• YAKHAK HOEJI
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• v.41 no.4
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• pp.512-517
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• 1997

Antihyperlipidemic effect of taurine was investigated in the hyperlipidemic rats induced by feeding a diet supplemented with cholesterol (1.5% in diet), vitamin $D_2$(1.25 million IU/kg of diet) and cholic acid (0.5% in diet). The rats were fed the diet containing 1% and 3% of taurine for 8 weeks. The contents of the cholesterol and triglycerides in the serum and liver of the hyperlipidemic rats were increased as compared with those of the control group. Feeding taurine resulted in decreases in total cholesterol and triglyceride levels. The HDL-cholesterol level in serum was decreased in the hyperlipidemic rats, but by administration of taurine its level was increased. In the aorta of the animals, total cholesterol and triglycerides contents were reduced significantly by treatment with taurine. The contents of calcium in the heart of hyperlipidemic rats were greatly increased as compared with those of the control group. Treatment of taurine produced significant decreases in calcium contents in the heart muscle of the animals. These results showed that the hyperlipidemic states in this model of rats were reversed by treatment of taurine.

• The Journal of Internal Korean Medicine
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• v.18 no.2
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• pp.195-206
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• 1997

In order to study the effects of Ohwangsahwatang on Hyperchole-sterolemia, experimental study were performed on Hypercholesterolemia Rats induced by 2% cholesterol diet. Also the level of total cholesterol. triglyceride, LDL-cholesterol. HDL-cholesterol, phospholipid, transami-nase(GOT, GPT) were measured. The results were summerized as follows : In the model of Hypercholesterolemia induced by 2% cholesterol diet in rats, Ohwangsahwatang showed decreasing effects on total cholesterol, triglyceride, LDL-cholesterol, phospholipid level, and transaminase (GOT, GPT) activity in serum significantly, depending on the concentration, and showed increasing effects on HDL-cholesterol level in serum significantly depending on the concentration. According to the above results, Ohwangsahwatang showed significant decreasing effects on Hypercholesterolemia, and it is considered that it is appropriate to apply for Hypercholesterolemia.

• Pediatric Infection and Vaccine
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• v.2 no.2
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• pp.186-192
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• 1995

We measured plasma concentrations of high density lipoprotein, total cholesterol and triglycerides in 31 patients with history of kawasaki disease during acute stage and convalescence stage. High density lipoprotein cholesterol and total cholesterol concentrations were significantly lower(P<0.001) in samples taken within 11 days of the onset of illness($28.7{\pm}12.4mg/dl$ and $145.20{\pm}29.60mg/dl$) than in the second samples taken 1-2months after onset of disease($51.5{\pm}15.2mg/dl$ and $175.4{\pm}29.0mg/dl$). Change of triglycerides was not significant. There was no correlation between the serum cholesterol cencentration and coronary aneurysm and continued long term surveillance of much population is necessary to monitor lipid level and their relation to development of premature coronary atherosclerosis.

• The Korea Journal of Herbology
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• v.23 no.1
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• pp.17-22
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• 2008

Ojectives : Cheonggukjang(natto) is known to have anti-hyperlipidemic action. This study was designed to investigate whether Herbal-cheonggukjang (HC, Herbal-natto) is more effective than cheonggukjang only, Methods : We investigated anti-hyperlipidemic effects of HC in hyperlipidemic rats induced by high-fat diet in terms of observation on levels of total cholesterol, HDL-cholesterol and triglyceride in serum. HC was made by cheonggukjang added Codonopsis Lanceolata, Houttuynia cordata and Lentinus edodes in indicated concetrations. Results : In this experiment, hyperlipidemic rats showed elevated levels of total cholesterol and triglyceride, and also showed lowered level of HDL-cholesterol. Oral administration of HC decreased levels of total cholesterol and triglyceride, Cheonggukjang(natto) did not affect levels of total cholesterol, HDL cholesterol and triglyceride. Conclusions : In these results, oral administration of HC decreased total cholesterol and triglyceride effectively. These results demonstrate that HC is useful to modulate cholesterol and triglyceride in serum.

• YAKHAK HOEJI
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• v.6 no.1
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• pp.8-10
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• 1962

Total saponin and oil fraction of Polygala tenuifolia were tested for their anticholesterolemic properties by a "Three day fasting method" on rabbits. It has been reported that saponin have the anticholesterolemic activity, however this activity is not general property of all kinds of saponin. As shown in Table, Polygala saponin has not significant anticholesterolemic activity on rabbits. On administering oil fraction of Radix Polygala, serum cholesterol level in rabbits increased to 224.7% while the control group 43.2%.oup 43.2%.

• Korean Journal of Clinical Laboratory Science
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• v.36 no.2
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• pp.215-221
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• 2004

To determine the effects of caloric restriction on obese type 2 diabetes we measured body blood glucose and serum lipid level in dietary restricted Otsuka Long Evans Tokushima Fatty (OLETF) rats. OLETF rats (obese diabetic rats) and Long Evans Tokushima Otsuka (LETO) rats (control rats) were grouped into 2 groups; control (free feed) group and 30% caloric restricted (30% CR) group. At 24 weeks of age the 30% CR animals were provided a diet at a level of 30% less food (by weight) than control rats consumed during the previous week. Blood glucose levels and serum triglyceride, total cholesterol, and high density lipoprotein (HDL)-cholesterol levels of CR rats were determined every 2 weeks for 8 weeks total. Blood glucose, triglyceride and total cholesterol levels of OLETF rats were significantly higher compared to LETO rats. In OLETF rats, the blood glucose levels were decreased to 61% by 8 weeks in the 30% CR compared to the non-CR control group, but changes of blood glucose levels were not observed in LETO rats during the 8weeks in the 30% CR. The serum triglyceride levels of OLETF rats were decreased significantly in the 30% CR but no change in the serum of LETO rats was found. The total cholesterol level was not changed by dietary restriction in LETO rats, but significant changes were observed in OLETF rats by 30% dietary restriction. HDL-cholesterol levels were also increased by dietary restriction in both LETO and OLETF rats. These results suggested that elevated blood glucose, triglyceride and total cholesterol levels in diabetes II patients may be reduced by caloric restriction.

• Korean Journal of Psychosomatic Medicine
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• v.1 no.1
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• pp.35-44
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• 1993

This study was aimed at investigating the relationship of stress perception and psychopathology with biological variables such as systolic and diastolic blood pressure. serum total cholesterol high density lipoprotein and triglyceride in 50 adult patients with essential hypertension and 50 normotensive individuals. Both of the groups were matched to each other regarding age, sex, the level of education and BMI(body mass index). Stress perception and psychopathology between the two groups were compared using GARS and SCL-90-R scales. Biological variables such as blood pressure(systolic. diastolic), serum total cholesterol, high density lipoprotein and triglyceride were measured in all the subjects. The results were as follows ; 1) Hypertensive patients scored significantly higher than normotensive individuals in stress perception related to unusual happenings, change or no change in routine and overall global area, respectively. 2) Regarding psychopathology, hypertensive patients scored significantly higher than normotensive individuals in depression. hostility and interpersonal sensitivity. respectively. 3) Systolic blood pressure had a significantly positive correlation with scores of stress perception related to sickness and injury, and change or no change in routine, respectively. Diastolic blood pressure had a significantly positive correlation with scores of stress perception related to change or no change in routine. 4) In hypertensive patients. the level of serum total cholesterol had a significantly positive correlation with scores of stress perception related to unusual happenings. However, the level of serum triglyceride had a significantly negative correlation with scores of stress perception related to changes in relationships, sickness or injury, and change or no chang in routine. 5) There were no significant correlations between scores of stress perception and biological factors in the normotensive group. 6) The level of serum triglyceride correlated negatively with phobic anxiety in hypertensive group. whereas it correlated positively with PSDI in normotensive group. In conclusion, these results suggest that hypertensive patients have higher level of stress perception and psychopathology than normal individuals. In hypertensive patients, their stress perception is suggested to be correlated with serum cholesterol.

• Journal of the Korean Society of Food Science and Nutrition
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• v.16 no.1
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• pp.18-21
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• 1987

Influence of magnesium and calcium on the serum cholesterol concentration in rabbit blood serum was studied. The subjects were fed with the basal diet and magnesium, calcium and Korea Ginseng. The results obtained are summarized as follows: The subjects body weight fed a basal diet, magnesium, calcium and ginseng powder added did not increased, but the weight of liver was increased. Total cholesterol level of the subject fed ginseng powder 4mg. added diet group showed the lowest concentration. The subjects fed with a basal diet and magnesium/calcium(1:2) added diet showed the lower than anyother group. In case of free cholesterol and cholesterol ester, the subject fed with ginseng powder tap. magnesium/calcium(1:2) added diet showed the lowest concentration. The subjects of the lowest concentration of total cholesterol showed the lowest concentration of low density lipoprotein(LDL) and high density lipoprotein(HDL)/total cholesterol ratio was the higher level than any other group. In case of triglyceride and phospholipid, the subject fed with ginseng powder showed the triglyceride concentration gradually do creased, but phospholipid level was increased positively. In case of electrolytes, sodium and potassium of the subject fed with magnesium, calcium and ginseng powder 4mg added diet showed 120mEq/l 1 and 6.8mEq/l, respectively.

• Journal of Nutrition and Health
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• v.26 no.8
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• pp.933-941
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• 1993

The present study was carried out to investigate the effects of magnesium supplement levels and periods on lipid metabolism in male Sprague-Dawley rats given low protein and magnesium deficient diets. The effect of magnesium supplement levels and periods on lipid metabolism in rats given a low protein and magnesium deficient diet for 2 weeks were investigated. Serum total lipid and triglyceride contents were significantly lower in magnesium supplement group compared with magnesium deficient group. Serum HDL-cholesterol/total cholesterol ratio was significantly increased as magnesium supplement level was increased. Liver total lipid, triglyceride, total cholesterol and phospholipid contents were significantly lower in magnesium supplement group than those in magnesium deficient group. Serum ALP, GOT and GPT activities were significantly decreased in magnesium supplement group compared with magnesium deficient group. In summary, the effect of magnesium supplement on lipid metabolism and enzyme activities were significant and we can see that magnesium supplement level propered to be requirement level(400 mg/kg diet)in the other cases except serum lipid contents.

• The Journal of Internal Korean Medicine
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• v.19 no.1
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• pp.202-218
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• 1998

In order to evaluate the effects of SIMNETONG, GANGJIYOUNSOODAN and CHUNGSIMJOKITANG(Xinnao-Tong, Jiangzhiyanshou-Dan and Qingxintiaoqi-Tang) on hyperlipidemia, the experimental study was performed in rats without or with hyperlipidemia induced by 2% cholesterol fed-diet or Triton WR-1339. And the levels of serum total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol and phospholipid were measured. The results are summarized as follows : In the model of hyperlipidemia induced by 2% cholesterol Fed-diet 1. Both low & highly concentrated GANGJIYOUNSOODAN showed significantly decreasing effects on the level of serum total cholesterol while SIMNETONG & CHUNGSIMJOKlTANG didn't. 2. GANGJIYOUNSOODAN, SIMINETONG and CHUNGSIMJOKITANG showed decreasing effects on the level of serum triglyceride with no statistical significance. 3. Only highly concentrated GANGJIYOUNSOODAN showed increasing effects on the level of serum HDL-cholesterol while the others had no effects. 4. Only highly concentrated GANGJIYOUNSOODAN had decreasing effects on the level of serum LDL-cholesterol while the others had no effects. 5. Highly concentrated GANGJIYOUNSOODAN and CHUNGSIMJOKITANG showed significantly decreasing effects on the level of serum phospholipid while the other had no effects. In the model of hyperlipidemia induced by Triton WR-1339 6. SIMNETONG, GANGJIYOUNSOODAN and CHUNGSIMJOKITANG showed slightly decreasing effects on the levels of serum total cholesterol and triglyceride with no statistical significance. 7. None of SIMNETONG, GANGJIYOUNSOODAN and CHUNGSIMJOKITANG showed any effects on the level of serum HDL-cholesterol. 8. Highly concentrated GANGJIYOUNSOODAN and CHUNGSIMJOKITANG showed decreasing effects on the level of serum LDL-cholesterol but the other had no effects. 9. All of highly concentrated SIMNETONG, GANGJIYOUNSOODAN and CHUNGSIMJOKITANG showed decreasing effects on the level of serum phospholipid with statistical significance. These results show that GANGJIYOUNSOODAN and CHUNGSIMJOKITANG, in orders, have antihyperlipidemic effects. Further study on the mechanism and on the herb screening of these prescription should be followed.