• 한국식품영양학회지
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• 제19권2호
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• pp.169-175
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• 2006

단세포 조류 생물인 Chlorella vulgaris(클로렐라)는 다양한 생리 활성을 가진 기능성 소재로 이용되고 있다. 본 연구에서는 강제 수영 부하 실험과 혈액 생화학적 지표에 대한 클로렐라의 효과에 대해 연구하였다. 혈액 생화학적 지표로는 Blood urea nitrogen(BUN), creatine kinase(CK), lactic dehydrogenase(LDH), glucose(Glc), total protein(TP), albumin을 혈액 생화학적 지표로 측정하였다. 매일 0.05, 0.1, 0.15 g/kg 농도의 클로렐라를 각각 실험 군별로 마우스에 구강 투여했다. 클로렐라를 투여한지 3일, 7일째 되는 날 강제 수영 부하 실험을 시행한 결과 0.15 g/kg 클로렐라를 투여한 그룹에서 유의적으로 부동시간을 감소시켰다. 또한 혈청 중 BUN 수치를 낮췄으며, CK, LDH 수치는 감소하는 경향을 나타냈다. 클로렐라 투여 시 혈 중 Glc 수치는 높아졌으나, TP 와 albumin 수치는 변화가 없었다. 이상의 결과들은 클로렐라가 육체적 지구력 향상 효과가 있는 것을 시사하고 있다.

• 혜화의학회지
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• 제8권1호
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• pp.865-878
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• 1999

With advances in neonatal medicine, smaller and sicker infants are surviving premature birth. As these tiny patients battle for their lives, their parents also struggle with psychological consequences of an unexpected role. The birth of a sick infants has long been documented as stressful events for the parents. High stress levels may alter parents' interaction with their baby and impair their communication with health professionals, which can in turn affect parents' participation in care planning and decision making. Nursing interventions aimed at reducing the parental stress and anxiety levels during this crisis may have a positive impact on their ability to form an attatchment to their baby and make prudent decisions about his care. The planning of such interventions would be inhanced if the contributions of various factors to increased parental stress levels were identified. This descriptive study was conducted to understand the contents and degree of parental stress in the NICU during their premature's hospitalization, and to give a baseline data in developing nursing intervention program. Subjects were the 60 mother of hospitalized newborn in NICU of 2 University Hospital in Taejon City from April 1st, 1999 to June 30th, 1999, who agreed to take part in this study. The instrument used in this study were Parental Stressor Scales:NICU(PSS:NICU) developed by Miles et al.. and validated by 3 NICU practitioners and 3 child health nursing faculties. The questionnaire has 4 dimensions and 45 items; sight and sounds of NICU(5 items), babies' appearance and behavior nursing intervention(19 items), parental role alteration and relationship with their baby(10 items), health team communication(11 items). The questionnaire asks parents to rate each item on a five-point Likert type scale that ranges from "not stressful" (1) to "extremely stressfu1"(5). Total scores representing overall stress from the NICU environment are calculated by summing response to each item. A high score indicates high stress. A subscale score is calculated by summing the responses to each item in the subscale. Cronbach's ${\alpha}$ coefficients were .93. The data was analyzed as average, Frequency, Standard deviation, t-test, ANOVA, Pearson correlation coefficient by use of SPSS/PC+. The results of this study is summarized as follows ; 1. The total perceived stress level score of mothers of premature baby was slightly high($3.66{\pm}1.1$). The highest scored dimension was 'relationship with their baby and parental role change'($4.21{\pm}0.9$), and next were 'appearance and behavior of the baby'($3.92{\pm}1.1$), 'communication with health team'($3.32{\pm}1.3$), 'sight and sounds of NICU'($3.30{\pm}1.1$). 2. There were statistically significant correlation noted ; mother's perceived severity of the baby's condition(F=8.0012, P= .0125) and baby's gestational age(r = -.4724, P = .0500). In summary, information about physical environment of NICU, the mother's perceived severity of premature baby's state, maternal role change related variables and the knowledge of characteristics of premature baby must be included in nursing intervention program of mother's of premature baby in reducing the parental stress and anxiety level. It is suggested that each NICU needs to develop a nurse managed supportive care program for parents of premature baby. Also, it is suggested that there need to investigate the coping mechanism of mother of premature baby.

• 대한화장품학회지
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• 제49권3호
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• pp.231-245
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• 2023

화장품 업계에서는 미백, 주름, 항산화, 항노화 등 기능성 화장품의 신소재 개발과 더불어 실제로 피부에 적용 시 피부흡수율을 높이는 기술이 중요하다. 이에 본 연구에서는 실험설계법인 반응표면분석법(RSM)을 활용하여 나노에멀젼 제형을 최적화하고자 하였다. Glabridin을 활성성분으로 하여 고압유화 방법으로 나노에멀젼을 제조하였으며, 최종적으로 최적화한 나노에멀젼의 피부흡수율을 평가하였다. RSM 인자로서 계면활성제 함량, 콜레스테롤 함량, 오일 함량, 폴리올 함량, 고압유화 압력, 고압유화 횟수를 달리하여 나노에멀젼을 제조하였다. 그 중 입자 크기에 가장 큰 영향을 미치는 인자인 계면활성제 함량, 오일 함량, 고압유화 압력, 고압유화 횟수를 독립변수로 하였고, 나노에멀젼의 입자 크기와 피부흡수율을 반응변수로 하였다. 중심점 5 회 반복실험을 포함하여 총 29 회 실험이 무작위로 수행되었으며, 제조된 나노에멀젼의 입자 크기와 피부흡수율을 측정하였다. 그 결과를 바탕으로 최소 입자 크기, 최대 피부흡수율을 갖는 제형을 최적화하였으며, 계면활성제 함량 5.0 wt%. 오일 함량 2.0 wt%, 고압유화 압력 1,000 bar, 고압유화 횟수 4 pass를 최적 조건으로 도출하였다. 최적 조건으로 제조한 나노에멀젼의 물성으로 입자 크기는 111.6 ± 0.2 nm, 다분산지수는 0.247 ± 0.014, 제타전위는 -56.7 ± 1.2 mV로 측정되었다. 나노에멀젼과 일반 에멀젼 피부흡수 시험 결과, 24 h 후 나노에멀젼의 누적 투과량은 79.53 ± 0.23%이며, 대조군으로서 에멀젼의 누적 투과량은 66.54 ± 1.45%로 나노에멀젼이 에멀젼보다 13% 높았다.

• 대한물리치료과학회지
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• 제9권3호
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• pp.31-49
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• 2002

The purpose of this study was to investigate discomforts and sexual life and to identify the relation between the discomforts and sexual life with low back pain. The data were collected from March 2 through July 31, 2001. Four hundred forty-two questionnaires were returned (response rate=88.0%). Analysis of the data was done with SPSS PC+ and use descriptive statistics, $x^2$-test, t-test, ANOVA. regression. The statistics shows that over than 80% of the adults experienced lumbago at least one time in their life, and Back pain is known as one of the most common complaints made by the patients of all ages in the general hospital or local medical clinics throughout. However, in certain case it leads to a chronic condition which can cause a great deal of problems in management and in financial burden to individuals and society. The result of this study was summarized as follows: 1) It appeared that regarding the distribution of gender, male was the higher(63.6%) then that of female, the portion of forties was 28.5%. Sitting for long time was 23.1% in men and 21.7% in women. Unknown reason including sexual behaviour was 12.9% in men and 15.5% in women. Patients treated medicine and physical therapy were 36.4%. In level of educational background, the rate of high school was 31.0%, technical college was 28.5%. The highest proportion by occupation was 18.3% of office workers, occupation posture was 41.9% of sitting. 2) Men(26.0%) and most of women(34.8%) were not satisfied in the explanation satisfaction rate of sex life concerned disease. 23.8% in men and 23.6% in women considered flexibility of waist good. Man(33.3%) and most of woman(35.0%) considered that Health education is necessary. 32.7% in men and 27.3% in women did't mind educator is whoever. Preventing of lower back pain(LBP) and proper Health education of sex life are demanded in daily life. 3) 58.0% of man and 64.0% of woman mostly had a posture which is man over woman. 28.5% in men and 27.8% in women considered that proper information finding of LBP and sex life was very few and few. 37.7% in men and 42.7% in women have acquired information about sex life flung their friends. 4) The number of sex life was decreased from 2.96 0.98 to 2.61 1.63 and also the time of sex life was decreased from 3.65 1.89 to 226 1.64. The satisfaction rate of sex life changed from 3.60 0.86 to 2.77 1.10. In the number of sex life, The non correct group was 2.62 1.91 and the correct group was higher in 2.68 1.65. In the time of sex life, The non correct group was 2.02 1.47 and the correct group was higher in 229 1.65. The satisfaction rate of sex life was 2.76 0.86 in non correct group and 2.88 1.10 in correct group. So there was a difference. 5) In the satisfaction rate of sex life, Men who have a lower back pain were higher than women and no attack group was higher than attack group. As they had many sex life, the satisfaction rate was higher significantly in statistics. As the time of sex life was short, the satisfaction rate was lower significantly in statistics. As the age was low, the demand rate of Health education was high and as means of patient who had a lower back pain was high, the demand rate of Health education was high. As the patient who had a lower back pain had a long married life, the demand rate of Health education was high and as education level was high, the demand rate of Health education was high. It is necessary to provide patients with conservative treatment, educational teaching, and training to prevent further injuries in the future. In general, it is important to educate the public how to prevent back injuries and how to treat themselves in an onset period to prevent further injuries sliding into a chronic state. Sexuality is an integral part of normal and healthy relationships, but patients are unable to enjoy sex because they are riot able to get into a comfortable position due to back pain. Many conditions of the spine can make certain positions uncomfortable. Health educator should make the education program of the discomforts and the sexual pattern for low back pain in workplace and/or hospital. Further study Is needed on how to integrate the educational program on sexuality into the total rehabilitation program.

• 한국심리학회지 : 문화 및 사회문제
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• 제29권4호
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• pp.537-567
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• 2023

본 연구는 잔인한 범죄현장으로부터 비롯된 혐오 정서와 성 소수자인 피고인에 대한 고정관념에서 나온 혐오 정서의 속성 및 각 혐오 정서가 증거평가와 법적 판단에 미치는 영향을 비교하고자 하였다. 총 600명의 참가자(남 300명, 평균 44.40)가 혐오 정서의 출처(범죄현장, 성 소수자 피고인, 통제조건), 추가 무죄 증거의 존부(있음, 없음), 그리고 사법적 지시문 존부 조건(있음, 없음)에 무작위로 할당되었다. 연구결과 핵심적 혐오(physical disgust) 요소가 강한, 잔인한 범죄현장 조건에서 나온 혐오 정서가 피고인이 성 소수자인 경우의 혐오 정서보다 유의미하게 높았으며, 제시된 증거를 더 유죄방향으로 해석하였고, 피고인이 유죄일 확률을 더 높게 보았다. 눈에 띄는 것은 혐오 출처가 성 소수자인 조건에서는 혐오 정서와 유죄확률 판단 간에 증거평가가 유의미한 조절 변인이었으나 통제조건과 범죄현장 조건에서는 그렇지 않았다는 점으로, 이는 피고인이 성 소수자일 경우 유발된 혐오 정서가 법적 판단에 미치는 영향은 직접적이지 않을 수 있음을 의미한다. 또한, 지시문의 제시는 형량을 유의미하게 감소시켰고, 사후 단순 효과(simple effect) 분석 결과 오직 통제조건에서만 지시문 제시가 유죄확률을 낮추었다. 이는 범죄현장이나 피고인의 특성에서 비롯된 혐오 정서는 지시문으로는 교정되기 어려운 사건관련 정서(integral emotion)로 인식될 수 있다는 것을 추론케 한다. 분석 결과 성 소수자 조건에서 범죄현장 조건과 통제조건에서보다 피고인에 대한 동정심이 높게 나타났는데, 이는 성 소수자에 대해서는 혐오 외에 동정심이라는 정서적 반응이 나타날 수 있다는 것을 보여준다. 이 결과를 기반으로 혐오 정서의 본질(physical disgust/moral disgust), 혐오의 출처 및 정도에 따른 법적 판단, 그리고 성 소수자인 피고인에 대한 혐오와 동정심의 의미에 대해 논의하였다.

• 대한소아치과학회지
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• 제31권3호
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• pp.459-473
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• 2004

본 연구는 보다 효과적인 치료계획 수립과 행동조절을 시행하는데 도움을 얻고자, 1999년 1월 1일부터 2002년 12월 31일까지 강릉대학교 치과병원 소아치과에 내원한 환아를 진료기록부를 통해 조사하고, 진정치료를 받은 환아들 및 보호자의 특성을 진료기록부 및 초진시 설문지를 통해 진정치료를 받지 않은 환아들과 비교, 분석하여 다음과 같은 결과를 얻었다. 1. 내원 환아수 증가와 함께 진정치료환아들의 수가 1999년부터 2002년의 4년 동안 계속적으로 증가하였다. 2. 진정환아군은 비진정환아군에 비해 어린 연령 대에 집중되어 유의할만한 분포의 차이를 보였다(p<0.001). 3. 월별 내원경향에 있어서 진정환아군은 3, 7, 11월에 높은 비율을 보여 전체 환아에 비해 내원빈도 분포에 유의할 만한 차이를 보였다(p<0.001). 4.보호자 직업의 분포에서도 추후 계속된 연구가 필요하지만, 진정환아와 비진정환아군 간에 통계적으로 유의한 차이가 있었다(p<0.001). 5. 진정환아군은, 비진정환아군에 비해 예방, 교정적인 치료보다는 충치치료를 주소로 내원하는 비율이 높아 내원동기의 분포에 유의할만한 차이가 있었다(p<0.001). 6. 이전 치과치료시 진정환아군에서 부정적 반응을 보인 비율이 더 높았고, 보호자 기대치에서도 진정환아군에서 부정적 반응을 기대한 비율이 더 높았다(p<0.001). 7. 진정환아군의 31.2%는 소개를 통해 소아치과에 내원하였으며, 치과의사에 의한 소개가 가장 높은 58.3%를 차지하였다. 8. 달래도 치료를 거부할 경우, 진정환아군의 보호자들은 50.9%가 진정치료를 선호한 반면, 비진정환아군의 보호자들은 물리적 방법을 54.6%로 선호하여 유의할만한 분포의 차이를 보였다(p<0.001).

• Child Health Nursing Research
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• 제6권2호
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• pp.224-239
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• 2000

This descriptive study was conducted to understand the contents and degree of parental stress level in the NICU patients, and to give a baseline data in developing nursing intervention program. Subjects were the 62 mother of hospitalized newborn in NICU of 1 University Hospital in Taejon City from May 1st, 1999 to November 30th, 1999, who agreed to take part in this study. The instrument used in this study were Parental Stressor Scales : NICU(PSS:NICU) developed by Miles et al. and validated by 3 NICU practitioners and 3 child health nursing faculties. The questionnaire has 4 dimensions and 45 items; sight and sounds of NICU(5 items), babies' appearance and behavior(19 items), parental role alteration and relationship with their baby(10 items), communication with health team(11 items). The questionnaire asks parents to rate each item on a five-point Likert type scale that ranges from (1) to (5). Total scores representing overall stress from the NICU environment are calculated by summing response to each item. A high score indicates high stress. A subscale score is calculated by summing the responses to each item in the subscale. Cronbach's α coefficients were .93. The data was analyzed as average, Frequency, Standard deviation, t-test, ANOVA, Pearson correlation coefficient by use of SPSS/PC+. The results of this study is summarized as follows ; 1. The total perceived stress level score of mothers was slightly high(3.6±.7). The highest scored dimension was 'appearance and behavior of the baby'(3.9±1.5), and next were 'relationship with their baby and parental role change'(3.5±1.4), 'communication with health team'(3.4±.9), 'sight and sounds of NICU'(3.2±.8). 2. Two variables were statistically significant with PSS:NICU total scale ; mother's perceived severity of the baby's condition (r=.482, P=.002) and mother's religious attendance(t=2.83, P=.01). The more the mother perceive their baby's condition severe, the higher the total stress score. There were high stress score noted in the mother of no religious attendance. 3. Four variables were statistically significant with NICU environment subscale ; mother's educational background(F=3.45, P=.04), religious attendance(t=2.28, P=.04), sex of the baby(t=2.83, P=.01) and NICU patients' hospital day(r=.359, P=.004). That is mother with high educational background and girl baby were high NICU environment subscale score. 4. Four variables were statistically significant with appearance and behavior of the baby subscale ; when first saw baby(F=3.52, P=.04), incubator care(t=2.83, P=.01), mother's perceived severity of the baby's condition(r=.303, P=.017), number of NICU visit(r=.441, P=.002). That is, seeing the baby first in the NICU and recieved incubator care was very stressful. Also, the more the mother perceive their baby's condition severe and more NICU visit, the higher the appearance and behavior of the baby subscale stress score. 5. Four variables were statistically significant with relationship with their baby and parental role change subscale ; when first saw baby(F=3.37, P=.04), sex of the baby(t=2.36, P=.03), incubator care(t=5.60, P=.00), mother's perceived severity of the baby's condition(r=.401, P=.001). That is, seeing the baby first in the NICU and girl baby was very stressful. Also, the more the mother perceive their baby's condition severe, the higher the relationship with their baby and parental role change subscale stress score. 6. Three variables were statistically significant with communication with health team subscale ; mother's educational background (F=3.63, P=.04), incubator care(t=4.24, P=.00), gestational age(r=-.394, P=.047), and birth weight(r=-.460, P=.004). That is, mother with high educational background and receiving incubator care were high communication with health team subscale score. Also, the shorter the gestational age and smaller the baby's birth weight, the higher the communication with health team subscale score. In conclusion, information about physical environment of NICU, the mother's perceived severity of baby's illness state, maternal role change related variables and the knowledge of characteristics of NICU patients must be included in nursing intervention program of mother's of NICU patients in reducing the maternal stress and anxiety level.

• Ecology and Resilient Infrastructure
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• 제10권3호
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• pp.85-96
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• 2023

국내 호소를 상류 저수지 (<0.3 psu), 하구 저수지 (0.3 - 2 psu), 기수성 석호 (>2 psu)로 분류하여 호소별 퇴적물 총질소 (T-N), 총인 (T-P) 농도의 차이를 일원분산분석 (ANOVA) 하였으며, 실험실 코어 배양법 (laboratory core incubation)을 이용해 송지호 (11.80 psu), 간월호 (0.73 psu), 장군 저수지 (0.08 psu)의 호기 (aerobic)와 무산소 (anoxic) 조건에서의 질소 및 인 용출량 (benthic nutrient flux)을 측정하였다. 국내 호소의 퇴적물 내 총질소와 총인 농도는 염분 농도가 다른 호소별로 유의한 차이가 있는 것으로 분석되었다 (p<0.05). 사후 검정 (post-hoc)을 통해 총질소의 경우 상류 저수지 (2,918 mg/kg)와 하구 저수지 (2,094 mg/kg)에서 유의한 차이를 확인하였고 (p<0.001), 총인의 경우 상류 저수지 (789 mg/kg)와 기수성 석호 (533 mg/kg)가 유의한 차이를 보였다 (p<0.01). 실험을 통해 산정된 NH₄⁺-N의 용출량은 간월호에서 가장 높게 나타났으며, 폐쇄성 수역인 물리적인 특성과 염분으로 인한 질산화의 저해 등에 의한 것으로 판단된다. NO₃^--N의 용출량은 호기 조건에서 염분이 높은 호소일수록 낮게 나타났으나 무산소 조건에서는 염분이 높은 호소일수록 용출량이 높게 관측되었고, 이는 염분이 질산화 및 탈질이 억제되었기 때문이다. PO₄^3--P의 경우 송지호, 간월호, 장군 저수지 순으로 용출량이 높게 나타나, 염분이 음이온 흡착 경쟁 등을 통해 인산염의 용출을 촉진시키는 것으로 조사되었다. 퇴적물의 용출량 산출 시 미생물 군집, 성장률, 산화, 환원, 영양염류의 결합 형태 등의 요인이 염분에 의해 영향을 받으므로 염분화 된 호소의 퇴적물 용출 조사 시 염분에 의한 영향을 고려해야 할 것으로 사료된다.

• 한국ITS학회 논문지
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• 제13권1호
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• pp.1-14
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• 2014

국가정책 및 사회적 여건의 변화에 따라 도시부의 교통혼잡 완화를 위한 물리적 도로 확대가 한계에 다다른 지금 혼잡 완화를 위해서는 기존 도로의 효율성을 재고하는 방안이 간구되어야한다. 또한 지능형교통체계(ITS)는 과거 루프 및 영상검지기 등을 통한 도로기반 지점검지 중심의 교통정보 수집체계에서 도로, 자동차 및 보행자간의 다양한 수집 체계를 통한 실시간 구간검지 체계 중심의 차세대 지능형교통체계(C-ITS :Co-operative ITS)로 빠르게 진화하고 있으나 현재 교차로의 운영 및 제어를 위한 교통정보의 수집방법은 지점검지체계에 국한되어 있는 실정이다. 따라서 본 연구는 현재 Hi-pass에 적용된 DSRC기술을 통해 수집이 가능한 구간정보를 이용하여 접근로의 대기행렬 길이를 산정하고 이를 활용하는 독립교차로의 실시간 신호제어모형의 개발 및 평가를 목적으로 하였다. 대기행렬길이 추정을 위해 구간검지기를 통해 수집된 개별차량의 통행시간을 이용하여 시공도 상에 4개의 좌표값을 추정하였으며 한 주기동안 추정된 좌표값들을 통해 대기행렬이 생성되는 충격파의 속도 및 대기행렬길이를 추정하였다. 실시간 신호제어를 위해 각 방향별 추정된 대기행렬길이를 통해 전체 교차로의 대기행렬길이의 합이 최소가 되는 신호시간을 산정하였으며 API 기능을 제공하는 미시적 시뮬레이션 프로그램인 VISSIM을 활용하여 총 3개의 시나리오를 평가하여 알고리즘에 의해 교차로의 대기행렬 길이의 합이 최소가 되는 신호시간의 산정이 가능함을 확인하였다.

• Journal of Korean Neurosurgical Society
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• 제47권5호
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• pp.345-351
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• 2010

Objective : In this study, the Mindfulness Based Stress Reduction (MBSR) program was applied to patients presenting with depression and anxiety after surgery from spontaneous subarachnoid hemorrhage (SAH) and the effects were assessed. Methods : The subjects were patients admitted for cerebral aneurysm rupture and treated by means of surgery from March to December, 2007. More than 6 months had passed after surgery, without any special lesions showing up on computed tomography (CT), and the Glasgow outcome scale (GOS) was 5 points. Among patients with anxiety and depression symptoms, 11 patients completed the program. The MBSR program was conducted once a week, 2.5 hours each, for 8 weeks. The evaluation criteria were : 1) the Beck Depression Inventory (BDI): it measures the type and level of depression, 2) the State-Trait Anxiety Inventory : the anxiety state of normal adults without mental disorder, and 3) Heart Rate Variability (HRV) : the influence of the autonomous nervous system on the sinoarterial node varies continuously in response to the change of the internal/external environment. Results : The BDI value was decreased from 18.5 ${\pm}$ 10.9 to 9.5 ${\pm}$ 7.1 (p = 0.013) : it was statistically significant, and the depression level of patients was lowered. The state anxiety was decreased from 51.3 ${\pm}$ 13.9 to 42.3 ${\pm}$ 15.2; the trait anxiety was reduced from 50.9 ${\pm}$ 12.3 to 41.3 ${\pm}$ 12.8, and a borderline significant difference was shown (p = 0.091, p = 0.056). In other words, after the treatment, although it was not statistically significant, a decreased tendency in anxiety was shown. In the HRV measurement, standard deviation normal to normal (SDNN), square root of the square root of the mean sum of squared differences between adjacent normal to normal intervals (RMSSD), and total power (TP) showed significant increase, Physical Stress Index (PSI) showed a significant reduction, and thus an improvement in the homeostatic control mechanism of the autonomic nervous system was ween. Conclusion : The MBSR program was applied to the patients showing anxiety and depression reaction after SAH treatment, and a reduction in depression symptoms and physiological reactions were observed. The application of the MBSR program may be considered as a new tool in improving the quality of life for patients after surgery.