• Title/Summary/Keyword: Time-series Analysis

Search Result 3,264, Processing Time 0.029 seconds

The Concurrent Use of Rhus verniciflua Stokes as Complementary Therapy with Second or More Line Regimens on Advanced Non-small-cell Lung Cancer: Case Series

  • Lee, Sang-Hun;Kim, Kyung-Suk;Choi, Won-Cheol;Yoon, Seong-Woo
    • The Journal of Korean Medicine
    • /
    • v.30 no.6
    • /
    • pp.112-117
    • /
    • 2009
  • Objective: Rhus verniciflua Stokes (RVS) has anticancer effect confirmed by preclinical studies and historical records. We thus tried to evaluate retrospectively the effect of RVS as a complementary medicine for patients with advanced non-small-cell lung cancer (NSCLC) showing refractory to conventional chemotherapy. Patients and Methods: From June 1, 2006 to June 30, 2007, patients with advanced NSCLC who received both the standardized RVS extract and a standard course of second or more line therapy such as pemetrexed ($Alimta^{(R)}$), erlotinib ($Tarceva^{(R)}$), and gefitinib ($Iressa^{(R)}$) were checked. A total of 13 patients were eligible for the final analysis after fulfilling inclusion/exclusion criteria. Time to progression (TTP) of these patients treated with the standardized RVS extract was checked in the aftercare period. Results: Patients received RVS treatment for a median period of 296 (range 84-698) days. The median TTP was 220.5 (range 36-489) days, and three patients (23.1%) had TTP values of 15 more months. No significant side effects from RVS treatment have been observed. Conclusion: The standardized RVS extract might have synergetic effects by assisting apoptosis in advanced NSCLC with concurrent standard therapy agents, since it prolonged TTP without significant adverse effects. This study suggests that the standardized RVS extract is beneficial to patients with chemotherapy-refractory NSCLC. Further clinical trials and preclinical studies are necessary to determine the efficacy and safety of the standardized RVS extract in NSCLC.

  • PDF

Analyzing Regional Public Hospitals' Efficiency and Productivity Change (지방의료원의 효율성 및 생산성변화 분석)

  • Jeon, Jin-hwan;Kim, Jong-Ki
    • The Journal of the Korea Contents Association
    • /
    • v.10 no.5
    • /
    • pp.303-313
    • /
    • 2010
  • The purpose of this study is to evaluate the performance efficiency and productivity change of the regional public hospital in Korea. We use DEA(Data Envelopment Analysis) for CCR, BCC model, and MPI(Malmquist Productivity Index). DEA is a useful nonparametric technique for measurement of efficiency of a DMU(Decision Making Unit) and MPI is a evaluation method to measure DMU's productivity change. We utilize 34 regional public hospital's time-series data over 6 years from 2003 to 2008.The results of this study were as follows. First, technical efficiency(TE) shows that approximately 3.6% of inefficiency exists on the regional public hospitals and it reveals that the cause for technical inefficiency is due to scale inefficiency. Second, MPI's results show that regional public hospital made effort to improve total factor productivity change to raise technical efficiency. In order to raise efficiency, the regional public hospitals should deploy internal innovation and the government should support welfare policies.

Wind-driven Current in the East Sea Observed from Mini-met Drifters (기상뜰개로 관측된 동해에서의 취송류)

  • Lee, Dong-Kyu
    • Ocean and Polar Research
    • /
    • v.36 no.2
    • /
    • pp.103-110
    • /
    • 2014
  • A wind-driven current in the East Sea from Lagrangian measurements of wind and current at 15 m using MiniMet drifters was analyzed. Spectral analysis of the current from 217 pieces of a 10 day-long time series shows the dominant energy at the inertial frequency for the current at 15 m. Wind has energy peaks at a 0.2-0.5 cycles per day (cpd) frequency band. The power spectrum of the clockwise rotating component is predominant for the current and was 1.5-2 times larger than the anticlockwise rotating component for wind. Co-spectra between the wind and current show two peak frequency bands at subinertial frequency and 0.5-0.3 cpd. Coherences between the wind and current at those peak frequencies are significant with 95% confidence and phase differences were $90-100^{\circ}$. From the phase differences, the efolding depth is estimated as 17 m and this e-folding depth is smaller than the estimation by Chereskin's (1999) 25 m using a moored Acoustic Doppler Current Profiler and an anemometer installed at the surface buoy. The angle between the wind-driven current (or ageostrophic current) and wind from this study was also much larger than the global estimate by Rio and Hernandez (2003) using reanalysis wind and drifters. The possible explanation for the discrepancy comes from the fact that the current is driven by a wind of smaller length scale than 250 km but the satellite or the reanalysis products do not resolve winds of length scale smaller than 250 km. Large rms differences between Mini-Met and QuickSCAT wind on spatial lags smaller than 175 km substantiate this explanation.

Law Sociological Analysis on Decision Tendency of Appeals for Teachers (법사회학적 접근을 통한 교원소청심사 사건수 및 인용율 경향 분석)

  • Um, Sang-Heon
    • The Journal of the Korea Contents Association
    • /
    • v.13 no.1
    • /
    • pp.199-209
    • /
    • 2013
  • This study seeks to use the law sociological system model, to define the internal and external environmental changes that influence decisions of teacher appeals, and to analyze time-series trends of teacher appeals. This study analyzed appeal cases for 21 years from 1991 to examine number of lawsuits and relief rates by year. As a result, overall, in the case of the 1990s, the relief rates changed irregularly. However, after 2000, overall relief rates declined. This result was discussed to come from the societal request for responsibility of teachers and schools. It was suggested that, to achieve the original objective of appeal system for teachers, there should be a change toward the legal stability.

Analysis of Performance of Focused Beamformer Using Water Pulley Model Array (수차 모형 배열을 이용한 표적추정 (Focused) 빔형성기 성능분석)

  • 최주평;이원철
    • The Journal of the Acoustical Society of Korea
    • /
    • v.20 no.5
    • /
    • pp.83-91
    • /
    • 2001
  • This paper proposes the Focused beamforming to estimate the location of target residing near to the observation platform in the underwater environment. The Focused beamforming technique provides the location of target by the coherent summation of a series of incident spherical waveforms considering distinct propagation delay times at the sensor array. But due to the movement of the observation platform and the variation of the underwater environment, the shape of the sensor array is no longer to be linear but it becomes distorted as the platform moves. Thus the Focused beamforming should be peformed regarding to the geometric shape variation at each time. To estimate the target location, the artificial image plane comprised of cells is constructed, and the delays are calculated from each cell where the target could be proximity to sensors for the coherent summation. After the coherent combining, the beam pattern can be obtained through the Focused beamforming on the image plane. Futhermore to compensate the variation of the shape of the sensor array, the paper utilizes the Nth-order polynomial approximation to estimate the shape of the sensor array obeying the water pulley modeling. Simulation results show the performance of the Focused beamforming for different frequency bands of the radiated signal.

  • PDF

The dynamic stiffness of resilient materials for floor impact sound according to temperature change (온도변화에 따른 바닥충격음 완충재의 동탄성계수 변화)

  • Yeon, Junoh;Goo, Heemo;Lee, Sungchan
    • The Journal of the Acoustical Society of Korea
    • /
    • v.37 no.5
    • /
    • pp.338-342
    • /
    • 2018
  • In order to solve the floor impact sound problem in the upper and lower floors, the Ministry of Land, Transport and Maritime Affairs also notifies the physical properties of the resilient material affecting the floor impact sound level. The dynamic modulus of elasticity and the loss factor before and after heating are most related to the floor impact noise, especially for the cushioning material. Therefore, in this study, the rate of change with respect to the dynamic modulus and loss factor with temperature change was examined by increasing $10^{\circ}C$ by $10^{\circ}C$ from the temperature condition of $70^{\circ}C$ specified in the standard. The dynamic modulus of elasticity and the loss modulus were measured by using the pulse excitation method for eight kinds of samples. The calculation method was calculated by the time series analysis method using the damped vibration waveform.

Demand Forecasting and Activation Policies for Tourism of Fishing Regions (어촌지역 관광의 수요현황.예측과 활성화 정책: 강원도 동해안을 중심으로)

  • Kang, Yun-Ho;Jung, Mun-Soo;Woo, Yang-Ho;Kim, Sang-Gu
    • Journal of Navigation and Port Research
    • /
    • v.33 no.10
    • /
    • pp.757-769
    • /
    • 2009
  • This paper is intended to forecast the demand for tourism of fishing regions and find the public policies to activate it. The paper focuses on the east coast regions in Gangwon-do. The analysis was conducted through time series analyses and surveys of the tourists in the regions. The results of analyses showed that, while the number of tourists(both domestic and foreign) to the regions has increased, the regions have not been able to accommodate them enough to help improve economies of the regions. It was forecasted that the number of tourists will significantly increase in the future. However, that rates of increase, especially the rates of increase of foreign tourists, cannot be evaluated positively compared to those of the past. These results suggested a few local governmental policies to activate tourism in the regions.

An Empirical Study on the Openness and Competition of Special Contractors Market in Korea (전문건설 시장의 개방성과 경쟁성에 관한 실증적 분석)

  • Lee, Jong-Gwang;Hong, Sung-Ho;Kim, Yong-Su
    • Proceedings of the Korean Institute Of Construction Engineering and Management
    • /
    • 2006.11a
    • /
    • pp.431-434
    • /
    • 2006
  • The purpose of this study is to examine the degree of openness and competition in special contractor's market. And the result of this study will present the basis of rational policy making. The literature research and time series analysis are adopted as research method. And the findings of this study are as followed. The study has shown that the degree of openness is high in korean special contractor's market by gradual deregulation of entrance barriers into special contractor's market. And the study has revealed that the degree of competition in special contractor's market is high, revealing that the rate of increase of contract account and the subcontract bid rate have decreased.

  • PDF

Forecasting Daily Demand of Domestic City Gas with Selective Sampling (선별적 샘플링을 이용한 국내 도시가스 일별 수요예측 절차 개발)

  • Lee, Geun-Cheol;Han, Jung-Hee
    • Journal of the Korea Academia-Industrial cooperation Society
    • /
    • v.16 no.10
    • /
    • pp.6860-6868
    • /
    • 2015
  • In this study, we consider a problem of forecasting daily city gas demand of Korea. Forecasting daily gas demand is a daily routine for gas provider, and gas demand needs to be forecasted accurately in order to guarantee secure gas supply. In this study, we analyze the time series of city gas demand in several ways. Data analysis shows that primary factors affecting the city gas demand include the demand of previous day, temperature, day of week, and so on. Incorporating these factors, we developed a multiple linear regression model. Also, we devised a sampling procedure that selectively collects the past data considering the characteristics of the city gas demand. Test results on real data exhibit that the MAPE (Mean Absolute Percentage Error) obtained by the proposed method is about 2.22%, which amounts to 7% of the relative improvement ratio when compared with the existing method in the literature.

Low-Carbon, Green-Growth and Empirical Analysis on Potential for Accomplishment by Industries (저탄소 녹색성장과 산업의 잠재성과에 관한 실증분석)

  • Lee, Myunghun
    • Environmental and Resource Economics Review
    • /
    • v.20 no.1
    • /
    • pp.99-118
    • /
    • 2011
  • 'Low Carbon, Green Growth' may be the achievable target in industry section, depending on whether less reliance on fossil-fuels use can bring higher productivity growth in the long run. This paper tests for the short-run and long-run effects of investment on energy-saving equipments on productivity growth in the Korean manufacturing industries. The investment in energy efficiency causes an increase in costs (measurement effect) in the short-run, but in the long-run likely improve energy intensity and reduce costs (positive real effect) despite the delay in new other investment for technical innovation (negative real effect). A 2SLS regression was attempted to deal with endogeneity of energy-saving investment. The productivity effects were tested for five manufacturing sub-industries showing relatively high energy intensity with annual time series data from 1982 through 2006. No productivity effects were accepted for all five sub-industries except Chemical products. Positive real effect was considered to be exceeded by negative real effect, resulting in decreased productivity growth for Chemical products.

  • PDF