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Inhibitory effects of the Juglans sinensis Walnut Ethanol Extract on Carbon Tetrachloride-induced hepatic fibrosis in Rats  

Jang Seong Il (Department of Immunology, Institute of Immunopia)
Lim Chang Kyung (Department of Oriental Medical Prescription, Wonkwang University)
Ryu Jin Duk (Department of Oriental Medical Prescription, Wonkwang University)
Kim Hui Soo (Department of Oriental Medical Prescription, Wonkwang University)
Yun Yong Gab (Department of Oriental Medical Prescription, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.17, no.5, 2003 , pp. 1264-1269 More about this Journal
Abstract
The inhibitory effects of the Juglans sinensis walnut ethanol extract (JSWE) on carbon tetrachloide (CCl₄)-induced fibrosis, serum transaminases (GOT and GTP), hepatic glutathione (GSH), serum pro-inflammatory cytokines (IL-1β and IL-6) were investigated in rats. JSWE significantly inhibited on CCl₄-induced fibrosis in dose-dependent manner. Moreover, JSWE significantly inhibited on the serum levels of GOT, GTP, IL-1β, and IL-6 in dose-dependent manner in CCl₄-induced fibrosis rat. However, JSWE markedly increased the production of hepatic GSH in a dose-dependent manner. These results show that JSWE may explain some known biological activities of Juglans sinensis walnut including their anti-fibrotic and anti-inflammatory effects, and is of considerable benefit in the treatment for live diseases.
Keywords
Juglans sinensis Walnut; Fibrosis; Transaminases; Glutathione; Pro-inflammatory Cytokines;
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