• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.2
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• pp.416-425
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• 2009

Angiogenesis is important for promoting cardiovascular disease, wound healing, and tissue regeneration. We here investigated the pharmacological effects of Korea red ginseng water extract (KRGE) on angiogenesis and its underlying signal mechanism. This study showed that KRGE increased in vitro proliferation, migration, and tube formation of human umbilical endothelial cells, as well as stimulated in vivo angiogenesis. KRGE-induced angiogenesis was accompanied by phosphorylation of ERK1/2, Akt, and endothelial nitric oxide synthase (eNOS) as well as an increase in NO production. Inhibition of PI3K activity by wortmannin completely inhibited KRGE-induced angiogenesis and phosphorylation of Akt, ERK1/2, and eNOS, indicating that PI3K/Akt activation is an upstream event of KRGE-mediated angiogenic pathway. The MEK inhibitor PD98059 completely blocked KRGE-induced angiogenesis and ERK phosphorylation without affecting Akt and eNOS activation. However, the eNOS inhibitor NMA effectively inhibited tube formation, but partially blocked proliferation and migration as well as ERK phosphorylation without altering Akt and eNOS activation, revealing that eNOS/NO pathway is in part involved in ERK1/2 activation. This study first demonstrated the critical involvement of both ERK1/2 and eNOS activation in KRGE-induced angiogenesis, which lie on downstream of PI3K/Akt. Thus, these results indicate that KRGE requires activation of both the PI3K/Akt-dependent ERK1/2 and eNOS signal pathways and their cross-talk for its full angiogenic activity.

• The Journal of Traditional Korean Medicine
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• v.15 no.1
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• pp.56-69
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• 2006

In Oriental Medicine, Atopic dermatitis(AD) belongs to the category of the Naesun, Taesun(胎癬), Taeryumchang(胎斂瘡), Eczema(濕疹), Seupchang(濕瘡), Samanpung(四彎風), Chimumchang(浸淫瘡). The Basic Prescriptions which have been used for treatment of Atopic dermatitis are saengryusamultang(生料四物湯), Onchungeum(溫淸飮), Seungmagalgeuntang(升麻葛根湯),Hoichunryangkyuksan(回春凉膈散), Doghengsan(導赤散), Pyungweesan(平胃散), Heungbangpaedoksan(荊防敗毒散), Goomigangharltang(九味羌活湯), Baekhotang(白虎湯), Gaegytang(桂枝湯), Yukmigihyuangtang(六味地黃湯). AD can divide three groups, Acute-Type, Semiacute-Type, Chronic-Type, according to it's condition. This study shows that it can be applicate Seungmagalgeuntang(升麻葛根湯), Hoichunryangkyuksan(回春凉膈散), Doghengsan(導赤散), Heungbangpaedoksan(荊防敗毒散), Goomigangharltang(九味羌活湯), Baekhotang(白虎湯), Gaegytang(桂枝湯) for treatment of Acute-Type, Pyungweesan(平胃散) for treatment of Semiacute-Type, and saengryusamultang(生料四物湯), Onchungeum(溫淸飮) for treatment of Chronic-Type.

• Journal of Korean Medical classics
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• v.22 no.2
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• pp.305-313
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• 2009

With the recent increase of social demand of knowledge on traditional medicine, the construction of database is becoming a pressing matter. The reality is that while the social desire to adapt the high quality knowledge is growing fast, the field of Oriental Medicine has yet to organize its system. The number of Oriental Medical Doctors are limited, and there is no structured means of communication to expand the professional knowledge of these specialists to the public. Accordingly, an effective and structured knowledge system is in great need. In the process of building an Oriental Medicine database, prescription[方劑] and medicines[本草] are first in line. Consequently, we have taken the first step by organizing various methods to build the database containing information such as the formula, ingredients, composition, handling methods of herbal medicine written in traditional medical publications and herbal texts before the Song(宋) dynasty.

• Herbal Formula Science
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• v.16 no.2
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• pp.31-45
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• 2008

This report describes 54 prescriptions related to the use of Talcum mainly blended prescriptions in Dongeuibogam. The following conclusion were reached through investigations on the prescriptions that use Talcum as a key ingredient. Prescriptions that Talcum was taken as a monarch drug are utilized for 22 therapeutic purposes. In particular, 35.2% of prescriptions appear in the chapter of urine, 7.4% of those appear in the chapter of heat. Prescriptions that utilize Talcum as the main ingredient are used in the treatment of uric disease, gonorrhea, heat disease, febrile disease, and they are also used for treating 16 different types of diseases. Talcum is used in pathogenic factors such as heat, wind with heat, and used in pathology related to the fever of small intestine and bladder. The dosage of Talcum is 3jeon(about 11.25g) to 2.5pun(about 0.94g), however 1jeon(about 3.75g) has been taken the most for clinical application. Ikwonsan is the most useful base prescription which use the Talcum as the main ingredient.

• Korean Journal of Oriental Medicine
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• v.16 no.3
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• pp.127-133
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• 2010

The purpose of this study is to develop the order communication system for Traditional Korean Medicine(TKM) which can support prescribing decisions and provide the toxicological information. The relative vulnerability of the infrastructure of TKM has made us start the study. We carried out the benchmarking for TKM charting solution firstly, and then designed the intelligent search and supporting method for prescription decisions. We developed of the medical herbs database and the web-based order communication program which can be used in medical field actually. This system supplies a various functions to oriental medical doctors such as management for prescription history, search for herb's effects, generating prescriptions, inventory management, alerting of toxicity and taboo, guideline for taking medicine, and so on. The design and implementation process has been described in this research. We expect that this system will play an important role in electronic medical record(EMR) or electronic health record(EHR) binding diagnosis and management functions.

• Journal of Korean Medical classics
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• v.20 no.3
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• pp.33-48
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• 2007

Before the advent of febrile disease theory, people had used Sanghallon's theory to cure febril disease. Therefore, Wu-Tang both suggested new prescription and used the former prescription of Sanghallon(傷寒論) in curing febrile disease. However, he didn't use the original prescription of Sanghallon and modified the quantity and ingredients properly. Through this process, the fault of Sanghallon was supplemented and the method of curing febrile disease was advanced. To research about this, it will be much easier to understand prescription of Sanghallon and even the treatments and views of Wu-Tang about febrile disease. In this study, I researched the way Wu-Tang applied prescription of Sanghallon, focusing on Decoction for Purgation, White Tiger Decoction, Decoction for Restoring Pulse which was used by Wu-Tang in various ways and applied in treatment of febrile disease.

• Journal of Korean Medical classics
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• v.19 no.1 s.32
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• pp.202-206
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• 2006

Yinqiao San is the medicine for the outer part disease of the human body. In ${\ulcorner}$Wenbingtiobian${\lrcorner}$, this medicine is the most useful when it is used within short time after the starting boiling it. In this study, the volatile ingredients of the Yinqiao San were observed by GC and compared with each other in time scale. Most of the ingredients were observed about 5 min after the starting boiling it, after10 min., the GC peaks were smaller and smaller, and after 2 hours and 30 min. the GC peaks were almost gone. It is confirmed that was written about the Yinqiao San in ${\ulcorner}$Wenbingtiobian${\lrcorner}$.

• Journal of Korean Medical classics
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• v.23 no.4
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• pp.155-167
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• 2010

Two Fructus Jujubae & three Rhizoma Zingiberis Rencns are usually used in parts of prescriptions in oriental medicine. In "Dongeuibogam", those are prescribed as drugs. However, those are not exactly same with original books, which "Dongeuibogam" had quoted. In original books, those are sometimes mentioned just as 'Fructus Jujubae & Rhizoma Zingiberis' or different amount of them. Therefore, authors try to compare with "Dongeuibogam" and its original books to find out the reason of discordance. As a result, we could conclude that Two jujubes & three pieces of ginger are more commonly prescribed than original books and are fixed to use more conveniently and to give standard for doctor.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.6
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• pp.1543-1547
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• 2004

In this study, symptoms, pathologies, compositions and clinical applications of 52 prescriptions for woman-related disease treatment descripted in Bang Yahk Hap Peun were investigated. The results were same as following; Classification of prescriptions for woman-related disease treatments was 23 prescriptions in high-chepter, prescriptions in 16 medium-chepter, and prescriptions in 13 low-chepter prescriptions and the frequency of clinical applications for high-chepter, medium-chepter and low-chepter prescriptions was 44%, 31% and 25%, respectively. Clinical applications of woman-related disease prescriptions were identified aocording to pre-pregnancy and post-birth, uterus, breast disease, before pregnancy. Infertile, emmeniopathy, uterus Blooding made practical application to high frequency in the treatments. Oriental Medical Pathology applied with prescriptions were Biheo(脾虛), Ganbinoyool(肝脾怒鬱), Infirmity(虛弱), 熱入血室, Jungpung(中風), Gihyulguheo(氣血俱虛), hyulheo(血虛), Aeohyul(瘀血) etc. Prescriptions applied with the most frequency in woman-related disease were Samuoltang(四物湯), Sagunjatang(四君子湯), Gungkuitang(芎歸湯), Boanbaekchuolsan(保安白朮散), Dangguibohyeltang(當歸補血湯), Sanhyointang(酸棗仁湯), Dohongsamuoltang(桃紅四物湯), Jipeisan(芷貝散), Silsosan(失笑散).

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.5
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• pp.1264-1269
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• 2003

The inhibitory effects of the Juglans sinensis walnut ethanol extract (JSWE) on carbon tetrachloide (CCl₄)-induced fibrosis, serum transaminases (GOT and GTP), hepatic glutathione (GSH), serum pro-inflammatory cytokines (IL-1β and IL-6) were investigated in rats. JSWE significantly inhibited on CCl₄-induced fibrosis in dose-dependent manner. Moreover, JSWE significantly inhibited on the serum levels of GOT, GTP, IL-1β, and IL-6 in dose-dependent manner in CCl₄-induced fibrosis rat. However, JSWE markedly increased the production of hepatic GSH in a dose-dependent manner. These results show that JSWE may explain some known biological activities of Juglans sinensis walnut including their anti-fibrotic and anti-inflammatory effects, and is of considerable benefit in the treatment for live diseases.