• The Korea Journal of Herbology
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• v.33 no.1
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• pp.9-15
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• 2018

Objectives : The root bark of Dictamnus dasycarpus has been frequently used to treat patients with skin diseases in Korea. Recently, wild root of D. dasycarpus are reported to induce liver injury. Methods : Traditional uses of D. dasycarpus for skin diseases were analysed bibliographically. In addition, reported cases were collected and analysed using pubmed and national digital library. Results : In taiwan, D. dasycarpus revealed to be one of major herbs for skin diseases and many researchers in worldwide had reported its dermatological efficacies. Reported cases related in liver injury described that hepatocellular or cholestatic liver injury were seen in patients eating wild root of D. dasycarpus. In addition, 6 cases in worldwide and 1 case in Korea showed that patients with drug induced liver injury (DILI) ingested not root bark of D. dasycarpus but prescriptions containing root bark of D. dasycarpus. These mean that wild root of D. dasycarpus (Bongsam or Bongwhangsam) was estimated to be closely related in DILI. Whereas, it was difficult to confirm direct correlation between root bark of D. dasycarpus used as herbal medicine by doctor of Korean medicine and DILI. Conclusions : these results imply that wild root of D. dasycarpus is closely related in DILI and strong recommendation not to take it without consultation by experts is needed. In addition, although there are no evidences of direct correlation between root bark of D. dasycarpus and DILI, doctor of Korean medicines should pay attention to use root bark of D. dasycarpus in their clinics.

• Journal of Physiology & Pathology in Korean Medicine
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• v.36 no.6
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• pp.213-220
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• 2022

We investigated the current status of research using extracorporeal shock waves on the basis of meridian and acupoint theory. By March 2022, five foreign databases (CAJ, Pubmed, Web of Science, EMBASE, Cochrane Library) and six Korean databases (Dbpia, RISS, KMBASE, scienceON, KISS, NDSL) were searched with the terms using 'Extracorporeal shock wave' and '(Acupoint or Acupuncture point)'. The search terms were adapted according to the language of the database. There were no restrictions on the study design. As a result of the search, twenty-seven papers were selected for analysis. One study was searched in English database, and the remaining twenty-six studies were searched in Chinese database. There were nineteen pain-related diseases, four obsterics and gynecology diseases, two bone-related diseases, and two other diseases. The most frequently used acupoints were GB34, ST36, and KI3. A total of six adverse events were reported in five papers. The use of extracorporeal shock wave on the basis of meridian and acupoint theory is considered to have sufficient meaning in Korean Medicine. It is expected to use extracorporeal shock wave as a new treatment method for Korean Medicine doctors in the near future.

• The Journal of Korean Obstetrics and Gynecology
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• v.36 no.2
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• pp.20-35
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• 2023

Objectives: The purpose of this study is to review clinical studies and investigate the efficacy and safety of oriental medicine on memory in menopausal women. Methods: 'menopause', 'memory', 'oriental medicine' were searched on 4 online databases (Cochrane Library, Pubmed, CNKI, OASIS). Randomized controlled trials (RCTs) that evaluated menopausal memory with oriental medicine treatment were included. The methodological quality of each RCT was assessed by using Cochrane risk of bias tool. Results: 8 RCTs were selected among 1067 articles. The overall risk of bias was evaluated as uncertain. 5 studies showed that oriental medicine alone was significant effective, but 1 long-term study with the same oriental medicine did not sustain the effect, and 2 studied were not statistically significant. Conclusions: Oriental medicine can be an effective option for improving memory in menopausal women. but considering the small number and quality of studies, inconsistent and insufficient evidence, further well-designed studies are needed to confirm the efficacy and safety of this treatment.

• Journal of Acupuncture Research
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• v.39 no.2
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• pp.96-104
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• 2022

This study aimed to examine the clinical efficacy of electroacupuncture treatment for carpal tunnel syndrome by reviewing published randomized controlled trials. Among the 186 studies retrieved from 7 online databases (PubMed, Cochrane library, CNKI, NDSL, RISS, OASIS, KMbase) on October 29, 2021, 4 studies were selected according to the inclusion, exclusion criteria, and were evaluated using risk of bias. Control groups for electroacupuncture were wearing a splint at night, traditional acupuncture, and medication. Methods such as total effective, functional status scale, symptom severity scale, electromyography, tip pinch strength, visual analogue scale, numeric rating scale, and ultrasound were used to evaluate the therapeutic effect. Electroacupuncture was reported to have significant treatment results compared with the control group in methods such as total effectiveness, electromyography, and tip pinch strength. However, the quality of the studies (using risk of bias) does not allow reliable conclusions to be made. Many high quality (low risk of bias) randomized controlled trials are needed to examine the efficacy of electroacupuncture treatment for carpal tunnel syndrome.

• Proceedings of the Korea Water Resources Association Conference
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• 2021.06a
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• pp.268-268
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• 2021

Groundwater resource is mostly used in Abomey-calavi (southern region of Benin) as main source of water for domestic, industrial, and agricultural activities. Groundwater intake across the region is not perfectly controlled by a network due to the presence of many private boreholes and traditional wells used by the population. After some decades, this important resource is becoming more and more vulnerable and needs more attention. For a better groundwater management in the region of Abomey-calavi, the present study attempts to predict a future probable groundwater drought using Recurrent Neural Network (RNN) for future groundwater level prediction. The RNN model was created in python using jupyter library. Six years monthly groundwater level data was used for the model calibration, two years data for the model test and the model was finaly used to predict two years future groundwater level (years 2020 and 2021). GRI was calculated for 9 wells across the area from 2012 to 2021. The GRI value in dry season (by the end of March) showed groundwater drought for the first time during the study period in 2014 as severe and moderate; from 2015 to 2021 it shows only moderate drought. The rainy season in years 2020 and 2021 is relatively wet and near normal. GRI showed no drought in rainy season during the study period but an important diminution of groundwater level between 2012 and 2021. The Pearson's correlation coefficient calculated between GRI and rainfall from 2005 to 2020 (using only three wells with times series long period data) proved that the groundwater drought mostly observed in dry season is not mainly caused by rainfall scarcity (correlation values between -0.113 and -0.083), but this could be the consequence of an overexploitation of the resource which caused the important spatial and temporal diminution observed from 2012 to 2021.

• Journal of Korean Medicine Rehabilitation
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• v.33 no.3
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• pp.67-78
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• 2023

Objectives To evaluate the evidence supporting the efficacy and safety of electroacupuncture for lumbar spinal stenosis. Methods We searched eight electronic databases (PubMed, EMBASE, Cochrane Library, Chinese Academic Journals, Research Information Sharing Service, ScienceOn, KMBASE, DBpia) and related two journals up to March 2023. We included randomized controlled trials of testing electroacupuncture for lumbar spinal stenosis patients. The methodological quality of relevant randomized controlled trials assessed by the Cochrane risk of bias tool. Results Among 90 articles that were searched, seven randomized controlled trials involving 474 participants were finally selected in this systematic review. Electroacupuncture was more effective on lumbar spinal stenosis compared with other treatments including analgesics, acupuncture, bed rest and exercise therapy, but showed ambiguous effect compared with physical therapy. Most of the side effects and adverse reactions were reported as minor and temporary. Conclusions Electroacupuncture for lumbar spinal stenosis was more effective than analgesics, acupuncture, bed rest and exercise therapy. In terms of safety, it was limited because there are many papers that do not mention side effects and adverse reactions related to electroacupuncture. Additional studies are needed to determine the effect of electroacupuncture on lumbar spinal stenosis.

• The Journal of Korean Medicine
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• v.44 no.2
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• pp.201-201
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• 2023

Objectives: Cupping therapy (CT) has been widely used in traditional medicine worldwide for various indications, including stroke. The aim of this study was to systematically review the clinical evidence of CT for stroke. Methods: To identify randomized controlled trials (RCTs) reporting the effectiveness and/or safety of CT, seven databases including PubMed, EMBASE, and Cochrane Library were searched for articles published from January 2000 to February 2021 without language restrictions. Meta-analysis was performed using Review Manager 5.4 software and the results were presented as mean difference (MD) or standard mean difference (SMD) for continuous variables and odds ratio (OR) for diverse variables with 95% confidence intervals (CIs). Assessment of the methodological quality of the eligible trials was conducted using the Cochrane Collaboration tool for risk of bias in RCTs. Results: Twenty-two RCTs with 1653 participants were included in the final analysis. CT provided additional benefit in improving upper limb motor function (Fugl-Meyer assessment for upper limb motor function, MD 6.91, 95% CI 4.64 to 1.67, P<0.00001) and spasticity (response rate, OR 3.28, 95% CI 1.31 to 8.22, P=0.08) in stroke survivors receiving conventional medical treatment. These findings were supported with a moderate level of evidence. CT did not significantly increase the occurrence of adverse events. Conclusions: This study demonstrated the potential of CT to be beneficial in managing a variety of complications in stroke survivors. However, to compensate for the shortcomings of the existing evidence, rigorously designed large-scale RCTs are warranted in the future.

• Convergence Security Journal
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• v.23 no.4
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• pp.61-70
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• 2023

Clustering is an unsupervised learning method that involves grouping data based on features such as distance metrics, using data without known labels or ground truth values. This method has the advantage of being applicable to various types of data, including images, text, and audio, without the need for labeling. Traditional clustering techniques involve applying dimensionality reduction methods or extracting specific features to perform clustering. However, with the advancement of deep learning models, research on deep clustering techniques using techniques such as autoencoders and generative adversarial networks, which represent input data as latent vectors, has emerged. In this study, we propose a deep clustering technique based on deep learning. In this approach, we use an autoencoder to transform the input data into latent vectors, and then construct a vector space according to the cluster structure and perform k-means clustering. We conducted experiments using the MNIST and Fashion-MNIST datasets in the PyTorch machine learning library as the experimental environment. The model used is a convolutional neural network-based autoencoder model. The experimental results show an accuracy of 89.42% for MNIST and 56.64% for Fashion-MNIST when k is set to 10.

• Mass Spectrometry Letters
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• v.15 no.2
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• pp.95-106
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• 2024

Taraxacum coreanum, known as the native Korean white dandelion, has been historically used in traditional medicine due to its various therapeutic properties. However, the specific benefits and mechanisms of white dandelion in alleviating particular symptoms or diseases remain uncertain due to the complexity of its phytochemical profile. In this study, we aimed to elucidate the phytochemical profiles of methanolic extracts of different parts of the white dandelion (flower, leaf, stem, and root) using hybrid ion-mobility Q-TOF MS. Using the trapped ion mobility-based PASEF technique, 3715 and 2114 molecular features with MS2 fragments were obtained in positive and negative ion modes, respectively, and then a total of 360 and 156 phytochemical compounds were annotated by matching with a reference spectral library in positive and negative ion modes, respectively. Subsequent feature-based molecular networking analysis revealed the phytochemical differences across the four different parts of the white dandelion. Our findings indicated that the methanolic extracts contained various bioactive compounds, including lipids, flavonoids, phenolic acids, and sesquiterpenes. In particular, lipids such as linoleic acids, lysophosphatidylcholines, and sesquiterpenoids were predominantly present in the leaf, while flavonoid glycosides and lysophosphoethanolamines were notably enriched in the flower. An assessment of the total phenolic content (TPC) and total flavonoid content (TFC) of the methanolic extracts revealed that the majority of phytochemicals were concentrated in the flower. Interestingly, despite the root extract displaying the lowest TPC and TFC values, it exhibited the highest radical scavenging rate when normalized to TPC and TFC, suggesting a potent antioxidant effect. These findings and further investigations into the biological activities and medicinal potential of the identified compounds, particularly those exclusive to specific plant parts, may contribute to the development of novel therapeutic agents derived from white dandelion.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.37 no.4
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• pp.11-31
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• 2019

Taking the painting, 「Landscape of the Jiuqu River in the Wuyi Mountain」 as the study object, which was produced in the middle of Qing Dinasty and collected by the British Library, this paper analyzes the scenery names recorded in the painting, and describes the landscape of the mountain, port and ships, architectural elements, civil elements, character, stone inscription and other scenery in the painting. The investigation results of the cultural landscape properties of each Gok are as follows: According to statistics, there are 28 architectural elements in the painting, including 7 pavilions (25%), 4 temples (14.3%), 3 Colleges and Taoist temple (10.7%), 2 Dowon(道院) and villages (7.1%); 29 civil elements, including 9 holes (31%), 6 Historical Sites (20.7%), 3 Stations(臺) (10.3%), 2 Ferries, 2 Bridges, and 2 Ponds (6.9%), 1 Garden, 1 Gate, 1 Mine(坑), 1 Well and 1 Remains(3.4%). These physical factors and civil factors are the important relics reflected the cultural landscape attributes of Wuyi-Gugok in the middle of the 18th century. Among the shape element in each Gok, the 1^st Gok have 12 shape elements(21.1%), the 5^th Gok 11(19.3%), the 4^th Gok 9(15.8%), the 9^th Gok 8(14%), the 3^rd Gok 7(12.3%), the 6^th Gok 4(7%), the 2^nd Gok 3(5.3%), the 7^th Gok 2(3.5%), and the 8^th Gok 1(2%). Through collation, it is found that the 1^st Gok, 5^th Gok and 4^th Gok have more prominent cultural landscape characteristics. In addition, according to the description of scenic spot types in 『Muisanji(武夷山志)』, there are 38 types of scenery description in the painting, of which, the three scenery of big rock, peak, small rock occupy the vast majority. This reflects the Danxia(丹霞) landform characteristics of Wuyi-Gugok. The cultural connotation of Wuyi Mountain expressed and contained in the painting is analyzed and interpreted, and it is found that the Jiuqu(九曲) River in the Wuyi Mountain has Neo-confucianism culture, Taoism culture, Buddhism culture, Tea culture and so on. In addition, among the 171 scenery names shown in the painting, there are altogether 7 stone inscriptions that are consistent with or have the same meaning as the rock inscriptions site, including 3 for inscriptions praising the landscape, 3 for philosophical inscription and 1 for auspicious language inscription, which is considered as the important basis for the mutual textuality between the pictures and the stone inscriptions.