• Archives of Pharmacal Research
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• v.28 no.5
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• pp.626-635
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• 2005

Liposome as a carrier of topotecan (TPT), a promising anticancer drug, has been reported in attempt to improve the stability and antitumor activity of TPT. However, the biodistr ibution pattern of TPT liposome in vivo and PEG-modified liposome containing TPT have not been studied systemically. In this paper, the in vitro stability and in vivo biodistribution behavior of several liposomes containing TPT with different lipid compositions and PEG-modification were studied. Compared with the 'fluid' liposome (S-Lip) composed of soybean phosphatidylcholine (SPC), the 'solid' liposome (H-Lip) composed of hydrogenated soybean phosphatidylcholine HSPC decreased the leaking efficiency of TPT from liposome and enhanced the stability of liposome in fetal bovine serum (FBS) or human blood plasma (HBP). The results of biodistribution studies in S$_{180}$ tumor-bearing mice showed that liposomal encapsulation increased the concentrations of total TPT and the ratio of lactone form in plasma. Compared with free TPT, S-Lip and H-Lip resulted in 5- and 19- fold increase in the area under the curve (AUC$_{0\rightarrow\propto}$), respectively. PEG- modified H-Lip (H-PEG) showed 3.7-fold increase in AUC$_{0\rightarrow\propto}$ compared with H-Lip, but there was no significant increase in t$_{1/2}$ and AUC$_{0\rightarrow\propto}$ for PEG-modified S-Lip (S-PEG) compared with S-Lip. Moreover, the liposomal encapsulation changed the biodistribution behavior, and H-Lip and H-PEG dramatically increased the accumulation of TPT in tumor, and the relative tumor uptake ratios were 3.4 and 4.3 compared with free drug, respectively. There was also a marked increase in the distribution of TPT in lung when the drug was encapsulated into H-Lip and H-PEG. Moreover, H-PEG decreased the accumulation of TPT in bore marrow compared with unmodified H-Lip. All these results indicated that the membrane fluidity of liposome has an important effect on in vitro stability and in vivo biodistribution pattern of liposomes containing TPT, and PEG-modified 'solid' liposome may be an efficient carrier of TPT.

• Korean Journal of Plant Taxonomy
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• v.45 no.4
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• pp.362-368
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• 2015

Two new and one unrecorded hybrids of the genus Asplenium were newly found in Korea. They were proved to be hybrid based on intermediate morphology between putative parents. The first hybrid is $A.{\times}uiryeongse$ C.S. Lee & K. Lee (Aspleniaceae), nom. nov. (vernacular name: geo-mi-sa-cheol-go-sa-ri). This new hydrid is a cross between the Asian walking fern, A. ruprechtii and A. pekinens in Uiryeong-gil, Mt. Bukansan, Seoul, Korea. The other new one occurs in Mt. Seongsan in Yeoncheon-gun, Gyeonggi-do, Korea, $A.{\times}montanus$ C.S. Lee & K. Lee, nom. nov. (vernacular name: san-kko-ri-go-sa-ri) which might have experienced multiple hybridization events between A. ruprechtii ${\times}$ A. trichomanes and A. incisum following the hybrid between A. ruprechtii and A. trichomanes. In addition, one unrecorded hybrid, $A.{\times}kitazawae$ Kurata & Hutoh (vernacular name: geo-mi-dol-dam-go-sa-ri), reported first from Japan, is found in natural habitats in Do-dong, Daegu-si, and is a hybrid, between the Asian walking fern and A. sarelli. These hybrid taxa grow in sympatric regions with both putative parental species. The diagnostic characters for each taxon and evidence for their hybridization have been suggested. Descriptions, illustrations, and photographs of these hybrid taxa in their habitats are provided from Korea.

• Journal of dental hygiene science
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• v.7 no.3
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• pp.197-200
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• 2007

This study was carried out to assess anticariogenic activity from natural products. The hexane extracts of 11 medicinal plants were tested for the antimicrobial activities against a cariogenic bacterium, S. sobrinus B13. The hexane extracts of 11 medicinal plants such as Alisma orientale, Cyperus rotundus, Saussurea lappa, Atractylodes japonica, Kalopanax pictus, Angelica gigas, Salvia miltorrhiza, Lonicera japonica, Gardenia jasmoides, Aurantii nobilis percarpium and Bupleurum lorgiradiatum were used for this study, and S. sobrinus B13 was cultured with 0.5% extracts of the medicinal plants, in trypticase soy broth medium under 5% $CO_2$ for 0, 6, 12, 24 hours at $37^{\circ}C$. The obtained results were as follows. Immediately after culturing for inoculation, Kalopanax pictus and Cyperus rotundus showed better antimicrobial activities than those of others. After culturing for 6 hours, the order of effective antimicrobial activity was Salvia miltorrhiza, Angelica gigas. After incubation for 12 hours, Salvia miltorrhiza showed the best antimicrobial activity. After incubation for 24 hours Salvia miltorrhiza, Cyperus rotundus, Saussurea lappa, Atractylodes japonica had better antimicrobial activity than others. In conclusion, among Hexane extracts of 11 medicinal plants, Cyperus rotundus, Saussurea lappa, Atractylodes japonica showed effective antimicrobial activity.

• Journal of dental hygiene science
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• v.8 no.4
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• pp.375-380
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• 2008

This study evaluated the effect of an school-based oral health program supplied to primary school children in Anyang city. This program included oral health education, pit and fissure sealing, fluoride mouth rinsing and professional tooth brushing. The numbers of the subjects were 311 children in the program participant group and 165 children in the control group which were not in the program. Data were analyzed with t-test, one way ANOVA and pearson's correlation coefficient using SPSS WIN 12.0 program. In attitude, behavior of oral hygiene, participant group was better than the control group. In case of the perceived oral health, satisfaction of oral health, need oral treatment there was no significant difference between the two groups. These results suggest that school children can learn the good attitude and behaviors and oral health promotion can be achived from the oral health program run by shool dental clinic.

• Journal of the Korean Dietetic Association
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• v.12 no.4
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• pp.378-389
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• 2006

The purpose of this study was to investigate the status of magnesium, iron, copper and zinc nutrition in 28 normal and 28 obese male elementary school students who have over 30% obesity index. The anthropometric measurements, dietary intakes and serum levels of magnesium, iron, copper and zinc were determined by 24-hr recall method and blood analysis, respectively. The mean age, height, weight, and obesity index were 10.9years, 147.4cm, 61.1kg, and 50.5% in obese group and 10.8years, 145.4cm, 40.2kg, and 3.3% in normal group. There was no significant difference in average daily food intake between obese and normal group, but meats(p＜0.05) intake of obese group was significantly lower than that of normal group. The intakes of energy, magnesium, iron, copper were not significantly difference between obese and normal group, but heme iron(p＜0.05) intake of obese group was significantly lower than that of normal group. Zinc(p＜0.05) intake of obese group was significantly higher than that of normal group. Serum magnesium(p＜0.001) level of obese group was significantly higher than that of normal group, but there were no significant differences in serum iron, copper, zinc levels between obese and normal group. There was a significantly positive correlation between serum magnesium and weight(p＜0.05), and obesity index(p＜0.05). There was a significantly positive correlation between serum magnesium and energy intake(p＜0.05), protein intake(p＜0.05), animal protein intake(p＜0.05), phosphorus intake(p＜0.05) and animal iron intake(p＜0.05). There was a significantly positive correlation between serum magnesium and seaweeds intake(p＜0.05), milks intake(p＜0.001). Also, there was significantly positive correlation between serum copper and oils and fat intake(p＜0.05). These results suggest that there should be careful considerations for micronutrients nutrition status among male obese elementary school students.

• Journal of Digital Convergence
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• v.16 no.1
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• pp.117-124
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• 2018

The purpose of this study was to evaluate the effects of PAIR leadership program which can make one's own for solving problems of conflicts through understanding of self and the environmental. For this, the PAIR leadership were administered in 10 sessions for 60 minutes with 16 of the adjustment soldiers and 20 of the maladjustment soldiers of the military alternative social workers. The pre-post on the behavioral change will, interpersonal efficacy and the self-regulation level were assessed. The results were as the PAIR he maladjustment soldiers group reported significantly higher score on level of the behavioral change will, interpersonal efficacy and the self-regulation. Also the adjustment soldiers reported significantly on interpersonal efficacy and the self-regulation. This results suggest that the PAIR readership program can be applied effectively for promotion of the behavioral change will, the self-regulation.

• Journal of the East Asian Society of Dietary Life
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• v.15 no.4
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• pp.386-396
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• 2005

The effects of spirulina-added salad dressing on lipid profiles and antioxidant biomarkers such as total glutathionine, TBARS value, carbonyl value, GPx, GR, SOD and paraoxonase activity in plasma or liver of mice were evaluated Sixteen male ICR mice weighing 20$\pm$2 g were divided into two groups and fed low fat ($5\%$ fat) diet (low fat control: LFC) and low fat control plus dressing diet (LFD) for eight weeks. Body weight, tissue weights of liver, heart and kidney, and the distribution of body fat deposition were not significantly different between two groups. Also, the profile of TG, TC, LDL and HDL cholesterol were similar between two groups. The DNA damage was determined using the comet assay (single cell gel assay) with alkaline electrophoresis and quantified by measuring tail length (TL). Spirulina salad dressing consumption resulted in significant decrease in lymphocyte DNA damage expressed by TL (LFC: $28.8{\mu}m$, LFD: $20.3{\mu}m$). Additionally, salad dressing consumption for 8 wks decreased the lipid peroxidation assayed by TBARS to $12.6\%$ compared with the control. The levels of antioxidant vitamins such as $\beta$-carotene were significantly higher in plasma of LFD group than those in LFC group based on HPLC method This study shows that spirulina-added salad dressing exerts degenerative disease-protective effects on oxidative DNA damage and lipid peroxidation possibly via a free radical levels.

• Korean Journal of Environment and Ecology
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• v.25 no.3
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• pp.267-283
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• 2011

Endangered species designated by The Ministry of Environment in region of Naejangsan National Park were found Lycoris chinensis var. sinuolata K.H.Tae & S.T.Ko, Iris koreana Nakai, Cymbidium macrorrhizum Lindl and Vexillabium yakushimensis (Yamam.) F.Maek.(4 taxa). The floristic special plants were recorded to a total of 159 taxa; that is, class I species (91 taxa) were containing as Chloranthus fortunei (A.Gray) Solms, Vicia anguste-pinnata Nakai and Euscaphis japonica (Thunb.) Kanitz, etc, class II species (17 taxa) were Pseudostellaria coreana (Nakai) Ohwi, Dryopteris expansa (C.Presl) Fraser-Jenkins et Jermy and Gymnocarpium dryopteris (L.) Newman, etc, class III species (32 taxa) were containing; Cirsium setidens (Dunn) Nakai, Parasenecio pseudotaimingasa (Nakai) B.U.Oh and Saussurea eriophylla Nakai, etc, class IV species (9 taxa) were Deutzia paniculata Nakai, Carex ligulata Nees and Thuja orientalis L., etc, and class V species (10 taxon) were Orobanche filicicola Nakai, Lycoris chinensis var. sinuolata K.H.Tae & S.T.Ko and Lycoris sanguinea var. koreana (Nakai) T.Koyama, etc. Endemic species of korea were identified 40 taxa such as Broussonetia kazinoki var. humilis Uyeki, Pseudostellaria coreana (Nakai) Ohwi and Silene seoulensis Nakai, etc. Plant species designated as Natural Monument were 2 species that Daphniphyllum macropodum forest(No. 91) and Torreya nucifera forest(No. 153) receive protection. The naturalized plants were identified 30 taxa; Fallopia dumetorum (L.) Holub, Persicaria orientalis (L.) Spach and Rumex crispus L., etc. Among them the ecosystem disturbance wild plants was not discovered.

• Korean Journal of Environment and Ecology
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• v.24 no.2
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• pp.194-201
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• 2010

This study was carried out to analyze vegetation and soil characteristic, and ordination of subalpine forest vegetation of Daecheongbong area, Mt. Seorak. Communities by characteristic in species composition of subalpine forest were classified into Rhododendron mucronulatum var. ciliatum - Betula ermani community group, Pinus pumila, Abies nephrolepis, Thuja koraiensis, and Rhododendron mucronulatum var. ciliatum - Betula ermanii typical community. The results of the correlation between forest communitie sand soil conditions of Daecheongbong area by DCCA ordination method are as follows: The Pinus pumila community and Thuja koraiensis community were mainly found in the high percentage area of total nitrogen, available phosphorous, organic matter in comparison with Abies nephrolepis community and Rhododendron mucronulatum var. ciliatum - Betula ermanii typical community. The Abies nephrolepis community and Rhododendron mucronulatum var. ciliatum - Betula ermanii typical community were mainly found in the high elevation area in comparison with Pinus pumila community and Thuja koraiensis community. The Pinus pumila community and Thuja koraiensis community were mainly found in the northern and northwestern direction, but Abies nephrolepis community and Rhododendron mucronulatum var. ciliatum - Betula ermanii typical community were mainly found in the southwestern direction.

• Clean Technology
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• v.18 no.3
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• pp.229-249
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• 2012

At present, global warming and depletion of fossil fuels have been one of the big issues which should be solved for sustainable development in the future. CCS (carbon capture and sequestration) technology as the post $CO_2$ reduction technology has been considered as a promising solution for global warming due to increased carbon emission. However, the environmental and ecological effects of CCS have drawn concerns. There are needs for noble post reduction technology. More recently, CCU (carbon capture and utilization) Technology, which emphasizes transforming carbon dioxide into value-added chemicals rather than storing it, has been attracted attentions in terms of preventing global warming and recycling the renewable carbon source. In this paper, various technologies developed for carbon dioxide conversion both in gas and liquid phase have been reviewed. For the thermochemical catalysis in gas phase, the development of the catalytic system which can be performed at mild condition and the separation and purification technology with low energy supply is required. For the photochemical conversion in liquid phase, efficient photosensitizers and photocatalysts should be developed, and the photoelectrochemical systems which can utilize solar and electric energy simultaneously are also in development for more efficient carbon dioxide conversion. The energy needed in CCU must be renewable or unutilized one. CCU will be a key connection technology between renewable energy and bio industry development.