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A literature study on dermatological efficacy and drug induced liver injury of Dictamnus dasycarpus Turcz

백선피(白鮮皮)의 피부과적 효능과 약인성 간손상에 대한 문헌 연구

  • Lee, Youjung (Division of Pharmacology, School of Korean medicine, Pusan National University) ;
  • Kim, Seoyoung (Division of Pharmacology, School of Korean medicine, Pusan National University) ;
  • Kim, Hyungwoo (Division of Pharmacology, School of Korean medicine, Pusan National University)
  • 이유정 (부산대학교 한의학전문대학원 약물의학부) ;
  • 김서영 (부산대학교 한의학전문대학원 약물의학부) ;
  • 김형우 (부산대학교 한의학전문대학원 약물의학부)
  • Received : 2017.11.10
  • Accepted : 2018.01.15
  • Published : 2018.01.30

Abstract

Objectives : The root bark of Dictamnus dasycarpus has been frequently used to treat patients with skin diseases in Korea. Recently, wild root of D. dasycarpus are reported to induce liver injury. Methods : Traditional uses of D. dasycarpus for skin diseases were analysed bibliographically. In addition, reported cases were collected and analysed using pubmed and national digital library. Results : In taiwan, D. dasycarpus revealed to be one of major herbs for skin diseases and many researchers in worldwide had reported its dermatological efficacies. Reported cases related in liver injury described that hepatocellular or cholestatic liver injury were seen in patients eating wild root of D. dasycarpus. In addition, 6 cases in worldwide and 1 case in Korea showed that patients with drug induced liver injury (DILI) ingested not root bark of D. dasycarpus but prescriptions containing root bark of D. dasycarpus. These mean that wild root of D. dasycarpus (Bongsam or Bongwhangsam) was estimated to be closely related in DILI. Whereas, it was difficult to confirm direct correlation between root bark of D. dasycarpus used as herbal medicine by doctor of Korean medicine and DILI. Conclusions : these results imply that wild root of D. dasycarpus is closely related in DILI and strong recommendation not to take it without consultation by experts is needed. In addition, although there are no evidences of direct correlation between root bark of D. dasycarpus and DILI, doctor of Korean medicines should pay attention to use root bark of D. dasycarpus in their clinics.

Keywords

References

  1. Lee WJ, Kim HW, Lee HY, Son CG. Systematic review on herb-induced liver injury in Korea. Food Chem Toxicol. 2015; 84: 47-54. https://doi.org/10.1016/j.fct.2015.06.004
  2. McRae CA, Agarwal K, Mutimer D, Bassendine MF. Hepatitis associated with Chinese herbs. Eur J Gastroenterol Hepatol. 2002; 14(5): 559-62. https://doi.org/10.1097/00042737-200205000-00015
  3. Yoon YJ, Shin BC, Shin WJ, Jang IS. The guideline for assessment of DILI occurred during or after the use of herbal medicine. J. Kor. orient. int. med. 2009; 30(1): 181-90.
  4. An SY, Cheong JY, Kim SS, Lee DM, Seok JY, Kim YB, Cho SW. One case of fulminant hepatic failure related to Dictamnus dasycarpus. Kor. J. Med. 2010; 78(4): 490-4.
  5. The textbook compilation committee of Korean herbology. Bonchohak. Seoul. Younglimsa. 2010: 228-9.
  6. Kim CM, Shin MK, An DG, Lee KS. The encyclopedia of oriental herbal medicine. Seoul. Jeongfdam. 1997: 1648-51.
  7. Li SZ. Ben Cao Gang Mu. Seoul. Iljungsa. 1991: 802-3.
  8. Lin YH, Chen YC, Hu S, Chen HY, Chen JL, Yang SH. Identifying core herbal treatments for urticaria using Taiwan's nationwide prescription database. J Ethnopharmacol. 2013; 148(2): 556-62. https://doi.org/10.1016/j.jep.2013.04.052
  9. Chien PS, Tseng YF, Hsu YC, Lai YK, Weng SF. Frequency and pattern of Chinese herbal medicine prescriptions for urticaria in Taiwan during 2009: analysis of the national health insurance database. BMC Complement Altern Med. 2013; 13: 209. https://doi.org/10.1186/1472-6882-13-209
  10. Chen HY, Lin YH, Huang JW, Chen YC. Chinese herbal medicine network and core treatments for allergic skin diseases: Implications from a nationwide database. J Ethnopharmacol. 2015; 168: 260-7. https://doi.org/10.1016/j.jep.2015.04.002
  11. Kim H, Kim M, Kim H, Lee GS, An WG, Cho SI. Anti-inflammatory activities of Dictamnus dasycarpus Turcz., root bark on allergic contact dermatitis induced by dinitrofluorobenzene in mice. J Ethnopharmacol. 2013; 149(2): 471-7. https://doi.org/10.1016/j.jep.2013.06.055
  12. Han HY, Ryu MH, Lee G, Cheon WJ, Lee C, An WG, Kim H, Cho SI. Effects of Dictamnus dasycarpus Turcz., root bark on ICAM-1 expression and chemokine productions in vivo and vitro study. J Ethnopharmacol. 2015; 159: 245-52. https://doi.org/10.1016/j.jep.2014.11.020
  13. Jiang S, Nakano Y, Rahman MA, Yatsuzuka R, Kamei C. Effects of a Dictamnus dasycarpus T. extract on allergic models in mice. Biosci Biotechnol Biochem. 2008; 72(3): 660-5. https://doi.org/10.1271/bbb.70050
  14. Lee YS, Han JK, Kim YH. Therapeutic effects of Dictamni Radicis Cortex extracts on atopic dermatitislike skin lesions of NC/Nga mouce induced by DNCB. J Pediatr Korean Med. 2014; 28(4): 01-29.
  15. Kang HG, Lyu JH, Kang GH, Yoon HJ, Kim YH, Kim KY, Lee SY, Go US. The Anti-allergic Effects of Dictamni Radicis Cortex on the PMA plus A23187-stimulated RBL-2H3 Cells. J Korean Med Ophthalmol Otolaryngol Dermatol. 2007; 20(1): 201-8.
  16. Park JS, Shin TY, Kim DK. The Effects of Dictamni Radicis Cortex on the iNOS Expression and Proinflammatory Cytokines Production. Kor. J. Pharmacogn. 2011; 42(4): 348-53.
  17. Yoon JS, Jeong EJ, Yang H, Kim SH, Sung SH, Kim YC. Inhibitory alkaloids from Dictamnus dasycarpus root barks on lipopolysaccharide-induced nitric oxide production in BV2 cells. J Enzyme Inhib Med Chem. 2012; 27(4): 490-4. https://doi.org/10.3109/14756366.2011.598151
  18. Kim JH, Park YM, Shin JS, Park SJ, Choi JH, Jung HJ, Park HJ, Lee KT. Fraxinellone inhibits lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by negatively regulating nuclear factor-kappa B in RAW 264.7 macrophages cells. Biol Pharm Bull. 2009; 32(6): 1062-8. https://doi.org/10.1248/bpb.32.1062
  19. Chang J, Xuan LJ, Xu YM, Zhang JS. Cytotoxic terpenoid and immunosuppressive phenolic glycosides from the root bark of Dictamnus dasycarpus. Planta Med. 2002; 68(5): 425-9. https://doi.org/10.1055/s-2002-32077
  20. Sun Y, Qin Y, Gong FY, Wu XF, Hua ZC, Chen T, Xu Q. Selective triggering of apoptosis of concanavalin A-activated T cells by fraxinellone for the treatment of T-cell-dependent hepatitis in mice. Biochem Pharmacol. 2009; 77(11): 1717-24. https://doi.org/10.1016/j.bcp.2009.03.002
  21. Kim JH, Kim H. Combination treatment with herbal medicines and Western medicines in atopic dermatitis: Benefits and considerations. Chin J Integr Med. 2016; 22(5): 323-7. https://doi.org/10.1007/s11655-016-2099-0
  22. Lee WJ, Kim HW, Lee HY, Son CG. Systematic review on herb-induced liver injury in Korea. Food Chem Toxicol. 2015; 84: 47-54. https://doi.org/10.1016/j.fct.2015.06.004
  23. Jeong JH, Kim SH, Ko GH, Jeong KH, Hwang SY, Ko PG, Park NH, Nam GW, Kim JI, Moon HS, Lee US. Clinical features of 28 acutely toxic hepatitis patients who ingested Dictamnus dasycarpus: a single center clinical experience. Korean J. Med. 2010; 78(4): 457-65.
  24. An SY, Jeong JY, Kim SS, Lee DM, Seok JY, Kim YB, Cho SW. One case of fulminant hepatic failure related to Dictamnus dasycarpus. Korean J. Med. 2010; 78(4): 490-4.
  25. Kim SH, Cho WH, Kim HG, Jang JY, Shim CS, Kim BS, Jin SY. Case reports: gastroenterology; a case of acute hepatitis caused by ingesting Dictamnus dasycarpus. Korean J. Med. 2009; 76(4): 476-80.
  26. Jang JS, Seo EG, Han C, Chae HB, Kim SJ, Lee JD, Wang JH. Four cases of toxic liver injury associated with Dictamnus dasycarpus. Korean J Hepatol. 2008; 14(2): 206-12. https://doi.org/10.3350/kjhep.2008.14.2.206
  27. Lee JH, Lee HY, Ko GC, Lee JG, Lee PL, Kim JJ, Baek SY, Lee JC, Oh YL, Ji YJ. Drug-induced liver disease caused by ingestion of Dyctamnus dasycarpus. Korean J. Gastroenterol. 1998; 31(2): 251-7.
  28. Kane JA, Kane SP, Jain S. Hepatitis induced by traditional Chinese herbs; possible toxic components. Gut. 1995; 36(1): 146-7. https://doi.org/10.1136/gut.36.1.146
  29. Han CW, Seong HS, Ryu KY, Kim YC, Lee JH,Hong JW. One Case of Drug Induced HepatitisCaused by Dyctamnus dasycarpus. Kor. J. Orient.Int. Med. 2003; 24(2): 374-79.
  30. Wang L, Li Z, Li L, Li Y, Yu M, Zhou Y, Lv X,Arai H, Xu Y. Acute and sub-chronic oral toxicityprofiles of the aqueous extract of Cortex Dictamniin mice and rats. J Ethnopharmacol. 2014; 158:207-15. https://doi.org/10.1016/j.jep.2014.10.027
  31. Ago today's. The efficacies and side effects of Bongsam. 2017 Nov 20. Available from:URL: http://agotoday.tistory.com/118
  32. Jeongbomaeul. The efficacies of Bongsam. 2017 Nov20. Available from:URL: http://infovill.tistory.com/80