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http://dx.doi.org/10.3839/jabc.2019.042

Effect of increasing nitric oxide and dihydrotestosterone by Taraxacum coreanum extract  

Mo, SangJoon (Medical Laser Research Center, Dankook University)
Publication Information
Journal of Applied Biological Chemistry / v.62, no.3, 2019 , pp. 305-313 More about this Journal
Abstract
Men's climactic syndrome, andropause, or testosterone deficit syndrome, is one of the new problems with the health of older men in the age of aging. This phenomenon is a natural phenomenon occurring in men as they age, clinically characterized by a decrease in blood testosterone levels and a marked decrease in physical and mental activity. The purpose of this study was to investigate the effect of hydrothermal extract of Taraxacum coreanum by comparing the levels of nitric oxide (NO) in the cavernosum and the levels of male hormone in the blood. Taraxacum coreanum extract increased NO production in vitro and in vivo in a dose-dependent manner. Levels of dihydrotestosterone and 17-hydroxyysteroid dehydrogenases, as well as levels of neurogenic nitric oxide synthase and cGMP, increased significantly in elderly rats (22 weeks) after 4 weeks of daily intake of Taraxacum coreanum extract. However, prostaglandin $E_2$, testosterone, and sexually-hormone-binding globulin levels were not different among all groups. Furthermore, total sperm and motile sperm counts were also no significant difference. Overall, these results suggest the possibility of Taraxacum coreanum extract as a safe and effective natural substance for enhancing NO, cGMP and free testosterone.
Keywords
Cyclic guanosine monophosphate; Dihydrotestosterone; Nitric oxide; Taraxacum coreanum; Testosterone Deficit Syndrome;
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Times Cited By KSCI : 2  (Citation Analysis)
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