• 대한한의진단학회지
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• 제13권2호
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• pp.88-116
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• 2009

Background : EBM (the evidence based medicine) is the direction of the development for oriental medicine. The pulse meter-analyzer is the important part to standardize the pulse diagnosis. When we set up the direction of the study on the pulse meter-analyzer, the awereness about the pulse meter and analyzer of the clinical oriental medical doctors as consumers is very important. Objectives : In order to prepare for the mutual study and the export strategy on the pulse meter-analyzer of Korea and China, the attitude of the study and the grasp of the awereness about the pulse meter-analyzer of the Chinese medical doctors are very important. Methods : We developed the several items as the important factor of the development of the pulse meter and analyzer. They were translated by chinese medical doctor. The investigation for demend was conducted during 3 months in Guangzhou City, Guangdong Province, China. The results of the investigation was done the statistical method of frequency analysis, Chi-squared test, correspondence analysis. Results : The most important differentiation of symptom is the symptom of JANG-BU(臟腑). The method of the utility in the pulse diagnosis is Chon-Gu (寸口) pulse diagnosis and the research on Chon-Kwan-Cheok(寸關尺) is the most important measurement factor. And the typical the old pulse is the little-fine weak pulse. The pulse meter-analyzer is most suitable to the diagnosis of the hypertension and the arteriosclerosis. Conclusion : The development of the pulse analyzer including the requests of Korean and Chinese medical doctors is very important. Specially the researches on the influence factors of the traditional diagnosis and the environment of the measurement are important for developing the pulse analyze.

• 한국축산식품학회지
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• 제40권4호
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• pp.527-540
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• 2020

Donkey in China is well known for its draft purpose and transportation; however, donkey meat has attracted more and more consumers in recent years, yet it lacks sufficient information on its flavor components compared to other main meats. Therefore, in this study, volatile flavor compounds in neck meat of donkey, swine, bovine, and sheep were classified by electronic nose, then confirmed and quantified by gas chromatography-mass spectrometry. High-performance liquid chromatography (HPLC) and gas chromatography were used to quantify free fatty acid, amino acid, and flavor nucleotide. A total of 73 volatile compounds were identified, and aldehydes were identified as the characteristic flavor compounds in neck meat of donkey, bovine, swine and sheep in proportion of 76.39%, 46.62%, 31.64%, and 35.83%, respectively. Particularly, hexanal was the most abundant volatile flavor. Compared with other neck meat, much higher unsaturated free fatty acids were present in donkeys. Furthermore, neck meat of donkeys showed essential amino acid with highest content. Thus, special flavor and nutrition in donkey neck meat make it probably a candidate for consumers in other regions besides Asia.

• Asian Pacific Journal of Cancer Prevention
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• 제13권8호
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• pp.3713-3716
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• 2012

Objective: Transmembrane protein 166 (TMEM166) expression in esophageal squamous cell carcinoma (ESCC) and remote normal esophageal tissues was examined to assess any role in tumour biology. Methods: TMEM166 mRNA expression in 36 cases with ESCC (36 tumour samples, 36 remote normal esophageal tissue samples) was detected by RT-PCR. TMEM166 protein expression was analysed in paraffin-embedded tissue samples from the same cases by immunohistochemistry. Results: Semi-quantitative analysis showed TMEM166 mRNA expression in ESCCs to be significantly lower than in remote normal esophageal tissues ($0.759{\pm}0.713$ vs. $2.622{\pm}1.690$, P=0.014). TMEM166 protein expression was also significantly reduced (69.4% vs. 94.4%, P<0.01). Conclusion: TMEM166 mRNA and protein expression demonstrated significant reduction in ESCCs compared with remote esophageal tissues, albeit with no correlation with tumour size, differentiation, stage, and lymph node metastasis, suggesting a role in regulating autophagic and apoptotic processes in the ESCC.

• 한국의사학회지
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• 제22권2호
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• pp.1-6
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• 2009

This paper analyzes the relationship of international exchange of Medical School of Sin-an (新安醫學) at the time of Myung and Chung Dynasty, which is one of the most famous regional traditional medicine. The internal reason for the active exchange of Medical School of Sin-an (新安醫學) throughout the ocean was that its major theories were mostly based on Confucianism, which was also the major current in Korea and Japan at the time. This leaded to active interchange between Medical School of Sin-an (新安醫學) of China and Japan and Korea. Secondly, the proliferation of Medical School of Sin-an (新安醫學) was achieved with great help from developing printing operations at the time. Also, the active operation of practitioners of Medical School of Sin-an (新安醫學) such as the attempt to advance to foreign countries along with the 徽州商人 offered an opportunity to introduce Medical School of Sin-an (新安醫學). The international traits of Medical School of Sin-an (新安醫學) can be easily proved by numerous quotes of its classics in many significant classics of Korea and Japan. The influence of Medical School of Sin-an (新安醫學) to Korea started from the Chosun Dynasty; the Treasured Mirror of Eastern Medicine "東醫寶鑑" of Huh Jun and "麻科會通" of 丁若鏞 are the few examples of classics of Korea with quotes of Medical School of Sin-an (新安醫學). The influence of Medical School of Sin-an (新安醫學) on Japanese medicine can be found much before, since Nanbeichao Dynasty. However, the time when many books were imported was during Myung and Chung Dynasty. Also, some of the classics of Medical School of Sin-an (新安醫學) mentioned in "醫籍考" remain only in Japan and not in China; this shows the active exchange between the two countries.

• Journal of Evidence-Based Herbal Medicine
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• 제2권1호
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• pp.7-12
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• 2009

Velvet antlers from Cervus elaphus species are one of most famous, expensive and commonly used medicinal materials in traditional oriental medicine. Some distributor had illegal practice of disguising the origin of antlers in Korea market. Therefore, a test to distinguish antler essential to ensure the healthy development of the herbal industry. In this study, the variation in DNA sequences of the mitochondrial ATPase8 and cytochrome-coxidaseI (COI) genes of Cervus elaphus from China, the Republic of Altai, and Canada were evaluated. In addition, the sequence variation among, Rein deer and Cervus elaphus species was also evaluated. Although the sequences of deer from the Republic of Altai and Canada were very similar, polymorphisms that were conserved in each species were observed in the ATPase8 and COI genes. Therefore, these polymorphic markers could be used to distinguish Cervus elaphus antlers from different locations.

• 생약학회지
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• 제48권4호
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• pp.339-342
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• 2017

Quercus mongolica (QM) is a species of Quercus native to Eastern Mongolia, Siberia, China, Japan, and Korea. QM has been used as Korean traditional medicine for the treatment of inflammation of the skin. Present work, the validation and content determination of the phenolic compounds which were isolated from the leaves of QM, including pedunculagin (1) and kaempferol-3-O-(6"-galloyl)-${\beta}$-D-glucopyranoside (2) were conducted through High-Performance Liquid Chromatography (HPLC). As a result, the contents of these compounds were 4.14% and 0.76% in QM extract, respectively.

• 동의생리병리학회지
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• 제27권3호
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• pp.289-298
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• 2013

The purposes of this article are understanding the meaning of yin deficiency interpreted with a perspective of Traditional Korean Medicine and a modern perspective a study and assigning modern diseases to yin deficiency pattern types. Clinical papers were searched in China National Knowledge Infrastructure(CNKI) from 1995 to 2013. Results are as follows. First, yin deficiency written in the "Neijing" has been understood in many ways. It is translated such as deficiency of yin qi, inner qi, essence, cubit pulse, yin meridians qi, viscera yin and kidney. Second, yin deficiency pattern are related with disorders of the endocrine system, immunity, energy metabolism, blood circulation, cytokine, microelements, lipid metabolism and capability of getting rid of oxygen free radicals. Third, from pattern types, diverse diseases classified in types involving the heat from yin deficiency, which reflects pathologic conditions of deficiency heat which is distinct characteristics of yin deficiency pattern. Various diseases classified in types related with liver or kidney are reported, which reflects two viscera are more related with yin deficiency than other viscera. Fourth, levels of pattern types surveyed are more specific than Korean Standard Classification of Diseases(KCD) and specific enough to be applied clinically. This article surveyed the categories of modern diseases yin deficiency pattern types is assigned to but the detailed relation between them will be necessary to be studied in the future.

• 생약학회지
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• 제40권3호
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• pp.251-256
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• 2009

Cordyceps bassiana is a parasitic fungus and used as a Chinese traditional medicine. It has been called as DongChungHaCho(summer-plant, winter-worm) in China. Acute oral toxicity was examined in male and female ICR mice. Butanol fraction from Cordyceps bassiana(BuCb) was administered orally at a dose of 2,500 mg/kg, 5,000 mg/kg, 10,000 mg/kg. No death and abnormal clinical signs were observed throughout the administration period. The acute toxicity test on mouse did not show any oversign in net body weight gain, food and water consumptions, organ weights, gross pathological findings by different doses of BuCb. Also, biochemical examination revealed no evidence of specific toxicity. These findings show that BuCb has wide margin of safety on acute toxicity with single exposure.

• Journal of Pharmaceutical Investigation
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• 제41권3호
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• pp.143-146
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• 2011

Scutellariae Radix is widely used in the traditional herbal medicine for the treatment of fever, cough, dysentery, hepatitis and hypertension in Korea, China and Japan. In this study, we investigated the effects of 70% ethanolic extract of Scutellariae Radix (SRE) on CYP450-mediated drug metabolism in the in vitro systems using human liver microsomes and hepatocytes. The microsomal incubation assay showed that SRE inhibited the drug metabolism reactions catalyzed by CYP1A2, CYP2C8 and CYP2C9 in a dose-dependent manner. In particular, SRE was shown to strongly inhibit the metabolic activity of CYP1A2 with an $IC_{50}$ value of 4.6 ${\mu}g/mL$. When SRE was evaluated for its effect on the induction of CYP450 enzyme activities in cryopreserved human hepatocytes, SRE did not exhibit any effect.

• 대한한의학원전학회지
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• 제31권2호
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• pp.17-47
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• 2018

Objectives: The three nations of far Northeastern Asia, namely China, Korea, and Japan, have developed a tradition of Asian medicine within a common cultural realm. Studying Japan's Yunqi not only helps our understanding of Japanese traditional medicine, but the course of development taken by the three nations' traditional Asian medicine as a whole. Methods: All books relating to Yunqi published in Japan were studied, with special focus on books that are especially more important. Results: It is assumed that Japan's first book on Yunqi is 吉田宗桂's Ungiileonjib. The Japanese mainstream study on Yunqi is the annotations and studies on Suwenrushiyungilunao, written by Liuwenshu. YunQiLunAoKouYiis the first annotation on Suwenrushiyungilunao and had the greatest impact. Yunqilunjujie is an annotation book written by a Confucian scholar, and Yunqilunaoshuchao an annotation book composed by a Confucian doctor who was a thorough expert on sinology and the annotations ranged greatly from medical books, Confucian books, historical books and hundred schools of books. Aotouyunqilun is the most slight in terms of annotations compared to other annotation books, and Yunqilunaoyanjie is special in that it writes with both Chinese characters and Japanese language in order to help easier understanding by the novice scholars. Conclusions: Suwenrushiyunqilunao includes astronomy, geography, delivery sound, calendar, the eight trigrams, the Twelve laws, Shier chen, Constellation of twenty eight, Thirty-six birds, and secret days, which is leading to further study in these fields. Suwenrushiyunqilunao also contains excerpts from Suwen Liujiecangxianglun to describe the algorithm of the operation of Sun and Moon, which is also leading a further study in the field.