• Advances in Traditional Medicine
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• 제7권1호
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• pp.26-33
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• 2007

Genetic polymorphism and molecular authentication were investigated with the commercial medicinal herb, Peony (Paeonia spp.), using random amplified polymorphic DNA (RAPD) markers. To identify the polymorphism of the RAPD patterns among plant origins, 20 different random primers were applied to the genomic DNA extracted from Paeonia spp. plants such as Paeonia (P.) lactiflora, P. officinale and P. japonica. Ten primers out of 20 primers could be used to discriminate the plant species in the same genus and 72 out of 81 scored DNA fragments (88.9%) generated with these primers were polymorphic. Especially, four primers, such as OPA1, OPA3, OP9, and OPA13, were useful to discriminate the plant origins among the species of Peony. In the results of cluster analysis using RAPD data obtained from the 10 primers, Peony (Paeonia spp.) plants used in this study were grouped into the two distinctive clusters, genetically. Herb medicine, especially P. lactiflora, were easily identified, when species-specific primers were applied to the investigation for discriminating herb medicine currently traded in domestic herb market, Kyungdongmart. Consequently, RAPD analysis was useful method to discriminate plant origins and the commercial medicinal herbs, Paeonia spp..

• 대한한의학회지
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• 제26권2호
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• pp.195-200
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• 2005

Objecitves: Peel of Citrus unshiu (Rutaceae) has been used in traditional herbal prescriptions. Hesperidin and naringin contents of Citri Unshii Pericarpium were determined and compared to herbal prescriptions. Then, the different extractions from prescriptions are explained with traditional herbal theories. Methods: The herb and herbal prescriptions were extracted in boiled water. A quantitative analysis was made of hesperidin and naringin using HPLC with-reversed-phase CIS column and a UV detector at 204nm. Elution was carried out at 1.0ml/min with $38\%$ methanol. Results and Conclusions: The extract of Citri Unshii Pericarpium for 180 min was the better method for extracting naringin and hesperidin. The flavonoid contents in remedies are different among several traditional herbal prescriptions. The reason for the difference can be explained with traditional drug interaction theories.

• 동의신경정신과학회지
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• 제20권3호
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• pp.297-307
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• 2009

Objectives : Insomnia, depression and anxiety disorder are widespread in elderly patients. Mood disorder and insomnia share complex theoretical and clinical relationships. We investigated if traditional Korean medical treatment and breathing meditation are effective in patient with insomnia, depression and anxiety disorder. Methods : We treated one patient with traditional Korean medical treatment such as accupuncture, herb-medication, moxa and breathing meditation Results : After Treatment, the chief complaint and accompanying symptoms were improved, and the score of BAI, SADS, BDI, PSQI, IQ were decresed. Conclusions : According to this study traditional Korean medical treatment is effective for the cure of insomnia, depression and anxiety disorder and breathing meditation forifies the traditional Korean medical treatment.

• 동의신경정신과학회지
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• 제27권1호
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• pp.11-21
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• 2016

Objectives: This study was performed to review the research trends in the treatment of eating disorder in traditional Chinese medicine (TCM). Methods: The CNKI database (China National Knowledge Infrastructure) was searched under the key words ‘Eating Disorder’, ‘Anorexia Nervosa’, and ‘Bulimia Nervosa’. Results: Thirteen articles were selected. These included 2 studies on bulimia nervosa, and 11 studies on anorexia nervosa. According to study design, studies were classified into 1 randomized controlled trial, 2 single group before-and-after studies, and 8 case reports. According to therapy method, they included 11 herbal medicine studies, and 2 complex treatment studies. The most common pattern identification was ‘liver qi depression’ (肝氣鬱結), and the most used herb was ‘Root of Bupleurum falcatum’ (柴胡). Most of the studies showed effective results. Conclusions: The results of our study indicated that TCM clinical studies on eating disorder were being conducted more actively than in Korean medicine. Korean medical treatment might be effective to relieve eating disorder symptoms. In the future, more scientifically designed clinical studies should be performed to prove the effectiveness of traditional Korean medicine treatment on eating disorder.

• 동의신경정신과학회지
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• 제29권4호
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• pp.291-303
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• 2018

Objectives: The objective of this study is to analyze the Clinical reports of treatment of obsessive compulsive disorder (OCD) in traditional Chinese medicine (TCM). Methods: Clinical reports on obsessive compulsive disorder treatment from 2001 to 2017 were searched using the following key words in the China National Knowledge Infrastructure (CNKI). 'OCD', 'qiangpo zheng'. Results: A total of 22 papers were selected, 12 of which were clinical research papers and 10 case report papers. The acupuncture and moxa treatment was more effective in relieving the clinical symptoms of OCD patients as compared to only using western medicine, and it was also possible to reduce the adverse effects of western medicine. Conclusions: It was established that Traditional Chinese medicine has some effect on the treatment of OCD, but there were limitations as follows. The selected papers were retrieved from only one site of CKNI and did not follow a systematic review methodology. Therefore generalized results could not be derived, further studies should therefore be carried out.

• 생약학회지
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• 제46권2호
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• pp.160-166
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• 2015

Yijung-tang (YJT) is a traditional herbal formula comprising 4 medicinal herbs. In the present study, we performed the simultaneous analysis for three compounds of YJT and examined anti-allergic effects in vitro. The column for separation of three compounds was used Gemini C18 column and maintained at 40$^{\circ}C$. The mobile phase for gradient elution consisted of two solvent systems. To evaluate Th2 chemokines, YJT was treated into tumor necrosis factor (TNF)-${\alpha}$ and interferon (IFN)-${\gamma}$-stimulated HaCaT cells, and performed ELISA for thymus and activation regulated chemokine (TARC) and regulated on activation, normal T-cell expressed and secreted (RANTES). To measure Th2 cytokines, YJT was added into primary mouse splenocytes, and performed ELISA for interleukin (IL)-4, 5, 13. Calibration curves were acquired with r² >0.9999. The contents of liquiritin, glycyrrhizin, and 6-gingerol in YJT were 4.50 mg/g, 11.10 mg/g, and 1.33 mg/g, respectively. YJT inhibited production of TARC and RANTES in TNF-${\alpha}$ and IFN-${\gamma}$-treated HaCaT cells. YJT also reduced production of IL-4, 5, and 13 in primary mouse splenocytes. In conclusion, our data will be a valuable information to improve quality control and anti-allergic effects of YJT.

• Journal of Acupuncture Research
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• 제29권4호
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• pp.71-79
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• 2012

Objectives : The purpose of this study is to set the explanatory duty on traditional Korean medical(TKM) treatment by analyzing the judicial precedents. Methods : The study was performed by analyzing nine cases of lawsuits related to Korean medicine doctor and explanatory duty among the medical dispute cases in Korea from 1968 through 2012. Results : Nine closed claims occurred regarding the violation of explanatory duties in the field of TKM practice. Two claims were decided by supreme court, three were decided by high court, and four were decided by district court. The causes of lawsuits were categorized as follows : bee venom pharmacopuncture, herb treatment, and an explanation for safety. Conclusions : To perform an explanatory duty has important legal implications for the protection of patients' rights and Korean Medicine doctors' autonomy on TKM treatment.

• 한국약용작물학회지
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• 제23권6호
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• pp.489-499
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• 2015

Background : Plants belonging to 5 species of the genus Eleutherococcus are currently distributed in the Korean peninsula. The traditional medicine 'Ogapi', derived from Eleutherococcus sessiliflorus and other related species, and 'Gasiogapi', derived from Eleutherococcus senticosus, are frequently mixed up and marketed. Therefore, accurated identification of their origins in urgently required. Methods and Results : Candidate genes from nuclear ribosomal DNA (nrDNA) and chloroplast DNA (cpDNA) of Eleutherococcus plants were analyzed. Whereas the nrDNA-internal transcribed spacer (ITS) regions were useful in elucidating the phylogenetic relationships among the plants, the cpDNA regions were not as effective. Therefore, a combined analysis with nrDNA-ITS was performed. Various combinations of nrDNA and matK were effective for discriminating among the plants. However, the matK and rpoC1 combination was ineffective for discriminating among some species. Based on these results, it was found that OG1, OG4, OG5, OG7, GS1, GS2, and GS3 were derived from E. sessiliflorus. In particular, it was confirmed that GS1, GS2, and GS3 were not derived from E. senticosus. However, more samples need to be analyzed because identification of the origins of OG2, OG3, OG6 and GS4 was not possible. Conclusion : The ITS2, ITS5a, and matK combination was the most effective in identifying the phylogenetic relationship among Eleutherococcus plants and traditional medicines based on Eleutherococcus.

• 대한간호학회지
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• 제8권2호
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• pp.25-38
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• 1978

A survey was made with regard to understanding attitude and practical use of modern and traditional methods of health care in a rural village with 742 inhabitants which comes under one of the whole three types of Korean rural community, to find out the following facts. 1. Among the five types of health-care given, the most understood, chosen and used one was the doctor followed next by pharmacy and continually herb doctor, folkways method, shamanistic treatment; the last shown method was principally chosen to use by only one among 139 housewives as respondants available, 2. Between herb medicine and folkways method of care, the former was more relief upon than the latter while the latter was more used than the former, seemingly because of relative low cast of the latter. 3. A considerable part of those who mainly used the doctor or pharmacy also used herb doctor or folkways care； modern and traditional care methods coexisted in the pertaining community. 4. Nearly all of the respondants ware, reasonably, aware of effectiveness of modern types of health-care; but, at the same time, more than a half of them had a positive attitude towards traditional method as well. 5, On the whole, the respondants made a distinction between traditional health-care methods and shamanism, regarding the latter as ineffective. 6. The result hints that it would be desirable for health-care professionals to inquire into traditional methods of health-care with a view to being more acquainted with rural residents and so raising their use of services by experts. 7. It should be added that the results of this piece of study may have a general significance only within those communities which shares the same socio-cultural background and characteristic of the surveyed one.

• 대한한의학회지
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• 제19권1호
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• pp.271-298
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• 1998

During these days of new understanding, western medicine has developed remarkably and a revaluation of traditional medicine has been achieved. This appears to have resulted from the sound criticisms of what western medicine has achieved up to now; excessive subdivisions of clinical medicine, severe toxicity of chemical drugs, lack of understanding about patients complaints which cannot be understood objectively, and etc. It is thought that the role of traditional medicine will be more important in the future than it is now. Someone said that the research methods of traditional medicine depends on the way of experimental science too much. That there was no consideration of a system for traditional medicine and the critic also went so far as to assert that in some cases the characteristics of eastern ideas is to permit irrationalism itself. In view of this thinking, the term traditional medicine seems to have been used somewhat too vaguely. However, traditional medicine is a medical treatment which has existed since before the appearance of modern medicine and it was formed from a traditional culture with a long history. One form of traditional medicine, oriental medicine based upon ancient Chinese medicine, was received in such countries as Korea, Japan, Thailand, Vietnam, Tibet, and Mongolia. Oriental medicine then developed in accordance with its own environment, race, national characteristics, and history. Although there are some simultaneous differences between them, three nations in Eastern Asia; Korea, Japan, and China, have especially similar features in their clinical prescriptions and medical literature. These three nations are trying to understand each others unique traditional medicines through numerous exchanges. Even though many differences in their ways of studying have developed over history exist, recent academic discussions have been made to explore new ways into oriental medicine. Therefore a comparative study of oriental medicine has gradually been thought to be more important. In Korea the formation of a new future-oriented paradigm for oriental medicine is being demanded. The purpose of the new paradigm is to create a new recognition of traditional culture which creates an understanding of oriental medicine to replace the diminished understanding of oriental medicine that was brought about by the self-denial of traditional culture in modem history and cultural collisions between oriental and occidental points of view. Therefore, to make a new paradigm for oriental medicine which is suitable for these days, and fortifies the merit of oriental medicine while compensating its defects, the author has compared the characteristics of oriental medicines in Korea, Japan, and China. The conclusions of this research are as follows: 1. The fundamental differences of the traditional medicines of these three nations are caused by the differences in the systems of Naekyung and Sanghannon. 2. The pattern-identification of illnesses is generally divided into two categories; the pattern identification of Zang-Fu and the pattern identification of prescription. 3. There are many differences in the definition of terms, such as Yin and Yang, Deficiency and Excess, and etc. 4. Chinese traditional medicine has some new concepts about pattern identification and epidemic febrile disease. 5. Japanese traditional medicine has some characteristics about pattern identification of the whole bodys condition and signs of abdominal palpation. 6. In terms of the effects of herbal drugs, Chinese traditional medicine attaches great importance to the experiential efficacy of the herb, and Japanese traditional medicine is taking a serious view of the effects of experimental medical actions.