• The Journal of the Korea Contents Association
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• v.17 no.9
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• pp.426-436
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• 2017

The purpose of this study was to analyze factors affecting malnutritional status of elders with dementia in facilities. The subjects were 140 elders with dementia residing in three nursing facilities in Chungnam, South Korea. Data were collected from May 30 to September 30 in 2016, using questionnaires. The collected data were tested by t-test, ANOVA, correlation, regression analysis. The malnutritional status of elders with dementia in facilities was high in the high-risk group (84, 60.0%), and the nutritional status was appeared to be related to sex, long-term care grade, Korean version-Activities of Daily Living and feeding difficulty and cognitive function. As a result of multiple regression analysis, significant influence variables on malnutritional status were Activities of Daily Living(${\beta}=0.379$, p=.001), feeding difficulty(${\beta}=0.264$, p=.001), cognitive function(${\beta}=-0.187$, p=.014) and these variables showed an explanatory power of 35.9% on malnutritional status. The results of this study are expected to be used as basic data for the development of malnutritional status improvement program for elders in facilities with dementia.

• Journal of the Korea Society of Computer and Information
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• v.19 no.11
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• pp.33-41
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• 2014

In this paper, we implemented a system to measure respiration rate with nonrestraint sensors comfortable for people to do their everyday life. The proposed system consists of a pad covered with a Piezoelectric sensor, a respiration measuring device able to send the signal data after amplifying and filtering the source signals to the viewer, a viewer providing sensor data visualization and implementing the respiration measuring algorithm. The algorithm is based on a breathing cycle with the local peak points extracted from threshold on sensor data. Respiration measurements on 3 subjects were performed by changing moving averages and thresholds. The proposed system showed less than 5% error rate when proper moving averages are N=50~60 and a range of thresholds is 800~1300. The system will contribute to preventing suffocation during sleep for infants and the elderly living alone.

• Journal of Biomedical and Translational Research
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• v.19 no.4
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• pp.92-102
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• 2018

The objectives of this study were to find out the plant to enhance immune activity among 42 kinds of foods frequently consumed by the Korean elderly consisting of 5 food groups and 5 wild plants. Each sample was assessed the immunoactive effect by measuring $NF-{\kappa}B/AP1$ gene expression, nitric oxide and cytokine production in $RAW-Blue^{TM}$ cell. Soybean sprouts of 47 plants showed the highest $NF-{\kappa}B/AP1$ gene expression at the level of $1.13{\pm}0.03$ (O.D. 650 nm) and Soritae, sweet potato, banana, apple, garlic, crown daisy, cabbage and Ailanthus altissima also had high activity of $NF-{\kappa}B/AP1$ gene in $RAW-Blue^{TM}$ cell stimulated by LPS. NO production of Ailanthus altissima was significantly higher than that of other plants and 16 plants of glutinous sorghum, black rice, Seoritae, Heuktae, sweet potato, banana, apple, garlic, mungbean sprouts, spinach, crown daisy, young pumpkin, cabbage, soybean sprouts, Actinidia arguta and Aster scaber were the next best activity. The above results selected 17 out of 47 plant samples. Moreover, soybean sprouts was significantly shown to increase $TNF-{\alpha}$ ($1,509.55{\pm}1.38pg/mL$) and $IL-1{\beta}$ ($54.56{\pm}1.08pg/mL$) cytokines in comparison with RAW-Blue cell stimulated by LPS. According to the results of in vitro evaluation, the ethanol extract of soybean sprout increased the production of immune-enhancing cytokines by proliferation of macrophages. In addition, $NF-{\kappa}B$ transcription factor activity and NO production ability were excellent, and it was selected as a material having excellent immunological activity.

• Clinics in Shoulder and Elbow
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• v.21 no.4
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• pp.220-226
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• 2018

Background: This study introduces a surgical technique with good clinical outcome useful in the treatment of osteoporotic displaced 3- or 4-part proximal humeral fractures. Methods: From May 2014 to February 2016, 16 patients with displaced 3- or 4-part proximal humeral fractures were treated by application of a locking plate with an endosteal strut allograft via a deltoid splitting approach with a minimum follow-up of 12 months. The allograft was inserted through a fractured gap of the greater tuberosity to support the humeral head and then fixed by a locking plate with meticulous soft tissue dissection to protect the axillary nerve. Surgical outcomes were evaluated by the American Shoulder and Elbow Surgeons (ASES) and visual analogue scale (VAS) scores, radiological imaging, and clinical examination. Fixation failure on radiographs was defined as a >$5^{\circ}$ loss of neck shaft angle (NSA) compared to that on an immediate postoperative radiograph. Avascular necrosis (AVN) of the humeral head was also evaluated. Results: In all cases, complete union was achieved. The ASES and VAS scores were improved to $85.4{\pm}2.1$ and $3.2{\pm}1.3$, respectively. Twelve patients (75.0%) had greater than a $5^{\circ}$ change in NSA; the average NSA change was $3.8^{\circ}$. Five patients (31.3%) had unsatisfactory ranges of motion exhibiting a <$100^{\circ}$ active forward flexion. No axillary nerve injuries or AVN were observed at the last follow-up. One patient was converted to reverse total arthroplasty due to severe pain and functional deficit. Conclusions: Minimally invasive fixation via a locking compression plate and an endosteal fibula strut allograft in Neer classification 3-or 4-part fractures with severe osteoporosis in elderly patients can achieve good clinical results.

• Journal of Applied Biological Chemistry
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• v.62 no.3
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• pp.305-313
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• 2019

Men's climactic syndrome, andropause, or testosterone deficit syndrome, is one of the new problems with the health of older men in the age of aging. This phenomenon is a natural phenomenon occurring in men as they age, clinically characterized by a decrease in blood testosterone levels and a marked decrease in physical and mental activity. The purpose of this study was to investigate the effect of hydrothermal extract of Taraxacum coreanum by comparing the levels of nitric oxide (NO) in the cavernosum and the levels of male hormone in the blood. Taraxacum coreanum extract increased NO production in vitro and in vivo in a dose-dependent manner. Levels of dihydrotestosterone and 17-hydroxyysteroid dehydrogenases, as well as levels of neurogenic nitric oxide synthase and cGMP, increased significantly in elderly rats (22 weeks) after 4 weeks of daily intake of Taraxacum coreanum extract. However, prostaglandin $E_2$, testosterone, and sexually-hormone-binding globulin levels were not different among all groups. Furthermore, total sperm and motile sperm counts were also no significant difference. Overall, these results suggest the possibility of Taraxacum coreanum extract as a safe and effective natural substance for enhancing NO, cGMP and free testosterone.

• Journal of Oral Medicine and Pain
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• v.46 no.2
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• pp.33-40
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• 2021

Purpose: Oral candidiasis is the most common fungal infection in the oral cavity which is usually diagnosed from clinical findings. A retrospective study was conducted to identify risk factors for oral candidiasis and to characterize the demographic and clinical features of affected patients. Methods: From January 1, 2019 to December 31, 2019, it consisted of 90 oral candidiasis patients diagnosed based on clinical finding and treated with antifungal drugs. As a retrospective study of those people, surveys were conducted on sex, age, systemic disease, a use of dentures, complaints of dry mouth, smoking and alcohol consumption, culture on potato dextrose agar (PDA) medium, culture on chromogenic agar (CA) medium and a duration of antifungal treatment. Results: Among 90 selected patients, the male and female ratio was 41:49. Overall, female had a higher infection rate than male in all age groups. In this study, oral candidiasis was not clearly susceptible to dry mouth, smoking or drinking, wearing dentures and association with systemic disease. Among 90 patients with oral candidiasis, 83 had colonies formed on PDA medium and 53 had colonies formed on CA medium. The duration of antifungal treatment was highest between 5 and 8 weeks. In addition, there was statistical significance between the culture results in CA medium and the duration of antifungal treatment. Conclusions: Generally, old age or infants, dry mouth, smoking, a use of dentures and endocrine abnormalities are risk factors to increase oral candidiasis; however, in this study, it was mainly found in the elderly aged 60 or older regardless of sex and the incidence of oral candidiasis was not obviously related with patients with dry mouth, smoking or drinking, denture wearers and endocrine abnormalities. Interestingly, when the fungi were cultured in CA medium, the duration of antifungal treatment was increased.

• Journal of Ginseng Research
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• v.45 no.6
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• pp.744-753
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• 2021

Background: Gintonin-enriched fraction (GEF) is a new non-saponin component glycolipoprotein isolated from ginseng root. This study examined the effect of GEF on age-related sarcopenia in old C57BL/6J mice. Methods: Young (3-6 months) and old (20-24 months) C57BL/6J mice received oral GEF (50 mg/kg/day or 150 mg/kg/day) daily for 5 weeks. During the oral administration period, body weight and grip strength were measured weekly. After sacrifice, muscles from the hindlimb were excised and used for hematoxylin and eosin staining and western blotting to determine the effects of GEF on sarcopenia. The thymus was photographed to compare size, and flow cytometry was performed to examine the effect of GEF on immune homeostasis in the thymus and spleen. Blood samples were collected, and the concentrations of pro-inflammatory cytokines and IGF-1 were measured. Results: GEF caused a significant increase in muscle strength, mass, and fiber size in old mice. GEF restored age-related disruption of immune homeostasis by maintaining T cell compartments and regulating inflammatory biomarkers. Thus, GEF reduced common low-grade chronic inflammatory parameters, which are the main cause of muscle loss. Conclusion: GEF maintained immune homeostasis and inhibited markers of chronic inflammation, resulting in anti-sarcopenia effects in aged C57BL/6J mice. Thus, GEF is a potential therapeutic agent that slows sarcopenia in the elderly.

• Journal of the Society of Disaster Information
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• v.18 no.3
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• pp.433-443
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• 2022

Purpose: In this paper, we propose a study of deep learning algorithms that estimate and predict sarcopenia by exploiting the high penetration rate of smart devices. Method: To utilize deep learning techniques, experimental data were collected by using the inertial sensor embedded in the smart device. We implemented a smart device application for data collection. The data are collected by labeling normal and abnormal gait and five states of running, falling and squat posture. Result: The accuracy was analyzed by comparative analysis of LSTM, CNN, and RNN models, and binary classification accuracy of 99.87% and multiple classification accuracy of 92.30% were obtained using the CNN-LSTM fusion algorithm. Conclusion: A study was conducted using a smart sensoring device, focusing on the fact that gait abnormalities occur for people with sarcopenia. It is expected that this study can contribute to strengthening the safety issues caused by sarcopenia.

• 한국노년학
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• v.30 no.3
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• pp.803-814
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• 2010

This study was conducted to understand current management status of welfare medical device centers and to suggest complementary point. Method: We surveyed 194 welfare medical device centers through the mail. The survey was done in three domains, i. e. management of service, assuring the health resources, offering the service. Results & Conclusions: According to the result of our study, several problems, which should be improved in the near future, were suggested. That were improving facilities(especially in sanitization of the devices), operating an education or training program for the personnel, and making up for the current management. It was very important for soft landing of long-term care insurance and improving quality of the elderly's life that 'Ministry of Health and Welfare' and 'National Health Insurance corporation' must support welfare medical device centers for discharging their roles

• 한국노년학
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• v.29 no.3
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• pp.1025-1041
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• 2009

The purpose of this study is to evaluate the effects of a web-based senescence preparation program for the provision of information and education on aging. A non-equivalent control group pretest-posttest design was used. The subjects were 70 middle-aged adults (experimental group: 36, control group: 34) living in Daegu city. The experimental group participated in a web-based senescence preparation program for 10 weeks, where 10 subjects were covered (5 physical, 3 mental/psychological, and 2 social/environmental). As compared to the control group, the knowledge of the experimental group increased significantly, and there was a significant change in their attitudes toward the elderly and old age plans. These results suggest that a web-based senescence preparation program can predict people's old age and help in their preparation. Further, this program is expected to offer individualized learning opportunities to many learners in various settings.