• Molecules and Cells
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• v.41 no.6
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• pp.506-514
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• 2018

The transcriptional regulation of genes determines the fate of animal cell differentiation and subsequent organ development. With the recent progress in genome-wide technologies, the genomic landscapes of enhancers have been broadly explored in mammalian genomes, which led to the discovery of novel specific subsets of enhancers, termed super-enhancers. Super-enhancers are large clusters of enhancers covering the long region of regulatory DNA and are densely occupied by transcription factors, active histone marks, and co-activators. Accumulating evidence points to the critical role that super-enhancers play in cell type-specific development and differentiation, as well as in the development of various diseases. Here, I provide a comprehensive description of the optimal approach for identifying functional units of super-enhancers and their unique chromatin features in normal development and in diseases, including cancers. I also review the recent updated knowledge on novel approaches of targeting super-enhancers for the treatment of specific diseases, such as small-molecule inhibitors and potential gene therapy. This review will provide perspectives on using super-enhancers as biomarkers to develop novel disease diagnostic tools and establish new directions in clinical therapeutic strategies.

• Proceedings of the Korean Institute of Landscape Architecture Conference
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• 2007.10b
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• pp.19-29
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• 2007

The making of mountains and waters are recognized as essential to traditional Chinese landscapes and it is this concept that guided the Beijing Olympic Landscape, "Axis to Nature". The Olympic landscape extends the central axis of Beijing north until it is punctuated by the Forest Park Hill and dissipated by Forest Park Lake. Traditional landscape gardens, paintings, and poetry were researched and the plan assessed by eminent scholars and experts to conceive and construct an ecological park that features unique design and traditional Chinese landscape art.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.34 no.1
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• pp.1-17
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• 2016

The purpose of this paper is to understand the value of Dongji(東池), Seoji(西池) and Namji(南池), the lotus ponds of Fortress Wall of Seoul as part of the cultural landscape of the period through a consideration of personal behavior and impressive landscape characteristics via various old writings on each pond. The objects of this study include poems, diaries, travelogues and essays describing these ponds. The results are as follows. First, the preferred landscape elements of these three ponds were lotuses, willows and water itself. Second, while Dongji was recognized as a natural landscape, the composition of Seoji was a mixture of with natural and urban landscapes, and Namji was more urban altogether. Third, in aspects of personal behavior, while Dongji was a place where people broke their journeys to gaze at the scenery or looked down distantly, in Seoji, people stayed for a long time in a pavilion called Cheonyeon-jeong(天然亭) and engaged in various leisure activities, and in Namji, there were many gatherings under a temporary shelter or at a friend's house near the pond. Night was the best time to enjoy Namji because during the day, the area was crowded with people, horses, carts and so on. Fourth, the landscapes of fortress walls were impressively described often. Fifth, because these ponds were integrated into the surrounding area, they were like public openspaces mixed with water spaces, natural environment and adjacent facilities. The lotus ponds of the Fortress Wall of Seoul were located in a place connecting inside and outside of fortress, supplemented the cultural features in city, were valued as public openspace, and made it possible to experience the unique landscape of Hanyang. Although these ponds were buried and have now disappeared, they still hold great cultural meaning and potential value as water landscapes of the old city.

• Journal of the Korean Institute of Landscape Architecture
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• v.37 no.1
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• pp.87-99
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• 2009

This research is an introductory study that hopes to interpret the cultural scenic landscape by analyzing Korea's mountains, streams, topography, color, light, human behavior, and more based on real landscape paintings. It places its purpose on understanding our intrinsic cultural scenic landscape by investigating the changed topography and the differing life patterns caused bythe active national land development after the modern era. With Seoul, which is now difficult to find images of its past, and the surrounding areas of the Han riverbed, the interpretation related to its original topography, landscape, climate, weather, and human behaviors was observed while the main focus was placed on the climate of the perception held by people regarding Mt. Geumgang and other ranges which are not fully opened to the public yet. In order to comprehensively analyze the figures of features and appearing landscapes including color, light, and more, it was described through the concept called climate. Hereupon, the real landscape paintings by Gyunjae(Jeong-Seon), mainly bearing features of existing Korean mountains, wereutilized as visual historical material. However, not having all his works, other pieces with representative characteristics were utilized such as "Gyeong-Gyo-Myeong-Seung-Chup(a painting with picturesque sceneries around old Seoul)" and "Hae-Ak-Jeon-Shin-Chup(a landscape painting including even the spirits of the seas and mountains)" which contain the regions' distinct scenery. As a result, the old cultural scenic landscapes of Korea are regarded as containing diverse mountains and where the conceptions of the treatment of mountains were reflected.

• Korean Journal of Heritage: History & Science
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• v.42 no.1
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• pp.100-121
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• 2009

This study is subjected to those gardens of the Korean Folk Village 'Oeam-Ri' designed in 1920s. - transitional period of traditional gardens - and define socio-cultural change's influences and through documents on garden design, descendant's testimony and measured drawings, to understand that period's garden culture's characteristics according to garden design elements. This study applied following analysis methods and procedures to derive out characteristics of transitional garden culture. Analysis on socio-cultural characteristics in 1920s. Analysis on actual condition of transitional garden's design. In this point Outline of the Garden, Space formation, Garden designing elements are (1) water landscape, (2) plant, (3) structures, (4) paving, to derive out characteristics of the transitional garden. The results follow as below; First, during the transitional period 1920s, the economical development, fueled by opening nation's door to foreign countries and indication of collapse of statue systems together with idea of practical science and Enlightenment Thought, was element of changes in garden style. Second, Garden Designers of transitional gardens in 'Oeam-Ri' were limited to upper class of the society. They were wealthy enough to maintain their high social statue in rapidly changing society. As results, tendency of returning to nature developed gardens located in a site of scenic beauty and development of geographical features arranging techniques, and also showed copying foreign styles. Third, arrangement of garden and space composition, in most cases, composed of buildings and yards. Changes in water landscape features and garden spaces are centered to main-yard. Major changes of the garden spaces are water landscapes and plants that showing foreign influences. Fifth, scenic appearance techniques appears with dense garden space and emphasizing visual scenic view. Sixth, the characteristics of transitional garden design techniques are development of geographical feature arranging techniques, changes and mixture of the materials and garden types, emphasizing garden's decorative beauty, change of concept of yard within house into garden, changes from 'borrowing of landscapes' to 'selecting landscapes', changes of front garden from emptiness to fullness, changes of attitudes of enjoying gardens from 'staying calm in the garden' to 'moving or walking in the garden', changes to inner-oriented view, and changes from 'just watching and enjoying the nature' to 'enjoying specific objects'. This study is one of the efforts to restore the identity of Korean Traditional Garden by approaching and observing modern era which function as bridge between tradition and present day, and we observed transitional aspects of changes of traditional garden into modern garden. Hereafter, more studies will be needed to Modern Garden Design be recognized as part of Korean Garden Design History and these would be author's next assignment.

• Journal of the Korean Institute of Landscape Architecture
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• v.34 no.2 s.115
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• pp.57-71
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• 2006

The purpose of this study was to find common characteristics in everyday landscape cognition that the residents share and to restore the resulting characteristics through citizen-participatory town design. Through the residents participatory workshop supported by the Gwangju Buk-gu District Autonomy and Citizen Academy of Gwangju YMCA, 304 people from eight administrative districts participated in three programs. In each program, photographed landscape images representing everyday conditions of the townscape were presented in several ways: in program 1, the residents' mental map was studied; in program 2, landscape images of real places were matched to locations on a map; and in program 3, the landscapes were scored on a scale from 1 to 5 according to five descriptive categories. The elements that were recognized as common landscape features were public facilities, pedestrian spaces, school areas, and parks and natural green spaces. Additional results including recognition of the participants affection for the village and a common landscape image shared by the people, as inhabitants looked around at the space of their own lives. It seems possible that more creative townscapes can be created by residents through participatory programs.

• Journal of the Korean housing association
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• v.21 no.6
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• pp.109-117
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• 2010

With the IMF crisis in the late 1990's, coupled with the excessive supply of housing stock from the past, construction companies are adopting various differentiating strategies to address the decreasing apartment sales rates. Most of those strategies tend to follow the recent trend of 'eco-friendliness,' creating images of the apartments as 'well-being housing types.' In doing so, green spaces and water features are actively being used in outdoor landscapes design. One specific trend that can be witnessed is the efforts to make reference to the traditional Korean design languages, known as the 'Korean Style.' However, the applications of the 'Korea Style' on landscape design are being explored only by the construction companies, while most researches on the 'Korean Style' focus on its application on the indoor housing units. In this context, this series of case studies of the application of 'Korea Style' on landscape design attempts to extract design elements that can be set as basic guidelines.

• Journal of The Geomorphological Association of Korea
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• v.24 no.1
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• pp.105-116
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• 2017

This article is written in the viewpoint of landscape ecological geography. The coast of South Chung-chong Province will make new characters of region in the development strategies program. This study is to describe geomorphological landscapes of South Chung-chong Province relating with it's environment based on the coast. Although landforms constitute prominent landscape features as tidal flats and rock cliff do, it is nonetheless the features such as beaches, sanddunes, and coastal plains that have various ramifications for human communities. Tidal flats, beaches and coastal sanddunes are special in that their formation is attributable to the combined action of tidal flows, waves and winds. To some extent, the erosion of sand has been a global phenomenon. Human impact are involved. The influence of globalization and expansion of liberal trade appears in regions variously. Individual regions need to secure its competitiveness in the world market. Regions are not value-neutral abstract conception, but must be informal commercialized characters of region. The coast of South Chung-chong Province has experienced rapid and dramatic changes. In industrial times, the middle of west coast Korea turned into a major reclamation at larger scale. Reclaimed land was based on location of industry and mechanized agriculture. The west coast highway and bridges between island and land contributed to the development of west coast transportation. As information society matured, trend and value are changing. Environment and ecology emphasize and rediscover the value of tidal flats and sanddunes. The west coast region now receives attention as eco-tour and sustainable course.

• Journal of Information Science Theory and Practice
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• v.10 no.4
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• pp.3-22
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• 2022

This paper provides an overview of the emergence of resource discovery systems and services, along with their advantages, best practices, and current landscapes. It outlines some of the key services and functionalities of a comprehensive discovery model suitable for academic libraries in developing countries. The proposed model (VuFind as a discovery tool) performs like other existing web-scale resource discovery systems, both commercial and open-source, and is capable of providing information resources from different sources in a single-window search interface. The objective of the paper is to provide seamless access to globally distributed subscribed as well as open access resources through its discovery interface, based on a unified index. This model uses Koha, DSpace, and Greenstone as back-ends and VuFind as a discovery layer in the front-end and has also integrated many enhanced search features like Bento-box search, Geodetic search, and full-text search (using Apache Tika). The goal of this paper is to provide the academic community with a one-stop shop for better utilising and integrating heterogeneous bibliographic data sources with VuFind (https://vufind.org/vufind).

• Journal of The Geomorphological Association of Korea
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• v.18 no.4
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• pp.247-259
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• 2011

This research aimed to analyse geomorphic resources of Mt. palgong(in Daegu city and Gyeongbuk province) through some field surveys, and then to clarify geomorphic features. The main results are as follows. 1) The geological boundary of the south slope(granite) is more clear than one of the north slope(granite bedrock and metamorphic sedimentary rock). Small basins are along with fault line between granite bedrock and metamorphic sedimentary rock. 2) It is estimated that relatively big valleys on the north slope are due to local climate, geomorphic and geological features. 3) Tor, sheeting joint, gutter are well developed both on the south slope and on the north slope, however the development of polygonal cracking and boulder stream are more dominant on the south slope; river cliff, pool, waterfall are more dominant on the north slope with valleys that well developed. 4) Scenic geomorphic landscapes are mainly developed in Dongsan valley and Chisan valley on the north slope. 5) There are many interesting geomorphic resources in the viewpoint of storytelling in Mt. Palgong. So the specific design to utilize such resources is required