• 제목/요약/키워드: Two stage approach

검색결과 556건 처리시간 0.028초

Development of High Performance Liquid Chromatography for Paclitaxel Purification from Plant Cell Cultures

  • Kim, Jin-Hyun;Choi, Hyung-Kyoon;Hong, Seung-Suh;Lee, Hyun-Soo
    • Journal of Microbiology and Biotechnology
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    • 제11권2호
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    • pp.204-210
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    • 2001
  • Paclitaxel can be produced in high yield and with a high degree of purify from plant cell cultures of Taxus chinensis. The complete purification method was systematically established and described. This method was an efficient procedure for the purification of paclitaxel from crude paclitaxel, consisting or reverse-phase chromatography, followed by a normal-phase chromatography. The two-stage HPLC purification scheme serves as an effective and economical approach for resolving paclitaxel from complex mixtures of taxoids, with high purify (>99%) and low impurities (<0.1%). The process is readily scalable to a pilot plant and eventually to a production environment where multikilogram quantities of material are expected to be produced. The process has been optimized to minimize solvent usage, complexity, and operating costs.

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실 주행조건을 고려한 군용 소형트럭의 가상 내구해석 (Virtual Fatigue Analysis of a Small-sized Military Truck Considering Actual Driving Modes)

  • 서권희;임현빈;송부근;안창순
    • 한국자동차공학회논문집
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    • 제16권4호
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    • pp.120-127
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    • 2008
  • A military vehicle undergoes normal to extreme driving conditions, which consequently induce the fatigue and fracture of cabin and frame. So, it is important to estimate the fatigue life of two components at an initial design stage. In this paper, Modal Superposition Method(MSM) was applied to evaluate the durability performance of a small-sized military truck. For reliable durability analysis, a Virtual Test Lab(VTL) Model was established by correlation with experimental results. These data were extracted from actual driving test, modal test, and SPMD(Suspension Parameter Measuring Device) test. This process shows that Virtual Fatigue Analysis can be a useful approach in the development of military vehicles as well as commercial vehicles.

Multistage Point and Confidence Interval Estimation of the Shape Parameter of Pareto Distribution

  • Hamdy, H.I.;Son, M.S.;Gharraph, M.K.;Rashad, A.M.
    • Communications for Statistical Applications and Methods
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    • 제10권3호
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    • pp.1069-1086
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    • 2003
  • This article presents the asymptotic theory of triple sampling procedure as pertain to estimating the shape parameter of Pareto distribution. Both point and confidence interval estimation are considered within the same inference unified framework. We show that this group sampling technique possesses the efficiency of Anscome (1953), Chow and Robbins (1965) purely sequential procedure as well as reduce the number of sampling operations by utilizing Stein (1945) two stages procedure. The analysis reveals that the technique performs excellent as far as the accuracy is concerned. The present problem differs from those considered by many authors, in multistage sampling, in that the final stage sample size and the parameter's estimate become highly correlated and therefore we adopted different approach.

Polyphase Representation of the Relationships Among Fullband, Subband, and Block Adaptive Filters

  • Tsai, Chimin
    • 제어로봇시스템학회:학술대회논문집
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    • 제어로봇시스템학회 2005년도 ICCAS
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    • pp.1435-1438
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    • 2005
  • In hands-free telephone systems, the received speech signal is fed back to the microphone and constitutes the so-called echo. To cancel the effect of this time-varying echo path, it is necessary to device an adaptive filter between the receiving and the transmitting ends. For a typical FIR realization, the length of the fullband adaptive filter results in high computational complexity and low convergence rate. Consequently, subband adaptive filtering schemes have been proposed to improve the performance. In this work, we use deterministic approach to analyze the relationship between fullband and subband adaptive filtering structures. With block adaptive filtering structure as an intermediate stage, the analysis is divided into two parts. First, to avoid aliasing, it is found that the matrix of block adaptive filters is in the form of pseudocirculant, and the elements of this matrix are the polyphase components of the fullband adaptive filter. Second, to transmit the near-end voice signal faithfully, the analysis and the synthesis filter banks in the subband adaptive filtering structure must form a perfect reconstruction pair. Using polyphase representation, the relationship between the block and the subband adaptive filters is derived.

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VCO Design using NAND Gate for Low Power Application

  • Kumar, Manoj
    • JSTS:Journal of Semiconductor Technology and Science
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    • 제16권5호
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    • pp.650-656
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    • 2016
  • Voltage controlled oscillator (VCO) is widely used circuit component in high-performance microprocessors and modern communication systems as a frequency source. In present work, VCO designs using the different combination of NAND gates with three transistors and CMOS inverter are reported. Three, five and seven stages ring VCO circuits are designed. Coarse and fine tuning have been done using two different supply sources. The frequency with coarse tuning varies from 3.31 GHz to 5.60 GHz in three stages, 1.77 GHz to 3.26 GHz in five stages and 1.27 GHz to 2.32 GHz in seven stages VCO respectively. Moreover, for fine tuning frequency varies from 3.70 GHz to 3.94 GHz in three stages, 2.04 GHz to 2.18 GHz in five stages and 1.43 GHz to 1.58 GHz in seven stages VCO respectively. Results of power consumption and phase noise for the VCO circuits are also been reported. Results of proposed VCO circuits have been compared with previously reported circuits and present circuit approach show significant improvement.

Flow simulation and efficiency hill chart prediction for a Propeller turbine

  • Vu, Thi;Koller, Marcel;Gauthier, Maxime;Deschenes, Claire
    • International Journal of Fluid Machinery and Systems
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    • 제4권2호
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    • pp.243-254
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    • 2011
  • In the present paper, we focus on the flow computation of a low head Propeller turbine at a wide range of design and off-design operating conditions. First, we will present the results on the efficiency hill chart prediction of the Propeller turbine and discuss the consequences of using non-homologous blade geometries for the CFD simulation. The flow characteristics of the entire turbine will be also investigated and compared with experimental data at different measurement planes. Two operating conditions are selected, the first one at the best efficiency point and the second one at part load condition. At the same time, for the same selected operating points, the numerical results for the entire turbine simulation will be compared with flow simulation with our standard stage calculation approach which includes only guide vane, runner and draft tube geometries.

로보트 매니플레이터의 제어를 위한 강인한 적응 제어기의 설계 (A STUDY OF ROBUST CONTROLLER FOR ROBOT MANIPULATOR)

  • 박경희;홍석교
    • 대한전기학회:학술대회논문집
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    • 대한전기학회 1989년도 추계학술대회 논문집 학회본부
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    • pp.450-455
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    • 1989
  • In this paper we investigate the application to the motion control of n-link robotic manipulators of recently developed stable factorization approach to tracking and disturbance rejection. Given control scheme consists of an approximate "Computed Torque" based upon a simplified model together with additional state feedback and feedforward compensation, and then, nonlinear control gain has more useful than constant control gain to guarantee robustness to parameter uncertainty and external disturbance. At this stage, we design high gain nonlinear state feedback controller and simulate this controller at the SCARA type robot manipulator of two joint.

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자율분사협조형 시스템에 있어서의 자율형 AGV를 위한 경로계획에 관한 응용연구 (A study on path planning for autonomous AGV in an autonomous distributed & cooperated system)

  • 임재국
    • 한국경영과학회:학술대회논문집
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    • 한국경영과학회 1996년도 추계학술대회발표논문집; 고려대학교, 서울; 26 Oct. 1996
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    • pp.99-102
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    • 1996
  • Research regarding the Autonomous Distributed & Cooperated System has not yet been defined because we need to apply the interdisciplinary approach before so. In this paper, we use a clear definition, compare characteristics of the Autonomous Distributed & Cooperated System and examine the possibility of an actualization through path planning of Autonomous AGV. We propose a new algorithm about the generation method of a moving path at the first stage and a cooperative action generation for a collision avoidance. Lastly, we performed simulation analysis of these two in order to confirm efficiency.

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Using a Genetic-Fuzzy Algorithm as a Computer Aided Breast Cancer Diagnostic Tool

  • Alharbi, Abir;Tchier, F;Rashidi, MM
    • Asian Pacific Journal of Cancer Prevention
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    • 제17권7호
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    • pp.3651-3658
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    • 2016
  • Computer-aided diagnosis of breast cancer is an important medical approach. In this research paper, we focus on combining two major methodologies, namely fuzzy base systems and the evolutionary genetic algorithms and on applying them to the Saudi Arabian breast cancer diagnosis database, to aid physicians in obtaining an early-computerized diagnosis and hence prevent the development of cancer through identification and removal or treatment of premalignant abnormalities; early detection can also improve survival and decrease mortality by detecting cancer at an early stage when treatment is more effective. Our hybrid algorithm, the genetic-fuzzy algorithm, has produced optimized systems that attain high classification performance, with simple and readily interpreted rules and with a good degree of confidence.

차량의 후미등을 이용한 야간 고속도로상의 실시간 차량검출 및 카운팅 (Real Time Vehicle Detection and Counting Using Tail Lights on Highway at Night Time)

  • 칼릴로브 발리존;오염덕;김봉근
    • 한국컴퓨터정보학회:학술대회논문집
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    • 한국컴퓨터정보학회 2017년도 제56차 하계학술대회논문집 25권2호
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    • pp.135-136
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    • 2017
  • When driving at night time environment, the whole body of transports does not visible to us. Due to lack of light conditions, there are only two options, which is clearly visible their taillights and break lights. To improve the recognition correctness of vehicle detection, we present an approach to vehicle detection and tracking using finding contour of the object on binary image at night time. Bilateral filtering is used to make more clearly on threshold part. To remove unexpected small noises used morphological opening. In verification stage, paired tail lights are tracked during their existence in the ROI. The accuracy of the test results for vehicle detection is about 93%.

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