• 한국의학물리학회지:의학물리
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• 제20권4호
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• pp.324-330
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• 2009

본 연구에서는 정위방사선수술시 움직이는 목표점에 대한 사이버나이프 호흡동기추적장치의 위치 정확성 및 유용성을 평가하고자 한다. 본 연구를 위해 움직이는 목표점을 재현할 수 있는 동적팬톰을 사용하였으며 움직이는 목표점 추적을 위하여 사이버나이프의 호흡동기추적장치인 $Synchrony^{TM}$ 시스템을 사용하였다. 움직이는 목표점의 치료계획을 위하여 4D CT를 이용한 영상획득을 하였고 움직이는 목표점에서의 선량분포와 점선량 측정을 위하여 gafchromic EBT 필름과 0.62 cc 이온 전리함을 사용하였다. 호흡동기추적장치의 정확성을 평가하기 위하여 팬톰의 목표점을 움직였을 때와 정지 상태일 때 목표점에서의 선량분포(처방선량기준 선량분포의 80%)를 비교하였으며 목표점에서의 점선량을 측정하였다. 위치추적장치와 호흡동기추적장치 상호간의 동기화에 의한 정확성은 동기화 되지 않을 경우 평균 $11.5{\pm}3.09\;mm$였으며 동기화 되었을 경우 $0.14{\pm}0.08\;mm$의 차이를 나타내었다. 목표점 정지상태시의 영상과 4D CT를 이용한 움직이는 목표점에 대한 영상을 이용하여 치료계획상의 정확성은 평균 $0.18{\pm}0.06\;mm$의 차이를 나타내었다. 또한 호흡동기추적장치의 정확성은 1 mm 이하로 나타났다. 호흡동기추적장치의 유효성을 확인하기 위하여 움직이는 목표점에 대하여 호흡동기추적장치를 중지하여 측정한 결과 평균 $17.39{\pm}0.14\;mm$였으며 가동하였을 때 $1.37{\pm}0.11\;mm$로 나타났다. 목표점에서의 선량값을 비교한 결과 목표점이 정지상태일 때 $0.68{\pm}0.38%$, 호흡동기추적장치를 이용한 움직이는 목표점에서는 $1.31{\pm}0.81%$의 차이를 나타내었다. 위치추적장치와 호흡동기추적장치 상호간의 동기화에 의한 정확성 확인에서 장치사이에서 동기화가 매우 정확하게 수행됨을 확인하였다. 본 연구의 결과 움직이는 목표점에 대한 정위방사선수술시 호흡동기추적장치를 필수적으로 사용해야하며 본 연구에서 사용된 사이버나이프의 호흡동기추적장치인 Synchrony 시스템의 유용성과 정확성을 평가한 결과 매우 정확함을 확인하였다.

• Animal Bioscience
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• 제35권9호
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• pp.1444-1453
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• 2022

Objective: Acetate plays an important role in host lipid metabolism. However, the network of acetate-regulated lipid metabolism remains unclear. Previous studies show that mitogen-activated protein kinases (MAPKs) and mechanistic target of rapamycin (mTOR) play a crucial role in lipid metabolism. We hypothesize that acetate could affect MAPKs and/or mTOR signaling and then regulate lipid metabolism. The present study investigated whether any cross talk occurs among MAPKs, mTOR and acetate in regulating lipid metabolism. Methods: The ceramide C6 (an extracellular signaling-regulated kinases 1 and 2 [ERK1/2] activator) and MHY1485 (a mTOR activator) were used to treat rabbit adipose-derived stem cells (ADSCs) with or without acetate, respectively. Results: It indicated that acetate (9 mM) treatment for 48 h decreased the lipid deposition in rabbit ADSCs. Acetate treatment decreased significantly phosphorylated protein levels of ERK1/2 and mTOR but significantly increased mRNA level of hormone-sensitive lipase (HSL). Acetate treatment did not significantly alter the phosphorylated protein level of p38 MAPK and c-Jun aminoterminal kinase (JNK). Activation of ERK1/2 and mTOR by respective addition in media with ceramide C6 and MHY1485 significantly attenuated decreased lipid deposition and increased HSL expression caused by acetate. Conclusion: Our results suggest that ERK1/2 and mTOR signaling pathways are associated with acetate regulated HSL gene expression and lipid deposition.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1997년도 추계학술대회
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• pp.47-50
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• 1997

Drug development began with the finding of biologically active compounds which are obtained by chemical synthesis or from natural sources. The advent of Combinatorial Chemistry is recognized as a strategy which has a potential to change the methodology of research and development(R&D) of new drugs. Drug development has been carried out with diverse strategies. In the past several decades a variety of new methodology have been introduced in R&D. Random screening of accumulated synthetic samples which had been synthesized for development of other drugs led to the discovery of new drugs. The typical examples are anti-asthma drug trimethoquinol and calcium antagonist diltiazem. (herbesser). In particular the latter drug has been used as a calcium antagonist worldwide, however it was first synthesized to find new tranquilizer and this is the reason why diltiazem has benzodiazepam skeleton. The random screening contributed in the finding of new drugs were carried out with whole animal test and it is a standard methodology in R&D of new drugs. Aspirin is the first synthetic non-steroidal antiinflammatory drug(NSAID) and has been used for more than one hundred years. It is the first example of drug developed from natural product. Salicin is the main constituent of willow bark which had been used in Europe for a long time to treat arthritis and aspirin was developed from salicin. Most of NSAID used clinically were developed from the structure of aspirin, however it took 70 years to clarify why aspirin exhibits its antiinflammatory, analgesic and antipyretic activities. The target of aspirin is cyclooxygenase(COX)which is the first enzyme involved in arachidonate cascade leading to the production of prostaglandins(PG) and thromboxan(TX). Side effect of aspirin causing ulcer in stomach is rather serious problem, since aspirin is so popular drug easily obtained in drug store(OTP). This problem is now going to be solved by a new finding on COX, which have two different types, one is constitutionally expressed COX 1 in almost all organs and the other is inducible COX 2. COX 2 is the responsible enzyme in inflammation etc and now the search of COX 2 specific inhibitors is the target of R&D of next generation NSAID.

• Radiation Oncology Journal
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• 제30권1호
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• pp.27-35
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• 2012

Purpose: To evaluate the effect of common three photon energies (6-MV, 10-MV, and 15-MV) on intensity-modulated radiation therapy (IMRT) plans to treat prostate cancer patients. Materials and Methods: Twenty patients with prostate cancer treated locally to 81.0 Gy were retrospectively studied. 6-MV, 10-MV, and 15-MV IMRT plans for each patient were generated using suitable planning objectives, dose constraints, and 8-field setting. The plans were analyzed in terms of dose-volume histogram for the target coverage, dose conformity, organs at risk (OAR) sparing, and normal tissue integral dose. Results: Regardless of the energies chosen at the plans, the target coverage, conformity, and homogeneity of the plans were similar. However, there was a significant dose increase in rectal wall and femoral heads for 6-MV compared to those for 10-MV and 15-MV. The $V_{20Gy}$ of rectal wall with 6-MV, 10-MV, and 15-MV were 95.6%, 88.4%, and 89.4% while the mean dose to femoral heads were 31.7, 25.9, and 26.3 Gy, respectively. Integral doses to the normal tissues in higher energy (10-MV and 15-MV) plans were reduced by about 7%. Overall, integral doses in mid and low dose regions in 6-MV plans were increased by up to 13%. Conclusion: In this study, 10-MV prostate IMRT plans showed better OAR sparing and less integral doses than the 6-MV. The biological and clinical significance of this finding remains to be determined afterward, considering neutron dose contribution.

• 산업경영시스템학회지
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• 제44권1호
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• pp.45-50
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• 2021

Machines and facilities are physically or chemically degenerated by continuous usage. The representative type of the degeneration is the wearing of tools, which results in the process mean shift. According to the increasing wear level, non-conforming products cost and quality loss cost are increasing simultaneously. Therefore, a preventive maintenance is necessary at some point. The problem of determining the maintenance period (or wear limit) which minimizes the total cost is called the 'process mean shift problem'. The total cost includes three items: maintenance cost (or adjustment cost), non-conforming cost due to the non-conforming products, and quality loss cost due to the difference between the process target value and the product characteristic value among the conforming products. In this study, we set the production volume as a decreasing function rather than a constant. Also we treat the process variance as a function to the increasing wear rather than a constant. To the quality loss function, we adopted the Cpm+, which is the left and right asymmetric process capability index based on the process target value. These can more reflect the production site. In this study, we presented a more extensive maintenance model compared to previous studies, by integrating the items mentioned above. The objective equation of this model is the total cost per unit wear. The determining variables are the wear limit and the initial process setting position that minimize the objective equation.

• IMMUNE NETWORK
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• 제21권1호
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• pp.8.1-8.17
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• 2021

The global crisis caused by the coronavirus disease 2019 (COVID-19) led to the most significant economic loss and human deaths after World War II. The pathogen causing this disease is a novel virus called the severe acute respiratory syndrome coronavirus 2 (SARSCoV-2). As of December 2020, there have been 80.2 million confirmed patients, and the mortality rate is known as 2.16% globally. A strategy to protect a host from SARS-CoV-2 is by suppressing intracellular viral replication or preventing viral entry. We focused on the spike glycoprotein that is responsible for the entry of SARS-CoV-2 into the host cell. Recently, the US Food and Drug Administration/EU Medicines Agency authorized a vaccine and antibody to treat COVID-19 patients by emergency use approval in the absence of long-term clinical trials. Both commercial and academic efforts to develop preventive and therapeutic agents continue all over the world. In this review, we present a perspective on current reports about the spike glycoprotein of SARS-CoV-2 as a therapeutic target.

• 대한방사선치료학회지
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• 제15권1호
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• pp.35-40
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• 2003

I. 목적 방사선 치료에서 인접한 두 target을 가진 두경부 환자의 target간의 이동시, 육안으로 판별하여 수동으로 couch를 이동하는 방식에서 나타날 수 있는 오차를 확인하기 위하여, couch의 좌표값을 분석하고 target간의 이동에 대한 재현성의 정확성을 평가하고자 한다. II. 대상 및 방법 방사선 치료에 있어서 치료하고자 하는 인접한 두 target간의 이동시 operator에 의한 수동이동에서 나타날 수 있는 이동오차를 확인하기 위하여, couch의 좌표값(vertical, longitudinal, lateral 세 방향)을 이용, 수동으로 위치잡이시 이동거리에 대한 정확도를 평가하기 위해 치료장비( CL 2100C, Varian, USA) 의 console monitor에 나타난 좌표값을 기록하였다. 매 치료마다 vertical, longitudinal, lateral 세 방향에서 기록된 좌표의 이동거리를 구한 후에, 이를 RTP(Pinnacle, ADAC, USA)에 의한 target간의 거리와 비교하여 오차값을 구하였다. 동일환자를 10회에 걸쳐 실제 set-up시의 좌표이동의 평균값과 오차정도, 그리고 표준편차를 구하였다. III. 결과 환자의 skin mark를 육안으로 확인하며 수동으로 couch를 이동하는 방식에서 두 target간 이동의 평균 표준편차가 각 방향에서 vertical 1.4mm, longitudinal 0.9mm, lateral 2.2mm로 나타났고, 직선상의 이동오차는 평균 약 3.6mm, 최대 5.1mm의 오차가 나타났다. Lateral 방향에서 오차정도가 가장 커서 최대 5mm까지 오차가 발생하였으며, 각 방향에서 오차평균값은 vertical 1mm, longitudinal 0.7mm, lateral 2.7mm이고 이중에서 가장 오차가 큰 lateral방향의 오차평균값을 크게 넘어서는 경우는 전체의 $30\%$정도로 나타났다. IV. 결론 Couch를 수동으로 이동하여 target간을 이동시, 평균 약 3.6mm정도의 오차가 발생하였다. 3D conformal therapy나 IMRT처럼 높은 정밀도를 요구하는 치료의 경우에는 인접한 target간의 정확한 이동을 요구하므로, couch의 실제 좌표의 오차를 확인하는 일이 중요하다. 따라서 couch의 좌표확인을 이용한 치료의 재현성과 정확성 평가를 더욱 발전시켜 응용한다면 양질의 방사선 치료를 실시할 수 있을 것이라 사료된다.

• 한국환경복원기술학회지
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• 제25권6호
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• pp.65-75
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• 2022

Urban flood management(UFM) strategy ought to consider the connections and interactions between existing and new infrastructures to manage stormwater and improve the capacity to treat water. It is also important to demonstrate strategies that can be implemented to reduce the flow at flooding sources and minimize flood risk at critical locations. Although the general theory of spatial impact is popular, modeling guidelines that can provide information for implementation in real-world plans are still lacking. Under such background, this study conducted a modeling research based on an actual target site to confirm the hypothesis that it is appropriate to install green infrastructure(GI) in the source area and to take structural protection measures in the impact area, as summarized in previous studies. The results of the study proved the hypothesis, but the results were different from the hypothesis depending on which hydrological performance indicators were targeted. This study will contribute to demonstrating the effectiveness of strategies that can be implemented to reduce the flow at flooding sources and minimize the risk of flooding in critical locations in terms of spatial planning and regeneration.

• 복식
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• 제12권
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• pp.55-67
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• 1988

The purpose of this study lies in giving a help to the rational life of clothing of consumer and presenting some measures for solving problems of the marketing policy of knitwear and the searching of feasibility of the women's knitwear market. The results of this study are as follows; 1. The characteristics of each brand is not clearly introduced to the consumer. This is owing to the lack of the establishment of the policy that emphasize the special feature of each brand. 2. The target of brand almost coincides real consumer, but fashion mood and age group are declined to specific area. So, the scarcity of casual and young age brand is prominent. 3. All brand ought to treat design as the supreme priority other than anything else on the product differentiation strategy dispite the characteristics of the brand. 4. The distribution centered department store is observed very desirable in this study. 5. According to the result of the consmer's behaviors, it has been clarified that display is the most effective sale promotion. 6. Consumer is used to make improvised decision making in the purchasing activities. Thus, it is required to improve consumer's ability of appraisal for quality and material and to establish the calculable, rational consumption pattern.

• 대한치과의사협회지
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• 제55권5호
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• pp.365-369
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• 2017

In clinical dentistry, botulinum toxin is generally used to treat the square jaw, bruxism, and temporomandibular joint diseases. Recently, this procedure has been expanded and applied for cosmetic purposes, and it is becoming a key task to be aware of the precise anatomical structure of the target muscles to be cautious during treatment and how to prevent side effects. Therefore, the purpose of this study is to observe the anatomical structure of the superficial layer of masseter muscle and to provide a most effective botulinum toxin injection method through clinical anatomical consideration. It was observed that the muscle belly of superficial part of the superficial layer was originated from the deep to the aponeurosis of masseter muscle and descend, then changed gradually into the tendon structure attaching to the inferior border of the mandible. In this study, we named this structure deep inferior tendon. This structure was observed in all specimens. We conclude that the use of superficial layer and deep layer injection should be considered to prevent paradoxical masseteric bulging in consideration of the deep inferior tendon of superficial part of superficial layer of masseter muscle.