• The Pure and Applied Mathematics
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• v.19 no.4
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• pp.315-325
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• 2012

Let A and B denote a point, a line or a circle, respectively. For a positive constant $a$, we examine the locus $C_{AB}$($a$) of points P whose distances from A and B are, respectively, in a constant ratio $a$. As a result, we establish some equivalent conditions for conic sections. As a byproduct, we give an easy way to plot points of conic sections exactly by a compass and a straightedge.

• Proceedings of the Safety Management and Science Conference
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• 2003.11a
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• pp.105-111
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• 2003

This paper examines to focus on General Strategy of e-logistics activity for SCM(Supply Chain Management) Build-up, especially the field service logistics Integration. And this research analyzes the case study (Business of Strategy Group Unit) Survey) involving effective logistics management that leads customer satisfaction, seeking to find out the key elements of competitive policy. Because problems arise from the differences between their goals and structures, which cause each sied to feel vulneralbe to opportunism or shirking of responsibilities by the other. The goal of a logistics system is to ensure that every family planning client always receives the contraceptives partner wants, and that they are in good condition and have not expired. In order to select, procure, and distribute the right Quantities of the right contraceptives, managers of the logistics system must keep informed of the rates of use of each contraceptive and of the Quantity of available supplies. As a result, We propose that a firm's e-logistics strategy is an important locus innovation and a crucial source of value creation for the firm its suppliers, partners, and customers.

• Journal of the Korea Safety Management & Science
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• v.5 no.4
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• pp.117-130
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• 2003

This paper examines to focus on General Strategy of e-logistics activity for SCM(Supply Chain Management) Build-up, especially the field service logistics Integration. And this research analyzes the case study(Business of Strategy Group Unit) Survey) involving effective logistics management that leads customer satisfaction, seeking to find out the key elements of competitive policy. Because problems arise from the differences between their goals and structures, which cause each sied to feel vulneralbe to opportunism or shirking of responsibilities by the other. The goal of a logistics system is to ensure that every family planning client always receives the contraceptives partner wants, and that they are in good condition and have not expired. In order to select, procure, and distribute the right quantities of the right contraceptives, managers of the logistics system must keep informed of the rates of use of each contraceptive and of the quantity of available supplies. As a result, We propose that a firm's e-logistics strategy is an important locus innovation and a crucial source of value creation for the firm its suppliers, partners, and customers.

• The Microorganisms and Industry
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• v.16 no.1
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• pp.7-17
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• 1990

In summary, the nature of the amino acid changes that impart oncogenicity in either the focus formation or tumorigenicity assay can be inferred by analysis of PCR-amplified DNA from tumor-derived NIH3T3 transformants and confirmed by analysis of primary liver tumors. Putative activating mutations in the c-K-ras genetic locus have been shown to involve a single-base modification of either G-C base pair at codon 12 leading to aspartate or cystein substitutions for glycine. The oncogenicity of an N-ras oncogene containing the N-ras C gene region may be related to an amino acid substitution of valine for glycine at codon 13.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.2031-2037
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• 2012

Background: Analysis of gene-gene and gene-environment interactions for complex multifactorial human disease faces challenges regarding statistical methodology. One major difficulty is partly due to the limitations of parametric-statistical methods for detection of gene effects that are dependent solely or partially on interactions with other genes or environmental exposures. Based on our previous case-control study in Chongqing of China, we have found increased risk of colorectal cancer exists in individuals carrying a novel homozygous TT at locus rs1329149 and known homozygous AA at locus rs671. Methods: In this study, we proposed statistical method-crossover analysis in combination with logistic regression model, to further analyze our data and focus on assessing gene-environmental interactions for colorectal cancer. Results: The results of the crossover analysis showed that there are possible multiplicative interactions between loci rs671 and rs1329149 with alcohol consumption. Multifactorial logistic regression analysis also validated that loci rs671 and rs1329149 both exhibited a multiplicative interaction with alcohol consumption. Moreover, we also found additive interactions between any pair of two factors (among the four risk factors: gene loci rs671, rs1329149, age and alcohol consumption) through the crossover analysis, which was not evident on logistic regression. Conclusions: In conclusion, the method based on crossover analysis-logistic regression is successful in assessing additive and multiplicative gene-environment interactions, and in revealing synergistic effects of gene loci rs671 and rs1329149 with alcohol consumption in the pathogenesis and development of colorectal cancer.

• Electronics and Telecommunications Trends
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• v.39 no.3
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• pp.13-24
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• 2024

The capabilities of the metaverse have been demonstrated by representative examples such as Roblox, Fortnite, and Zepeto, and it can enable gaming, social networking services, and other applications. Nevertheless, research on the metaverse has been fragmented owing to conflicting definitions, core values, and characteristics. This ambiguity in metaverse conventions has hindered related research, analysis, and policy establishment. As the confusion seems to aggravate, consistent concepts should be established. Although the coronavirus disease pandemic led to a collapse in metaverse usage, it is regaining public interest since 2022. To promote the metaverse development, we structure core values based on existing research and surveys of consumer expectations. We found that consumers perceive the metaverse as a realistic virtual space and a potential economic opportunity. Hence, it seems necessary to track the extent to which the metaverse core values satisfy consumer demands. Such core values should be consistently reflected in policies and technology development.

• BMB Reports
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• v.49 no.11
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• pp.598-606
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• 2016

ARF is an alternative reading frame product of the INK4a/ARF locus, inactivated in numerous human cancers. ARF is a key regulator of cellular senescence, an irreversible cell growth arrest that suppresses tumor cell growth. It functions by sequestering MDM2 (a p53 E3 ligase) in the nucleolus, thus activating p53. Besides MDM2, ARF has numerous other interacting partners that induce either cellular senescence or apoptosis in a p53-independent manner. This further complicates the dynamics of the ARF network. Expression of ARF is frequently disrupted in human cancers, mainly due to epigenetic and transcriptional regulation. Vigorous studies on various transcription factors that either positively or negatively regulate ARF transcription have been carried out. However, recent focus on posttranslational modifications, particularly ubiquitination, indicates wider dynamic controls of ARF than previously known. In this review, we discuss the role and dynamic regulation of ARF in senescence and cancer.

• Journal of vocational education research
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• v.37 no.5
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• pp.55-78
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• 2018

The purpose of this study is to investigate the recognition of the professionalism required for strengthening the effective career guidance capacity of the secondary career teachers who are required to prepare for the coming fourth industrial revolution era. Based on these research objectives, we derived the required roles(8), the required competencies(20), and the contents(23) for enhancing professionalism by the required competencies, based on this, the questionnaire was composed and 217 respondents were collected and analyzed. First, the t-test was conducted to confirm the statistically significant difference between the current level and the important level of each content item by each role. As a result, it was found that in all roles except role of 'administrator' The t-value is statistically significant and the t-value distribution is high. Second, the demand value calculation and the priority ranking using the Borich demand calculation formula were found, and as a result, the directionality between the t value and the Borich demand was in agreement. Third, as a result of prioritizing using the Locus for Focus model, the contents of all 5 (middle school 7, high school 2) education contents were given priority. Fourth, three middle schools and five high schools were derived from the subordinate. Finally, we confirmed the relevance of the contents of education to actual educational necessity. Although this study has many limitations and limitations due to the fact that there are few prior data due to the segmentation of the subject related to the 4th Industrial Revolution and career guidance, it is necessary to develop educational training program I hope to be able to use it as basic data of various follow-up studies and make some suggestions.

• Journal of Korean Home Economics Education Association
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• v.35 no.2
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• pp.41-59
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• 2023

This study aimed at analyzing the educational needs of home economics teachers for food literacy cultivation education in secondary school home economics. A total of 192 home economics teachers were surveyed about their perceptions of importance and performance of food literacy education content categories and elements, and their priorities were identified. Among the 38 content elements presented, home economics teachers recognized that the current performance level was significantly lower than that of the importance over 34 content elements. Based on the Borich educational needs assessment and the Locus for Focus Model, we identified five content elements with 'very high' educational needs ('food security/food sovereignty', 'reducing food-related waste', 'food waste management and recycling', 'food-related waste recycling', and 'country of origin information'), and four content elements with 'high' educational needs ('genetically modified food', 'ethical food consumption', 'food additives', and 'eco-friendly agricultural products'). These results indicate that dietary education in secondary school home economics should emphasize both the production and disposal of food. The findings of this study suggest implications for the needs for a new dietary education in secondary school home economics that allows students to learn all stages of food system. These results can also be used as a basis for dietary education for cultivating food literacy in secondary school home economics education.

• Journal of Korean Society of Disaster and Security
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• v.13 no.3
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• pp.29-43
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• 2020

The purpose of this study was to identify the priority of the ISO auditors' specialized knowledge and job skills required to perform their duties, along with their personal characteristics, in order to enhance field-based auditing capability. For achieving the objectives of the study, the questionnaire consisted of a total of 50 competency factors, adding personal characteristics area to the ISO 19011-based specialized knowledge and job skills areas and the survey was conducted on the currently active ISO auditors with a five-point recert scale. Based on the results of the survey, the importance and present of ISO auditors in 3 competency areas were verified statistically significant difference through a t-test. The top priority and next priority competency factors for the overall competency and each competency areas were obtained through the Borich coefficient and the Locus for Focus Model. Considering the top priority competency factors in each competency areas identified from the study results, it can help develop related auditing curriculum. for improving the auditors' competency, and furthermore, it is expected to help strengthen ISO management system including quality, health & safety, environment and business continuity for companies.