• 제목/요약/키워드: Teucrium

검색결과 12건 처리시간 0.026초

Iridoids from Teucrium yemense

  • Essam, Abdel-Sattar
    • Archives of Pharmacal Research
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    • 제21권6호
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    • pp.785-786
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    • 1998
  • The aerial parts of Teucrium yemense yielded two iridoid glycosides. Their structures were elucidated by spectral means as teucardosid and 8-O-acetylharpagid.

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Anticancer Properties of Teucrium persicum in PC-3 Prostate Cancer Cells

  • Tafrihi, Majid;Toosi, Samane;Minaei, Tayebeh;Gohari, Ahmad Reza;Niknam, Vahid;Arab Najafi, Seyed Mahmoud
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권2호
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    • pp.785-791
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    • 2014
  • Crude extracts or phytochemicals obtained from some plants have potential anti-cancer properties. Teucrium persicum is an Iranian endemic plant belonging to the Lamiaceae family which has traditionally been used to relieve abdominal pains. However, the anti-cancer properties of this species of the Teucrium genus have not been investigated previously. In this study, we have used a highly invasive prostate cancer cell line, PC-3, which is an appropriate cell system to study anti-tumor properties of plants. A methanolic extract obtained from T persicum potently inhibited viability of PC-3 cells. The viability of SW480 colon and T47D breast cancer cells was also significantly decreased in the presence of the T persicum extract. Flow cytometry suggested that the reduction of cell viability was due to induction of apoptosis. In addition, the results of wound healing and gelatin zymography experiments supported anti-cell invasion activity of T persicum. Interestingly, sublethal concentrations of T persicum extract induced an epithelial-like morphology in a subpopulation of cells with an increase in E-Cadherin and ${\beta}$-Catenin protein levels at the cell membrane. These results strongly suggest that T persicum is a plant with very potent anti-tumor activity.

Characterization of Anti-complementary Polysaccharide from Teucrium viscidum var. miquelianum

  • Min, Jin-Gi;Kim, Tae-Jin;Lee, Doo-Seog;Ch, Sang-Won;Yoon, Ho-Dong;Park, Jeong-Heum
    • Preventive Nutrition and Food Science
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    • 제6권3호
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    • pp.137-141
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    • 2001
  • Water-soluble crude polysaccharide (TM-1) prepared from the leaves of Teucrium viscidum var. miquelianum was fractionated into three polysaccharide fractions, TM-2, TM-3 and TM-4 by the addition of cetyltrimethylammonium bromide. The major polysaccharide fraction, TM-2, consisted of glucose, galactose, rhamnose, mannose, glucuronic acid and galacturonic acid, and all fractions contained galactose and glutose as the major neutral sugars. TM-4 showed the highest anti-complementary activity. When TM-4 was futher fractionated by anion exchange chromatography, TM4- II a and TM4-II b showed the most Potent anti-complementary activity. TM4- II a was composed mainly of galactose, arabinose and glucose in the molar ratios of 2.13 : 0.94 : 1.00 respectively, and contained a small amount of galacturonic acid and glucuronic acid.

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Teucrium polium L. Improved Heart Function and Inhibited Myocardial Apoptosis in Isolated Rat Heart Following Ischemia-Reperfusion Injury

  • Mahmoudabady, Maryam;Talebian, Faezeh Sadat;Zabihi, Narges Amel;Rezaee, Seyed Abdolrahim;Niazmand, Saeed
    • 대한약침학회지
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    • 제21권3호
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    • pp.159-167
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    • 2018
  • Objectives: Myocardial reperfusion is the only logical cure for ischemic heart disease. However, ischemic-reperfusion (I/R) injury is one of the underlying factors facilitating and accelerating the apoptosis in the myocardium. This study set to investigate the impact of Teucrium polium (TP) hydro-alcoholic extract on I/R induced apoptosis in the isolated rat heart. Methods: Isolated rat hearts were classified into six groups. The control samples were subjected to 80 min of perfusion with Krebs-Henseleit bicarbonate (KHB) buffer; in control-ischemia group, after primary perfusion (20 min) the hearts were exposed to global ischemia (20 min) and reperfusion (40 min). Pretreated groups were perfused with $500{\mu}M$ of vitamin C and various TP concentrations (0.5, 1, 2 mg/ml) for 20 min, and then the hearts were exposed to ischemia and reperfusion for 20 min and 40 min, respectively. Cardiodynamic parameters including rate pressure product (RPP), heart rate (HR), the maximum up/down rate of left ventricular pressure (${\pm}dp/dt$), left ventricular developed pressure (LVDP), and coronary artery flow (CF) were achieved from Lab Chart software data. The Bax and BCl-2 gene expressions were measured in heart samples. Results: Hearts treated with TP extract and vit C represented a meaningful improvement in cardiac contractile function and CF. The overexpression of Bcl-2, downregulation of Bax, and improvement of apoptotic index (Bax/Bcl-2) were observed in pretreated TP extract and vit C hearts. Conclusion: The TP extract was found to ameliorate the cardiac function in the reperfused myocardium. Also, it can hinder apoptotic pathways causing cardioprotection.

위생적인 장기 보존을 위한 감마선 조사가 곽향(Teucrium veronicoides)의 생리활성에 미치는 영향 (Effect of Gamma Irradiation for Hygienic Long-Term Storage on Biological Activity of Teucrium veronicoides)

  • 박혜진;박기태;조영제
    • 한국식품영양과학회지
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    • 제46권5호
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    • pp.581-591
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    • 2017
  • 약용식물의 장기 저장을 위한 위생처리법으로 감마선 조사처리의 적용 가능성을 확인하고자 한국산 약용식물인 곽향에 감마선 조사처리 후 항산화 효능 및 생리활성 변화에 미치는 영향을 검토하였다. 먼저 곽향의 감마선 조사처리에 따른 조사 판별 마커 확인을 위해 광자극발광법(PSL), 열발광분석법(TL), 전자스핀공명법(ESR)을 이용하여 조사처리 여부를 확인하였으며, 그 결과 비조사구 0 kGy와 조사구 5 kGy, 10 kGy에서 조사선량에 따라 명확하게 패턴의 차이를 나타내어 음성 시료와 양성 시료로 판단할 수 있었다. 따라서 약용식물인 곽향의 위생처리 및 장기 보존을 위한 감마선 조사처리 시 PSL, TL, ESR 시험 검지법을 적용하여 감마선 조사 여부 판별이 가능한 것을 입증하였다. 감마선 조사처리에 따른 유용성분의 추출 수율 비교를 위해 물과 에탄올을 용매로 하여 비조사구 0 kGy와 조사구 10 kGy의 total phenolics 함량을 비교한 결과, 감마선 조사처리에 따라 열수 및 에탄올 추출물 모두 감마선 조사처리에 따라 추출 수율이 증대되는 것을 확인할 수 있었다. Total phenolics 추출 수율이 가장 우수한 열수 추출물과 50% 에탄올 추출물을 이용하여 total phenolics 농도를 각각 $50{\sim}200{\mu}g/mL$로 조절하여 항산화 및 생리활성 변화를 비교 검증하였다. 수용성 물질의 항산화 활성 확인을 위한 DPPH 라디칼 저해 효과와 ABTS 라디칼 저해 효과를 비교한 결과, 열수와 50% 에탄올 추출물 모두 감마선 조사처리에 의한 효능 변화 폭이 높게 나타나지 않았다. 지용성 물질의 항산화 활성 확인을 위한 antioxidant protection factor 효과에서도 감마선 조사처리가 효능의 변화에 크게 영향을 미치지 않았으나, TBARS 저해 효과에는 감마선 조사처리에 의해 열수 및 50% 에탄올 추출물 모두 유의적으로 곽향의 TBARS 저해 효과를 증대시키는 양상을 나타내었지만 그 변화 폭은 크지 않았다. 이상의 결과를 통해 감마선 조사처리가 곽향의 항산화 효능 변화에 크게 영향을 주지 않는 것으로 판단되며, 곽향이 지닌 고유의 항산화력을 일부 보전하는 것으로 판단되었다. 감마선 조사처리에 따른 xanthine oxidase 억제 효과를 비교한 결과는 항산화력과 유사하게 효소 억제 활성에 유의적인 변화를 주지 않는 것으로 나타났다. 반면 감마선 조사처리에 따른 ${\alpha}-amylase$ 억제 효과를 비교한 결과는 곽향 열수 추출물 $200{\mu}g/mL$ phenolics 농도에서 10 kGy 조사처리 시 63.57%의 저해율을 보여주었으며, 비조사구 0 kGy에 비해 저해율이 23.26% 증가하는 양상을 나타내어 감마선 조사처리에 따라 ${\alpha}-amylase$ 억제 효과가 유의적으로 증가하는 것을 확인할 수 있었다. 이상의 결과를 바탕으로 곽향의 위생처리를 위한 10 kGy의 감마선 조사처리 시 곽향 열수 및 50% 에탄올 추출물의 항산화 활성에 유의적인 변화를 일으키지 않는 것을 확인하였으며, 감마선 조사처리가 곽향이 지닌 고유한 기능성을 보전하거나 소폭 증대시켜 긍정적인 영향을 미치는 것으로 생각하였다. 따라서 본 연구결과가 감마선 조사처리 기술의 기능성 소재 개발 연구에 적용하기 위한 기초자료로 활용이 가능할 것으로 기대된다.

곽향 추출물의 염증성세포활성물질 억제효과 (Inhibitory Effect of Extract of Teucrium veronicoides on the Production of Inflammatory Cytokines)

  • 배기상;박희제;김도윤;서상완;박경배;김병진;송제문;이경용;나철;신병철;박성주;송호준;황성연
    • 대한본초학회지
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    • 제23권3호
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    • pp.119-125
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    • 2008
  • Objectives : The purpose of this paper was to investigate the anti-inflammatory effects of extract from Teucrium veronicoides (TV) on the RAW 264.7 cells. Methods : To evaluate of anti-inflammatory of TV, we examined the cytokine productions on lipopolysacchride (LPS)-induced RAW 264.7 cells and also inhibitory mechanisms using Western blot. Furthermore, We examined LPS-induced endotoxin shock. Results : 1. Extract from TV itself does not have any cytotoxic effect. 2. Extract from TV reduced LPS-induced Nitric oxide (NO),interleukin (IL)-1b, IL-6 and IL-10, tumor necrosis factor-a (TNF-a) production in RAW 264.7 cells. 3. TV inhibited the activation of mitogen-activated protein kinases (MAPKs) such as p38, extracelluar signal-regulated kinase (ERK 1/2) and c-Jun NH2-terminal kinase (JNK) and also the degradation of inhibitory kappa B a (Ik-Ba) in the LPS-stimulated RAW 264.7 cells. 3. TV slightly increased the duration of survival after LPS-induced endotoxin shock. Conclusions : TV down-regulated LPS-induced NO and cytokines production, which could provide a clinical basis for anti-inflammatory properties of TV.

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소음인(少陰人) 보중익기탕(補中益氣湯)의 기원, 변천과정 및 구성 원리 (The Origin, Change, and Composition of Soeumin's Bojungikgi-tang)

  • 송은영;이의주;이준희;고병희
    • 사상체질의학회지
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    • 제24권1호
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    • pp.1-12
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    • 2012
  • 1. Objective : The purpose of this study is to understand the origin, changes and composition of Soeumin's Bojungikgi-tang. 2. Methods : 1) Analyzed the context of the progressive transformation of soeumin's Bojungikgi-tang in related passages from "Donguibogam (東醫寶鑑)", "Donguisusebowon Chobongwon (東醫壽世保元 草本卷)", "Donguisusebowon Gabobon (東醫壽世保元 甲午 本)", "Donguisusebowon Sinchukbon (東醫壽世保元 辛丑本)", "Dongmuyugo (東武遺稿)" 2) Examined the differences between the utilization of Soeumin's Bojungikgi-tang in pre-existing manuscripts according to pathological pattern and more specifically at a pathological stage. 3) Analyzed the total primary effect of the herbs as a prescriptive category, as well as the herbal properties of each component. 3. Results and Conclusions : 1) Originally Dongwon's Bojungikgi-tang was prescribed as a stomach & spleen organ tonifying medicine so it was easily applied and established as a prescription appropriate for Soeumin constitutional types with a weaker spleen organ. 2) From Gabobon(甲午本), Soeumin's Bojungikgi-tang was modified, excluding Bupleurum falcatum(柴胡), Cimicifuga heracleifolia (升麻) and substituting Teucrium chamaedrys(藿香), Ophiopogon japonicus(蘇葉) which are herbs appropriate for the Soeumin constitutional type. 3) In the Gabobon(甲午本), the Gegi-tang which has yang raising properties is included in the Soeumin's Bojungikgi-tang. In Sinchukbon(辛丑本), the Gegi-tang of the Soeumin's Bojungikgi-tang in the Gabobon was excluded and the Gegi-tang mutated into Hwangigyeji-tang. 4) In the Gabobon(甲午本), as the Soeumin's Bojungikgi-tang was prescribed for Soeumin disease regardless of favorable-unfavorable patterns and mild-severe patterns, the stage of the disease when to prescribe Soeumin's Bojungikgi-tang was not clarified. 5) As of the Sinchukbon(辛丑本) edition, as Soeumin's prescriptions have been obvious, the soeumin's Bojungikgi-tang was applied to Mang-yang disease with Hwangigyeji-tang and Seungyangikki-tang 6) As of the Sinchukbon(辛丑本) edition, the Soeumin's Bojungikgi-tang has been applied to parients having both exterior-heat Mang-yang disease and Greater-yin disease, at the same time. 7) As of the Sinchukbon(辛丑本) edition, finally, the Soeumin's Bojungikgi-tang formula has been established as gathering Qi and middle tonification with Panax ginseng(人蔘), Astragalus membranaceus(黃芪), keeping the spleen healthy with Artractylodes japonica(白朮), keeping the spleen strong with Angelica acutiloba(當歸), rooting the spleen with Citrus reticulata(陳皮), raising Yang and middle jiao with Teucrium chamaedrys(藿香), Ophiopogon japonicus(蘇葉), middle tonification with Glycyrrhiza glabra(甘草灸), Zingiber officinale(生薑), Zizyphus jujuba(大棗).

Evaluation of Chemical Composition and In vitro Digestibility of Appennine Pasture Plants Using Yak (Bos grunniens) Rumen Fluid or Faecal Extract as Inoculum Source

  • Tufarelli, V.;Cazzato, E.;Ficco, A.;Laudadio, V.
    • Asian-Australasian Journal of Animal Sciences
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    • 제23권12호
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    • pp.1587-1593
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    • 2010
  • Pastures of the Apennines of Central Italy contribute to feed resources of high altitude (above 1,300 m sea level) grazing systems. The objective of this study was to evaluate the effectiveness of faecal extract from the yak (Bos grunnienes) as an alternative microbial inoculum to rumen fluid for estimation of digestibility of several forage species. Forage samples produced at high altitude were tested in this study: four legumes (Lathyrus sativus L., Lotus corniculatus L., Onobrychis viciaefolia L. and Trifolium pratense L.), three forbs (Achillea millefolium L., Potentilla reptans L. and Teucrium flavum L.) and one grass (Brachipodyum pinnatum L.) were incubated with yak rumen fluid or faecal extract. A large variability in chemical composition was observed among the species collected. Rumen liquor and faecal samples were collected from adult healthy yak. The $Daisy^{II}$ incubator was used to evaluate the nutrient digestibility of forages using rumen liquor as control and faecal extract as alternative microbial inoculum sources. Filter bags containing samples of browse species were added to the four digestion vessels along with their respective inoculum and then incubated for 48 h and dry matter (DM), organic matter (OM), crude protein (CP), neutral and detergent fiber (NDF) digestibility was determined. There was a significant relationship between estimates, indicating that faecal liquor has the potential to be used instead of rumen fluid for estimation of in vitro digestibility of plants. It is concluded that the $Daisy^{II}$ incubator results are appropriate for the determination of in vitro digestibility of nutrients using faecal liquor to define the potential for adaptation of yak to new pastures.

한국에서의 오이모자익 바이러스의 기주범위에 관한 연구 (Studios on the Host Range of Cucumber Mosaic Virus in Korea)

  • 정봉조;박해철;이순형
    • 한국응용곤충학회지
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    • 제14권4호
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    • pp.185-192
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    • 1975
  • 가. CMV의 기주조사결과, 43과 145종을 공시하여 27과 71종이 기주로 판명되었으며 그중 24두 57종이 Systemic mosaic을 나타내었다. 나. CM V의 새로운 기주로 확인된 식물은 쇠별꽃 쇠무릎, 아게라탐, 중대가리풀, 천인국, 지칭개, 씀바귀, 그늘취, 유채, 다닥냉이, 수염가래꽃, 좀명아주, 실사초, 깨풀, 새콩, 벌노랑이, 팥, 큰기린초, 들깨풀, 들깨, 개곽량, 아마, 주름잎, 버어베나의 24종이 판명되었다. 다. 다른 연구자의 보고에는 감수성으로 나타났으나 본 시험에서 음성으로 나타난 식물은 양파, 맨드라미, 당근, 쑥, 과꽃, 망초, 해바라기, 만수국, 봉선화, 양배추, 배추, 스위트알리슘, 무, 고구마, 대두, 강남콩, 나팔백합, 양귀비, 수수, 밀, 옥수수, 소루쟁이, 채송화 등 23종이었다.

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보길도(전남) 적자봉 일대의 관속식물상 유형별 특성 (Characteristics Type of Vascular Plants in Jeokjabong, Bogil Island(Jeonnam))

  • 오현경;변무섭
    • 한국환경복원기술학회지
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    • 제14권4호
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    • pp.25-40
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    • 2011
  • The vascular plants in Jeokjabong, Bogil Island were listed 350 taxa composed of 89 families, 233 genera, 309 species, 1 subspecies, 36 varieties and 4 forms. Divided into woody plants were 142 taxa (40.6%) and herbaceous plants were 208 taxa (59.4%). Based on the list of rare and endangered species by Korea Forest Service and Korea National Arboretum, 3 taxa were recorded; Celtis choseniana, Asarum maculatum, Rubus sorbifolius, and endemic plants, 10 taxa were recorded; Asarum maculatum, Cephalotaxus koreana, Carpinus coreana, Celtis choseniana, Lespedeza maritima, Indigofera koreana, Dendropanax morbifera, Ligustrum quihoui var. latifolium, Weigela subsessilis, Carex okamotoi, and plant species subject to permission for taking abroad, 4 taxa were recorded; Celtis choseniana, Asarum maculatum, Vaccinium oldhami, Carex okamotoi. Based on the list of floristic regional indicator plants by Korean Ministry of Environment were total 64 taxa (18.3% of all 350 taxa of vascular plants); Ligustrum quihoui var. latifolium in class IV, 19 taxa (Stauntonia hexaphylla, Cinnamomum japonicum, Zanthoxylum ailanthoides, Daphniphyllum macropodum, Centella asiatica, Verbena officinalis, Mitchella undulata, etc.) in class III, 5 taxa (Potentilla dickinsii, Ostericum melanotilingia, Sanicula rubriflora, Caryopteris incana, Teucrium veronicoides) in class II and 39 taxa (Gleichenia dichotoma, Cyrtomium fortunei, Aphananthe aspera, Rubus hirsutus, Meliosma myriantha, Hedera rhombea, Ainsliaea apiculata, etc.) in class I. Based on the list of naturalized plants, 5 families, 17 genera, 20 taxa (Phytolacca americana, Lepidium virginicum, Robinia pseudo-acacia, Verbesina alternifolia, Lolium perenne, etc.) and naturalization rate was 5.7% of all 350 taxa of vascular plants. Hereafter natural ecosystem into disturbance on naturalized plants and legal protection species and rare and endangered species distribute in the Bogil Island, precision investigation after management counterplan of the monitoring a point of view be required.