• Journal of Biomedical Engineering Research
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• v.37 no.2
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• pp.84-89
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• 2016

In this study, we proposed ameliorated method for region of interest (ROI) study to improve its accuracy using partial volume effect (PVE). PVE which arose in volumetric images when more than one tissue type occur in a voxel, could be used to reduce an amount of gray matter and cerebrospinal fluid within ROI of diffusion tensor image (DTI). In order to define ROIs, individual b0 image was spatially aligned to the JHU DTI-based atlas using linear and non-linear registration (http://cmrm.med.jhmi.edu/). Fractional anisotropy (FA) and mean diffusivity (MD) maps were estimated by fitting diffusion tensor model to each image voxel, and their mean values were computed within each ROI with PVE threshold. Participants of this study consisted of 20 healthy controls, 27 Alzheimer's disease and 27 normal-pressure hydrocephalus patients. The result showed that the mean FA and MD of each ROI were increased and decreased respectively, but standard deviation was significantly decreased when PVE was applied. In conclusion, the proposed method suggested that PVE was indispensable to improve an accuracy of DTI ROI study.

• Communications for Statistical Applications and Methods
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• v.18 no.2
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• pp.171-177
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• 2011

In order to construct approximation functions for real data, it is necessary to remove the outliers from the measured raw data before constructing the model. Conventionally, visualization and maximum residual error have been used for outlier detection, but they often fail to detect outliers for nonlinear functions with multidimensional input. Although the standard support vector regression based outlier detection methods for nonlinear function with multidimensional input have achieved good performance, they have practical issues in computational cost and parameter adjustments. In this paper we propose a practical approach to outlier detection using support vector regression that reduces computational time and defines outlier threshold suitably. We apply this approach to real data examples for validity.

• Journal of Biosystems Engineering
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• v.38 no.2
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• pp.129-137
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• 2013

Purpose: Modeling has been used for elucidating the mechanism of complex biosystems. In spite of importance and uniqueness of adolescent calcium (Ca) metabolism characterized by a threshold Ca intake, its regulatory mechanism has not been covered and even not proposed. Hence, this study aims at model-based proposing potential mechanisms regulating adolescent Ca metabolism. Methods: Two different hypothetic mechanisms were proposed. The main mechanism is conceived based on Ca-protein binding which induces renal Ca filtration, while additional mechanism assumed that active renal Ca re-absorption regulated Ca metabolism in adolescents. Mathematical models were developed to represent the proposed mechanism and simulated them whether they could produce adolescent Ca profiles in serum and urine. Results: Simulation showed that both mechanisms resulted in the unique behavior of Ca metabolism in adolescents. Based on the simulation insulin-like growth factor-1 (IGF-1) is suggested as a potential regulator because it is related to both growth, a remarkable characteristic of adolescence, and Ca metabolism including absorption and bone accretion. Then, descriptive modeling is employed to conceptualize the hypothesized mechanisms governing adolescent Ca metabolism. Conclusions: This study demonstrated that modeling is a powerful tool for elucidating an unknown mechanism by simulating potential regulatory mechanisms in adolescent Ca metabolism. It is expected that various analytic applications would be plausible in the study of biosystems, particularly with combination of experimental and modeling approaches.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.11 no.9
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• pp.4180-4196
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• 2017

In this paper, we analyze average capacity of an amplify-and-forward (AF) cooperative communication system model in multi-relay multiuser networks. In contrast to conventional cooperative networks, relays in the considered network have no embedded energy supply. They need to rely on the energy harvested from the signals broadcasted by the source for their cooperative information transmission. Based on this structure, a two-step selection scheme is proposed considering both channel state information (CSI) and battery status of relays. Assuming each relay has infinite or finite energy storage for accumulating the energy, we use the infinite or finite Markov chain to capture the evolution of relay batteries and certain simplified assumptions to reduce computational complexity of the Markov chain analysis. The approximate closed-form expressions for the average capacity of the proposed scheme are derived. All theoretical results are validated by numerical simulations. The impacts of the system parameters, such as relay or user number, energy harvesting threshold and battery size, on the capacity performance are extensively investigated. Results show that although the performance of our scheme is inferior to the optimal joint selection scheme, it is still a practical scheme because its complexity is much lower than that of the optimal scheme.

• Journal of Animal Environmental Science
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• v.20 no.2
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• pp.41-48
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• 2014

This study was conducted to investigate the dispersion prediction of odor from swine farms in Korea. Gaussian Plume model used in considering of farm size, wind velocity, atmospheric stability and threshold odor unit to prediction of odor dispersion based on the survey on current state of odor emission and control from 48 site of swine farms. Farm size, wind velocity and atmospheric stability were affected the distance of odor dispersion, showed longer distance in cases of large farm, low wind velocity and stable atmospheric condition. We will suggestion the adjusted distance of odor dispersion according to farm size was estimated to 180 m in small farm and 320 m in large farm when apply the 3 OU, 5 m/s wind velocity and stable atmospheric condition.

• Geomechanics and Engineering
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• v.1 no.3
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• pp.193-204
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• 2009

A 10.4-m high highway embankment retained behind mechanically stabilized earth (MSE) walls is under construction in the northeastern part of the Indian state of Bihar. The structure is constructed with compacted, micaceous, grey, silty sand, reinforced with polyester (PET) geogrids, and faced with reinforced cement concrete fascia panels. The connections between the fascia panels and the geogrids failed on several occasions during the monsoon seasons of 2007 and 2008 following episodes of heavy rainfall, when the embankment was still under construction. However, during these incidents the MSE embankment itself remained by and large stable and the collateral damages were minimal. The observational data during these incidents presented an opportunity to develop and calibrate a simple procedure for estimating rainfall induced pore water pressure development within MSE embankments constructed with backfill materials that do not allow unimpeded seepage. A simple analytical finite element model was developed for the purpose. The modeling results were found to agree with the observational and meteorological records from the site. These results also indicated that the threshold rainwater infiltration flux needed for the development of pore water pressure within an MSE embankment is a monotonically increasing function of the hydraulic conductivity of backfill. Specifically for the MSE embankment upon which this study is based, the analytical results indicated that the instabilities could have been avoided by having in place a chimney drain immediately behind the fascia panels.

• Proceedings of the Ginseng society Conference
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• 1984.09a
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• pp.141-144
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• 1984

With microorganism as a single cell model to investigate the cellular effect of total extract of ginseng powder, it was found that ginseng affects cellular respiration biphasically (Tso and Fung, 1980; Tso, 1981). As ginseng is recognized to be a tonic medicinal herb, this finding suggests a possible role of ginseng in altering cellular energy metabolism. Along this line, the same effect on mitochondrial oxygen consumption was studied. It was found that under a controlled pH condition, a significant stimulation of the mitochondrial respiration was observed. This stimulation was ginseng dose-dependent. However, when ginseng was applied at an above threshold concentration, an inhibitory effect was noted. This confirms the previous observation with single cell organism and suggests a universal regulation of energy metabolism effect that transcends cell origin.

• Nuclear Engineering and Technology
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• v.39 no.5
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• pp.627-636
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• 2007

The present work is aimed at further discussing the effectiveness of dimensionless parameters recently proposed for the analysis of flow stability in heated channels with supercritical fluids. In this purpose, after presenting the main motivations for the introduction of these parameters in place of previously proposed ones, additional information on the theoretical bases and on the consequences of this development is provided. Stability maps, generated by an in-house program adapted from a previous application to boiling channels, are also shown for different combinations of the operating parameters. The maps are obtained as contour plots of an amplification parameter obtained from numerical discretization and subsequent linearization of governing equations; as such, they provide a quantitatively clear perspective of the effect of different boundary conditions on the stability of heated channels with supercritical fluids. In order to assess the validity of the assumptions at the basis of the in-house model, supporting calculations have been performed making use of the RELAP5/MOD3.3 computer code, detecting the values of the dimensionless parameters at the threshold for the occurrence of instability for a heated channel representative of SCWR proposed core configurations. The obtained results show reasonable agreement with the maps, supporting the applicability of the proposed scaling parameters for describing the dynamic behaviour of heated channels with supercritical fluids.

• Nuclear Engineering and Technology
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• v.10 no.2
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• pp.65-72
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• 1978

In this paper, it is attempted to investigate the phenomena of iodine stress corrosion cracking of Zircaloy-4 cladding failures in reactor through the results of similar out-of-pile test in iodine vapour. The main result of this experiment is a finding of the relation between the threshold stress which can lead to iodine stress corrosion cracking of Zircaloy-4 tube and the iodine concentration. The values of critical stress and the critical iodine concentration are also obtained. A model which relates failure time of Zircaley-4 tube to failure stress and iodine concentration is suggested as follows: log t$_{F}$ =5.5-(3/2)log$_{c}$-4log $\sigma$ where t$_{F}$ : failure time, minutes c: iodne concentration, mg/㎤ $\sigma$: stress, 10$^4$psi.

• Journal of Magnetics
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• v.6 no.4
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• pp.132-141
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• 2001

The switching characteristics and the magnetization-flop behavior in magnetic tunnel junctions exchange biased by synthetic antiferromagnets (SyAFs) are investigated by using a computer simulations based on a single-domain multilayer model. The bias field acting on the free layer is found to be sensitive to the thickness of neighboring layers, and the thickness dependence of the bias field is greater at smaller cell dimensions due to larger magnetostatic interactions. The resistance to magnetization flop increases with decreasing cell size due to increased shape anisotropy. When the cell dimensions are small and the synthetic antiferromagnet is weakly, or not pinned, the magnetization directions of the two layers sandwiching the insulating layer are aligned antiparallel due to a strong magnetostatic interaction, resulting in an abnormal magneto resistance (MR) change from the high-MR state to zero, irrespective of the direction of the free-layer switching. The threshold field for magnetization-flop is found to increase linearly with increasing antiferromagnetic exchange coupling in the synthetic antiferromagnet. Irrespective of the magnetic parameters and cell sizes, magnetization flop does not exist near zero applied field, indicating that magnetization flop is driven by the Zeeman energy.