• Journal of Life Science
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• v.29 no.11
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• pp.1179-1191
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• 2019

Cancer cells undergo the epithelial-mesenchymal transition (EMT) and show unique oncogenic metabolic phenotypes such as the glycolytic switch (Warburg effect) which are important for tumor development and progression. The EMT is a critical process for tumor invasion and metastasis. High-mobility group box 1 (HMGB1) is a chromatin-associated nuclear protein, but it acts as a damage-associated molecular pattern molecule when released from dying cells and immune cells. HMGB1 induces the EMT, as well as invasion and metastasis, thereby contributing to tumor progression. Here, we show that HMGB1 induced the EMT by activating Snail. In addition, the HMGB1/Snail cascade was found induce a glycolytic switch. HMGB1 also suppressed mitochondrial respiration and cytochrome c oxidase (COX) activity by a Snail-dependent reduction in the expression of the COX subunits COXVIIa and COXVIIc. HMGB1 also upregulated the expression of several key glycolytic enzymes, including hexokinase 2 (HK2), phosphofructokinase-2/fructose-2,6-bisphosphatase 2 (PFKFB2), and phosphoglycerate mutase 1 (PGAM1), in a Snail-dependent manner. However, HMGB1 was found to regulate some other glycolytic enzymes including lactate dehydrogenases A and B (LDHA and LDHB), glucose transporter 1 (GLUT1), and monocarboxylate transporters 1 and 4 (MCT1 and 4) in a Snail-independent manner. Transfection with short hairpin RNAs against HK2, PFKFB2, and PGAM1 prevented the HMGB1-induced EMT, indicating that glycolysis is associated with HMGB1-induced EMT. These findings demonstrate that HMGB1 signaling induces the EMT, glycolytic switch, and mitochondrial repression via Snail activation.

• Korea journal of population studies
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• v.19 no.1
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• pp.5-44
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• 1996

Wornen's lahor market participation as well as the policy concern for wider utilization of married women, have continuously grown up. However, research efforts on the determinants of women's labor market participation, in the context of the relationship hetween life courses and active entry into lahor market, has been far behind the growing interest in this field. This study has conducted an event histoiry analysis of women's labor market transition utilizing personal occupational history data collected by the Korea Institute for Women's Development in 1991. The analysis is divided into tow parts: First part introduces logit regression to analyze the determinants of women's labor market participation and exit. The second part employs Cox regression to see the variation of transition rate between employment and non-employment. The result shows that there is a wide variation in women's labor market participation according to age, cohort, and family formation. Special note is needed for the significantly negative effect of marriage and child birth on labor market participation. The transition pattern of lower class women with less education fits well to the prediction of neo-classical economics; but the tendency of highly educated women's regression to non-employment reveals the strong influence of the unfavorable labor market structure, which can be better explained by the neo-structuralist perspective. There is a strong trade-off between productive and reproductive labor of women, which can only be corrected by strong policy implementation, such as extended child care facilities, abolition of discriminatory employment practices, and expansion of flexible part-time employment.

• Journal of the Korean association of regional geographers
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• v.5 no.1
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• pp.1-24
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• 1999

This is a study on village names in a plain region of Changnyeong-Gun, a mountain region of Bonghwa-Gun and an island region of Namhae-Gun. The three regions differ in geographical features. The data are based on 455 village names in Changnyeong-Gun, 552 village names in Bonghwa-Gun and 275 village names in Namhae-Gun found in the 1 : 50,000 topographic map. The method of this study is to analyze the word structures of village names in the five basic concepts in geography : Man-Land(Natural Environment and Human Activities). Spatial Relation, Distribution, Region and Transition. The main results of this study are as follows: 1. Naming of villages are related to Natural Environment(41%), Human Activities(23%), Region(17%), Spatial Relation(13%), Distribution(5%), and Transition(3%). Of these six factors, Changnyeong-Gun is relatively dominant in village names related to Spatial Relations, Region and Transition ; Bonghwa-Gun Natural Environment and Namhae-Gun Human Activities and Spatial Relations. But the three Guns are absolutely dominant in village names related to Natural Environment and Human Activities. 2. A village name is divided into the specific name part(given name) and the generic name part(classified name). Names related to Human Activities, Spatial Relations, Distribution and Transition are more frequently found in the specific name part. Therefore, they are used as the given name of a village name. Whereas names related to Natural Environment and Region are more frequently found in generic name part, which means that they are used as the classified name of a village. 3. The word structure of a village name usually has two parts a frontal part(given name) and a rear part(classified name). The two parts have a particular pattern in the geographic concept when they are combined. 1) In the village names related to in their frontal part of the word structure, is more frequently combined as their rear part in Bonghwa-Gun, in Namhae-Gun and in Changnyeong-Gun. 2) In the village names related to in their frontal part of the word structure, is more frequently combined as their rear part in Changnyeong-Gun, in Namhae-Gun and in Bonghwa-Gun. Accordingly, Man(Human Activities) - Land (Natural Environment) can be considered the most important concept in the naming of villages, because the concept is most frequently used in the word structures of village names.

• Economic and Environmental Geology
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• v.56 no.1
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• pp.13-21
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• 2023

X-ray powder diffraction study was conducted on the bulk modulus and phase transition behavior of synthetic zeolite X under high temperature and high pressure. Water and HCO₃^- solution were used as a PTM. Sample was heated and pressurized up to 250 ℃ and 5.18 GPa. The change of unit cell volume and phase transition were observed by X-ray diffraction. The lattice constants and unit cell volume of zeolite X, gmelinite, natrolite, and smectite were calculated using the GSAS2 program to which Le Bail's whole powder pattern decomposition (WPPD) method was applied. The bulk modulus of each zeolite X and smectite were calculated using the EosFit program to which the Birch-Murnaghan equation was applied. The bulk modulus of zeolite X is 89(3) GPa in water run, and zeolite X is 92(3) GPa in HCO₃^- solution run. In both run, pressure induced hydration (PIH) occurred due to the inflow of PTM into the zeolite X framework at initial pressure. Zeolite X transited to gmelinite, natrolite, and smectite in water run. Zeolite X, however, transited to smectite in HCO₃^- solution run. Interzeolite transformation occurred in water run, and did not occur in HCO₃^- solution run, which is assumed that conflict between the environment to form zeolite and the pH of the HCO₃^- solution.

• Communications of Mathematical Education
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• v.38 no.2
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• pp.121-144
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• 2024

This study analyzes how the academic achievement of students in Korea changes as they transition from 4th grade of elementary school to 2nd grade of middle school, considering that the 4th graders in the previous TIMSS cycle become 2nd graders in the next cycle. In particular, this study selects and compares the eight main countries in the TIMSS math evaluation (Korea, Singapore, Taiwan, Japan, USA, UK, Australia, and Russia) to analyze the trend of change in academic achievement of Korean students according to school grade transition. The trend of change in academic achievement of students was analyzed not only overall but also by content area (number, geometry and measurement, data representation (data and probability/data and probability), gender, and regional scale. The analysis focused on the average score and the proportion of students by achievement level. The results of the study are as follows. First, there was no significant change in the average score of Korean students' academic achievement as the school grade transitioned, but the achievement gap widened in terms of the proportion by achievement level. Second, there were differences in students' academic achievement by content area according to school grade transition, and the pattern differed depending on the evaluation cycle. Third, there was a significant gap in students' math academic achievement depending on gender and regional scale of school location. This study reveals that the achievement gap among students in our country widens as they transition between school levels. The gap is found to vary in terms of achievement level, math content area, student gender, and school location. To alleviate these disparities, more substantial research and support are proposed in addition to policy implementation by the government or provincial offices of education.

• The Research Journal of the Costume Culture
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• v.19 no.2
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• pp.296-308
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• 2011

The purpose of this study is to understand Qipao, that Chinese traditional women's cloth, and analysis the aesthetic characteristics of that. Joining WTO in 2002 and 2008 Beijing Olympic made China get the attention by the world and get the opportunity that advent of China style. Chinese fashion cultural contents have abundant meanings in internal or external, therefore characteristics aesthetic of Chinese traditional fashion had much influence in world fashion design. Qipao that has influence in contemporary fashion design could be used special fashion design data for China market. A variety of literature and prior researches for Qipao's history and transition process was studied. Internal and external documents, fashion magazines, internet information were investigated to study features of Qipao. Total 20 seasons fashion collections from 2000S/S to 2009F/W was examined, and selected 22 brands that showed Qipao style, after then extracted 418 photos among them. By the seasons, Eit showed 193 pieces in S/S and 225 pieces in F/W, and was put to practical use in F/W season than S/S. The results are as follows. The contemporary fashion collections shown in the Qipao style silhouette, detail, color, material, pattern and the results obtained by each, were in all respects diversity. In silhouette, including traditional tight silhouettes, 'H' silhouettes, boxy silhouette was such a variety. The five colors traditionally preferred color from the color was more of a tendency to be gorgeous. Modern reinterpretation of pattern designs by graphic pattern that has emerged. Also, shown in a contemporary fashion collection Qipao style leather material in application utilizing the glossy feel of a plastic material and has emerged feeling.

• Journal of Korean Tunnelling and Underground Space Association
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• v.21 no.6
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• pp.825-835
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• 2019

When the tunnel is designed, the ground is classified into several grades and the corresponding support system is applied according to the support pattern table. However, a simple pattern application based on rock grade does not take into account the longitudinal stress transitions occurring at rock grade boundaries. In this study, three-dimensional numerical analysis was performed to estimate the stress change in the longitudinal rock grade change of NATM tunnel, and the influence zone of load transfer was investigated using the influence line and trend line. As a result, the downward change of rock grade in the direction of tunnel excavation occurs in the range of 0.35~0.7D from low-strength rock to high-strength rock around the grade change boundary. It is necessary to apply a downward pattern of about 1.0D to the safety direction in consideration of the influence range of 0.35D to 0.7D.

• Korea journal of population studies
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• v.35 no.1
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• pp.151-179
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• 2012

This study investigates birth cohort and educational differences in the marital and fertility life course using the Hernes model. First, lifetime marriage rates remain high across birth cohorts but men in the youngest birth cohort(1965-74) experience a somewhat significant reduction in ever-marriage rates. Second, this study also finds educational differences in lifetime marriage rates across birth cohorts. The likelihood of being never married is particularly high for poorly educated men in the youngest birth cohort but women show the opposite pattern. Third, quantum changes in the fertility transition are more likely to be the changes in higher-order births, while the changes in first and second births are mainly tempo changes. Fourth, the negative association between education and fertility is significantly larger for higher-order births. Finally, marriage and fertility show the opposite pattern in their association with education. Overall, educational differences in lifetime marriage rates become stronger across birth cohorts but the association between education and higher-order births shows the opposite pattern.

• Korean Journal of Biological Psychiatry
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• v.19 no.1
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• pp.65-69
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• 2012

Objectives : Much is still unknown about the neurophysiological mechanisms or dynamics of the sleep onset process. Detrended fluctuation analysis (DFA) is a new tool for the analysis of electroencephalography (EEG) that may give us additional information about electrophysiological changes. The purpose of this study is to analyze long-range correlations of electroencephalographic signals by DFA and their changes in the sleep onset process. Methods : Thirty channel EEG was recorded in 61 healthy subjects (male:female=34:27, age=$27.2{\pm}3.0$ years). The scaling exponents, alpha, were calculated by DFA and compared between four kinds of 30s sleep-wakefulness states such as wakefulness, transition period, early sleep, and late sleep (stage 1). These four states were selected by the distribution of alpha and theta waves in O1 and O2 electrodes. Results : The scaling exponents, alpha, were significantly different in the four states during sleep onset periods, and also varied with the thirty leads. The interaction between the sleep states and the leads was significant. The means (${\pm}$ standard deviation) of alphas for the states were 0.94 (${\pm}0.12$), 0.98 (${\pm}0.12$), 1.10 (${\pm}0.10$), 1.07 (${\pm}0.07$) in the wakefulness, transitional period, early sleep and late sleep state respectively. The mean alpha of anterior fifteen leads was greater than that of posterior fifteen leads, and the two regions showed the different pattern of changes of the alpha during the sleep onset periods. Conclusions : The characteristic findings in the sleep onset period were the increasing pattern of scaling exponent of DFA, and the pattern was slightly but significantly different between fronto-temporal and parieto-occipital regions. It suggests that the long-range correlations of EEG have a tendency of increasing from wakefulness to early sleep, but anterior and posterior brain regions have different dynamical process. DFA, one of the nonlinear analytical methods for time series, may be a useful tool for the investigation of the sleep onset period.

• Korea journal of population studies
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• v.6 no.1
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• pp.3-42
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• 1983

The purposes of this paper is to introduce a technique for construction of nuptiality tables using proportion single of synthetic cohorts between times at two consecutive censuses, and to observe patterns of change in marriage habit of Korean through the nuptiality tables for single population from 1925 to 1980. In this paper abridged gross and net nuptiality tables for single population of Korea have been constructed for the four quinquinial period: 1925-1930, 1955-1960, 1970-1975, and 1975-1980. Significant time trend has been observed in the nuptiality rates among the single population. The major findings observed in each table are as follows; (1)During 1925-1930, the rates are initially small, but increase rapidly until they reach a maximum at ages 25-29 for bachelors and 20-24 for spinsters, following which they are still in high level. (2)During 1955-1960, the age pattern of nuptiality begins to change; for female population, the rates increase rapidly in the same pattern as in l925-l930 untill they reach the highest level at ages 25-29, after which they gradually decline. During the period, however, there were an unprecedented high level of marriage rates for male population at a relatively later ages. (3)During 1970-1975, Korea had experienced a transition in marriage habits; at this times, nuptiality rates for both sexes showed the same pyramid shaped patterns as in western countries as age increases. The mean ages at marriage for both sexes also reached the highest level of 27.5 years for males and 24.1 years for females. (4)During 1975-1980, the age patterns of nuptiality showed almost the same patterns as in 1970-1975. In the later age group, however, age-specific marriage rates for both sexes greatly declined compared to the level of 1970-1975, while the rate in age group of 20-24 for male population greatly increased.