to the public in order to secure safety of publics. River Recreation Index (RRI) is an integrated water quality information for recreation activities in rivers and expressed as the point from 0 to 100. The proposed RRIM consisted of two sub models: Fecal Coliform Model (FCM) and Water Quality Index Model (WQIM). FCM predicted Fecal Coliform Grade (FCG) using a logistic regression and WQIM synthesized water quality parameters of, DO, pH, turbidity and chlorophyll a into Water Quality Index (WQI). FCG and WQI were integrated into RRI by the integrating algorithm. The proposed model was applied to upstream of Gangjeong Weir in Nakdong River, and compared with Real Time Water Quality Index (RTWQI) which is the existing water quality information system for recreation use. The results show that calculated RRI reflected change of integrated water quality parameters well. Especially chlorophyll a showed Pearson correlation coefficient -0.85 with RRI. Also, RRIM produced more conservative index than RTWQI because RRI was calculated considering uncertainty of water quality criteria. Further, RRI showed especially low values when fecal coliform was predicted as low grade.

A Study on the Relations Between a Health Promoting Daily Life Style and Self-Efficiency in University Students (대학생의 건강증진행위와 자기효능감과의 관계연구)

  • Huh, Eun Hee;Chung, Yeon Kang;Yeoum, Soon Gyo
    • Journal of the Korean Society of School Health
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    • v.11 no.2
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    • pp.203-215
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    • 1998
  • The purpose of this study is to inquire into the degree of health promotion activity in university students, and to find out the relationship between self-efficiency and health promotion behavior, Thus, we can offer basic data for developing an educational method or program for health promotion. For this research, data was collected from university men and women through a questionnaire from February 18 to March 20, 1998. A measuring instrument was based on lating reviews of health promotion behavior in chronic disease protection, perceived self efficiency, demographic factors, biological factors, and circumstatial factors. The content validity of the instrument was authenticated by two professors of nursing, and reliability was confirmed by 'cronbach' (${\alpha}^{\prime}$ after mortifying content through a pre-test on 30 students. 475 persons were analyzed in terms of average, percentage, t-test, ANOVA, Pearson's Correlation Coefficient, and Multiple Stepwise Regression by 'SPSS-PC'. The analyzed data is as follows: 1. Higher self-efficiency, as a cognitive-perceptual factor, has a beneficial effect on health promotion behavior (r=.479, p=.000). The result of analyzing the differences among a low group, a middle group, a high group in terms of self-efficiency reveals that the relationship between self-efficiency and health promoting behavior is meaningful. 2. The degree of health promoting behavior is 3.26 out of 6. Other figuresrelating to health promoting behavior, are as follows. self-actualization area (4.62), interpersonal area (4.60), stress management area (4.01), nutrition area (3.68), responsibility of health area (3.11), liquid and cigaret area (2.85), and exercise area (2.33). 3. The degree of self-efficiency was 6.81 out of 10. Other figures relating to self-efficiency are as follows. interpersonal area (7.89), self-actualization area (7.84), liquid and cigarette area (7.72), exercise area (6.88), stress management area (6.84), responsibility of health area (6.35), and nutrition area (6.34). 4. The different lerels of health promoting behavior according to a subject's general factos are following: age (p=0.003), sex (p=0.000), health concern of parents (p= 0.000), taking health programs (p=0.007), case history of familes (p=0.048). Health promoting behavier is also positirely affeted by the following: higher age, social sciences focus, religion, living the relatives', and the higher health concerns of parents. 5. The difference of self-efficiency according to a subject's general factors is positirely affected by sex (p=.008), the health concerns of parents (p=.004), body indexes (p=.001), and the higher health concerns of parents. 6. As the result of analyzing major factors, the most powerful factor appears to be self-efficiency, 26.6% of health promoting behavior. Suggestions: 1. Results of this study point to self-efficiency as a major factor in the health promoting behavior of university students. It is crucial, therefore, to develop a health program to promote self-efficiency and to study how to promote prerention of certain diseases. 2. That health promoting behavior appears low in this study shows that health education should be taken into the university class, with a focus on the daily life of students as its goal.

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Chromosome Imbalances and Alterations of AURKA and MYCN Genes in Children with Neuroblastoma

  • Inandiklioglu, Nihal;Yilmaz, Sema;Demirhan, Osman;Erdogan, seyda;Tanyeli, Atila
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.11
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    • pp.5391-5397
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    • 2012
  • Background: Neuroblastoma (NB), like most human cancers, is characterized by genomic instability, manifested at the chromosomal level as allelic gain, loss or rearrangement. Genetics methods, as well as conventional and molecular cytogenetics may provide valuable clues for the identification of target loci and successful search for major genes in neuroblastoma. We aimed to investigate AURKA and MYCN gene rearrangements and the chromosomal aberrations (CAs) to determine the prognosis of neuroblastoma. Methods: We performed cytogenetic analysis by G-banding in 25 cases [11 girls (44%) and 14 boys (66%)] and in 25 controls. Fluorescence in situ hybridization (FISH) with AURKA and MYCN gene probes was also used on interphase nuclei to screen for alterations. Results: Some 18.4% of patient cells exhibited CAs., with a significant difference between patient and control groups in the frequencies (P<0.0001). Some 72% of the cells had structural aberrations, and only 28% had numerical chnages in patients. Structural aberrations consisted of deletions, translocations, breaks and fragility in various chromosomes, 84% and 52% of the patients having deletions and translocations, respectively. Among these expressed CAs, there was a higher frequency at 1q21, 1q32, 2q21, 2q31, 2p24, 4q31, 9q11, 9q22, 13q14, 14q11.2, 14q24, and 15q22 in patients. 32% of the patients had chromosome breaks, most frequently in chromosomes 1, 2, 3, 4, 5, 8, 9, 11, 12, 19 and X. The number of cells with breaks and the genomic damage frequencies were higher in patients (p<0.001). Aneuploidies in chromosomes X, 22, 3, 17 and 18 were most frequently observed. Numerical chromosome abnormalities were distinctive in 10.7% of sex chromosomes. Fragile sites were observed in 16% of our patients. Conclusion: Our data confirmed that there is a close correlation between amplification of the two genes, amplification of MYCN possibly contributing significantly to the oncogenic properties of AURKA. The high frequencies of chromosomal aberrations and amplifications of AURKA and MYCN genes indicate prognostic value in children with neuroblastomas and may point to contributing factors in their development.

The Relationship between Modified Mallampati Grade, Tonsillar Grade and Apnea-Hypopnea Index (변형 Mallampati 지수 및 편도 지수와 무호흡-저호흡지수의 지수의 상관관계)

  • Ahn, Byung-Hoon;Choi, Jong-Won;Park, Youn-Ho;Song, In-Hyuk;Nam, Young-Jin;Song, Dal-Won
    • Sleep Medicine and Psychophysiology
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    • v.11 no.2
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    • pp.84-88
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    • 2004
  • Objectives: Obstructive sleep apnea (OSA) syndrome is diagnosed through history, physical examination, imaging studies and polysomnography. Clinical examination of this condition may point to hypertrophic tonsils and crowded oropharynx. The objective of this study is to investigate the usefulness of modified Mallampati grade (MMG) and tonsil grade (TG) in predicting the severity of obstructive sleep apnea. Methods: MMG and TG were divided into 4 and 5 groups, respectively, according to their severity. Medical records were collected from 94 patients who had received polysomnography and otorhinolaryngologic examination for snoring and sleep apnea at Keimyung University Dongsan Medical Center from March 2002 through April 2004. Patients were divided into two groups according to the apnea-hypopnea index (AHI):control (n=24), and patients with sleep apnea (n=70). Results: Patients with higher MMG and TG had higher AHI, and MMG and TG proved to have a statistically significant correlation with AHI (p<0.05) Conclusion: MMG and TG were reliable predictors of OSA and helpful parameters in deciding treatment method.

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Relationship between Pedestrian Network and Pedestrian Volume Using Connectivity (연결도를 이용한 보행네트워크와 보행통행량의 상호관련성 연구)

  • Han, Sang-Jin;Kim, Young-Ook;Oh, Soon-Mi
    • Journal of Korean Society of Transportation
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    • v.26 no.1
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    • pp.137-144
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    • 2008
  • It is important to know pedestrian volume to carry out pedestrian safety analysis and pedestrian friendly design. However, it is too difficult to come across research work related to pedestrian volume analysis in the field of transport, due to lack of interests on pedestrian movement. Most transport research has been focused on vehicles and highways rather than pedestrian. On the other hand, in the field of urban studies, there comes an effective tool to estimate pedestrian volumes using Space Syntax theory. This theory twins out to be effective and economic because it only requires network information, which is easy to acquire from maps and field survey. However, this method is different in the way representing networks from the way that is common in the field of transport. To make up for this point, this paper develops a novel measure for estimating pedestrian volume using Dial's algorithm, and applies the model in the two test networks; Insadong and Soongryemoon networks. The application results reveals that developed measure is an effective tool to explain pedestrian volume; a correlation coefficient between the measure and pedestrian volume is 0.713 in Insadong and 0.492 in Soongryemoon, and the goodness of fit($R^2$) of regression models are 0.893 in Insadong and 0.671 in Soongryemoon. This estimation method is significantly less complicated to estimate the effect of a pedestrian network change than Space Syntax theory, which requires special softwares not readily available.

Establishment of Artificial Screening Methods and Evaluation of Barley Germplasms for Resistance to Fusarium Head Blight (보리 붉은곰팡이병 검정법과 저항성 품종 선발)

  • Han Ouk-Kyu;Kim Jung-Gon
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.50 no.3
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    • pp.191-196
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    • 2005
  • Fusarium head blight (FHB) is a severe disease problem that affects the quality and yield of barley grain. The evaluation of FHB resistance is difficult because environmental conditions greatly influence FHB infection and development. The objectives of this study were to: 1) establish an efficient screening method for selecting resistant barley to FHB, 2) compare FHB severity between the cut-spike method and pot-plant method for development of mass screening, and 3) estimate FHB resistance for barley germplasms. Barley cultivars and lines were evaluated for reaction to FHB in controlled-greenhouse condition. Spikes were spray-inoculated with a suspension $(5.0\times10^5\;macroconidia\;mL^{-1})$ of Fusarium graminearum SCK-O4 strain, and then kept in a greenhouse at $18-25^{\circ}C$ with $80-100\%$ relative humidity. Inoculation were employed at 3 different heading growth stages (heading date, three days after heading, and five days after heading). The inoculation was performed in 2 consecutive days in order to avoid escapes. The inoculated plants were maintained in the greenhouse at 4 different free moisture periods (1, 3, 5, and 7 days). The percentage of FHB severity was scored from 0 to 9 according to the rate of infected kernels per spike, and three spikes were evaluated per replication with 3 replicates. There were significant differences of FHB severity depending on the different free moisture periods, but not by the inoculation at different heading stages. The optimum evaluation point of FHB severity in the greenhouse condition was on the 7th day under free moisture condition after inoculation at the heading date. Infection level in cut-spike method highly correlated with that in pot-plant method. This suggested that cut-spike method is useful in evaluating of FHB resistance in barley. Six cultivars, such as Jinkwang, Buheung, Atahualpha 92, Chevron-b, Gobernadora-d, and MNBrite-c, were selected as resistant varieties to FHB. Correlation coefficient for the FHB severity evaluated by the pot-plant method between two seasons was 0.794, indicating the stability and accuracy of the screening method.

Correlation Analysis and Growth Prediction between Climatic Elements and Radial Growth for Pinus koraiensis (잣나무 연륜생장과 기후요소와의 상관관계 분석 및 생장예측)

  • Chung, Junmo;Kim, Hyunseop;Lee, Sangtae;Lee, Kyungjae;Kim, Meesook;Chun, Yongwoo
    • Korean Journal of Agricultural and Forest Meteorology
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    • v.17 no.2
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    • pp.85-92
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    • 2015
  • This study was conducted to analyze the relationship among climatic factors and radial growth of Pinus koraiensis in South Korea. To determine climate-growth relationships, cluster analysis was applied to group climatically similar surveyed regions, and dendroclimatological model was developed to predict radial growth for each climate group under the RCP 4.5 and RCP 8.5 scenarios for greenhouse gases. The dendroclimatological models were developed through climatic variables and standardized residual chronology for each climatic cluster of P. koraiensis. 2 to 4 climatic variables were used in the models ($R^2$ values between 0.35~0.49). For each of the climatic clusters for Pinus koraiensis, the growth simulations obtained from two RCP climate-change scenarios were used for growth prediction. The radial growth of the Clusters 2 and 3, which grow at high elevation, tend to increase. In contrast, Cluster 1, which grows at low elevation, tends to decrease with a large difference. Thus, the growth of Pinus koraiensis, which is a boreal species, could increase along with increasing temperature up to a certain point.

Prediction Model for Popularity of Online Articles based on Analysis of Hit Count (온라인 게시글의 조회수 분석을 통한 인기도 예측)

  • Kim, Su-Do;Cho, Hwan-Gue
    • The Journal of the Korea Contents Association
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    • v.12 no.4
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    • pp.40-51
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    • 2012
  • Online discussion bulletin in Korea is not only a specific place where user exchange opinions but also a public sphere through which users discuss and form public opinion. Sometimes, there is a heated debate on a topic and any article becomes a political or sociological issue. In this paper, we propose how to analyze the popularity of articles by collecting the information of articles obtained from two well-known discussion forums such as AGORA and SEOPRISE. And we propose a prediction model for the article popularity by applying the characteristics of subject articles. Our experiment shown that the popularity of 87.52% articles have been saturated within a day after the submission in AGORA, but the popularity of 39% articles is growing after 4 days passed in SEOPRISE. And we observed that there is a low correlation between the period of popularity and the hit count. The steady increase of the hit count of an article does not necessarily imply the final hit count of the article at the saturation point is so high. In this paper, we newly propose a new prediction model called 'baseline'. We evaluated the predictability for popular articles using three models (SVM, similar matching and baseline). Through the results of performance evaluation, we observed that SVM model is the best in F-measure and precision, but baseline is the best in running time.

Greenhouse Gas (CH4, CO2, N2O) Emissions from Estuarine Tidal and Wetland and Their Characteristics (온실기체 (CH4, CO2, N2O)의 하구언갯벌 배출량과 배출특성연구)

  • Kim, Deug-Soo
    • Journal of Korean Society for Atmospheric Environment
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    • v.23 no.2
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    • pp.225-241
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    • 2007
  • A closed flux chamber system was used for measuring major greenhouse gas (GHG) emission from tideland and/or wetland soils in estuarine area at Saemankum, Kunsan in southwestern Korea during from months of February to June 2006. Hourly averaged GHG soil emissions were measured two to three times a day during the ebb tide hours only. Site soils were analyzed for soil parameters (temperature, pH, total organic contents, N and C contents in soil) in the laboratory. Soil GHG fluxes were calculated based on the GHG concentration rate of change measured inside a closed chamber The analysis of GHG was conducted by using a Gas Chromatography (equipped with ECD/FID) at laboratory. Changes of daily, monthly GHGs' fluxes were examined. The relationships between the GHG emissions and soil chemical contents were also scrutinized with respect to gas production and consumption mechanism in the soil. Soil pH was pH $7.47{\pm}0.49$ in average over the experimental period. Organic matter contents in sample soil was $6.64{\pm}4.98\;g/kg$, and it shows relatively lower contents than those in agricultural soils in Kunsan area. Resulting from the soil chemistry data, soil nitrogen contents seem to affect GHG emission from the tidal land surface. The tidal soil was found to be either source or sink for the major GHG during the experimental periods. The annual average of $CH_{4}\;and\;CO_{2}$ fluxes were $0.13{\pm}0.86\;mg\;m^{-2}h^{-1}\;and\;5.83{\pm}138.73\;mg\;m^{-2}h^{-1}$, respectively, which will be as a source of these gases. However, $N_{2}O$ emission showed in negative flux, and the value was $-0.02{\pm}0.66\;mg\;m^{-2}h^{-1}$, and it implies tidal land surface act as a sink of $N_{2}O$. Over the experimental period, the absolute values of gas fluxes increased with soil temperature in general. Averages of the ambient gas concentration were $86.8{\pm}6.\;ppm$ in $CO_{2},\;1.63{\pm}0.34\;ppm\;in\;CH_{4},\;and\;0.59{\pm}0.15\;ppm\;in\;N_{2}O$, respectively. Generally, under the presence of gas emission from agricultural soils, decrease of gas emission will be observed as increase in ambient gas concentration. We, however, could not found significant correlation between the ambient concentrations and their emissions over the experimental period. There was no GHG compensation points existed in tide flat soil.