• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.10
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• pp.245-252
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• 2016

The purpose of this study was to examine the relationship between the attachment of college students to parents and peers as intimate or major attachment objects and their self-regulated learning ability. To accomplish this, we conducted a survey with the parents-peer attachment scale and self-regulated learning scale. As a result, it was found that the relationship between their self-regulated learning ability and parents-peer attachment was significant, while the explicit goal-oriented variable as an essential factor in the regulation of their motivation was excluded. In addition, it was found that the effect of peer and mother attachment on their self-regulated learning ability was relatively high. On the other hand, two variables, viz. the test anxiety in motivation regulation and timing and studying regulation in behavior regulation, were heavily influenced by father attachment. These results could be interpreted in two ways. First, there could be a lower relationship between positive relations and comparative advantages and, second, these two items could be closely related to the negative factors in the relationship between father and child.

• Journal of Genetic Medicine
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• v.20 no.2
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• pp.39-45
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• 2023

As advanced sequencing technologies continue to uncover an increasing number of variants in genes associated with human genetic diseases, there is a growing demand for systematic approaches to assess the impact of these variants on human development, health, and disease. While in silico analyses have provided valuable insights, it is essential to complement these findings with model organism studies to determine the functional consequences of genetic variants in vivo. Drosophila melanogaster is an excellent genetic model for such functional studies due to its efficient genetic technologies, high gene conservation with humans, accessibility to mutant fly resources, short life cycles, and cost-effectiveness. The traditional GAL4-UAS system, allowing precise control of gene expression through binary regulation, is frequently employed to assess the effects of monoallelic variants. Recombinase medicated cassette exchange or CRISPR-Cas9-mediated GAL4 insertion within coding introns or substitution of gene body with Kozak-Gal4 result in the loss-of-function of the target gene. This GAL4 insertion strategy also enables the expression of reference complementary DNA (cDNA) or cDNA carrying genetic variants under the control of endogenous regulatory cis elements. Furthermore, the CRISPR-Cas9-directed tissue-specific knockout and cDNA rescue system provides the flexibility to investigate candidate variants in a tissue-specific and/or developmental-timing dependent manner. In this review, we will delve into the diverse genetic techniques available in Drosophila and their applications in diagnosing and studying numerous undiagnosed diseases over the past decade.