• Title/Summary/Keyword: Transformation optimization

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Optimization of Fermentation Medium for Glycyrrhizin Biotransformation to Monoglucuronyl-glycyrrhetinic Acid by Plackett-Burman and Box-Behnken Design

  • Quan, Yanling;Wang, Lin;Liu, Yisheng;Cong, Jingxiang;Xie, Shengquan;Wu, Xiuhong
    • Korean Chemical Engineering Research
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    • v.53 no.3
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    • pp.321-326
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    • 2015
  • Plackett-Burman (PB) and Box-Behnken (BB) experimental designs were used to optimize fermentation variables for the biotransformation of glycyrrhizin (GL) to monoglucuronyl-glycyrrhetinic acid (MGGA). The PB design was first used to screen the important factors among the medium variables. The steepest ascent method was used to approach the optimum range for each of these factors. The BB design was finally used to analyze the response surfaces of the screened factors for further optimization. The optimized conditions for this system were 0.7 g/L $MgSO_4{\cdot}7H_2O$, 1.19 g/L GL, and cultivation for six days. The biotransformation of GL to MGGA could reach up to 35.72%, which is a good result for this kind of transformation.

Novel Optimization Method of Phase-Only Computer-Generated Hologram Using the Phase-Shift Characteristic (위상천이특성을 이용한 새로운 Phase-Only CGH 계산)

  • Kim, Tae-Hyeon;Kim, Bong-Sik;Park, Woo-Sang
    • Korean Journal of Optics and Photonics
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    • v.27 no.3
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    • pp.101-105
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    • 2016
  • In this study we propose the novel optimization method of the phase-only computer-generated hologram (CGH), to improve calculation speed compared to the conventional method. While the conventional method is calculated using numerical analysis, the novel method is calculated using the phase-shift characteristic of Fourier transformation. In addition, the selectivity of noise filtering lets it decrease the calculation time. The validity of the reconstructed image using the novel method is verified by comparing simulation results to ideal and conventional data, and the improvement of texture and sharpness of the reconstructed image is confirmed by simulation.

Implementation of Digital Management System for the Enterprises Development and Distribution in Aviation Industry

  • TIKHONOV, Alexey;SAZONOV, Andrey
    • Journal of Distribution Science
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    • v.20 no.9
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    • pp.39-46
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    • 2022
  • Purpose: At the industrial sites of aviation enterprises there is a significant optimization of the main production processes through the use of advanced digital technologies. The most promising are the latest technologies of industrial Internet of Things, active use of big data and practical application of artificial intelligence in production. Research design, data and methodology:The process of creating a competitive product in the high-tech aviation sector is actively linked to the investment appeal of aircraft and helicopter construction products, which is built on the basis of reducing production and time costs through the creation of an effective digital system. Results: The aviation cluster of Rostec State Corporation is currently being transformed in a significant way. The leading enterprises of the Russian aviation industry are actively mastering cooperation schemes using integrated digital management principles and the widespread introduction of digital products from leading Russian vendors. Conclusions: Following the transition to electronic aircraft design technologies and modern materials in the production of aircraft, UAC continues to improve all production processes through robotization and optimization of technological processes, due to the introduction of aircraft assembly technology in accordance with digital models.

Optimization of particle gun-mediated transformation system in Cymbidium (유전자총을 이용한 형질전환 심비디움 식물체 생산체계 최적화)

  • Noh, Hee-Sun;Kim, Mi-Seon;Lee, Yu-Mi;Lee, Yi-Rae;Lee, Sang-Il;Kim, Jong-Bo
    • Journal of Plant Biotechnology
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    • v.38 no.4
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    • pp.293-300
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    • 2011
  • This study is conducted to develop an efficient transformation system via particle bombardment with PLBs (Protocorm-like bodies) in Cymbidium. For this, pCAMBIA3301 vector which carries a herbicide-resistant bar gene and gus gene as a reporter gene was used for transformation with Cymbidium cultivars 'Youngflower ${\times}$ masako' line. To select transformants, proper concentration of herbicide, PPT (phosphinotricin), should be determined. As a result, 5 mg/l of PPT was selected as a proper concentration. Further, proper conditions for particle bombardment were determined to obtain a high frequency of transformation. Results showed that 1.0 ${\mu}g$ of DNA concentration, 1,100 and 1,350 psi for helium gas pressure, 1.0 ${\mu}m$ of gold particle and 6 cm of target distance showed the best result for the particle bombardment experiment. Also, pre-treatment with combination 0.2 M sorbitol and 0.2 M mannitol for 4 hrs prior to genetic transformation increased the transformation efficiency up to 2.5 times. Using transformation system developed in this study, 3.2 ~ 4.0 transgenic cymbidium plants can be produced from 100 bombarded PLBs on average. Putative transgenic plants produced in this system confirmed the presence of the bar gene by PCR analysis. Also, leaves from randomely selected five transgenic lines were applied for Basta solution (0.5% v/v) to check the resistance to the PPT herbicide. As a result, three of them showed resistance and one of them showed the strongest resistance with the maintenance of green color as non-transformed plants showed. Using this established transformation system, more genes of interests can be introduced into Cymbidium plants by genetic transformation in the future.

Optimization of Spacecraft Structure by Using Coupled Load Analysis (연성하중해석을 이용한 위성체 구조부재의 최적화)

  • Hwang, Do-Soon;Lee, Young-Sin;Kim, In-Gul
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.30 no.4
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    • pp.106-113
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    • 2002
  • In spacecraft system, structure subsystem has the mission of supporting all the components safely under various space environmental conditions. The safety of spacecraft structure is finally verified from the coupled load analysis, which is a branch of load analysis which combines the launch vehicle and satellite. This study introduces the optimization algorithm to reduce the weight of spacecraft structure under launch environmental conditions directly. The acceleration responses are obtained by the introduction of coupled load analysis, which lead to check the failure of spacecraft structural members. The results show a 12% saving of structural weight and this saving is mainly driven by the thickness of honeycomb core, which strongly affects the natural frequencies of platforms and panels.

A Study on Static Type Assignment for Static Single Assignment Form (정적 단일 배정 형태를 위한 정적 타입 배정에 관한 연구)

  • Kim, Ki-Tae;Yoo, Weon-Hee
    • The Journal of the Korea Contents Association
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    • v.6 no.2
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    • pp.117-126
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    • 2006
  • Although the Java bytecode has numerous advantages, there are also shortcomings such as slow execution speed and difficulty in analysis. In order to overcome such disadvantages, bytecode analysis and optimization must be performed. First control flow of the bytecode should be analyzed, after which information is required regarding where the variables are defined and used to conduct data flow analysis and optimization. There may be cases where variables with an identical name contain different values at a different location during the execution according to the value assigned to a variable in each location. Therefore, in order to statically determine the value and type, the variables must be separated according to allocation. In order to do so, the variables can be expressed using a static single assignment form. After the transformation into a static single assignment form, the type information of each node expressed by each variable and expression must be configured to perform static analysis and optimization. Based on the basic type information, this paper proposes a method for finding related equivalent nodes, setting the nodes with strongly connection components and efficiently assigning each node the type.

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Predictive Optimization Adjusted With Pseudo Data From A Missing Data Imputation Technique (결측 데이터 보정법에 의한 의사 데이터로 조정된 예측 최적화 방법)

  • Kim, Jeong-Woo
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.20 no.2
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    • pp.200-209
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    • 2019
  • When forecasting future values, a model estimated after minimizing training errors can yield test errors higher than the training errors. This result is the over-fitting problem caused by an increase in model complexity when the model is focused only on a given dataset. Some regularization and resampling methods have been introduced to reduce test errors by alleviating this problem but have been designed for use with only a given dataset. In this paper, we propose a new optimization approach to reduce test errors by transforming a test error minimization problem into a training error minimization problem. To carry out this transformation, we needed additional data for the given dataset, termed pseudo data. To make proper use of pseudo data, we used three types of missing data imputation techniques. As an optimization tool, we chose the least squares method and combined it with an extra pseudo data instance. Furthermore, we present the numerical results supporting our proposed approach, which resulted in less test errors than the ordinary least squares method.

Topology Optimization of Beam Splitter for Multi-Beam Forming Based on the Phase Field Design Method (페이즈 필드 설계법 기반의 다중 빔 형성을 위한 빔 분배기 위상최적설계)

  • Kim, Han-Min
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.32 no.3
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    • pp.141-147
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    • 2019
  • In this paper, a systematic beam splitter design for multi-beam forming is proposed. The objective of this research is to a design beam splitter that splits and focuses scattering microwaves into intense beams in multiple directions. It is difficult to split multi-beam to non-specific directions with theoretical approaches. Therefore, instead of using transformation optics(TO), which is a widely used process for controlling electromagnetic wave propagation, we used a systematic design process called the phase field design method to obtain an optimal topological structure of beam splitter. The objective function is to maximize the norm of electric field of the target areas of each direction. To avoid island structure and obtain the structure in one body, volume constraint is added to the optimization problem by using augmented Lagrangian. Target frequency is set to X-band 10GHz. The optimal beam splitter performed well in multi-beam forming and the transported electric energy of target areas improved. A frequency dependency test was conducted in the X-band to determine effective frequency range.

A Motion Planning Algorithm for Synchronizing Spatial Trajectories of Multi-Robots (다수 로봇간 공간궤적 동기화를 위한 모션계획 알고리즘)

  • Jeong Young-Do;Kim Sung-Rak;Lee Choong-Dong;Lim Hyun-Kyu
    • Journal of Institute of Control, Robotics and Systems
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    • v.10 no.12
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    • pp.1233-1240
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    • 2004
  • Recently the need for cooperative control among robots is increasing in a variety of industrial robot applications. Such a control framework enhances the efficiency of the real robotic assembly environment along with extending the robot application. In this paper, an ethernet-based cooperative control framework was proposed. The cooperative control of robots can multiply the handling capacity of robot system, and make it possible to implement jigless cooperation, due to realization of trajectory-synchronized movement between a master robot and slave robots. Coordinate transformation was used to relate among robots in a common coordinate. An optimized ethernet protocol of HiNet was developed to maximize the speed of communication and to minimize the error of synchronous movement. The proposed algorithm and optimization of network protocol was tested in several class of robots.

Spatial Selectivity Estimation Using Wavelet

  • Lee, Jin-Yul;Chi, Jeong-Hee;Ryu, Keun-Ho
    • Proceedings of the Korean Institute of Intelligent Systems Conference
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    • 2003.09a
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    • pp.459-462
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    • 2003
  • Selectivity estimation of queries not only provides useful information to the query processing optimization but also may give users with a preview of processing results. In this paper, we investigate the problem of selectivity estimation in the context of a spatial dataset. Although several techniques have been proposed in the literature to estimate spatial query result sizes, most of those techniques still have some drawback in the case that a large amount of memory is required to retain accurate selectivity. To eliminate the drawback of estimation techniques in previous works, we propose a new method called MW Histogram. Our method is based on two techniques: (a) MinSkew partitioning algorithm that processes skewed spatial datasets efficiently (b) Wavelet transformation which compression effect is proven. We evaluate our method via real datasets. With the experimental result, we prove that the MW Histogram has the ability of providing estimates with low relative error and retaining the similar estimates even if memory space is small.

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