• Journal of Nutrition and Health
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• 제40권5호
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• pp.428-434
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• 2007

본 연구에서는 무철분식이로 철분결핍성 빈혈 유발을 시킨 흰쥐에게 3주간 무철분식이를 섭취시키면서 saline, 참당귀 추출물 및 철분보충제를 투여한 후, 무철분식이를 일반식이로 대체하여 다시 3주간 같은 처리를 한 후 혈액학적 빈혈지표를 조사하여 결과를 요약하면 다음과 같다. 1) 실험동물의 체중은 무철분식이군에서 일반식이군에서 보다 유의적으로 낮게 나타났다. 무철분식이로 인한 저체중은 참당귀 추출물과 철분 보충제에 의해서 회복되지 않았다. 2) 혈액분석 결과 무철분식이는 모든 혈액 빈혈지표를 저하시켰으며, 철분보충제의 투여는 헤모글빈, 헤마토크릿, 평균 혈구 부피, 평균 혈구혈색소, 평균 혈구혈색소 농도, 총철결합능력이 유의적으로 회복시켰다. 무철분식이와 함께 투여한 참당귀 추출물은 혈액지표를 개선시키지 못하였다. 한편, 일반식이와 함께 섭취하였을 경우, 헤모글로빈, 헤마토크릿, 평균 혈구부피, 평균 혈구혈색소, 평균 혈구혈색소 농도, 총철결합능력 모두 유의적인 회복효과를 보였으나 일반식이만을 섭취한 군에서도 같은 회복효과를 보였다. 결론적으로, 장기간에 걸쳐 철분 섭취가 불량할 경우, 체중증가가 지연되며 후에 철분을 보충할 경우에도 체중의 회복은 개선되지 않았다. 철분결핍으로 인한 저체중의 경우, 철분보충제의 복용은 체중을 만회시키지 못하였으나 혈액학적 빈혈 지표들은 회복시키는 것으로 나타났다. 철분결핍 빈혈에서 식이철분이 부족할 경우, 참당귀의 회복효과는 미비한 것으로 나타났다. 향후 철분결핍 빈혈의 치료를 위한 생약제의 다양한 작용을 밝히기 위하여서는 영양학적인 관점에서 체내 이용률에 관한 심도 깊은 연구가 이루어져야 할 것으로 사료된다.

• 대한한의학방제학회지
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• 제21권2호
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• pp.110-120
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• 2013

Objectives : The object of this study was to observe the pharmacological effects of Yookmijihwang-tang-gamibang (Liuweidihuang-tang-jiaweifang, YGB) consisted of 17 types of herbs has been traditionally used in Korean medicine for treating various disorders in clinics, aqueous extracts on the genetically obese and type II diabetic C57BL/6JHam-ob/ob(ob/ob) mice. Methods :Three different dosages of YGB were orally administered, once a day for 28 days to ob/ob mice with ob/ob control and C57BL/6JJms normoglycemic intact mice. Four weeks after treatments of YGB: the changes on the body weight, food consumption, blood glucose levels, leptin and adiponectin contents were observed for monitoring the antiobese and antidiabetic effects of YGB. The effects were compared to those of CLA(conjugated linoleic acid) which improve type II diabetes and inhibit related obesity. Results : After end of 28 days of continuous treatments, ob/ob control showed increases of adipocyte hypertrophy, vasodilated atrophic glomerulus which were detected with marked hyperplasia of pancreatic islets, insulin and glucagon producing cells. These obese and related type II diabetes induced in ob/ob mice were markedly and significantly inhibited by 28 days of continuous treatment of three dosages of YGB. The YGB 50mg/kg showed similar favorable effects on the diabetes and related diabetic complications as compared with CLA 750mg/kg in ob/ob mice of the present study. Conclusions : The results obtained in this study suggest that over 25mg/kg of YGB extracts favorably retarded the obese and type II diabetes in genetically obese and type II diabetic ob/ob mice.

• 동의생리병리학회지
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• 제30권5호
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• pp.327-337
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• 2016

The objective of this study was to review the current clinical studies about the effect of herbal medicine for Parkinson's disease in China over the last 5 years and then to suggest the foundation for treatment and further studies. We had searched for studies in China National Knowledge Infrastructure(CNKI, http://www.cnki.net) and PubMed from January 2010 to December 2014. Key words were the various combinations of '帕金森', '湯', '丸', '散', '中醫藥', 'Parkinson's disease', and 'herbal medicine'. Total 53 clinical studies were selected and analyzed. The most frequently used diagnostic criteria of Parkinson's disease was the Unified Parkinson's Disease Rating Scale(UPDRS). The most frequently used medical herb was Paeoniae Radix alba(白芍藥) more 30 times and the highest amount was Astragali radix(黃芪) 100g per day. The most frequent syndrome differentiation was liver kidney yin deficiency(肝腎陰 虛). We found out there are many clinical studies of herbal medicine for Parkinson's disease in China. These studies would be able to provide the basis of clinical research on Parkinson's disease, and also applied to the treatment of Parkinson's disease in Korea.

• 대한예방한의학회지
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• 제26권3호
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• pp.87-96
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• 2022

Objective : We examined the literature of <Life Nurturing Method and Conduction Exercise(養生方導引法)> of 《Pathogenesis and Manifestations of Food Stagnation and Indigestion(宿食不消病諸候)》 in 『Treatise on the Pathogenesis and Manifestations of All Diseases(諸病源候論)』 and actually implement its movement to present conduction exercise based on the principle of Korean medicine treatment. Method : We used web services for traditional Eastern Asian medical classics and some literature on 『Treatise on the Pathogenesis and Manifestations of All Diseases(諸病源候論)』 and its <Life Nurturing Method and Conduction Exercise(養生方導引法)〉. The original text was interpreted and the movements of <Life Nurturing Method and Conduction Exercise> were implemented according to the literature. A qi-gong(氣功) expert demonstrated the movements and we took pictures. Results : <Life Nurturing Method and Conduction Exercise(養生方導引法)> was written in the symptom of Food Stagnation and Indigestion(宿食不消候) and the symptom of food damage and excessive eating(食傷飽候) among the chapters of 《Pathogenesis and Manifestations of Food Stagnation and Indigestion(宿食不消病諸候)》. With respect to the movements and breathing, stretching your back allows qi(氣) energy to enter the lower cinnabar field(下丹田) immediately, and when the lower stomach is full of qi it can be transported upper body, leading to better communication of qi around the body. Conclusion : The practical implementation of the movements and postures will contribute to understanding the characteristics, pathology, and contents of diseases related to indigestion, and furthermore it can be widely used clinically for prevention and treatment of digestive disorders.

• 동의신경정신과학회지
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• 제27권4호
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• pp.261-274
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• 2016

Objectives: To determine the general characteristics of clinical studies about Hwabyung and assess their limitations and alternatives. Methods: Clinical studies that examined the effects of traditional Korean medicine intervention on Hwabyung were included in this study. A systematic search of English, Chinese, Japanese, and Korean databases was performed. The characteristics of included articles were described and those articles were assessed by Risk of Bias (RoB) tool or Risk of Bias for Nonrandomized Studies (RoBANS) tool. Results: Sixteen articles were selected from 1,826 articles. Most clinical studies about Hwabyung were published in Korea. The number of conducted trials was insufficient. The prevailing study design was randomized controlled trial. Traditional Korean medicine intervention used in the trials were acupuncture, herbal medicine, counselling, meditation, emotional freedom technique (EFT), music therapy, art therapy, and multi intervention program. Herbal medicine study used placebo as control while non-pharmacological intervention study mostly used no treatment as control. Most of the trials were supported by the government. Therefore, financial conflict of interest might not exist for results. We judged that some studies had a high risk of bias. In general, most of the studies with a high risk of bias were non-pharmacological intervention studies, and the risk of bias was mainly due to lack of blinding. Conclusions: More clinical studies of Hwabyung are needed. There are some issues about a suitable comparison and effective blinding strategy for non-pharmacological study. Improving methodological quality is required.

• 대한한방내과학회지
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• 제37권5호
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• pp.893-902
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• 2016

Objective: To describe the effects of traditional Korean medicine on dizziness and gait disturbance arising after removal of a vestibular schwannoma. Methods: The patient was treated using Korean medical treatments, such as herbal medicines (Jaeumkunbi-tang-gagambang and Yookmijihwang-Insamyangyoung-tang-gagambang), acupuncture, and moxibustion. We measured the state and progress of this case with the Korean Vestibular Disorder Activities of Daily Living Scale (K-VADL), Berg Balance Scale (BBS), and a visual analogue scale (VAS). Results: After treatment, the K-VADL score decreased from 167 to 74 and the VAS score decreased from 10 to 5.7, while the BBS score increased from 3 to 42. Conclusion: Jaeumkunbi-tang-gagambang (滋陰健脾湯) and Yookmijihwang-Insamyangyoung-tang-gagambang(六味地黃湯 合 人蔘養榮湯 加減方) appear to be effective for controlling dizziness and gait disturbances occurring after removal of vestibular schwannomas.

• 대한본초학회지
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• 제25권3호
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• pp.43-51
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• 2010

Objectives : We investigated the repeated-dose toxicity of Wenpitang-Hab-Wulingsan(WHW), a Korean traditional medicine prescribed with twelve herbs, which has been used for the treatment of renal disease. Methods : WHW extract prepared by GLP company. WHW was supplemented by gavage at 0, 100, 500 and 1000 mg/kg/day for 13-week consecutive days. We recorded the clinical signs of toxicity, body weight, organ weights, hematology, gross and histological changes in target organs rats and clinical chemistry analysis for all rats. Results : WHW extract at all doses was shown no mortality or abnormal clinical signs in rats during at the observation period. Furthermore, there was no difference in body weight and food-take consumption, organ weight, gross pathological findings, and urine analysis among the groups of rats treated with different doses of WHW extract. The hematological analysis and clinical blood chemistry data were revealed no toxic effects from WHW-treated rats. Conclusions : The results suggest that WHW extract in rats is a wide margin of safety on a acute toxicity.

• BMB Reports
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• 제43권10호
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• pp.643-648
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• 2010

Sir William Osler (1849-1919) recognized that "variability is the law of life, and as no two faces are the same, so no two bodies are alike, and no two individuals react alike and behave alike under the abnormal conditions we know as disease". Accordingly, the traditional methods of medicine are not always best for all patients. Over the last decade, the study of genomes and their derivatives (RNA, protein and metabolite) has rapidly advanced to the point that genomic research now serves as the basis for many medical decisions and public health initiatives. Genomic tools such as sequence variation, transcription and, more recently, personal genome sequencing enable the precise prediction and treatment of disease. At present, DNA-based risk assessment for common complex diseases, application of molecular signatures for cancer diagnosis and prognosis, genome-guided therapy, and dose selection of therapeutic drugs are the important issues in personalized medicine. In order to make personalized medicine effective, these genomic techniques must be standardized and integrated into health systems and clinical workflow. In addition, full application of personalized or genomic medicine requires dramatic changes in regulatory and reimbursement policies as well as legislative protection related to privacy. This review aims to provide a general overview of these topics in the field of personalized medicine.

• Mycobiology
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• 제30권4호
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• pp.208-212
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• 2002

For comparison of mycelial colonization of Phellinus linteus on logs, several techniques of inoculation were tested; sterilized short log inoculation, drilling inoculation and log-end sandwich inoculation. The mycelial colonization of P. linteus on logs was good in the treatment of sterilized short log inoculation, but poor in the traditional methods such as drilling inoculation and log-end sandwich inoculation. The initial mycelial growth and the full mycelial colonization of P. linteus in logs were the best in case of 20 cm logs under the condition of 42% moisture content. Also, the initial mycelial growth of P. linteus was accelerated over 12 hours of sterilization. Burying method of logs after $5{\sim}6$ months of incubation was the best for formation of basidiocarps of P. linteus. The formation of fruiting body of P. linteus was quite good in the cultivation house at $31{\sim}35^{\circ}C$ and over 96% of relative humidity.

• Molecular & Cellular Toxicology
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• 제3권3호
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• pp.151-158
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• 2007

The failure of injured axons to regenerate in the mature central nervous system (CNS) has devastating consequences for victims of spinal cord injury (SCI). Traditional strategies to treat spinal cord injured people by using drug therapy and assisting devices that can not help them to recover fully various vital functions of the spinal cord. Many researches have been focused on accomplishing re-growth and reconnection of the severed axons in the injured region. Using cell transplantation to promote neural survival or growth has had modest success in allowing injured neurons to re-grow through the area of the lesion. Strategies for successful regeneration will require tissue engineering approach. In order to persuade sufficient axons to regenerate across the lesion to bring back substantial neurological function, it is necessary to construct an efficient biocompatible bridge (cell-free or implanted with different cell lines as hybrid implant) through the injured area over which axons can grow. Therefore, in this paper, spinal cord and its injury, different strategies to help regeneration of an injured spinal cord are reviewed. In addition, different aspects of designing a biocompatible bridge and its applications and challenges surrounding these issues are also addressed. This knowledge is very important for the development and optimalization of therapies to repair the injured spinal cord.