• Journal of Microbiology and Biotechnology
• /
• v.28 no.6
• /
• pp.893-901
• /
• 2018

Influenza viruses that cause recurrent seasonal epidemics to humans can be controlled with vaccine and antiviral therapy. However, the medical treatments often exhibit limited efficacy in the elderly or immunosuppressed individuals. In these cases, daily uptake of probiotics may be an option to bring in health benefits against influenza. Here, we demonstrate the effects of probiotics Lactobacillus plantarum (Lp) and Leuconostoc mesenteroides (Lm) against seasonal and avian influenza viruses. As assessed by the plaque size reduction of human H1N1 and avian influenza H7N9 viruses, including green fluorescent protein-tagged H1N1 strain in cells, the selected Lp and Lm strains restrained viral replication in mouse lungs with statistical significance. Against lethal viral challenge, the Lp and Lm strains exhibited their beneficial effects by increasing the mean days and rates of survival of the infected mice. These results suggest that, despite rather narrow ranges of protective efficacy, the dietary supplement of Lactobacillus and Leuconostoc probiotics may promote health benefits against influenza.

• Tuberculosis and Respiratory Diseases
• /
• v.54 no.6
• /
• pp.645-650
• /
• 2003

A malignant fibrous histiocytoma (MFH) is a major subset of soft tissue sarcomas, which occurs principally on the extremities or in the retroperitoneum, as well as on the head and neck of elderly patient. However, it is an extremely rare event when a MFH occurs primarily in the diaphragm of a young people. A 25-year-old woman visited our hospital complaining of right chest pain. The chest X-ray showed a diaphragmatic mass. An exploratory thoracotomic biopsy revealed a primary MFH of the diaphragm. The patient was treated with combined chemotherapy consisting of ifosfamide and doxorubicin. A partial response was seen after 6 cycles of chemotherapy. However, she died of brain metastasis 12 months after the diagnosis.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2006.05a
• /
• pp.421-425
• /
• 2006

An ubiquitous healthcare system for the home care of elderly persons was designed and implemented using wireless sensor network technology. The wireless technology for home-care purpose gives new possibilities for monitoring of vital parameter with wearable biomedical sensors, and will give the patient the freedom to be mobile and still be under continuously monitoring and thereby to better quality of patient care. Emphasis is placed on recent advances in wireless ECG system for cardiac event monitoring with particular attention to arrhythmia detection in patient. This paper presents a diagnostic system for cardiac arrhythmias from ECG data, using wireless sensor technology. The system also provides an application for recording activities, events and potentially important medical symptoms. The hardware allows data to be transmitted wirelessly from on-body sensor to the base station and then to PC/PDA. Data is also transmitted to a back-end server for analysis using wireless internet connection. Experiments were conducted using the system for activity monitoring, exercise monitoring and medical screening tests and present preliminary data and results.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2006.05a
• /
• pp.426-429
• /
• 2006

A distributed healthcare monitoring system prototype for clinical and trauma patients, was developed, using wireless sensor network node. The proposed system aimed to measure various vital physiological health parameters like ECG and body temperature of patients and elderly persons and transfer his/ her health status wirelessly in Ad-hoc network, to remote base station which was connected to doctor's PDA/PC or to a hospital's main Server using wireless sensor node. The system also aims to save the cost of healthcare facility for patients and the operating power of the system because sensor network is deployed widely and the distance from sensor to base station was shorter than in general centralized system. The wireless data communication will follow IEEE 802.15.4 frequency communication with ad-hoc routing thus enabling every motes attached to patients, to form a wireless data network to send data to base-station, providing mobility and convenience to the users in home environment.

• Journal of Chest Surgery
• /
• v.39 no.3 s.260
• /
• pp.230-235
• /
• 2006

Systemic arterialization of lung with/without sequestration (Sequestration/Anomalous Origin of Left Pulmonary Artery, AOLPA) is a rare form of congenital anomalous systemic arterial supply to the lungs. In this anomaly, the arterial supply of one or more arteries of the basal segments of the lower lobe derives from an aberrant vessel arising from the aorta. We report two adult cases of systemic arterialization of normal basal segments of left lower lobe lung with/without sequestration. The one (AOLPA) was treated by left lower basal segmentectomy and the other (Sequestration) by therapeutic angiographic embolization. Based on the favorable follow-up result in our patients, although lobectomy (segmentectomy) is the basic treatment modality, embolotherapy could also be a mode of treatment that could be selectively applied to elderly, infirm patients or high risk patients with poor pulmonary function.

• Journal of Fashion Business
• /
• v.17 no.2
• /
• pp.82-94
• /
• 2013

This study aims to investigate purchase attitude towards uniforms, wear condition and their requirements for functional school uniforms for high school boy students, and to help to present basic data for the development of functional school uniforms by reflecting requirements from high school students. First, research on school uniform brands purchased in Busan, Ulsan, and Kyungnam regions showed 2 brands were preferred, and the school uniform purchase expenses are primarily between two hundred thousand won and three hundred thousand won. Second, in terms of differences among fabrics of summer and winter uniforms, many students answered that 'they are similar' or 'there is no difference'. As for complaints about winter uniforms, thermal insulation accounts for the highest rate. As a result of research on underwear worn primarily in the winter, boy students tend to wear underwear to keep their lower bodies warm rather than their upper bodies. They tend to keep their upper bodies warm with outerwear such as vests, cardigans, and padding jumper. According to a survey on experience and satisfaction of functional uniforms, students showed satisfaction with more than three points to all questions except for two, which means their satisfaction about the functions of uniforms that they wear currently is above the average. Third, many boy students complains about the thermokeeping of winter uniforms, especially thigh parts of pants. It is required to make research for the improvement of functional pants for boy students.

• Journal of Preventive Medicine and Public Health
• /
• v.52 no.5
• /
• pp.308-315
• /
• 2019

Objectives: Estimating influenza-associated mortality is important since seasonal influenza affects persons of all ages, causing severe illness or death. This study aimed to estimate influenza-associated mortality, considering both periodic changes and age-specific mortality by influenza subtypes. Methods: Using the Microdata Integrated Service from Statistics Korea, we collected weekly mortality data including cause of death. Laboratory surveillance data of respiratory viruses from 2009 to 2016 were obtained from the Korea Centers for Disease Control and Prevention. After adjusting for the annual age-specific population size, we used a negative binomial regression model by age group and influenza subtype. Results: Overall, 1 859 890 deaths were observed and the average rate of influenza virus positivity was 14.7% (standard deviation [SD], 5.8), with the following subtype distribution: A(H1N1), 5.0% (SD, 5.8); A(H3N2), 4.4% (SD, 3.4); and B, 5.3% (SD, 3.7). As a result, among individuals under 65 years old, 6774 (0.51%) all-cause deaths, 2521 (3.05%) respiratory or circulatory deaths, and 1048 (18.23%) influenza or pneumonia deaths were estimated. Among those 65 years of age or older, 30 414 (2.27%) all-cause deaths, 16 411 (3.42%) respiratory or circulatory deaths, and 4906 (6.87%) influenza or pneumonia deaths were estimated. Influenza A(H3N2) virus was the major contributor to influenza-associated all-cause and respiratory or circulatory deaths in both age groups. However, influenza A(H1N1) virus-associated influenza or pneumonia deaths were more common in those under 65 years old. Conclusions: Influenza-associated mortality was substantial during this period, especially in the elderly. By subtype, influenza A(H3N2) virus made the largest contribution to influenza-associated mortality.

• Journal of Ginseng Research
• /
• v.47 no.1
• /
• pp.65-73
• /
• 2023

Background: Age-related macular degeneration (AMD) is a significant visual disease that induces impaired vision and irreversible blindness in the elderly. However, the effects of ginseng berry extract (GBE) on the retina have not been studied. Therefore, this study aimed to investigate the protective effects of GBE on blue light (BL)-induced retinal damage and elucidate its underlying mechanisms in human retinal pigment epithelial cells (ARPE-19 cells) and Balb/c retina. Methods: To investigate the effects and underlying mechanisms of GBE on retinal damage in vitro, we performed cell viability assay, pre-and post-treatment of sample, reactive oxygen species (ROS) assay, quantitative real-time PCR (qRT-PCR), and western immunoblotting using A2E-laden ARPE-19 cells with BL exposure. In addition, Balb/c mice were irradiated with BL to induce retinal degeneration and orally administrated with GBE (50, 100, 200 mg/kg). Using the harvested retina, we performed histological analysis (thickness of retinal layers), qRT-PCR, and western immunoblotting to elucidate the effects and mechanisms of GBE against retinal damage in vivo. Results: GBE significantly inhibited BL-induced cell damage in ARPE-19 cells by activating the SIRT1/PGC-1α pathway, regulating NF-kB translocation, caspase 3 activation, PARP cleavage, expressions of apoptosis-related factors (BAX/BCL-2, LC3-II, and p62), and ROS production. Furthermore, GBE prevented BL-induced retinal degeneration by restoring the thickness of retinal layers and suppressed inflammation and apoptosis via regulation of NF-kB and SIRT1/PGC-1α pathway, cleavage of caspase 3 and PARP, and expressions of apoptosis-related factors in vivo. Conclusions: GBE could be a potential agent to prevent dry AMD and progression to wet AMD.

• Journal of the Korea Society of Computer and Information
• /
• v.14 no.5
• /
• pp.195-200
• /
• 2009

This study aims to speculate the development of sponsors of social welfare facilities through marketing mix. This is the time when the logics of economy is applied for the area of social welfare. Since July 2008 when the long-term care insurance system for the elderly executed, a number of social welfare facilities which depend on governmental budget have competed for various resources, but most of them have still had serious financial difficulties. As a supplementary method to overcome the financial problem, we have to develop how to excavate and manage sponsors who fit for conditions of the facilities to secure financial resources. To develop sponsors of social welfare facilities through marketing mix in this aspect, this study is to present strategic methods for sponsor development in seven factors developed by Fine(1992): product, price, promotion, place, producer, purchaser, and probing.

• Journal of the Korea Society of Computer and Information
• /
• v.14 no.2
• /
• pp.129-138
• /
• 2009

While the issue of caring for the elderly that faces the modern society has reached a serious level, it is expected that it will be particularly true in the Republic of Korea where an aged, not an aging, society is impending. In this paper I did research on establishing behavioral model of residents who dwell in home or welfare facilities. I suggested a behavioral model in daily living, $W_{ip}(n)$, based on event triggering. A multi-hop routing-based wireless luminance/temperature sensor network was built based on the proposed resident's behavioral model. 1 did experiments on behavioral activities of residents on the wireless sensor network system. According to experimental results. I could classify whether the daily activity of a resident someday is regular or not. These experimental results show that the proposed behavioral model is highly applicable in caring for residents in home or welfare facilities effectively in the future.