• The Korean Journal of Pain
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• v.35 no.3
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• pp.271-279
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• 2022

Background: Inflammation is known to underlie the pathogenesis in neuropathic pain. This study investigated the anti-inflammatory and neuroprotective mechanisms involved in antinociceptive effects of co-administration of acetaminophen and L-carnosine in chronic constriction injury (CCI)-induced peripheral neuropathy in male Wistar rats. Methods: Fifty-six male Wistar rats were randomly divided into seven experimental groups (n = 8) treated with normal saline/acetaminophen/acetaminophen + L-carnosine. CCI was used to induce neuropathic pain in rats. Hyperalgesia and allodynia were assessed using hotplate and von Frey tests, respectively. Investigation of spinal proinflammatory cytokines and antioxidant system were carried out after twenty-one days of treatment. Results: The results showed that the co-administration of acetaminophen and L-carnosine significantly (P < 0.001) increased the paw withdrawal threshold to thermal and mechanical stimuli in ligated rats compared to the ligated naïve group. There was a significant (P < 0.001) decrease in the levels of nuclear factor kappa light chain enhancer B cell inhibitor, calcium ion, interleukin-1-beta, and tumour necrotic factor-alpha in the spinal cord of the group coadministered with acetaminophen and L-carnosine compared to the ligated control group. Co-administration with acetaminophen and L-carnosine increased the antioxidant enzymatic activities and reduced the lipid peroxidation in the spinal cord. Conclusions: Co-administration of acetaminophen and L-carnosine has anti-inflammatory effects as a mechanism that mediate its antinociceptive effects in CCI-induced peripheral neuropathy in Wistar rat.

• Journal of Practical Engineering Education
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• v.14 no.2
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• pp.413-423
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• 2022

The purpose of this study is to analyze the role of the job competency assessor who assess achievement of job performance ability based on NCS (educational training, qualifications, field experience, etc.) through competency assessment. For this purpose, job analysis including development and verification of the job model and selection of core task are conducted. As a result, main duties of the job competency assessor are to understand the NCS based assessment principle, establish an assessment plan, design and develop assessment tools, assess competence, provide feedback and re-assessment, record and manage assessment result, verify the internal assessment result, establish the RPL (recognition of prior learning) plan, implement the RPL and verify the RPL assessment result, and 48 task are derived. In addition, a total of 21 core tasks are derived based on the threshold value multiplied by the importance and difficulty of the task for each duty. Based on this, implications for job analysis of the job competency assessor are presented.

• Smart Structures and Systems
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• v.31 no.4
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• pp.421-436
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• 2023

This paper presents a vibration displacement measurement and damage identification method for a space truss structure from its vibration videos. Features from Accelerated Segment Test (FAST) algorithm is combined with adaptive threshold strategy to detect the feature points of high quality within the Region of Interest (ROI), around each node of the truss structure. Then these points are tracked by Kanade-Lucas-Tomasi (KLT) algorithm along the video frame sequences to obtain the vibration displacement time histories. For some cases with the image plane not parallel to the truss structural plane, the scale factors cannot be applied directly. Therefore, these videos are processed with homography transformation. After scale factor adaptation, tracking results are expressed in physical units and compared with ground truth data. The main operational frequencies and the corresponding mode shapes are identified by using Subspace Stochastic Identification (SSI) from the obtained vibration displacement responses and compared with ground truth data. Structural damages are quantified by elemental stiffness reductions. A Bayesian inference-based objective function is constructed based on natural frequencies to identify the damage by model updating. The Success-History based Adaptive Differential Evolution with Linear Population Size Reduction (L-SHADE) is applied to minimise the objective function by tuning the damage parameter of each element. The locations and severities of damage in each case are then identified. The accuracy and effectiveness are verified by comparison of the identified results with the ground truth data.

• Journal of Korean Neurosurgical Society
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• v.66 no.4
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• pp.409-417
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• 2023

Objective : The association between boule (BOLL) and endothelin receptor type A (EDNRA) loci and intracranial aneurysm (IA) formation has been reported via genome-wide association studies. We sought to identify genome-wide interactions involving BOLL and EDNRA loci for IA in a Korean adult cohort. Methods : Genome-wide pairwise interaction analyses of BOLL and EDNRA involving 250 patients with IA and 296 controls were performed using the additive effect model after adjusting for confounding factors. Results : Among 512575 single-nucleotide polymorphisms (SNPs), 23 and 11 common SNPs suggested a genome-wide interaction threshold (p<1.25×10^-8) involving rs700651 (BOLL) and rs6841581 (EDNRA). Rather than singe SNP effect of BOLL or EDNRA on IA development, they showed a synergistic effect on IA formation via multifactorial pair-wise interactions. The rs1105980 of PTCH1 gene showed the most significant interaction with rs700651 (natural log-transformed odds ratio [lnOR], 1.53; p=6.41×10^-11). The rs74585958 of RYK gene interacted strongly with rs6841581 (lnOR, -19.91; p=1.64×10^-9). Although, there was no direct interaction between BOLL and EDNRA variants, two EDNRA-interacting gene variants of TNIK (rs11925024 and rs1231) and FTO (rs9302654), and one BOLL-interacting METTL4 gene variant (rs549315) exhibited marginal interaction with BOLL gene. Conclusion : BOLL or EDNRA may have a synergistic effect on IA formation via multifactorial pair-wise interactions.

• Proceedings of the Korea Water Resources Association Conference
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• 2020.06a
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• pp.182-182
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• 2020

최근 지구 온난화나 기상이변으로 인해 세계각지에서 많은 자연재해가 발생하고 있고 우리나라도 최근 전국 각지에서 국지성호우에 의한 많은 피해가 발생하고 있다. 특히 국지성호우로 인해 발생하는 산간지역의 토석류는 많은 재산피해를 일으키고 있다. 최근 토석, 토사, 혹은 부유 잡목 등의 유출로 인한 피해를 막기 위해 많은 사방댐을 축조하고 있으나 표면침식에 의해서 유출되는 토석량 혹은 토사량을 정확히 예측하지 못한다면 축조된 사방댐은 금방 제구실을 못할 수 있거나 혹은 과대 설계 및 시공되어 건설비를 낭비할 수 있다. 따라서 최적의 사방댐 건설을 위해 정확한 토석량의 산정은 매우 중요한 전제조건이라 할 수 있다. 본 연구에서는 강원도 인제군 산간지역 4곳의 사방댐유역에 대해 토석량 예측모형 MSDPM(Multi-Sequence Debris Prediction Model)과 LADMP(Los Angeles District Method for Prediction of sediments yield)를 이용하여 산정한 토석량과 실제 준설량을 비교하였다. 이를 위해 강원 산간지역에 맞도록 예측모형을 보정하였으며 토석류 유발 강우강도(Threshold Maximum 1-hr Rainfall Intensity)와 토석류 유발 최소강우량(Total Minimum Rainfall Amount)개념을 도입하여 예측모형식을 적용하였다. 위 식이 갖고 있는 대표적 특징 중 하나인 산불계수를 사용해야 하지만 본 연구지역은 산불 피해규모가 미미하여 산불의 영향은 고려하지 않고 토석량을 산정하였다. 두 예측모형의 계산결과와 실제 준설량을 비교해본 결과, MSDPM의 결과가 LADMP의 결과보다 준설량과 더 일치하는 것으로 나타났다. 실제 준설량과 MSDPM의 계산결과는 평균 17.37%의 차이를 나타냈고 LADMP의 계산결과는 평균 41.87%의 차이를 나타냈다. 본 연구에서 사용된 토석량 예측 모형은 앞으로 많은 산지유역의 토석량 예측에 사용이 가능 할 것으로 판단된다. 하지만 본 연구에서 사용된 자료의 제한성 때문에 앞으로 많은 실측 준설자료를 통하여 예측모형식을 보정하는 작업이 우선되어야 할 것으로 판단된다. 이를 위해서 많은 산지유역의 토석량을 장시간 실측하여 데이터를 축적하고 이를 사용하여 다양한 토석량 예측모형을 검보정하는 노력이 필요할 것으로 판단된다.

• Korean Journal of Environmental Agriculture
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• v.41 no.4
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• pp.261-275
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• 2022

BACKGROUND: Prior to implementing a positive list system (PLS), there is a need to establish acceptable daily intake (ADI) and maximum residue limit (MRL) for veterinary drugs that have been approved a few decades ago in South Korea. On top of that, chronic dietary exposure assessment of veterinary drug residues should be performed to determine whether the use of these veterinary drugs would cause health concerns or not. METHODS AND RESULTS: To establish the ADI, the relevant toxicological data were collected from evaluation reports issued by international organizations. A slightly modified global estimate of chronic dietary exposure (GECDE) model was employed in the exposure assessment owing to the limited residual data. Therefore, only the ADI of ephedrine was established due to insufficient data for the other veterinary drugs. Thus, instead of ADI, the threshold of toxicological concern (TTC) value was used for the other drugs. Lastly, the hazard index (HI) was calculated, except for etizazole hydrochloride, due to the potential of mutagenicity. CONCLUSION(S): The HI values of ephedrine, menichlopholan, and anacolin were found to be as high as 6.4%, suggesting that chronic dietary exposure to the residues from these uses was unlikely to be a public health concern. Further research for exposure assessment of veterinary drug residues should be performed using up-todate Korean national health and nutrition examination survey (KNHANES) food consumption data. In addition, all relevant available data sources should be utilized for identifying the potentials of toxicity.

• Animal Bioscience
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• v.37 no.1
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• pp.16-27
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• 2024

Objective: The objective of this study was to investigate the effect of heat stress on the growth traits and genetic parameters of Thai native chickens. Methods: A total of 16,487 records for growth traits of Thai native chickens between 2017 and 2022 were used in this study. Data included the body weight at birth, body weight at 4, 8, and 12 weeks of age (BW0, BW4, BW8, BW12), average daily gain during 0 to 4, 4 to 8, and 8 to 12 weeks of age (ADG0-4, ADG4-8, ADG8-12), absolute growth rate at birth, at 4, 8, and 12 weeks of age (AGR0, AGR4, AGR8, AGR12). The repeatability test day model used the reaction-norm procedure to analyze the threshold point of heat stress, rate of decline of growth traits, and genetic parameters. Results: At temperature and humidity index (THI) of 76, Thai native chickens began to lose their growth traits, which was the onset of heat stress in this study. The estimated heritability, genetic correlation between animal and heat stress effect, and correlations between the intercept and slope of the permanent environmental effects were 0.27, -0.85, and -0.83 for BW, 0.17, -0.81, and -0.95 for ADG, 0.25, -0.61, and -0.83 for AGR, respectively. Male chickens are more affected by heat stress than female chickens with a greater reduction of BW, ADG, and AGR, values equal to -9.30, -0.23, -15.21 (in males) and -6.04, -0.21, -10.10 (in females) gram per 1 level increase of THI from the THI of 76. Conclusion: The influence of thermal stress had a strong effect on the decline in growth traits and genetic parameters in Thai native chickens. This study indicated that genetic models used in conjunction with THI data are an effective method for the analysis and assessment of the effects of heat stress on the growth traits and genetics of native chickens.

• Information Systems Review
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• v.25 no.3
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• pp.1-26
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• 2023

A theoretical model of information overload (Jackson and Farzaneh, 2012) with its three influential components (i.e., time, technology, and social networks) was empirically tested in the context of news consumption behavior considered as a communicative outcome. Using a national sample of South Korean adults (N = 1166), data analyses identified perceived information overload and large/diverse social networks positively associated with active and passive news consumption. Findings may imply the existence of individually varying cognitive threshold (i.e., tipping point), if crossed individuals cannot process information any further. News consumers may keep searching and receiving information to verify factuality of news even when they feel overloaded.

• Journal of Korea Society of Industrial Information Systems
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• v.29 no.2
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• pp.69-80
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• 2024

In this paper, we studied a discrete-time queuing system that operates under a mixed situation of D-policy and T-policy, one of the representative server control policies in queuing theory. A single server serves customers arriving by Bernoulli arrival process on a first-in, first-out basis(FIFO). If there are no customers to serve in the system, the server goes on vacation and returns, until the total service time (i.e., total amount of workload) of waiting customers exceeds predetermined workload threshold D. The operation of the system covered in this study can be used to model the efficient resource utilization of mobile devices using secondary batteries. In addition, it is significant in that the steady state waiting time and system sojourn time of the queuing system under a flexible mixed control policy were derived within a unified framework.

• The Journal of the Acoustical Society of Korea
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• v.28 no.5
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• pp.447-453
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• 2009

This paper introduces the method for detect voices and exact end point at low SNR by maximizing voice energy. Conventional VAD (Voice Activity Detection) algorithm estimates noise level so it tends to detect the end point inaccurately. Moreover, because it uses relatively long analysis range for reflecting temporal change of noise, computing load too high for application. In this paper, the SEM-VAD (Speech Energy Maximization-Voice Activity Detection) method which uses psycho-acoustical bark scale filter banks to maximize voice energy within frames is introduced. Stable threshold values are obtained at various noise environments (SNR 15 dB, 10 dB, 5 dB, 0 dB). At the test for voice detection in car noisy environment, PHR (Pause Hit Rate) was 100%accurate at every noise environment, and FAR (False Alarm Rate) shows 0% at SNR15 dB and 10 dB, 5.6% at SNR5 dB and 9.5% at SNR0 dB.