Archives of Pharmacal Research
- Volume 6 Issue 1
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- Pages.35-44
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- 1983
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Studies on the interaction of thiamines and cyclodextrins
- Im, In-Seon (College of Pharmacy, Seoul National University) ;
- Lee, Wang-Kyu (College of Pharmacy, Seoul National University) ;
- Park, Man-Ki (College of Pharmacy, Seoul National University) ;
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Kim, Bak-Kwang
(College of Pharmacy, Seoul National University)
- Published : 1983.06.01
Abstract
Interactions between thiamine.HCl and its disulfide derivatives TTFD. TPD and .alpha., .betha. cyclodextrins were investigated. By measuring the H-NMR, C-NMR chemical shifts, the assumption that cyclodextrin may from a inclusion complex with thiamines was supported qualitatively. To calculated the stability constants of them, anion exchange chromatography was applied. The simple, rapid HPLC method was proved to be pertinent thiamine/cyclodextrin system which was chemically unstable and less soluble.
Keywords
- Thiamine;
- Cyclodextrin;
- Complexes;
- ${1}^H$-NMR;
- ${13}^C$-NMR;
- Stability constants;
- Anion exchange chromatography