• Asian Pacific Journal of Cancer Prevention
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• v.14 no.10
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• pp.5719-5723
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• 2013

Pharmacological and preventive properties of Petroselinum sativum seed extracts are well known, but the anticancer activity of alcoholic extracts and oil of Petroselinum sativum seeds on human breast cancer cells have not been explored so far. Therefore, the present study was designed to investigate the cytotoxic activities of these extracts against MCF-7 cells. Cells were exposed to 10 to $1000{\mu}g/ml$ of alcoholic seed extract (PSA) and seed oil (PSO) of Petroselinum sativum for 24 h. Post-treatment, percent cell viability was studied by 3-(4, 5-dimethylthiazol-2yl)-2, 5-biphenyl tetrazolium bromide (MTT) and neutral red uptake (NRU) assays, and cellular morphology by phase contrast inverted microscopy. The results showed that PSA and PSO significantly reduced cell viability, and altered the cellular morphology of MCF-7 cells in a concentration dependent manner. Concentrations of $50{\mu}g/ml$ and above of PSA and $100{\mu}g/ml$ and above of PSO were found to be cytotoxic in MCF-7 cells. Cell viability at 50, 100, 250, 500 and $1000{\mu}g/ml$ of PSA was recorded as 81%, 57%, 33%, 8% and 5%, respectively, whereas at 100, 250, 500, and $1000{\mu}g/ml$ of PSO values were 90%, 78%, 62%, and 8%, respectively by MTT assay. MCF-7 cells exposed to 250, 500 and $1000{\mu}g/ml$ of PSA and PSO lost their typical morphology and appeared smaller in size. The data revealed that the treatment with PSA and PSO of Petroselinum sativum induced cell death in MCF-7 cells.

• Korean Journal of Heritage: History & Science
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• v.47 no.4
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• pp.162-177
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• 2014

This article examined the burial type, wooden coffin and its historical significance of Iksan Ssangneung, the royal tombs of Baekje. Ssangneung was found to be the royal tombs of King Mu(武王) and queen through the burial type, wooden coffin, articles such as chinese jade ornaments and the deep relationship between King Mu and Iksan region. The reason of constructing Baekje royal tombs in Iksan region can be examined at many aspects. First, Iksan was a very important place for King Mu. Because Iksan was the basis of his political growth. Also, Iksan was a important geopolitical location in relation with Silla(新羅). For this reason, Iksan was developed in earnest. The construction of major facilities such as royal palace and temples in Iksan suggest the transfer of the capital from Sabi(泗?) or the preparation and partial execution at least. However, the transfer of the capital was not completed. It can be seen as the incomplete city. However, even after King Mu Iksan was maintained as the important region by King Euja(義慈王). It can be seen through the maintenance of great temples such as Jeseoksa(帝釋寺) and Mireuksa(彌勒寺) built at later period of King Mu and royal palace area, even though royal palace had turned into the temple. These inherited consciousness may have been embodied in the act of building royal tombs of King Mu and queen.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.3
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• pp.1219-1225
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• 2014

Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenol molecule from green tea and is known to exhibit antioxidative as well as tumor suppressing activity. In order to examine EGCG tumor invasion and suppressing activity against adult T-cell leukemia (ATL), two HTLV-1 positive leukemia cells (HuT-102 and C91-PL) were treated with non-cytotoxic concentrations of EGCG for 2 and 4 days. Proliferation was significantly inhibited by 100 ${\mu}M$ at 4 days, with low cell lysis or cytotoxicity. HTLV-1 oncoprotein (Tax) expression in HuT-102 and C91-PL cells was inhibited by 25 ${\mu}M$ and 125 ${\mu}M$ respectively. The same concentrations of EGCG inhibited NF-kB nuclearization and stimulation of matrix metalloproteinase-9 (MMP-9) expression in both cell lines. These results indicate that EGCG can inhibit proliferation and reduce the invasive potential of HTLV-1-positive leukemia cells. It apparently exerted its effects by suppressing Tax expression, manifested by inhibiting the activation of NF-kB pathway and induction of MMP-9 transcription in HTLV-1 positive cells.

• Honam Mathematical Journal
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• v.40 no.2
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• pp.293-304
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• 2018

In this paper, we study ${\varphi}$-recurrent almost cosymplectic (${\kappa},{\mu}$)-space and prove that it is an ${\eta}$-Einstein manifold with constant coefficients. Next, we show that a three-dimensional locally ${\varphi}$-recurrent almost cosymplectic (${\kappa},{\mu}$)-space is the space of constant curvature.

• (The)Study of the Eastern Classic
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• no.72
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• pp.127-156
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• 2018

Kim Yoo-shin was highly evaluated in Silla, not only when he was alive, but also after his death. When he was alive, he was regarded as one of the best servants who accomplished the task of 'Iltong-Samhan' by supporting KiIng Tae-jong and King Mun-mu. Kim Yoo-shin was recognized as 'good servant' or 'sacred servant' who helped King Tae-jong even after he died. In addition, he was revered as 'two adults' with King Mun-moo. He was awarded the title of 'The Great King Heung-mu'. In the Goryeo period, it was supported as a national sacrifice in the shrine of Mt. Taeryeng of Jinchon. Kim Yoo-shin was regarded as a person who achieved great success with the absolute trust of King Tae-jong and King Mun-mu. In addition, Yoon-gwan recognized Kim Yoo-shin as a general who caused many miracles. Lee Seung-hyeo said that Kim Yoo-shin had a mysterious Military-Strategy Book and excelled in martial arts. Even during the Joseon Dynasty, the evaluation of Kim Yu-shin's success had been continued due to the absolute trusting relationship between King Taejong or King Mun-moo and his retainer Kim Yoo-shin. Kim Yoo-shin was either the representative of Silla's martial or the most outstanding figure in the entire history of the Silla Dynasty. Furthermore, he was recognized as a person with competence and aptitude comparable to Chinese characters. Kim Yoo-shin was superior in military strategy. Kim Yoo-shin was evaluated as a representative of martial in Korea's history. From a neo-Confucian point of view, they evaluated him as a loyal person through Kim's achievements.

• Journal of the Korean Institute of Landscape Architecture
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• v.26 no.1
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• pp.21-27
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• 1998

According to the Samkuk Saki(History of Three Nations), An-ap pond was constructed in the 14th year of the reign of King Mun-$\mu$ But this period precedes the unification of Shilla(in the 16th year the reign of king Mun-mu) and Shilla was at war. Therefore I suppose the 16th year of the King's reign is just the time of the commencement of the construction of the pond. But the real construction had not been started before the 16th year of the King's reign, after the unification of the three nations into Shilla Dynasty. Another record of making a larger pond(the 19th year of the reign of king Kyung-duk) may signify the enlargement of the very pond that had been built the 16th year of King Mun-mu's reign. Korean traditional belief was the belief in the Dragon, the Mountain God, and the Heavenly God and these was deeply rooted in the Royal family and perhaps had influenced the building of An-ap pond. Namely it is explained that Em-hae Jun sympolizes the An-ap pond itself as the sea and the Dragon lived in the sea and also the mountain built in the East bank of An-ap pond is related to the Mountain God. And also Taoism's Sin Sun Sa-Sang(Paradise philosophy) had influenced the building of the three legendary immortal islands, called Yong Ju, Bang-Jang, Bong-Rae in the An-ap pond. It is supposed that the age of An-ap pond from the above mentioned facts and inferences and we can also understand the influence of the Royal family customs on the building of An-ap pond. The inscriptions on the vessels and architectural accessories suggest us the influence of the Royal family customs on the construction of An-ap pond.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.16
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• pp.6633-6638
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• 2014

The Pharmacological potential, such as antioxidant, anti-inflammatory, and antibacterial activities of Portulaca oleracea (PO) and Petroselinum sativum (PS) extracts are well known. However, the preventive properties against hepatocellular carcinoma cells have not been explored so far. Therefore, the present investigation was designed to study the anticancer activity of seed extracts of PO and PS on the human hepatocellular carcinoma cells (HepG2). The HepG2 cells were exposed with $5-500{\mu}g/ml$ of PO and PS for 24 h. After the exposure, cell viability by 3-(4,5-dimethylthiazol-2yl)-2,5-biphenyl tetrazolium bromide (MTT) assay, neutral red uptake (NRU) assay, and cellular morphology by phase contrast inverted microscope were studied. The results showed that PO and PS extracts significantly reduced the cell viability of HepG2 in a concentration dependent manner. The cell viability was recorded to be 67%, 31%, 21%, and 17% at 50, 100, 250, and $500{\mu}g/ml$ of PO, respectively by MTT assay and 91%, 62%, 27%, and 18% at 50, 100, 250, and $500{\mu}g/ml$ of PO, respectively by NRU assay. PS exposed HepG2 cells with $100{\mu}g/ml$ and higher concentrations were also found to be cytotoxic. The decrease in the cell viability at 100, 250, and $500{\mu}g/ml$ of PS was recorded as 70%, 33%, and 15% by MTT assay and 63%, 29%, and 17%, respectively by NRU assay. Results also showed that PO and PS exposed cells reduced the normal morphology and adhesion capacity of HepG2 cells. HepG2 cells exposed with $50{\mu}g/ml$ and higher concentrations of PO and PS lost their typical morphology, become smaller in size, and appeared in rounded bodies. Our results demonstrated preliminary screening of anticancer activity of Portulaca oleracea and Petroselinum sativum extracts against HepG2 cells, which can be further used for the development of a potential therapeutic anticancer agent.

• Journal of Chest Surgery
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• v.51 no.3
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• pp.172-179
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• 2018

Background: This study aimed to compare preliminary data on the outcomes of sutureless aortic valve replacement (SU-AVR) with those of aortic valve replacement (AVR). Methods: We conducted a retrospective study of SU-AVR in moderate- to high-risk patients from 2013 to 2016. Matching was performed at a 1:1 ratio using the Society of Thoracic Surgeons predicted risk of mortality score with sex and age. The primary outcome was 30-day mortality. The secondary outcomes were operative outcomes and complications. Results: A total of 277 patients were studied. Ten patients (50% males; median age, 81.5 years) underwent SU-AVR. Postoperative echocardiography showed impressive outcomes in the SU-AVR group. The 30-day mortality was 10% in both groups. In our study, the patients in the SU-AVR group developed postoperative thrombocytopenia. Platelet counts decreased from $225{\times}10^3/{\mu}L$ preoperatively to 94.5, 54.5, and $50.1{\times}10^3/{\mu}L$ on postoperative days 1, 2, and 3, respectively, showing significant differences compared with the AVR group (p=0.04, p=0.16, and p=0.20, respectively). The median amount of platelet transfusion was higher in the AVR group (12.5 vs. 0 units, p=0.052). Conclusion: There was no difference in the 30-day mortality of moderate-to high-risk patients depending on whether they underwent SU-AVR or AVR. Although SU-AVR is associated with favorable cardiopulmonary bypass and cross-clamp times, it may be associated with postoperative thrombocytopenia.

• Journal of the Korean Society of Costume
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• v.55 no.5 s.95
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• pp.1-13
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• 2005

The results from the consideration of this are as follows. 1. Kokuryo has been the exchange foreign relationship with the Han dynasty era, from king DaiMuSin 25 years to Bojang 27 years. 2 King of Kokuryo, from The North-Wei-dynasty has been received ceremonial costumes, first-third class of China's official rank. After unification of China, Su, Dang dynasty's envoy and missionary and many commercial men and artist come from China to Kokuryo, therefore, influenced their costume habbits and behabiers from royal families costumes and common peoples costumes, without concern of that one's social position. 3. Kokuryo King's ceremonial costumes are not the same as the China. Kokuryo performed a religious service an emperor's ceremony. And the Kokuryo King's religious mind was the Budism and Daoism. So that mural painting just showing the symbolic of the king's costumes , Myunryukwanbok.

• Korean Chemical Engineering Research
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• v.53 no.5
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• pp.565-569
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• 2015

Envisaging the role of Co in theranautics and biomedicine it is immensely important to evaluate its antimicrobial activity. Hence in this study CoO thin nanosheets (CoO-TNs) were synthesized using wet chemical solution method at a very low refluxing temperature ($90^{\circ}C$) and short time (60 min). Scanning electron microscopy of the grown structure revealed microflowers ($2{\sim}3{\mu}m$) composed of thin sheets petals (60~80 nm). The thickness of each individual grown sheet varies from 10~20 nm. Antimicrobial activities of CoO-TNs against two Gram positive bacteria (Micrococcus luteus, and Staphylococcus aureus), and two Gram negative bacteria (Escherichia coli and Pseudomonas aeruginosa) were determined. A 98% and 65% growth inhibition of M. luteus and S. aureus respectively, was observed with $500{\mu}g/ml$ of CoO-TNs compared to 39 and 34% growth inhibition of E. coli and P. aeruginosa, respectively with the same concentration of CoO-TNs. Hence, synthesized CoO-TNs exhibited antimicrobial activity against Gram negative bacteria and an invariably higher activity against tested Gram positive bacteria. Therefore, synthesized CoO-TNs are less prone to microbial infections.