• Journal of Digital Convergence
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• v.13 no.3
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• pp.221-229
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• 2015

This study was performed to determine the occupational stress and its association with human nature factors, mental health factors and fatigue among some hospital administrative staff. The survey was administered to 189 staff in Jeonbuk area from June 1st to July 31th, 2014. The level of occupational stress was positively correlated with human nature, mental health and fatigue. The results of hierarchical multiple regression analysis show the following. The occupational stress of respondents turned out to be significantly higher in following groups: a group of female, a group that chance locus of control is higher, a group that external locus of control is lower, a group of the lower self-esteem, a group of higher situational fatigue, a group of higher psycho-social stress, and a group of higher depression. Their explanatory power was 60.4%. With the analysis of covariance structure, we could confirm relationship among the four factors such as human nature, mental health, fatigue and occupational stress. Also, the analysis showed that human nature factors were more influential on the occupational stress than mental health factors and fatigue.

• Environmental Mutagens and Carcinogens
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• v.21 no.1
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• pp.1-8
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• 2001

We have synthesized $^{99m}$Tc-mercaptoacetyltriglycine (MAG3)-biocytin as a new imaging agent for hepatobiliary scintigraphy. The aim of this study was to evaluate the usefulness of $^{99m}$Tc-MAG3-biocytin scintigraphy in differentiating carbon tetrachloride ( $CCl_4$)-induced hepatotoxicity from $\alpha$-naphthylisothiocyanate (ANIT)-induced cholestasis in mice, which reflecting the differential diagnosis of neonatal jaundice caused by neonatal hepatitis from congenital biliary atresia in humans. Methods: Balb/c mice (female, 20 g, n=4-6) were pretreated with $CCl_4$(0.5 or $1.0m\ell$/kg) and ANIT ($150 or 300 m\ell$/kg) 18 h before scintigraphy. Biochemical and histopathological examinations showed a pattern of typical acute hepatitis (increase of transaminases and hepatocellular necnsis) in $CCl_4$-treated mice and cholestasis (increase of alkaline phosphatase and ${\gamma}$-glutamyltransferase, and biliary hyperplasia) in ANIT-treated mice, respectively, Mice were fasted at least 4 hr prior to the intravenous injection of $^{99m}$Tc-MAG3-biocytin (18.5 MBq/20$\mu\textrm{g}$) in 2% human serum albumin in saline. Scintigraphy was performed with a ${\gamma}$-camera equipped with a 1-mm diameter pin-hole collimator for 30 min and images were acquired every 15 s. We compared the values of physical parameters, such as peak liver/heart ratio ($${\gamma}$_{max}$) and peak ratio time ($t_{max}$) far $^{99m}$Tc-MAG3-biocytin scintigraphy. Results: Scintigraphic parameters of the $CCl_4$-pretreated (0.5 $m\ell$/kg) group showed a 81.9% decrease of r$_{max}$, and 42.2% decrease of $t_{max}$, whereas the ANIT-pretreated ( $150m\ell$/kg) group showed a 53% decrease of $r_{max}$, and 2.36-fold increase of $t_{max}$, (P<0.05). These results demonstrate that the decrease of $r_{max}$ and the shortening of $t_{max}$ are characteristic features for hepatotoxicity, in contrast to the increase of $t_{max}$ and decrease of $r_{max}$ for biliary hyperplasia. Conclusion: $^{99m}$Tc-MAG3-biocytin hepatobiliary scintigraphy can distinguish hepatitis from cholestasis in mice model and may be similarly useful in humans which differentiating the cause of neonatal jaundice in clinical study.cal study.cal study.cal study.

• Korean Journal of Radiology
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• v.24 no.12
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• pp.1249-1259
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• 2023

Objective: This study aimed to evaluate the clinical outcomes and cost-effectiveness of dual-energy X-ray absorptiometry (DXA) for osteoporosis screening. Materials and Methods: Eligible patients who had and had not undergone DXA screening were identified from among those aged 50 years or older at Kaohsiung Veterans General Hospital, Taiwan. Age, sex, screening year (index year), and Charlson comorbidity index of the DXA and non-DXA groups were matched using inverse probability of treatment weighting (IPTW) for propensity score analysis. For cost-effectiveness analysis, a societal perspective, 1-year cycle length, 20-year time horizon, and discount rate of 2% per year for both effectiveness and costs were adopted in the incremental cost-effectiveness (ICER) model. Results: The outcome analysis included 10337 patients (female:male, 63.8%:36.2%) who were screened for osteoporosis in southern Taiwan between January 1, 2012, and December 31, 2021. The DXA group had significantly better outcomes than the non-DXA group in terms of fragility fractures (7.6% vs. 12.5%, P < 0.001) and mortality (0.6% vs. 4.3%, P < 0.001). The DXA screening strategy gained an ICER of US$ -2794 per quality-adjusted life year (QALY) relative to the non-DXA at the willingness-to-pay threshold of US$ 33004 (Taiwan's per capita gross domestic product). The ICER after stratifying by ages of 50-59, 60-69, 70-79, and ≥ 80 years were US$ -17815, US$ -26862, US$ -28981, and US$ -34816 per QALY, respectively. Conclusion: Using DXA to screen adults aged 50 years or older for osteoporosis resulted in a reduced incidence of fragility fractures, lower mortality rate, and reduced total costs. Screening for osteoporosis is a cost-saving strategy and its effectiveness increases with age. However, caution is needed when generalizing these cost-effectiveness results to all older populations because the study population consisted mainly of women.

• Journal of the Korean Society for Library and Information Science
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• v.56 no.3
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• pp.5-26
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• 2022

The purpose of this study is to analyze high school students' understanding and use of the recommended books lists. The survey distributed to high school students in seven high schools located in Seoul, and 311 students responded. Using SPSS 24, the data was analyzed by frequency, binary logistic model, and one-way ANOVA. Results show the followings. First, the meaningful factors affecting students' use of recommended books lists are gender, grade levels, and the degree to which students think recommended books lists include the books that are suitable and interesting. Particularly, the degree to which students think recommended books lists include the suitable books for them is the strong factor affecting students' use of the recommended books lists. Second, male students are less likely to use recommended books lists than female students. Male students consistently are less likely to use the recommended books lists made by school librarians, subject teachers, and reading experts and/or organizations. Third, teacher-librarians believed that the recommended books lists would help students who do not enjoy reading and have difficulties in reading. However, the study finds that students who enjoy reading and read well are more willing to use the recommended books lists made by school librarians, subjects teachers, and reading experts and/or organizations than those who do not. Fourth, students are most willing to use the recommended books lists for college preparation. The findings suggest the further research topics in designing the recommended books lists suitable for high school students and in scaffolding the high school students' use of book information reflected in recommended books lists.

• The Journal of the Korea Contents Association
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• v.14 no.10
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• pp.416-428
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• 2014

This study aimed to identify middle school students' perceptions and practices of handwriting, and factors affecting their attitudes towards handwriting. Data were collected by means of a survey targeting 346 students enrolled in 9 middle schools(Male=172, Female=172, Unknown=2, M=13.5 years old, SD= .94). Interviews, too, were conducted with 12 students in order to identify the students' perceptions of handwriting. The analyses of both survey and interview data revealed the following: (1) the majority of the interviewee students believed that handwriting is useful for memory and summarization so as to get a better school grade, including performance evaluations; (2) Many of the interviewee students were unsatisfied with their handwriting skills, giving higher scores to their peers' handwriting; (3) 45.7% of the students reported that mother was the one who taught them how to write for the first time; and 49.7% of them had no learning experience of taking notes; (4) Girls than boys and 1st graders than 2 or 3 graders showed more positive attitude towards handwriting; and (5) A multiple regression analysis showed that all the variables entered in the regression model, including sex, grade, affective attitude toward hands-on activities, physical abilities, time spent using a computer, and perceptions of Korean characters, had significant impacts on the students' attitudes towards handwriting.

• The korean journal of orthodontics
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• v.35 no.5 s.112
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• pp.331-340
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• 2005

Angulation and inclination of clinical crown is important for diagnosing, treatment planning and developing convenient orthodontic attachments. The aim of the study was to establish normative data with higher reliability on the angulation and inclination of clinical crown of Koreans with normal occlusion This study employed the dental casts of 307 (male. 187: female. 120) adult normal occlusion samples. The angulation and inclination of clinical crown were measured by set-up model checker In order to ensure reliability, intra- and inter-rater error were evaluated 3 times The resultant data obtained had excellent reliability however when compared with the previous data as well as with gender difference, clinically significant interpretation was impossible because the whithin-dataset normal variation was High which was common pattern of angulation and inclination measuring data of previous research The result of this biometric study seemed 4o suggest more substantive design of the multivariate. high-dimensional interpretation methodology of these normal variation is required if more compatible orthodontic appliance could be developed.

• Journal of Gastric Cancer
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• v.21 no.2
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• pp.191-202
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• 2021

Purpose: A near-infrared (NIR) fluorescence imaging is a promising tool for cancer-specific image guided surgery. Human epidermal receptor 2 (HER2) is one of the candidate markers for gastric cancer. In this study, we aimed to synthesize HER2-specific NIR fluorescence probes and evaluate their applicability in cancer-specific image-guided surgeries using an animal model. Materials and Methods: An NIR dye emitting light at 800 nm (IRDye800CW; Li-COR) was conjugated to trastuzumab and an HER2-specific affibody using a click mechanism. HER2 affinity was assessed using surface plasmon resonance. Gastric cancer cell lines (NCI-N87 and SNU-601) were subcutaneously implanted into female BALB/c nu (6-8 weeks old) mice. After intravenous injection of the probes, biodistribution and fluorescence signal intensity were measured using Lumina II (Perkin Elmer) and a laparoscopic NIR camera (InTheSmart). Results: Trastuzumab-IRDye800CW exhibited high affinity for HER2 (K_D=2.093(3) pM). Fluorescence signals in the liver and spleen were the highest at 24 hours post injection, while the signal in HER2-positive tumor cells increased until 72 hours, as assessed using the Lumina II system. The signal corresponding to the tumor was visually identified and clearly differentiated from the liver after 72 hours using a laparoscopic NIR camera. Affibody-IRDye800CW also exhibited high affinity for HER2 (K_D=4.71 nM); however, the signal was not identified in the tumor, probably owing to rapid renal clearance. Conclusions: Trastuzumab-IRDye800CW may be used as a potential NIR probe that can be injected 2-3 days before surgery to obtain high HER2-specific signal and contrast. Affibody-based NIR probes may require modifications to enhance mobilization to the tumor site.

• Korean Journal of Culture and Social Issue
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• v.17 no.2
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• pp.241-260
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• 2011

This study was to develop the fun perception scale measuring what conditions employees experience fun feeling in work and to examine the construct validity of it. For this, the pre-studies(open-ended questionnaire, in-depth interviews, literature survey, pre-survey) were conducted to develop the preliminary questions of fun scale. In main study, 250 employees(male: 125, female, 125) were responded to a questionnaire consisted of 40 questions of fun perception scale extracted by pre-studies. The results were as follow. First, through the item analysis, factor analysis and reliability analysis, 7 factors composed of 29 items were extracted: 'self-determination', 'extrinsic reward', 'goal achievement', 'pleasure in the process', 'contribution to the company', 'worthless', 'challenge'. Cronbach's alpha reliability coefficient of each factor was suitable. Secondly, EFA was conducted to test the construct validity of fun scale with AMOS 16.0. Several goodness of fit indexes were used to assess model fit: X2/df, TLI, CFI, RMSEA. The results were revealed that all the indexes were acceptable with no additional modification. Based on these findings, the theoretical and the practical implications of fun perception scale were discussed.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.28 no.2
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• pp.154-165
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• 2006

Objectives : It is difficult to place implants at a severely atrophied edentulous mandible because of vertical and horizontal alveolar defect. The autogenous and allogenic bone graft and guided bone regeneration are useful, but there are some limitations such as the resorption and infection of the grafted bone, and insufficiency of soft tissue. Distraction osteogenesis has recently evolved a challenging technique to overcome major draws of conventional augmentation procedures, we, therefore, report the four applications of implant placement after vertical alveolar distraction osteogenesis. Patients and Methods : Four patients(all female, mean age: $60{\pm}6$ years) with severe alveolar ridge deficiencies at their anterior mandible were treated with vertical alveolar distraction osteogenesis by intraoral device(Track 1.5, 15 mm model, KLS Martin, Tuttlingen, Germany) and placement of implants (Branemark MK III, TiUnite). After the latency periods of 5, 7, 8 days, distraction rhythm and rate were $0.5\;mm{\times}2\;times/day$ in the case of good bone quality, and $0.25\;mm{\times}3\;times/day$ in the case of poor bone quality. After consolidation periods of mean fifteen weeks, five implants for each patients were placed at the interforaminal area. Results : On average, a vertical gain of $11.38{\pm}1.38\;mm$ was obtained by distraction. And all distraction zone showed complete ossification by panoramic radiography. There were no postoperative complications other than numbness of lower lip in one case. Total twenty implants in four patients were placed and their outcomes were satisfactory. Conclusion : It is a useful method to place five implants after vertical distraction osteogenesis of the severely atrophied mandible for the implant-supported fixed prosthesis.

• Korean journal of applied entomology
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• v.39 no.4
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• pp.275-279
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• 2000

Development of Bracon hebetor Say parasitizing Indianmeal moth (Plodia interpunctella (Hubner) was studied at five temperature conditions (17, 20, 25, 28 and 32$\pm$0.5$^{\circ}C$) under a photoperiod of 16 : 8 (L : D). Developmental period (mean$\pm$s.e.) of B. hebetor from egg to eclosion decreased from 28.6$\pm$0.50 to 9.3 $\pm$0.09 days and 28.1 $\pm$0.51 to 9.2$\pm$0.09 days for female and male, respectively, as the temperature increased from 17 to $32^{\circ}C$. The combination model provided a good description of the relationship between temperature and development. The low temperature thresholds were estimated to be 14.0, 12.8, 15.1$^{\circ}C$ for development of egg, larva and pupa. The thresholds for normal development (outside of the boundary layer of the development) were 14.0, 17.5, $15.1^{\circ}C$ for egg, larva and pupa, respectively, indicating that the larval stage is more sensitive to the low temperature than the other stages. The results suggested that the present B. hebetor population could be another ecological race adapting to the seasonal temperature conditions of this area.