• Nuclear Engineering and Technology
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• 제52권2호
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• pp.230-237
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• 2020

In this part, an implicit time dependent solution is presented for the Boltzmann transport equation discretized by the analytic coarse mesh finite difference method (ACMFD) over the spatial domain as well as the simplified P₃ (SP₃) for the angular variable. In the first part of this work we proposed a SP₃-ACMFD approach to solve the static eigenvalue equations which provide the initial conditions for temp dependent equations. Having solved the 3D multi-group SP₃-ACMFD static equations, an implicit approach is resorted to ensure stability of time steps. An exponential behavior is assumed in transverse integrated equations to establish a relationship between flux moments and currents. Also, analytic integration is benefited for the time-dependent solution of precursor concentration equations. Finally, a multi-channel one-phase thermal hydraulic model is coupled to the proposed methodology. Transient equations are then solved at each step using the GMRES technique. To show the sufficiency of proposed transient SP₃-ACMFD approximation for a full core analysis, a comparison is made using transport peers as the reference. To further demonstrate superiority, results are compared with a 3D multi-group transient diffusion solver developed as a byproduct of this work. Outcomes confirm that the idea can be considered as an economic interim approach which is superior to the diffusion approximation, and comparable with transport in results.

• 한국전산구조공학회논문집
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• 제25권2호
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• pp.155-162
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• 2012

최근의 토목분야의 프로젝트에 있어 장대교량의 건설이 주를 이루고 있으며, 장대교량의 여러 형식 가운데서도 사장교가 현재 계획, 설계 중인 프로젝트에서 상당한 비중을 차지하고 있다. 사장교가 대형화 및 장경간화 됨에 따라, 구조물의 경량화를 위하여 강재를 사용한 사장교가 건설되어 왔다. 그러나 많은 사례에서 주탑은 구조적, 경제적인 이유로 콘크리트로 시공되고 있다. 콘크리트는 재료적 특성상 크리프와 건조수축에 의한 장기거동의 영향을 크게 받는데, 이러한 특성으로 인하여 응력의 재분배와 시공 중 구조계의 변화 등 해석상 고려해야 할 부분이 많아진다. 본 연구에서는 철근콘크리트의 비선형성을 고려한 유한요소해석 프로그램 RCAHEST를 사용하여 콘크리트 주탑을 채택한 사장교 중에 국내 최장의 강사장교인 인천대교를 선택하여 해석을 수행하였다. 실제 시공된 교량의 시공단계해석과 완공 후 시간해석을 통하여 콘크리트 주탑만의 시간 의존적 효과가 사장교 전체계에 미치는 영향을 파악하였다.

• 대한토목학회논문집
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• 제28권1A호
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• pp.15-24
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• 2008

본 논문에서는 프리캐스트 바닥판을 사용한 단순 강합성보에 교축방향으로 프리스트레스를 도입하는 경우, 콘크리트의 장기거동과 PS강재의 릴렉세이션에 의해 발생하는 프리스트레스의 손실과 장기처짐을 계산하기 위한 장기거동해석방법을 제시하였다. 또한 제시된 해석방법을 이용하여 장기거동해석을 수행하였으며, 이를 통해 합성보의 기하형상, 콘크리트강도 및 초기프리스트레스가 프리캐스트 바닥판을 사용한 강합성보의 장기거동에 미치는 영향을 평가하였다. 해석결과 합성보 기하형상의 영향에서 프리스트레스의 손실과 장기처짐에 영향을 미치는 주요인자는 각각 보의 단면적과 단면2차모멘트였다. 마지막으로, 총 프리스트레스 손실에서 크리프에 의한 손실과 건조수축에 의한 손실의 특성을 분석하여 소요 초기프리스트레스의 산정방법을 제안하였다.

• 한국안전학회지
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• 제15권2호
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• pp.8-12
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• 2000

The fatigue crack propagation tests were performed in triangular and holding-time stress waveforms at $650^{\circ}C$. The behavior of fatigue crack propagation was investigated according to waveform. The analysis of high temperature fatigue crack propagation by the stress intensity factor range ${\Delta}K$, elastic fracture mechanics parameter, was not available. The behaviors of high temperature fatigue crack propagation by the J-integral(${\Delta}J_f$, J' and ${\Delta}J_c$), elasto-plastic fracture mechanics parameter, were investigated in a number of stress waveforms. The fast-fast waveform exhibited cycle-dependent(fatigue type), the slow-fast and the hold time with 500sec waveforms appear to be time-dependent(creep type) and the fast-slow and the hold time with 5, 25sec waveforms exhibited conbined behavior of both types(fatigue-creep conbined type).

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 1997년도 가을 학술발표회 논문집
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• pp.42-49
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• 1997

In this paper, the method for soil-structure interaction analyses in the time domain is proposed. The far field soil region which is the outside of the artificial boundary is modeled by using explicit frequency-dependent two dimensional infinite elements which can include multiple wave components propagating into the unbounded medium. Since the dynamic stiffness matrix of the far field soil region using the proposed infinite elements is obtained explicitly in terms of exciting frequencies and constants in the frequency domain, the matrix can be easily transformed into the displacement unit-impulse response matrix, which corresponds to a convolution integral of it in the time domain. To verify the proposed method for soil-structure interaction analyses in the time domain, the displacement responses due to an impulse load on the surface of a soil layer with the rigid bed rock are compared with those obtained by the method in the frequency domain and those by models with extend finite element meshes. Good agreements have been found between them.

• Structural Engineering and Mechanics
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• 제8권6호
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• pp.561-578
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• 1999

The response of a reinforced concrete structure to loading is both immediate and time-dependent. Under a sustained load, the deflections caused by creep and shrinkage may be several times their instantaneous values. The paper describes a general finite element procedure, based on the so-called layered model, to analyse reinforced concrete members, and shows in particular how the simple Step by Step Method may be incorporated into this procedure. By invoking the Modified Newton Raphson Method as a solution procedure, the accuracy of the finite element method is verified against independent test results, and then applied to a variety of problems in order to demonstrate its efficacy. The method forms a general method for analysing highly indeterminate concrete structures in the time domain.

• Biomolecules & Therapeutics
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• 제22권6호
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• pp.519-524
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• 2014

We have previously shown that 2,4,3',5'-tetramethoxystilbene (TMS), a trans-stilbene analogue, induces apoptosis in human cancer cells. However, the detailed mechanisms of mitochondria-dependent apoptosis induced by TMS are not fully understood. In the present study, the possible roles of annexin A5 in TMS-mediated apoptosis were investigated in MCF7 human breast cancer cells. Quantitative real-time PCR analysis and Western blot analysis showed that the expression of annexin A5 was strongly increased in TMS-treated cells. TMS caused a strong translocation of annexin A5 from cytosol into mitochondria. Confocal laser scanning microscopic analysis clearly showed that TMS induced translocation of annexin A5 into mitochondria. TMS increased the expression and oligomerization of voltage-dependent anion channel (VDAC) 1, which may promote mitochondria-dependent apoptosis through disruption of mitochondrial membrane potential. When cells were treated with TMS, the levels of Bax, and Bak as well as annexin A5 were strongly enhanced. Moreover, we found that the cytosolic release of apoptogenic factors such as cytochrome c, or apoptosis-inducing factor (AIF) in mitochondria was markedly increased. Annexin A5 depletion by siRNA led to decreased proapoptotic factors such as Bax, Bak, and annexin A5. Taken together, our results indicate that annexin A5 may play an important role in TMS-mediated mitochondrial apoptosis through the regulation of proapoptotic proteins and VDAC1 expression.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 2003년도 추계학술발표대회 요약집
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• pp.56-56
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• 2003

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2005년도 춘계 학술발표회 논문집
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• pp.400-407
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• 2005

The reinforcing effect of modified structure of PSC beams is analyzed in this study. The PSC beams are closed by precast half panels embeding PS tendons at the bottom flange of I-bear The stiffness of box structure is larger and the PS force at half panels makes a time-dependent upward camber of superstructures. The superstructure becomes a second composite structure among 3 elements-PSC ben RC slab, PSC Panel. The time-dependent creep and shrinkage effect at PSC Panels and structural behavior is verified considering construction sequences. The optimal range of to-box reinforcing method is surveyed through reliability analysis.

• International Journal of Oral Biology
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• 제32권3호
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• pp.113-118
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• 2007

Treatment of oral cancers with chemotherapeutic agents become evaluated as an effective method to reduce cancer cell proliferation. Anti-proliferative and anti-oral cancer activities of momordin I on oral cancer cells were evaluated in this study. Momordin I was originally purified from a natural product, Ampelopsis radix and showed the antiproliferative activity against oral carcinoma, KB cells. Obtained $IC_{50}$ value was approximately $10.4{\mu}g/ml$. Time-and dose-dependent chromosomal DNA fragmentations were observed in momordin I-treated KB cells. Flow cytometry analysis showed time-dependent apoptotic cell appearance after treatment of momordin I. Approximately 18.6% apoptotic cells were observed at 72 hours after $20{\mu}g/ml$ of momordin I treatment. These observation were consistent with the results obtained in DNA fragmentation analysis. These data suggest that momordin I has anti-proliferative effect and induces cell death in KB cells through apoptosis.