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Antifatigue Effect of Chlorella vulgaris in Mice  

An Hyo-Jin (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University)
Seo Sang-Wan (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University)
Sim Kyung-Sik (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University)
Kim Jung-Suk (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University)
Kim Eun-Hee (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University)
Lee Mi-Ok (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University)
Park Hyeung-Suk (Daesang Corp. WellLife R&D Center)
Han Jae-Gab (Daesang Corp. WellLife R&D Center)
Lee Eun-Hee (Division of Beauty Arts, Jeonbuk Science College)
Um Jae-Young (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University)
Hong Seung-Heon (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University)
Kim Hyung-Min (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University)
Publication Information
The Korean Journal of Food And Nutrition / v.19, no.2, 2006 , pp. 169-175 More about this Journal
Abstract
A unicellular algae, Chlorella vulgaris(CV), was used as a biological response modifier. The effect of CV on forced swimming test and blood biochemical parameters related to fatigue was investigated. Blood urea nitrogen(BUN); creatine kinase(CK); lactic dehydrogenase(LDH); glucose(Glc); total protein(TP); and albumin were determined. CV was orally administered to mice in the range of 0.05 to 0.15 g/kg/day. A forced swimming test results on 3 and 7 day after administration of CV, showed that immobility time was decreased in the CV-administered group(0.15 g/kg). In addition, the contents of BUN in the blood serum were decreased in CV-fed group. The contents of CK and LDH were tended to decrease, but not statistically significant. The plasma Glc level was increased in CV-fed groups(0.05 and 0.1 g/kg) compared to control group. It had no effect on the elevation of TP and albumin level. The results indicate that CV could improve physical stamina.
Keywords
Chlorella vulgaris; forced swimming test; immobility time; blood parameters;
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