• Journal of Nutrition and Health
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• v.22 no.3
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• pp.167-174
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• 1989

The purpose of this study was to determine if vitamin B-2 and vitamin B-6 deficiency affects hematologic profile in vivo. Rats were fed a vitamin B-2 deficient (-B2) diet or a vitamin B-6 deficient (- B6) diet or a combined vitamin B-2 and vitamin B-6 deficient (-B2-B6) diet or a control diet for 6 weeks. Hematocrit (Ht), hemoglobin (Hb), plasma iron (PI), transferrin saturation (TS) and liver iron concentration (LI) were compared. In -B2 rats vs. control rats, PI, TS and LI were significantly lower but Ht and Hb were not. In - B6 rats vs. control, Ht and Hb were significanty lower but LI was higher. The -B2-B6 rats had intermediate effects in Hb, PI, TS and LI and a decrease in Ht. The repletion with a contro diet for 2 weeks resulted in significant improvements in hematologic indices and LI in both - B2 rats and - B6 rats. This study suggests that the intakes of vitamin B-2 and vitamin B-6 are important for preventive and therap\ulcornereutic approaches to improve the hematologic status in nutritionally anemic groups.

• Journal of Pharmaceutical Investigation
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• v.35 no.5
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• pp.329-332
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• 2005

HPMC-based novel gel formulations for the transdermal delivery of testosterone (TS) were developed, and the effect of various skin permeation enhancers was studied in vitro and in vivo. In vitro hairless mouse skin permeation of TS from the gel was investigated using Keshary-Chien diffusion cells for 8 hours at $37^{\circ}C$. In vivo plasma concentration profiles of TS after applying the gel on the abdominal skin of rat were determined using a commercial radioimmunoassay kit. Hairless mouse skin permeation of TS increased with the addition of permeation enhancers both in vitro and in vivo. Combination of diethanolamine (2%) and N-methylpyrrolidone (NMP, 6%) was the most effective among tested. Plasma concentration of TS significantly increased for at least 24 hours with the addition of diethanolamine and NMP. These results suggest the feasibility of the development of a HPMC-based gel formulation for the transdermal delivery of TS.

• Toxicological Research
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• v.28 no.4
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• pp.241-248
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• 2012

Exposure of cells to ultraviolet B (UVB) radiation can induce production of free radicals and reactive oxygen species (ROS), which damage cellular components. In addition, these agents can stimulate the expression of matrix metalloproteinase (MMP) and decrease collagen synthesis in human skin cells. In this study, we examined the anti-photoaging effects of extracts of Tetraselmis suecica (W-TS). W-TS showed the strongest scavenging activity against 2,2-difenyl-1-picrylhydrazyl (DPPH) and peroxyl radicals, followed by superoxide anions from the xanthine/xanthine oxidase system. We observed that the levels of both intracellular ROS and lipid peroxidation significantly increased in UVB-irradiated human skin fibroblast cells. Furthermore, the activities of enzymatic antioxidants (e.g., superoxide dismutase) and the levels of non-enzymatic antioxidants (e.g., glutathione) significantly decreased in cells. However, W-TS pretreatment, at the maximum tested concentration, significantly decreased intracellular ROS and malondialdehyde (MDA) levels, and increased superoxide dismutase and glutathione levels in the cells. At this same concentration, W-TS did not show cytotoxicity. Type 1 procollagen and MMP-1 released were quantified using RT-PCR techniques. The results showed that W-TS protected type 1 procollagen against UVB-induced depletion in fibroblast cells in a dose-dependent manner via inhibition of UVB-induced MMP-1. Taken together, the results of the study suggest that W-TS effectively inhibits UVB-induced photoaging in skin fibroblasts by its strong anti-oxidant ability.

• Journal of the Korean Data and Information Science Society
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• v.26 no.4
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• pp.957-970
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• 2015

The purpose of this study was to analyze records of Korean pro-basketball using general linear model (two-way ANOVA and hierarchical multiple regression analysis). Korea Basketball League (KBL) informed the records (2014-2015 season) of this study. The eight variables (TA, 2PA, 3PA, 2P, 3P, Ast, TFB, CH) were selected in content validity. SPSS program was used to analyze general linear model. All alpha level was set at 0.05. Major results were as follow. 3PA had significant interaction effect between victory & defeat variable and home & away variable. Victory teams showed that 3PA was higher in home games than away games, and defeat teams was the other. 2PA, AS, TFB, and CH were selected significant variables affecting victory and defeat. In result of hierarchical regression, Ast had significant moderation effect between 3PA and TS. TFB also had significant moderation effect between AS between 2P. The other construct (Ast between 2PA and TS; TFB between AS between 3P) had no significant moderation effect. In the effect of 2PA, 3PA and Ast to TS, CH also had no significant moderation effect.

• 한국신재생에너지학회:학술대회논문집
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• 2008.05a
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• pp.397-397
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• 2008

• Bulletin of the Korean Chemical Society
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• v.28 no.6
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• pp.1031-1034
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• 2007

The R- and Z-substituent effects for the gas-phase thermal decompositions of carbamates, R2NC(=O)- OCH2CH2Z, have been investigated theoretically at B3LYP level with 6-31G(d) and 6-31++G(d,p) basis sets. Both the Z- and R-substituent effects on reactivity (ΔH≠) were well consistent with experimental results, although the R-substituent effect was underestimated theoretically. No correlations were found between activation enthalpies and reaction enthalpies. The substituent effects on reactivity seemed to be complicated at a glance, but were understandable by concurrent electronic and steric factors. Variations of bond lengths at TS structures were well correlated with the Taft's σ* values and the TS structures became tighter as the Zsubstituent became a stronger electron-acceptor (δσ* > 0). However the effects of R-substituents on the TS structures were much smaller when compared to those of Z-substituents.

• Journal of the Korea Furniture Society
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• v.17 no.1
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• pp.1-10
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• 2006

Movement behavior, shrinkage and equilibrium moisture content (EMC), in this experiment reflected a change of hygroscopicity mainly affected by continuously compressive load during radio-frequency/vacuum (RF/V) drying and humidity changes during equilibrating. As a result of interaction of the compressive load and moisture content changing under the RF/V condition, the shrinkages in loading direction were significantly increased while those perpendicular to loading direction were decreased. The shrinkages were affected most in tangential, and least in longitudinal direction. The shrinkages showed higher values in continuous drying than in intermittent drying. In the direction of increased shrinkage, all the movements were also increased, for example, the tangential movement for the loaded-RS and the radial movement for loaded-TS; in the direction of decreased shrinkage, all the movements except the tangential movement for the loaded-TS were decreased such as the tangential and radial movements for the loaded-ES, and the radial movement for the loaded-RS, comparing with those of the load-free. EMCs of the loaded specimens were all higher than that of the load-free specimen, and the highest for the loaded-TS, the lowest for the loaded-ES. The transverse hygroscopicity of specimen was reduced for the loaded-ES, but increased for the loaded-TS.

• Earthquakes and Structures
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• v.22 no.3
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• pp.263-275
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• 2022

Structural collapses can occur as a result of a dynamic amplification of either, the building's seismic response or the ground shaking by local site effects; one of the reasons is a resonance effect due to the proximity of the structural elastic fundamental period TE and the soil fundamental period TS. We evaluate the vulnerability to resonance effects in Guadalajara, México, in a three-step schema: 1) we define structural systems in the building environment of western Guadalajara, in terms of their construction materials and structural components; 2) we estimate TE with different equations, to obtain a representative value in elastic conditions for each structural system; and, 3) we evaluate the resonance vulnerability by the analysis of the ratio between TE and TS. We observe that the larger the soil fundamental period, the higher the resonance vulnerability for buildings with height between 17 and 39 m. For the sites with a low TS, the most vulnerable buildings will be those with a height between 2 and 9 m. These results can be a helpful tool for disaster prevention, by avoiding the construction of buildings with certain heights and structural characteristics that would result in a dangerous proximity between TE and TS.

• Bulletin of the Korean Chemical Society
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• v.33 no.8
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• pp.2707-2710
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• 2012

The nucleophilic substitution reactions of O-ethyl phenyl phosphonochloridothioate with substituted anilines ($XC_6H_4NH_2$) and deuterated anilines ($XC_6H_4ND_2$) are kinetically investigated in acetonitrile at $55.0^{\circ}C$. The deuterium kinetic isotope effects (DKIEs) invariably increase from a secondary inverse DKIE ($k_H/k_D$ = 0.93) to a primary normal DKIE ($k_H/k_D$ = 1.28) as the substituent of nucleophile (X) changes from electron-donating to electron-withdrawing. These can be rationalized by the gradual transition state (TS) variation from a backside to frontside attack. A concerted $S_N2$ mechanism is proposed. A trigonal bipyramidal TS is proposed for a backside attack while a hydrogen-bonded, four-center-type TS is proposed for a frontside attack.

• Journal of environmental and Sanitary engineering
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• v.15 no.4
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• pp.84-90
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• 2000

5L laboratory-scale anaerobic digester was used to study the effects of food size and washing rate of food waste on the mixed digestion with sewage sludge. Food waste was crushed with particle diameters of 4mm and 2mm and washed two to three times, and seven to eight times before feeding the batch digester. The digester with crushed of washed food waste showed better performance than that with uncrushed of unwashed to produce methane gas of reduce volatile solids. The digester with 2mm food waste showed 17.4% higher VS/TS reduction rate and 18ml higher methane production rate per gram VS input than that with uncrushed food waste, where VS and TS are volatile solid and total solids in the liquid effluent, respectively. Also food waste crushed eight times gave 8% higher VS/TS reduction rate and 11ml higher methane production rate per gram VS input than unwashed food waste.