• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.21 no.1
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• pp.1-11
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• 2018

The emergence of mucosal healing as a treatment goal that could modify the natural course of Crohn's disease and the accumulating evidence showing that biologics are most effective in achieving mucosal healing, along with the success of early treatment regimens for rheumatoid arthritis, have led to the identification of early Crohn's disease and development of the concept of catching the therapeutic window during the early disease course. Thus, an increasing number of pediatric gastroenterologists are adopting an early biologic treatment strategy with or without an immunomodulator. Although early biologic treatment is effective, cost and overtreatment are issues that limit its early use. Currently, there are insufficient data on who will benefit most from early biologics, as well as on who will not need early or even any biologics. For now, top-down biologics should be considered for patients with currently known high-risk factors of poor outcomes. For other patients, close, objective monitoring and accelerating the step-up process by means of a treat-to-target approach seems the best way to catch the therapeutic window in early pediatric Crohn's disease. The individual benefits of immunomodulator addition during early biologic treatment should be weighed against its risks and decision on early combination treatment should be made after comprehensive discussion with each patient and guardian.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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• 2002.04a
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• pp.62-65
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• 2002

Permeable reactive barriers (PRBs) are in-situ barriers constructed in a subsurface to treat contaminated groundwater using various reactive media. The common reactive medium used in PRB is zero-valent iron, which has been widely used to treat chlorinated solvents (i.e., PCE, TCE). A disadvantage of iron media is high cost. In this study, waste foundry sands were tested to determine the feasibility of their use as a low cost reactive medium. Batch and column tests were conducted with TCE to determine transport parameters and reactivity of the foundry sands. The reactivities of foundry sands for common groundwater contaminants are comparable to or slightly higher than those for Peerless iron, a common medium used in PRBs. In addition, the TOC and clay in foundry sands can significantly retard the movement of target contaminant, which may result in lower effluent concentration of contaminant due to biodegradation. In general, PRBs 1-m thick can be constructed with many foundry sands to treat TCE provided the zero-valent iron content in the foundry sand is higher than 1%.

• Journal of Advanced Marine Engineering and Technology
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• v.38 no.10
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• pp.1318-1326
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• 2014

The purpose of a tracking control system is to track a moving target and to find the exact information of the target. If the platform of the tracking control system is equipped on a moving vehicle such as a ship, the tracking control system will treat even the additional platform motion. In order to avoid the complexity comprising the tracking control system, a process to treat the platform motion, named stabilizing system, must be separated from the tracking control system. In this paper, a method to comprise an attitude control system for the platform stabilization is proposed using an adaptive fuzzy control which is applicable to the system with structural and parametric uncertainty. The suggested adaptive fuzzy control algorithm is the 2nd/1st-type indirect adaptive fuzzy control algorithm using the advantages of 1st-type and 2nd-type indirect adaptive fuzzy control algorithm. Several experiments using the implemented stabilizing system are executed for verifying the effectiveness of the suggested method.

• International Journal of Internet, Broadcasting and Communication
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• v.12 no.4
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• pp.173-179
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• 2020

In this study, we present the difference in thoracic reposition sense in young people (24.00 ±2.20 years old) with and without habitual slouched posture in two target positions of half flexion and half extension. People with habitual slouched posture (n = 20; 11 men and 9 women) and people without slouched posture (n = 20; 10 men and 10 women) were recruited from three universities. Thoracic spine (T-spine) repositioning errors were measured in two target positions (half flexion and half extension). People with habitual slouched posture showed significantly higher thoracic repositioning error in the extension target position than did people without slouched posture (P<0.05). There was no difference in repositioning error in the flexion target position between the two groups (P>0.05). In conclusion, people with habitual slouched posture show lower T-spine repositioning sense in extension than do people without slouched posture. A rehabilitation program to treat habitual slouched posture, such as postural correction education, should be implemented for individuals with decreased position sense of the T-spine.

• The Korea Journal of Herbology
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• v.30 no.4
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• pp.45-49
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• 2015

Objectives : Through this study, it would be confirmed that specific expression for efficacy of medicinal material has multiple meanings. And through the methodology to determine the multi meaning, it could be contributed to lighten ambiguous expressions for efficacy of medicinal material.Methods : The premise is that the efficacy and treatment target data are related to each other. Word cloud has been used analyzing the efficacy and treatment target data for medicinal materials. Then classic and modern documents were analyzed by the search.Results : Even though searching all related references as well as comparing the efficacy and treatment target data were done, some medicinal materials having 'Salchung[殺蟲]' as an efficacy are not expected to treat the disease associated with the parasite. Through the analysis of classic and modern documents, it was found that 'Salchung[殺蟲]' is not used only as a means of anthelmintic efficacy. But through the above analysis method some medicinal materials having 'Guchung[驅蟲]' as an efficacy are expected to treat the disease associated with the parasite, and 'Guchung[驅蟲]' seems to be almost used as a means of anthelmintic efficacy.Conclusions : If a certain expression for efficacy of medicinal material is used as a single meaning obviously, ambiguous expressions need to be clear. And if a certain expression for efficacy of medicinal material seems to have multiple meanings, the additional informations are to be supplemented for exact wording.

• Journal of radiological science and technology
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• v.45 no.5
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• pp.433-438
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• 2022

Targeted radionuclides treatment (TRT) requires the establishment of treatment plans that consider various factors, such as the type of radionuclides, target organs, and administration methods. For this reason, in this study, the absorption dose of a single cell was analyzed according to the type of radioisotope used to treat target radionuclides. In this study, a simulation was performed on beta rays used in the treatment of target radionuclides at the cell level using MCNPX (ver. 2.5.0). First, according to the calculation formula, the beam path according to the type of radioisotope for treatment was calculated. Second, the amount of self-radiation by beta rays emitted from cell diameters of 5 ㎛ and 10 ㎛ cell nuclei was evaluated. As a result, it showed a high range proportional to the maximum energy of the beta-ray, and the highest self-dose distribution from 177 Lu radiation sources among therapeutic radioisotopes. This was analyzed as a result that is inversely proportional to the maximum energy of the beta-ray, and it suggests that the selection of a nuclide considering the range of the beta-ray is necessary in the treatment of target radionuclides in the future.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.6 no.1
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• pp.46-52
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• 2020

Radiopharmaceuticals that can be consumed in specific disease site play a key role In order to diagnose and treat the diseases. In addition, radiopharmaceuticals can be used for diagnostic or therapeutic purposes depending on the type of the labeled radioactive isotope. Recently, theragnostic radiopharmaceuticals that can simultaneously diagnose and treat are developed. Therefore, the development of target-specific radiopharmaceuticals is a very important research topic in the field of molecular imaging and therapy. This review paper summarizes the basic considerations for the development of radiopharmaceuticals. For new researchers or students who are now beginning in the field of radiopharmaceuticals, we intend to assist in the development of radiopharmaceuticals by describing the definition of radiopharmaceuticals, the ideal radiopharmaceutical conditions, the considerations for developing new radiopharmaceuticals, the factors affecting the design of radiopharmaceuticals, the requirements of radioisotope labeling reactions, and finally the definition and importance of molar activity in radiopharmaceuticals.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.2
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• pp.551-560
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• 2014

Colorectal cancer (CRC) is the third most common malignancy and fourth most common cause of cancer mortality worldwide. Untreated chronic inflammation in the intestine ranks among the top three high-risk conditions for colitis-associated colorectal cancer (CAC). Signal Transducer and Activator of Transcription 3 (STAT3) protein is a member of the STAT family of transcription factors often deregulated in CRC. In this review, we try to emphasize the critical role of STAT3 in CAC as well as the crosstalk of STAT3 with inflammatory cytokines, nuclear factor (NF)-${\kappa}B$, PI3K/Akt, Mammalian Target of Rapamycin (mTOR), Notch, $Wnt/{\beta}$-catenin and microRNA (MiR) pathways. STAT3 is considered as a primary drug target to treat CAC in humans and rodents. Also we updated the findings for inhibitors of STAT3 with regard to effects on tumorigenesis. This review will hopefully provide insights on the use of STAT3 as a therapeutic target in CAC.

• Journal of the Ergonomics Society of Korea
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• v.36 no.1
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• pp.53-67
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• 2017

Objective: The purpose of this study is to build basic data to systematically develop a hand function evaluation tool by determining the effects of age, gender and target force level on the difference in hand function according to the target force level. Background: Precise and objective evaluation of hand functionality is a very important factor in quantifying treatment progress in patients or elderly people, and in verifying treatment effects. However, most hand function evaluations lack objectivity and accuracy, and therefore it is difficult to properly treat patients according to the given situation. Method: Sixteen healthy subjects (eight elderly and eight young people) participated in this study to evaluate the effects of age, gender, and target force level on tracking performance through rRMSE in terms of the tracking force and actual exerted force, by carrying out a task of maintaining six different target force levels for 20 seconds. Results: The result of this experiment indicated that elderly people and women had a lower ability to maintain a certain level of force than young people and men by 16% and 10%, respectively. The target force level results showed that the tracking error of the lowest force level (5% MVC) was significantly higher than that of 15% MVC, which in turn showed a higher tracking error than that of the higher target force levels. Conclusion: The results of this study can thus be utilized to develop a rehabilitation program for elderly people or other patients. Application: The authors expect that the results of the present study will be valuable to develop a rehabilitation program and hand function evaluation tool.

• Journal of Korean Foot and Ankle Society
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• v.17 no.1
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• pp.17-22
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• 2013

Lesser toe deformities such as mallet toe, hammer toe and claw toe are annoying problems not only to patients but also to orthopaedic surgeons because they are not easy to manage or treat. Though they occupy very small portion in whole body, they are notorious for unpredictable surgical results. It can make clinical results better to understand these deformities more comprehensively and to make strategic surgical plan for each target deformity.