In vitro and In vivo Evaluation of Novel Gel Formulations of Testosterone for Transdermal Delivery |
Heo, Sung-Koun
(College of Pharmacy, Pusan National University)
Cho, Young-Seok (Dong Sung Pharm. Co., Ltd.) Han, Sang-Dae (Dong Sung Pharm. Co., Ltd.) Chang, Jin-Kang (Dong Sung Pharm. Co., Ltd.) Yoon, Eun-Ju (Dong Sung Pharm. Co., Ltd.) Ko, Dae-Woong (Dong Sung Pharm. Co., Ltd.) Lim, Chang-Baeg (Dong Sung Pharm. Co., Ltd.) Chung, Suk-Jae (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) Shim, Chang-Koo (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) Kim, Dae-Duk (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) |
1 | J.G. Hardman and L.E. Limbird, A Goodman and Gilman's the pharmacological basis of therapeutics, 9th ed., Macmillan, London, pp. 1459-1485 (1996) |
2 | R.L. Rosenfield, Role of androgens in growth and development of the fetus, child, and adolescent. Adv. Pediatr., 19, 172-213 (1972) |
3 | B.J. Anungst, J.A. Blake and M.A. Hussain, Contributions of drug solubilization, partitioning, barrier disruption, and solvent permeation to the enhancement of skin permeation of various compounds with fatty acids and amines. Pharm. Res., 7, 712-718 (1990) DOI ScienceOn |
4 | P.J. Lee, R. Langer and V.P. Shastri, Role of n-methyl pyrrolidone in the enhancement of aqueous phase transdermal transport. J. Pharm. Sci., 94, 912-917 (2005) DOI ScienceOn |
5 | B. Salehian, C. Wand, G. Alexander, T. Davidson, V. McDonald, N. Berman, R.E. Dudley, F. Zikl and R.S. Verdloff, Pharmacokinetics, bioefficacy and safety of sublingual tesosterone cyclodextrin in hypogonadal men: comparison to testosterone enanthate-A clinical research center study. J. Clin. Endocr. Metab., 80(12), 3567-3575 (1995) DOI |
6 | N.M. An, D, D. Kim, Y.H. Shin and C.H. Lee, Development of a novel soft hydrogel for the transdermal delivery of testosterone. Drug Devel. Ind. Pharm., 29, 99-105 (2003) DOI ScienceOn |
7 | A. Koizumi, M. Fujiu, M. Kondoh and Y. Watanabe, Effect of N-methyl-2-pyrrolidone on skin permeation of estradiol. Eur. J. Pharm. Biopharm., 57, 473-478 (2004) DOI ScienceOn |
8 | J.E. Royland, L.J. Weber and M. Fitzpatrick, Testes size and testosterone levels in a model for weightlessness. Life Sci., 54, 545-554 (1994) DOI ScienceOn |
9 | A.R. Gennaro, Remington: The Science and Practice of Pharmacy, 20th ed., Lippincott Williams & Wilkins, Philadelphia, U.S.A., pp. 1391 (2000) |
10 | L. Kikwai, R.J. Babu, N. Kanikkannan and M. Singh, Preformulation stability of Spantide II, a promising topical anti-inflmatory agent for the treatment of psoriasis and contact dermatitis. J. Pharm. Pharmacol., 56, 19-25 (2004) DOI ScienceOn |
11 | S. Satyannrana, S. Ganaga and J. Singh, Transport through rat skin from transdermal patch formulations. Pharmazie, 48, 467-468 (1993) |
12 | T.M. Morgan, B.L. Reed and B.C. Finnin, Enhanced skin permeation of sex hormones with novel topical spray vehicles. J. Pharm. Sci., 87, 1213-1218 (1998) DOI |
13 | T.M. Morgan, R.A. Parr, B.L. Reed and B.C. Finnin, Enhanced transdermal delivery of sex hormones in swine with a novel topical aerosol. J. Pharm. Sci., 87(1), 1219-1225 (1998) DOI ScienceOn |
14 | D.J. Kesler, D.C. Christenson and M.E. Wallace, The effect of esterification on their release of testosterone and estradiol from silicone implants. Drug Dev. Ind. Pharm., 22(3), 275-279 (1996) DOI |
15 | A.C. William and B.W. Barry, Skin permeation enhancers. Crit. Rev. Ther. Drug, 9, 305-353 (1992) |
16 | K. Sugibayashi, S. Nakyama, S. Seki, K. Hosoya and Y. Morimoto, Mechanism of skin penetration-enhancing effect by laurocapram. J. Pharm. Sci., 81, 58-64 (1992) DOI |
17 | M.K. Kim, H.Z., C.H. Lee and D.D. Kim, Formulation of a reservoir-type testosterone transdermal delivery system. Int. J. Pharm., 219, 51-59 (2001) DOI ScienceOn |
18 | H.Z., C.H. Lee, S.J. Chung, C.K. Shim and D.D. Kim, In, vitro and in vivo evaluation of a novel non-scrotal matrix-type transdermal delivery system of testosterone. Drug Dev. Ind. Pharm., 31, 257-261 (2005) DOI |
19 | M. Fuju, M. Bouno, S. Fujita, M. Yoshida, Y. Watanabe and M. Matsumoto, Preparation of griseofulvin for topical application using N-methyl-2-pyrrolidone. Bio. Pharm. Bull., 23, 1341-1345 (2000) DOI ScienceOn |