• Archives of Pharmacal Research
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• 제6권1호
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• pp.35-44
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• 1983

Interactions between thiamine.HCl and its disulfide derivatives TTFD. TPD and .alpha., .betha. cyclodextrins were investigated. By measuring the H-NMR, C-NMR chemical shifts, the assumption that cyclodextrin may from a inclusion complex with thiamines was supported qualitatively. To calculated the stability constants of them, anion exchange chromatography was applied. The simple, rapid HPLC method was proved to be pertinent thiamine/cyclodextrin system which was chemically unstable and less soluble.

• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2008년도 추계학술발표회
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• pp.338-339
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• 2008

• Journal of Nutrition and Health
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• 제4권4호
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• pp.1-8
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• 1971

• 대한수의사회지
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• 제16권2호
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• pp.78-78
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• 1980

• Journal of Nutrition and Health
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• 제8권1호
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• pp.1-4
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• 1975

• Molecules and Cells
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• 제43권11호
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• pp.964-973
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• 2020

Recent studies have highlighted that early enhancement of the glycolytic pathway is a mode of maintaining the proinflammatory status of immune cells. Thiamine, a wellknown co-activator of pyruvate dehydrogenase complex, a gatekeeping enzyme, shifts energy utilization of glucose from glycolysis to oxidative phosphorylation. Thus, we hypothesized that thiamine may modulate inflammation by alleviating metabolic shifts during immune cell activation. First, using allithiamine, which showed the most potent anti-inflammatory capacity among thiamine derivatives, we confirmed the inhibitory effects of allithiamine on the lipopolysaccharide (LPS)-induced pro-inflammatory cytokine production and maturation process in dendritic cells. We applied the LPS-induced sepsis model to examine whether allithiamine has a protective role in hyper-inflammatory status. We observed that allithiamine attenuated tissue damage and organ dysfunction during endotoxemia, even when the treatment was given after the early cytokine release. We assessed the changes in glucose metabolites during LPS-induced dendritic cell activation and found that allithiamine significantly inhibited glucose-driven citrate accumulation. We then examined the clinical implication of regulating metabolites during sepsis by performing a tail bleeding assay upon allithiamine treatment, which expands its capacity to hamper the coagulation process. Finally, we confirmed that the role of allithiamine in metabolic regulation is critical in exerting anti-inflammatory action by demonstrating its inhibitory effect upon mitochondrial citrate transporter activity. In conclusion, thiamine could be used as an alternative approach for controlling the immune response in patients with sepsis.

• The Plant Pathology Journal
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• 제32권5호
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• pp.469-480
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• 2016

Bacterial wilt and grey mould in tomato plants are economically destructive bacterial and fungal diseases caused by Ralstonia solanacearum and Botrytis cinerea, respectively. Various approaches including chemical and biological controls have been attempted to arrest the tomato diseases so far. In this study, in vitro growths of bacterial R. solanacearum and fungal B. cinerea were evaluated using four different vitamins including thiamine (vitamin B1), niacin (vitamin B3), pyridoxine (vitamin B6), and menadione (vitamin K3). In planta efficacies of the four vitamin treatments on tomato protection against both diseases were also demonstrated. All four vitamins showed different in vitro antibacterial activities against R. solanacearum in dose-dependent manners. However, treatment with 2 mM thiamine was only effective in reducing bacterial wilt of detached tomato leaves without phytotoxicity under lower disease pressure ($10^6$ colony-forming unit [cfu]/ml). Treatment with the vitamins also differentially reduced in vitro conidial germination and mycelial growth of B. cinerea . The four vitamins slightly reduced the conidial germination, and thiamine, pyridoxine and menadione inhibited the mycelial growth of B. cinerea. Menadione began to drastically suppress the conidial germination and mycelial growth by 5 and 0.5 mM, respectively. Grey mould symptoms on the inoculated tomato leaves were significantly reduced by pyridoxine and menadione pretreatments one day prior to the fungal challenge inoculation. These findings suggest that disease-specific vitamin treatment will be integrated for eco-friendly management of tomato bacterial wilt and grey mould.

• 한국융합학회논문지
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• 제13권2호
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• pp.93-101
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• 2022

지난 40년동안 한국산 채소의 영양성분에 변화가 있었는지, 있다면 그 변화의 특수성을 파악하고자 농촌진흥청의 영양성분 분석 자료를 바탕으로 1981년부터 2021년까지 40년간 채소의 주요 영양소 변화를 조사했다. 과채류에서 조사기간 동안 감소 경향을 보인 영양소는 단백질, 지질, 칼슘, 철분, 티아민, 리보플라빈, 아스코르브산 이었다. 뿌리채소에서는 에너지, 단백질, 지질, 회분, 칼슘, 티아민, 리보플라빈, 니아신, 아스코르브산이 감소하는 경향이 있었다. 잎채소에서는 에너지, 단백질, 지질, 인, 철, 니아신, 아스코르브산이 감소하는 경향이 있었다. 잎과 줄기 채소에서는 에너지, 단백질, 지질, 당류, 회분, 인, 철, 티아민, 리보플라빈, 니아신, 아스코르브산이 감소하는 경향이 있었다. 특히 식물성 섭취에서 중요한 의미를 갖는 티아민, 리보플라빈, 니아신, 아스코르브산 등의 비타민 감소가 지난 40년간 채소류에서 발생하였음이 확인됐다.

• 한국식품과학회지
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• 제20권6호
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• pp.808-811
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• 1988

국내에서 소비되는 산채류에 대하여 thiamine분해능을 thiochrome 형광법과 Lactobacillus viridescens를 이용한 미생물법으로 측정하였고 페놀 화합물의 함량 및 갈색도와의 관계를 규명하였다. 더덕, 도라지, 토란대, 호박꼬지, 표고버섯, 도토리 전분 등은 thiamine분해능이 크지 않았으나 가지, 고구마 줄기, 고사리, 고춧잎, 취, 즉 등은 상당량의 thiamine분해능을 가지고 있었다. Thiamine분해능이 큰 산채류는 페놀 화합물의 함량과 갈색도도 높았다. 따라서 산채류를 식용으로 할 때는 thiamine급원식품과 함께 조리하지 말 것이며 조리 즉시 섭취하는 것이 바람직하다.

• 한국응용과학기술학회지
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• 제22권3호
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• pp.212-218
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• 2005

Most of cosmetics are emulsion products that contain the source of nutrition vegetable oil, mineral oil, natural extract and carbohydrate etc. There are many possibilities to be contaminated by microbials. We investigated the effect of antimicrobial and minimum inhibitory concentration(MIC) with thiamine dilauryl sulfate(TDS), which was prepared to use cosmetic lotion formulation. Staphylococcus aureus(S. aureus) and Escherichia col(E. coli) were used as test organism. MIC value of TDS was determined aganist microorganism for the growth inhibition by concentration of TDS. From the MIC results, antimicrobial effect of TDS was generally more effective to gram positive than gram negative. Antimicrobial effect with pH value against some microorganism appeared in the following order : pH 5 > pH 6 > pH 7. It showed strong antimicrobial activities against S. aureus, and weak antimicrobial activities against E. coli. If it was possible to determine the formulations with TDS, it would be effective to reduce the artificial preservatives.