• 한국구조물진단유지관리공학회 논문집
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• 제6권2호
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• pp.183-194
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• 2002

A general procedure to evaluate the sensitivity of design variables to stresses and strains in PSC flexural members is proposed. To accomplish the purpose of this study, long-term losses including creep, shrinkage, and PS steel relaxation are formulated based on the equilibrium states of the deformed sectional geometry. Thereby, the formulation follows the basic steps which consider the fundamental formulas adopted by CEB-FIP, ACI, and KCI rather than the age adjusted effective modulus concept. Twenty-one design variable including the material and geometrical properties of concrete, nonprestressing steel and prestressing steel, and the geometry of the cross section are considered in the sensitivity analysis. The gradients of the stresses and strains needed for the sensitivity assessment are calculated in a closed format. The derived formulation is applied to the T-type section PSC beam with prestressing and nonprestressing steels for the sensitivity analysis. The analytically calculated sensitivity results are compared with those numerically calculated to ensure the validity of the proposed procedure.

• The Korean Journal of Physiology and Pharmacology
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• 제10권6호
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• pp.297-302
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• 2006

Melittin, a major component of bee venom, produces a sustained decrease in mechanical threshold, and an increase in spontaneous flinchings and paw thickness, which are characteristics similar to those induced by whole bee venom. Melittin-induced nociception has been known to be modulated by the changes in the activity of excitatory amino acid receptors, voltage-dependent calcium channels, cyclooxygenase and serotonin receptors. The present study was undertaken to investigate the role of calcium chelators (TMB-8 & Quin 2) in melittin-induced nociceptive responses. Changes of mechanical threshold and spontaneous flinching behaviors were measured at a given time point following intraplantar injection of melittin ($30{\mu}g/paw$). Intrathecal or intraplantar pre-administration and intrathecal posttreatment of TMB-8 and Quin 2 significantly prevented the melittin-induced reduction of mechanical threshold, and intraplantar or intrathecal pre-treatment of TMB-8 and Quin 2 suppressed melittininduced flinching behaviors. These results indicate that calcium ion in the spinal dorsal horn neurons and peripheral nerves plays an important role in the production and maintenance of mechanical allodynia and spontaneous pain by melittin.

• Nuclear Engineering and Technology
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• 제50권7호
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• pp.1068-1078
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• 2018

Experiments were performed to investigate bubble behaviors and pool boiling Critical Heat Flux (CHF) on a thin flat rectangular copper heater fabricated on Printed Circuit Board (PCB), at various inclination angles. The surface inclination angles were $0^{\circ}$, $45^{\circ}$, $90^{\circ}$, $135^{\circ}$, and $180^{\circ}$. Results showed the Onset of Nucleate Boiling (ONB) heat flux increased with increasing heater orientation from $0^{\circ}$ to $90^{\circ}$, while early ONB occurred when the heater faced downwards ($135^{\circ}$ and $180^{\circ}$). The nucleate boiling was observed to be unstable at low heat flux (1-21% of CHF) and changed into typical boiling when the heat flux was above 21% of CHF. The result shows the CHF decreased with increasing heater orientation from $0^{\circ}$ to $180^{\circ}$. In addition, the bubble departure diameter at the heater facing upwards ($0^{\circ}$, $45^{\circ}$, and $90^{\circ}$) was more prominent compared to that of the heater facing downward ($135^{\circ}$). The nucleation site density also observed increased with increasing heat flux. Moreover, the departed bubbles with larger size were observed to require a longer time to re-heat and activate new nucleation sites. These results proved that the ONB, CHF, and bubble dynamics were strongly dependent on the heater surface orientation.

• 한국산학기술학회논문지
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• 제21권6호
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• pp.603-610
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• 2020

이 연구는 우리나라 청소년의 정신건강 관련요인을 도출하고자 시도하였는데 특히, 인터넷 사용 영향을 중심으로 하였다. 2018년도에 조사된 제14차 청소년건강행태조사의 원시자료를 분석한 것이다. 대상자는 60,040명으로 남학생 50.7%, 여학생 49.3%였으며, 고등학생 49.7%, 중학생 50.3% 등이었다. 종속변수는 스트레스, 슬픔 및 절망감, 자살생각, 자살계획, 그리고 자살시도이며, 독립변수는 성, 연령, 건강생활 행동과 인터넷 사용시간 등으로 관련요인 도출을 위하여 로지스틱 회귀분석을 적용하였다. 모든 종속변수에 대하여 성, 학년, 경제수준, 학업성적 등이 주요 기여변수로 도출되었고 특히 인터넷 사용시간은 스트레스와 선형적인 관계가 있고, 슬픔, 절망감, 자살생각, 자살계획에서는 사용시간이 '상'인 학생이 더욱 유의한 영향을 보여 결론적으로 인터넷 사용시간은 청소년의 정신건강에 해로운 영향을 미친다는 것을 알 수 있었다.

• Biomolecules & Therapeutics
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• 제25권6호
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• pp.586-592
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• 2017

Sinomenium acutum has been long used in the preparations of traditional medicine in Japan, China and Korea for the treatment of various disorders including rheumatism, fever, pulmonary diseases and mood disorders. Recently, it was reported that Sinomenium acutum, has sedative and anxiolytic effects mediated by GABA-ergic systems. These experiments were performed to investigate whether sinomenine (SIN), an alkaloid derived from Sinomenium acutum enhances pentobarbital-induced sleep via ${\gamma}$-aminobutyric acid (GABA)-ergic systems, and modulates sleep architecture in mice. Oral administration of SIN (40 mg/kg) markedly reduced spontaneous locomotor activity, similar to diazepam (a benzodiazepine agonist) in mice. SIN shortened sleep latency, and increased total sleep time in a dose-dependent manner when co-administrated with pentobarbital (42 mg/kg, i.p.). SIN also increased the number of sleeping mice and total sleep time by concomitant administration with the sub-hypnotic dosage of pentobarbital (28 mg/kg, i.p.). SIN reduced the number of sleep-wake cycles, and increased total sleep time and non-rapid eye movement (NREM) sleep. In addition, SIN also increased chloride influx in the primary cultured hypothalamic neuronal cells. Furthermore, protein overexpression of glutamic acid decarboxylase ($GAD_{65/67}$) and $GABA_A$ receptor subunits by western blot were found, being activated by SIN. In conclusion, SIN augments pentobarbital-induced sleeping behaviors through $GABA_A$-ergic systems, and increased NREM sleep. It could be a candidate for the treatment of insomnia.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2008년도 춘계학술대회 및 기술 세미나 논문집 디스플레이 광소자
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• pp.27-28
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• 2008

We have studied an organic layer-thickness dependent electrical and optical properties of organic light-emitting diodes in a device structure of ITO/TPD/$Alq_3$/LiF/Al. While a hole-transport layer thickness of TPD was varied from 35 to 65nm, an emissive layer thickness of $Alq_3$ was varied from 50 to 100nm. A ratio of those two layers was kept to about 2:3. Variation of the layer thickness changes a traverse time of injected carriers across the organic layer, so that it may affect on the chance of probability of exciton formation. Current-voltage-luminance characteristics of the devices show that there are typical rectifying behaviors, and the luminance reaches about $30,000cd/m^2$. Thickness-dependent current efficiency shows that there is a gradual increase of the efficiency as the total layer thickness increases. The efficiency becomes saturated to be about 10cd/A when the total thickness is above 140nm. They show that emission was from the $Alq_3$ layer, because the peak wavelength is about 525nm. View angle-dependent emission spectra show that the emission intensity decreases as the angle increases.

• 대한기계학회논문집
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• 제19권9호
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• pp.2133-2141
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• 1995

The thermo-mechanical fatigue tests were performed on the specimens extracted from 1.5Cr-0. 67Mo-0.33V alloy. The characteristics of thermo-mechanical fatigue crack propagation were examined and reviewed in view of fracture mechanics. The results obtained from the present study are summarized as follows : (1) The propagation characteristics of isothermal low-cycle fatigue crack are dominated by .DELTA.J$_{f}$ in case of PP waveform, and .DELTA.J$_{c}$ in case of CP waveform. (II)The propagation characteristics of thermo-mechanical fatigue crack are dominated by .DELTA.J$_{c}$ for in-phase case, and by .DELTA.J$_{c}$ for out-of-phase. The present results were in good agreement with the equation of propagation law for isothermal low-cycle fatigue crack in case of thermo-mechanical fatigue.tigue.e.

• Steel and Composite Structures
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• 제29권1호
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• pp.53-66
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• 2018

A high-order nonlocal strain gradient model is developed for wave propagation analysis of porous FG nanoplates resting on a gradient hybrid foundation in thermal environment, for the first time. Material properties are assumed to be temperature-dependent and graded in the nanoplate thickness direction. To consider the thermal effects, uniform, linear, nonlinear, exponential, and sinusoidal temperature distributions are considered for temperature-dependent FG material properties. On the basis of the refined-higher order shear deformation plate theory (R-HSDT) in conjunction with the bi-Helmholtz nonlocal strain gradient theory (B-H NSGT), Hamilton's principle is used to derive the equations of wave motion. Then the dispersion relation between frequency and wave number is solved analytically. The influences of various parameters (such as temperature rise, volume fraction index, porosity volume fraction, lower and higher order nonlocal parameters, material characteristic parameter, foundations components, and wave number) on the wave propagation behaviors of porous FG nanoplates are investigated in detail.

• 콘크리트학회논문집
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• 제21권5호
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• pp.619-628
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• 2009

콘크리트구조물의 시간의존거동을 예측하기 위해서 콘크리트의 크리프와 건조수축 등 시간의존특성을 묘사하는 모델을 이용한다. 그러나 크리프와 건조수축 모델 자체의 불확실성과 환경조건의 불확실성 때문에 이러한 모델을 이용하여 얻은 처짐과 실제로 측정된 처짐 사이에는 상당한 차이가 있다. 이러한 오차와 불확실성을 줄이기 위하여 실제 구조물에 이용된 콘크리트를 이용한 크리프 시험에 의한 결과를 이용하여 모델의 불확실성을 줄이는 노력을 하기도 한다. 하지만 이 방법도 실제 구조물이 놓인 환경조건을 정확히 모사할 수 없다는 점과 재료 자체의 불확실성 때문에 실험에서 얻은 크리프와 건조수축의 예측 값이 실제 구조물에서 발생하는 값과 다를 수 있다. 이 연구에서는 콘크리트의 시간의존거동에 영향을 미치는 요소 중 크리프에 대하여 살펴보고, 크리프 모델 불확실성 인자를 오차요인으로 고려하여 콘크리트 부재에서 측정된 처짐으로부터 크리프 계수를 추정하는 방법을 제시하였다. 이중 강합성 거더와 콘크리트 보 부재의 해석 예제를 통하여 이 연구에서 제시하는 방법의 타당성을 검증하였다. 이 연구에서 제시된 크리프를 오차요인으로 보고 크리프 계수를 추정하는 방법은 특히, 장지간 PSC 교량이나 콘크리트 사장교처럼 처짐이 중요한 형상관리인자인 경우에 구조물의 장기거동에 대한 합리적 예측에 도움을 줄 것으로 사료된다.

• 마이크로전자및패키징학회지
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• 제17권2호
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• pp.21-28
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• 2010

본 논문에서는 온도 사이클이 진행되는 동안 비선형 거동과 크립 거동을 보이는 FC-PBGA 패키지 솔더볼의 변형거동을 알아보기 위하여 시간에 종속하는 거동을 적용 시킬 수 있는 점소성 모델과 크립 모델에 대하여 유한요소해석을 수행하였다. 유한요소해석 결과의 신뢰성을 평가하기 위하여 무아레 간섭계를 이용하여 온도변화에 따른 열변형 실험을 수행하였다. 전체적인 굽힘변위는 Anand 모델과 변형률 분리 모델 모두 실험결과와 잘 일치하였으나 솔더볼의 변형률은 Anand 모델의 경우 큰 차이를 보이고 변형률 분리 모델의 경우 상당히 일치하는 계산결과를 얻었다. 따라서 본 논문에서는 변형률 분리 모델을 이용하여 시간에 종속하는 FC-PBGA 패키지 솔더볼의 크립 거동을 검토하였다. 솔더를 포함한 패키지에 온도변화가 생길 때 고온에서는 시간이 지남에 따라 크립 거동에 의해 솔더의 응력이 점차 완화되는 현상을 나타내고 있음을 알 수 있었다.