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http://dx.doi.org/10.7314/APJCP.2014.15.2.785

Anticancer Properties of Teucrium persicum in PC-3 Prostate Cancer Cells  

Tafrihi, Majid (Department of Cell and Molecular Biology, University of Tehran)
Toosi, Samane (Department of Cell and Molecular Biology, University of Tehran)
Minaei, Tayebeh (Department of Cell and Molecular Biology, University of Tehran)
Gohari, Ahmad Reza (Medicinal Plants Research Center, Tehran University of Medical Sciences)
Niknam, Vahid (Department of Botany, School of Biology, University of Tehran)
Arab Najafi, Seyed Mahmoud (Department of Cell and Molecular Biology, University of Tehran)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.2, 2014 , pp. 785-791 More about this Journal
Abstract
Crude extracts or phytochemicals obtained from some plants have potential anti-cancer properties. Teucrium persicum is an Iranian endemic plant belonging to the Lamiaceae family which has traditionally been used to relieve abdominal pains. However, the anti-cancer properties of this species of the Teucrium genus have not been investigated previously. In this study, we have used a highly invasive prostate cancer cell line, PC-3, which is an appropriate cell system to study anti-tumor properties of plants. A methanolic extract obtained from T persicum potently inhibited viability of PC-3 cells. The viability of SW480 colon and T47D breast cancer cells was also significantly decreased in the presence of the T persicum extract. Flow cytometry suggested that the reduction of cell viability was due to induction of apoptosis. In addition, the results of wound healing and gelatin zymography experiments supported anti-cell invasion activity of T persicum. Interestingly, sublethal concentrations of T persicum extract induced an epithelial-like morphology in a subpopulation of cells with an increase in E-Cadherin and ${\beta}$-Catenin protein levels at the cell membrane. These results strongly suggest that T persicum is a plant with very potent anti-tumor activity.
Keywords
Teucrium persicum; PC-3 cells; epithelioid morphology; anti-tumor activity;
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