• Proceedings of the Korea Water Resources Association Conference
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• 2023.05a
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• pp.519-519
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• 2023

Estuarine dams are a recent and global phenomenon. While estuarine dams can provide the benefit of improved freshwater resources, they can also alter estuarine processes. Due to the wide range of estuarine types and estuarine dam configurations, the effect of estuarine dams on estuaries is not well understood in general. To develop a systematic understanding of the effect of estuarine dam location and freshwater discharge interval on a range of estuarine types (strongly stratified, partially mixed, periodically stratified, and well-mixed), this study used a coupled hydrodynamic-sediment dynamic numerical model (COAWST) and compared flow, sediment transport, and morphological conditions in the pre- and post-dam estuaries. For each estuarine type, scenarios with dam locations at 20, 55 and 90 km from the mouth and discharge intervals of a discharge every 0.5, 3, and 7 days were investigated. The results were analyzed in terms of change in tide, river discharge, estuarine classification, and sediment flux mechanism. The estuarine dam location primarily affected the tide-dominated estuaries, and the resonance length was an important length scale affecting the tidal currents and Stokes return flow. When the location was less than the resonance length, the tidal currents and Stokes return flow were most reduced due to the loss of tidal prism, the dead-end channel, and the shift from mixed to standing tides. The discharge interval primarily affected the river-dominated estuaries, and the tidal cycle period was an important time scale. When the interval was greater than the tidal cycle period, notable seaward discharge pulses and freshwater fronts occurred. Dams located near the mouth with large discharge interval differed the most from their pre-dam condition based on the estuarine classification. Greater discharge intervals, associated with large discharge magnitudes, resulted in scour and seaward sediment flux in the river-dominated estuaries, and the dam located near the resonance length resulted in the greatest landward tidal pumping sediment flux and deposition in the tide-dominated estuaries.

• Journal of the Korean Society of Groundwater Environment
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• v.1 no.2
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• pp.100-104
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• 1994

The rock matrix diffusion provides a retarding mechanism for sorbing and especially non-sorbing radionuclides. It has to be verified not only theoretically and experimentally but also from natural phenomena, before the mechanism can be incorporated fully into transport codes. The natural analogue studies, such as the concentration variation of radionuclides in profiles perpendicular to fluid-conducting fractures and to intrusive contact zones, have been believed to provide a validation. In thermal alteration zones of Naeduckri granite intruded by a pegmatite, large alkali and alkaline earth elements such as K, Rb, Sr, and Ba were moderately migrated during thermal alteration. Li, V. and Nb were also migrated about 9cm in width from the contact between the granite and the pegmatite. The concentration variation of these elements in thermally altered zones seems to be resulted from the local migration due to the re-equilibration among the elements released from the breakdown of primary minerals in the granite. Most of these natural analogue studies simply show only the concentration variation of elements without detailed informations on the diffusion time and other important data fir interpreting the behaviour of radionuclides, because of the absence of appropriate minerals for age data. Despite this problem, natural analogue studies will be needed for transport models of radionuclides in safety assessment.

• Asian-Australasian Journal of Animal Sciences
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• v.33 no.3
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• pp.398-407
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• 2020

Objective: The Yip1 domain family (YIPF) proteins were proposed to function in endoplasmic reticulum (ER) to Golgi transport and maintenance of the morphology of the Golgi, which were homologues of yeast Yip1p and Yif1p. YIPF3, the member 3 of YIPF family was a homolog of Yif1p. The aim of present study was to investigate the expression and regulation mechanism of porcine YIPF3. Methods: Quantitative realtime polymerase chain reaction (qPCR) was used to analyze porcine YIPF3 mRNA expression pattern in different tissues and pig kidney epithelial (PK15) cells stimulated by polyinosine-polycytidylic acid (poly [I:C]). Site-directed mutations combined with dual luciferase reporter assays and electrophoretic mobility shift assay (EMSA) were employed to reveal transcription regulation mechanism of porcine YIPF3. Results: Results showed that the mRNA of porcine YIPF3 (pYIPF3) was widely expressed with the highest levels in lymph and lung followed by spleen and liver, while weak in heart and skeletal muscle. Subcellular localization results indicated that it expressed in Golgi apparatus and plasma membranes. Upon stimulation with poly (I:C), the level of this gene was dramatically up-regulated in a time- and concentration-dependent manner. pYIPF3 core promoter region harbored three cis-acting elements which were bound by ETS proto-oncogene 2 (ETS2), zinc finger and BTB domain containing 4 (ZBTB4), and zinc finger and BTB domain containing 14 (ZBTB14), respectively. In which, ETS2 and ZBTB4 both promoted pYIPF3 transcription activity while ZBTB14 inhibited it, and these three transcription factors all played important regulation roles in tumorigenesis and apoptosis. Conclusion: The pYIPF3 mRNA expression was regulated by ETS2, ZBTB4, and ZBTB14, and its higher expression in immune organs might contribute to enhancing ER to Golgi transport of proteins, thus adapting to the immune response.

• The Korean Journal of Pharmacology
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• v.29 no.2
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• pp.195-202
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• 1993

Oxidative modification of cellular proteins and lipids may play a role in the development of diabetic complications. Diabetic cardiomyopathy has been suggested to be caused by the intracellular $Ca^{2+}$ overload in the myocardium, which is partly due to the defect of calcium transport of the cardiac sarcoplasmic reticulum (SR). In the present study, the possible mechanism of the functional defect of cardiac SR in diabetic rats was studied. Both of the maximal $Ca^{2+}$ uptake and the affinity for $Ca^{2+}$ were decreased in the diabetic rat SR in comparison with the control. To investigate whether the functional defect of the cardiac SR in streptozotocin-induced diabetic rat is associated with the oxidative changes of cardiac SR proteins, the carbonyl group content and glycohemoglobin levels were determined. The increase in carbonyl group content of cardiac SR (2.30 nmols/mg protein, DM; 1.78, control) and in glycohemoglobin level $(13{\sim}17%,\;DM;\;3{\sim}5%,\;control)$ were observed in the diabetics. The extent of increase in calcium transport by phospholamban phosphorylation was greater in the diabetic cardiac SR membranes than that in the control. The phosphorylation levels of phospholamban, as determined by SDS-PAGE and autoradiography with $[{\gamma}^{32}P]ATP$, were increased in diabetic cardiac SR. These results suggest that the impaired cardiac SR function in diabetic rat could be a consequence of the less-phosphorylation of phospholamban in the basal state, which is partly due to the depleted norepinephrine stores in the heart. Furthermore, the oxidative damages in cardiac SR membranes might be one of the additional factors leading to the diabetic cardiomyopathy.

• Journal of the Korean Ceramic Society
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• v.56 no.2
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• pp.111-129
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• 2019

Recently, all-solid-state batteries (ASSBs) have attracted increasing interest owing to their higher energy density and safety. As the core material of ASSBs, the characteristics of the solid electrolyte largely determine the performance of the battery. Thus far, a variety of inorganic solid electrolytes have been studied, including the NASICON-type, LISICON-type, perovskite-type, garnet-type, glassy solid electrolyte, and so on. The garnet Li₇La₃Zr₂O₁₂ (LLZO) solid electrolyte is one of the most promising candidates because of its excellent comprehensively electrochemical performance. Both, experiments and theoretical calculations, show that cubic LLZO has high room-temperature ionic conductivity and good chemical stability while contacting with the lithium anode and most of the cathode materials. In this paper, the crystal structure, Li-ion transport mechanism, preparation method, and element doping of LLZO are introduced in detail based on the research progress in recent years. Then, the development prospects and challenges of LLZO as applied to ASSBs are discussed.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.2 no.2 s.3
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• pp.73-84
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• 2003

Due to the problems of existing prepaid plastic card issued by Korea Highway Company, the prepaid electronic payment system using a smart card, called HipassPLUS Card, was developed to overcome the Problems. PSAM is one of the main component of the systea which can retrieve the value from HipassPLUS card, transmit the transaction data to CSAM, and store the accumulated account lists. For the safety of the elecoonic payment system, the functions of PSAM should be faultless. This paper developed a test module including the test method, the test checklist, and the test procedure. The test module examines the functionality and security of the payment mechanism to insure that the value stored in HipassPLUS card can be raid to PSAM by the merchants and the standardized SAM. The test module also inspects the transmission mechanism to send and store the transaction data kom PShM to CSAM correctly and safely. Ihe module is designed to test the standard items using the test checklists for PSAM. The test items and the test checklists of PShM was selected under the provision of the specification of Korea Highway Company and ISO standard. Ihe evaluation on PSAM using the test module indicates that PSAM satisfies the evaluation criteria on the quality characteristics of the functionality, security, and compatibility.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.9 no.6
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• pp.94-104
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• 2010

The capacity of highway is restricted and traffic congestion is caused by increasing traffic demand. Also, greenhouse gases are increased by traffic congestion. CDM (Clean Development Mechanism) is an idea of interest to reduce greenhouse gases. However, CDM's cases applied in traffic field are rare. Thus, it is necessary that methodology to reduce greenhouse gas should be developed and applied to CDM. A methodology for identifying greenhouse gas emissions was developed in this paper. This methodology was developed on the basis of baseline methodology registered at UN. Travel time and speed in the conventional traffic condition and in the automated traffic condition are compared by BPR function. The calculated speed applied to emission factor equation and then $CO_2$ emissions was calculated. A simulation was executed to evaluate the validity of the developed methodology. In the result, advanced vehicle's $CO_2$ emissions are more than conventional vehicle's $CO_2$ emissions in the stable flow condition. However, advanced vehicle's $CO_2$ emissions are less than conventional vehicle's $CO_2$ emissions in the unstable flow condition. It is assure that capacity of highway is enhanced and efficiency of highway is improved by adopting advanced safety vehicle in the smart road.

• Biomolecules & Therapeutics
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• v.5 no.1
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• pp.94-99
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• 1997

Capsaicin is known to be an analgesic agent, affecting the synthesis, storage, , transport and release of substance p, the principal neurotransmitter of pain from periphery to the central nervous system(CNS). DA-5018, a newly synthesized capsaicin derivative has shown potent analgesic effect comparable to that of morphine in various rat models of experimentally inducted acute pairs. In this study the mechanism of analgesic actlvity of DA-5018 was examined. First, the electrically-evoked contraction of guinea pig trachea was inhibited by DA-5018 and these inhibition was recovered by incubation with capsafepine(3$\muM$), capsaicin receptor antagonist and this result suggested that DA-5018 has affinity on capsaicin receptor. The correlation between the norciceptive threshold and the release of substance P was evaluated. In vivo perfusion of slices of the rat spinal cord with DA-5018(10, 100$\muM$) produced a significant increase of the release of substance P and this increase was less than that of capsaicin(10$\muM$). The norciceptive threshold of rat treated with DA-5018(1 mg/kg, p.o) in tall pinch test increased from 2.9$\pm$0.3 to 23.5 $\pm$6.61. Tail pinch latency increased to a maximun at 15 min after DA-5018 treatment and then declined to control values by 120 min. The capsaicin-evoked release ot substance P from the spinal cord slices of rat treated with DA-5018 reduced from 2.38$\pm$ 0.79 to 0.69$\pm$ 0.26 pg/mg wet weight. This reduction reached to a minium at 15 min after DA-5018 treatment and then recovered to control value by 120 min. These results mean that analgesic activity of DA-5018 is due to release of substance P The effect of DA-5018 cream on electrically-evoked neurogenic inflammation of rat saphenous nerve was compared with capsaicin (zostrix-HP). DA-5018 showed 34% inhibition of the neurogenic extravasation while capsaicin showed significant 67% inhibition. This result indicates that the potency of DA-5018 in the release of substance P is less than that of capsaicin. These results suggest that the release of substance P is partially involved in the mechanism of analgesic action of DA-50l8.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.10 no.8
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• pp.3474-3497
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• 2016

Network Function Virtualization (NFV) and Software Defined Networking (SDN) are recently considered as very promising drivers of the evolution of existing middlebox services, which play intrinsic and fundamental roles in today's networks. To address the virtual service deployment issues that caused by introducing NFV or SDN to networks, this paper proposes an optimal solution by combining quantum genetic algorithm with cooperative game theory. Specifically, we first state the concrete content of the service deployment problem and describe the system framework based on the architecture of SDN. Second, for the service location placement sub-problem, an integer linear programming model is built, which aims at minimizing the network transport delay by selecting suitable service locations, and then a heuristic solution is designed based on the improved quantum genetic algorithm. Third, for the service amount placement sub-problem, we apply the rigorous cooperative game-theoretic approach to build the mathematical model, and implement a distributed algorithm corresponding to Nash bargaining solution. Finally, experimental results show that our proposed method can calculate automatically the optimized placement locations, which reduces 30% of the average traffic delay compared to that of the random placement scheme. Meanwhile, the service amount placement approach can achieve the performance that the average metric values of satisfaction degree and fairness index reach above 90%. And evaluation results demonstrate that our proposed mechanism has a comprehensive advantage for network application.

• Asian-Australasian Journal of Animal Sciences
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• v.26 no.7
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• pp.921-929
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• 2013

Huoyan goose is a Chinese local breed famous for its higher laying performance, but the problems of variety degeneration have emerged recently, especially a decrease in the number of eggs laid. In order to better understand the molecular mechanism that underlies egg laying in Huoyan geese, gene profiles in the pituitary gland of Huoyan geese taken during the laying period and ceased period were investigated using the suppression subtractive hybridization (SSH) method. Total RNA was extracted from pituitary glands of ceased period and laying period geese. The cDNA in the pituitary glands of ceased geese was subtracted from the cDNA in the pituitary glands of laying geese (forward subtraction); the reverse subtraction was also performed. After sequencing and annotation, a total of 30 and 24 up and down-regulated genes were obtained from the forward and reverse SSH libraries, respectively. These genes mostly related to biosynthetic process, cellular nitrogen compound metabolic process, transport, cell differentiation, cellular protein modification process, signal transduction, small molecule metabolic process. Furthermore, eleven genes were selected for further analyses by quantitative real-time PCR (qRT-PCR). The qRT-PCR results for the most part were consistent with the SSH results. Among these genes, Synaptotagmin-1 (SYT1) and Stathmin-2 (STMN2) were substantially over-expressed in laying period compared to ceased period. These results could serve as an important reference for elucidating the molecular mechanism of higher laying performance in Huoyan geese.