Journal of radiological science and technology (대한방사선기술학회지:방사선기술과학)

Korean Society of Radiological Science (대한방사선과학회)
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Analysis of Radiation Dose on Single Cells Using Therapeutic Radioisotopes Using the Monte Carlo Method

몬테카를로 방법을 이용한 치료용 방사성동위원소 사용 시 단일 세포에 대한 선량 분석

  • Kim, Jung-Hoon (Department of Radiological Science, College of Health Sciences, Catholic University of Pusan) ;
  • Kim, Yu-Soo (Department of Radiological Science, College of Health Sciences, Catholic University of Pusan)
  • 김정훈 (부산가톨릭대학교 방사선학과) ;
  • 김유수 (부산가톨릭대학교 방사선학과)
  • Received : 2022.08.04
  • Accepted : 2022.09.26
  • Published : 2022.10.31
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Abstract

Targeted radionuclides treatment (TRT) requires the establishment of treatment plans that consider various factors, such as the type of radionuclides, target organs, and administration methods. For this reason, in this study, the absorption dose of a single cell was analyzed according to the type of radioisotope used to treat target radionuclides. In this study, a simulation was performed on beta rays used in the treatment of target radionuclides at the cell level using MCNPX (ver. 2.5.0). First, according to the calculation formula, the beam path according to the type of radioisotope for treatment was calculated. Second, the amount of self-radiation by beta rays emitted from cell diameters of 5 ㎛ and 10 ㎛ cell nuclei was evaluated. As a result, it showed a high range proportional to the maximum energy of the beta-ray, and the highest self-dose distribution from 177 Lu radiation sources among therapeutic radioisotopes. This was analyzed as a result that is inversely proportional to the maximum energy of the beta-ray, and it suggests that the selection of a nuclide considering the range of the beta-ray is necessary in the treatment of target radionuclides in the future.

Keywords

Acknowledgement

This paper was supported by RESEARCH FUND offered from Catholic University of Pusan in 2022

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