• Asian Pacific Journal of Cancer Prevention
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• 제14권3호
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• pp.1731-1735
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• 2013

Objective: We aimed to identify key genes, pathways and function modules in the development of diffuse large B-cell lymphoma (DLBCL) with microarray data and interaction network analysis. Methods: Microarray data sets for 7 DLBCL samples and 7 normal controls was downloaded from the Gene Expression Omnibus (GEO) database and differentially expressed genes (DEGs) were identified with Student's t-test. KEGG functional enrichment analysis was performed to uncover their biological functions. Three global networks were established for immune system, signaling molecules and interactions and cancer genes. The DEGs were compared with the networks to observe their distributions and determine important key genes, pathways and modules. Results: A total of 945 DEGs were obtained, 272 up-regulated and 673 down-regulated. KEGG analysis revealed that two groups of pathways were significantly enriched: immune function and signaling molecules and interactions. Following interaction network analysis further confirmed the association of DEGs in immune system, signaling molecules and interactions and cancer genes. Conclusions: Our study could systemically characterize gene expression changes in DLBCL with microarray technology. A range of key genes, pathways and function modules were revealed. Utility in diagnosis and treatment may be expected with further focused research.

• Advances in Energy Research
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• 제4권1호
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• pp.29-45
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• 2016

There has been a growing interest in the recent time for the development of solar power tower plants, which are mainly used for utility scale power generation. Combined heat and power (CHP) is an efficient and clean approach to generate electric power and useful thermal energy from a single heat source. The waste heat from the topping Brayton cycle is utilized in the bottoming HRSG cycle for driving steam turbine and also to produce process steam so that efficiency of the cycle is increased. A thermal storage system is likely to add greater reliability to such plants, providing power even during non-peak sunshine hours. This paper presents a conceptual configuration of a solar power tower combined heat and power plant with a topping air Brayton cycle. A simple downstream Rankine cycle with a heat recovery steam generator (HRSG) and a process heater have been considered for integration with the solar Brayton cycle. The conventional GT combustion chamber is replaced with a solar receiver. The combined cycle has been analyzed using energy as well as exergy methods for a range of pressure ratio across the GT block. From the thermodynamic analysis, it is found that such an integrated system would give a maximum total power (2.37 MW) at a much lower pressure ratio (5) with an overall efficiency exceeding 27%. The solar receiver and heliostats are the main components responsible for exergy destruction. However, exergetic performance of the components is found to improve at higher pressure ratio of the GT block.

• 한국주거학회논문집
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• 제17권5호
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• pp.159-167
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• 2006

This study is analyzed comparison about the component ratio of dwelling space in the existing plan and residents dwelling needs. Also, it is analyzed the residence factors of area component change that residence satisfaction and importance according to the behavioral patterns of residents. The results are as follows. 1) Total area component ratio of the existing plan was 39.5:40.8:19.7% and dwelling consciousness one was 36.4:44.0:19.6%. Compared private space with public space, public area requested increase rather than private area. 2) In the 17, 19pyung-types dwellers are not happy about dining kitchen and utility room and types of 21, 23pyung-types are dissatisfied in room-2 and room-3, living room and dining kitchen are dissatisfied, too. In case of areas over 25pyung-types are dissatisfied in room-3 and room-4. 3) The behavioral patterns of apartment residents were classified six acts, and the most significant factors are appeared associated the acts of ceremony, relation of neighborship, and reception. The next significant factors are appeared associated the acts of family relation, about food life. So, it is concerned with the scale of public room.

• 한국통신학회논문지
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• 제38A권6호
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• pp.535-544
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• 2013

본 논문은 단일 송신안테나를 갖는 다수의 모바일 터미널이 가상 MIMO 링크를 구성하는 MIMO 시스템에서의 역방향 전력 제어 방법을 제안한다. 기존의 성능을 향상 시키기 위하여 전력 벌칙 항을 추가하는 게임이론 기반의 전력 제어 방식과 달리, 전체 유효 간섭 전력에 대한 제한 조건 하에서 선형 수신 빔형성을 이용한 전송율의 유틸리티 함수를 최대화 하는 방법을 고려하였다. 또한, 전력제어 과정에 이너시아를 도입하여 제안 전력 제어가 수렴함을 보였다. 모의 실험을 통하여 간섭이 지배적인 다중셀 시스템에서 제안 전력 제어 방법이 시스템의 성능을 크게 향상 시킴을 입증하였다.

• 말소리와 음성과학
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• 제7권1호
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• pp.139-150
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• 2015

The data accumulated in this database will be used to develop a speaker identification system. This may also be applied towards, but not limited to, fields of phonetic studies, sociolinguistics, and language pathology. We plan to supplement the large-scale speech corpus next year, in terms of research methodology and content, to better answer the needs of diverse fields. The purpose of this study is to develop a speech corpus for standard Korean speech. For the samples to viably represent the state of spoken Korean, demographic factors were considered to modulate a balanced spread of age, gender, and dialects. Nine separate regional dialects were categorized, and five age groups were established from individuals in their 20s to 60s. A speech-sample collection protocol was developed for the purpose of this study where each speaker performs five tasks: two reading tasks, two semi-spontaneous speech tasks, and one spontaneous speech task. This particular configuration of sample data collection accommodates gathering of rich and well-balanced speech-samples across various speech types, and is expected to improve the utility of the speech corpus developed in this study. Samples from 639 individuals were collected using the protocol. Speech samples were collected also from other sources, for a combined total of samples from 1,012 individuals.

• Biomolecules & Therapeutics
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• 제22권4호
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• pp.355-362
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• 2014

We have developed a fully automated high throughput drug screening (HTDS) system based on the microfluidic cell culture array to perform combinational chemotherapy. This system has 64 individually addressable cell culture chambers where the sequential combinatorial concentrations of two different drugs can be generated by two microfluidic diffusive mixers. Each diffusive mixer has two integrated micropumps connected to the media and the drug reservoirs respectively for generating the desired combination without the need for any extra equipment to perfuse the solution such as syringe pumps. The cell array is periodically exposed to the drug combination with the programmed LabVIEW system during a couple of days without extra handling after seeding the cells into the microfluidic device and also, this device does not require the continuous generation of solutions compared to the previous systems. Therefore, the total amount of drug being consumed per experiment is less than a few hundred micro liters in each reservoir. The utility of this system is demonstrated through investigating the viability of the prostate cancer PC3 cell line with the combinational treatments of curcumin and tumor necrosis factor-alpha related apoptosis inducing ligand (TRAIL). Our results suggest that the system can be used for screening and optimizing drug combination with a small amount of reagent for combinatorial chemotherapy against cancer cells.

• Corrosion Science and Technology
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• 제11권5호
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• pp.173-178
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• 2012

To manage the wall thinning of carbon steel piping in nuclear power plants, the utility of Korea has performed thickness inspection for some quantity of pipe components during refueling outages and determined whether repair or replacement after evaluating UT (Ultrasonic Test) data. When the existing UT data evaluation methods, such as Band, Blanket, PTP (Point to Point) Methods, are applied to a certain pipe component, unnecessary re-inspecting situations may be generated even though the component does not thinned. In those cases, economical loss caused by repeated inspection and problems of maintaining the pipe integrity followed by decreasing of newly inspected components may be generated. EPRI (Electric Power Research Institute) in USA has suggested several statistical methods, TPM (Total Point Method), LSS (Least Square Slope) Method, etc. to distinguish whether multiple inspecting components have thinned or not. This paper presents the analysis results for multiple inspecting components over three times based on both NAM (Near Area of Minimum) Method developed by KEPCO-E&C and the other methods suggested by EPRI.

• 대한설비공학회:학술대회논문집
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• 대한설비공학회 2009년도 하계학술발표대회 논문집
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• pp.167-171
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• 2009

We conducted performance test of a 350 kW class wood pellet boiler installed at a dormitory whose total area is $1,354\;m^2$. The maximum heating capacity of the boiler is 350 kW(300,000 kcal/kg). The wood pellet boiler consists of 3 parts; boiler, hot water storage tank and wood pellet storage tank. In testing the boiler, we shut off hot water utility supply and open up floor heating water system in order to measure exact value of the heating output of the wood pellet boiler. To determine the efficiency and heating output of the wood pellet boiler, we measured mass flow rate of wood pellet, the lower heating value(LHV) of the wood pellet, mass flow rate and temperature of water for floor heating and so on. We measured the mass flow rate of fuel, wood pellet with respect to rotational speed of auger, wood pellet feeding screw. We also measured the flue gas concentration of the wood pellet boiler by using a gas analyser. The result shows that the efficiency of the wood pellet boiler is 80.6% based on lower heating value at 124 kW of heating output. At this condition, O2 concentration of the flue gas is 6.0%, CO and NOx concentrations are 85 and 102 ppm.

• 상하수도학회지
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• 제25권3호
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• pp.325-334
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• 2011

Market Environment around water work industry is rapidly changing. ISO, International Organization for Standardization, announced the international water work service standard for comparison and evaluation between nations and businesses. And developed countries in water work are introducing market principle for growth of nation's water industry and reinforcement of its competitiveness. Also, some local governments entrusted their water utilities for improvement of competitiveness of water work. However, as some failure cases from overseas came out with emphasis, there are many refuting perspective about entrusted operation achievements of domestic water market. Hence, this paper evaluated competitiveness of domestic local water utilities from the perspective of productivity. After evaluating productivity using Malmquist productivity index, the authors compared and analyzed whether there is a difference of productivity between two different operating types by using Mann-Whitney test. As a result of analysis, it has shown that local water utilities achieved higher productivity at entrusted operation type rather than direct operation type. The local water utilities which chose entrusted operation had increased the productivity 13.9% on total factor productivity(TFP) during experimenting period, while the local water utilities which chose direct operation had increased 0.2%. The background of achieving this high productivity in entrusted operation was analyzed as a result of the higher technological effectiveness of a special water company. The result of this study can be referred when local government needs to decide on what operating types they will use.

• 펄프종이기술
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• 제34권2호
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• pp.73-83
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• 2002

Gloss is very important optical property influencing the perceived quality of the paper surface as well as the surface after printing. Although the average gloss level of paper products or printed images is important to meet end use specifications, the occurrence of gloss mottle, or non-uniformity of gloss, is often of greater concern for meeting quality requirements, especially for the high gloss paper. Gloss variation originates from the irregularities of paper surface, especially surface roughness of paper. Roughness of paper can be divided into micro-roughness (under $1\mu m$ scale in variation) and macro-roughness (over $1\mu m$ scale in variation) depending on the scale of the irregularities. A clearer understanding of the gloss variation of paper can be achieved by separating the contributions of these two scales of roughness, and characterizing them independently. In order to do this, a novel gloss measuring method was introduced. This can detect local gloss with very high resolution. The effect of macro-roughness on gloss variation, which was identified by the measurable surface topography, was separated from the total gloss variation by using this method. The effect of micro-roughness was then estimated indirectly. The local gloss variations of various paper samples were then evaluated to demonstrate the utility of this approach.